Viedma ripening: a reliable crystallisation method to reach single chirality

Deracemization of conglomerates through Viedma ripening and asymmetric auto-catalysis with the Soai reaction have recently undergone significant progress.

“The topic has recently undergone significant progress thanks to numerous theoretical models and experimental validations, namely the deracemization of conglomerates through Viedma ripening 55 and the asymmetric auto-catalysis with the Soai reaction.56”

Viedma ripening was exploited for deracemization of conglomerate-forming achiral or chiral compounds.

“Viedma ripening was exploited for deracemization of conglomerate-forming achiral or chiral compounds (Fig. 15).55,382”

Under conditions of rare crystal nucleation, rapid growth, and fast racemization in solution, only monomers with chirality matching the primary nuclei crystallize, leading to SMSB.

“Under these circumstances, only monomers with matching chirality to the primary nuclei crystallize leading to SMSB.55,355”

A racemic mixture can result from a chemical reaction involving prochiral starting materials.

“The racemic mixture can result from chemical reaction involving prochiral starting materials (c).”

Primary nucleation of an enantiopure 'Eve crystal' of random chirality is slightly amplified by growing under static conditions and strongly amplified by secondary nucleation with magnetic stirring.

“Primary nucleation of an enantiopure 'Eve crystal' of random chirality, slightly amplified by growing under static conditions (top, Havinga-like), or strongly amplified by secondary nucleation thanks to magnetic stirring (bottom, Kondepudi-like) from rapidly racemizing chiral molecules, (S) and (R), or achiral molecules, A.”

Viedma ripening allows the preparation of enantiopure molecules displaying potent therapeutic activities.

“One example is the Viedma ripening, which allows the preparation of enantiopure molecules displaying potent therapeutic activities.”