Milk proteins as a source of tryptophan-containing bioactive peptides
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Tryptophan (W) is an essential amino acid which is primarily required for protein synthesis. It also acts as a precursor of key biomolecules for human health (serotonin, melatonin, tryptamine, niacin, nicotinamide adenine dinucleotide (NAD), phosphorylated NAD (NADP), quinolinic acid, kynureric acid, etc.). Among dietary proteins, milk proteins are particularly rich in W. W residues within milk proteins may be released by proteolytic/peptidolytic enzymes either as a free amino acid or as part of peptide sequences. Different W-containing peptides originating from milk proteins have been shown in vitro to display a wide range of bioactivities such as angiotensin converting enzyme (ACE) inhibition along with antioxidant, antidiabetic and satiating related properties. Free W has been shown in certain instances to have an effect on cognition and the aforementioned bioactive properties. However, a higher bioactive potency has generally been observed with specific W-containing peptides compared to free W. Since W is thermolabile, the impact of processing on the stability of W-containing peptides needs to be considered. Milk protein-derived W-containing peptides may have significant potential as natural health promoting agents in humans.
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Milk-based proteins can be digested via gastrointestinal peptidases to tryptophan-containing peptides, which in cell and biochemical assays can have biological activities that may positively impact human physiology from blood pressure control to satiation.
“Milk based proteins in particular can be digested via gastrointestinal peptidases to tryptophan containing peptides, which in cell and biochemical based assays can have biological activities which may positively impact human physiology from blood pressure control to satiation [114].”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [114]
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Sánchez, A., & Vázquez, A. (2017) · Food Quality and Safety · doi:10.1093/fqs/fyx006 · Cited by 868 · see citing works
New strategies in sport nutrition to increase exercise performance
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- Authors
- Nongonierma, A. B., & FitzGerald, R. J.
- Affiliations
- University of Limerick (IE)
- Corresponding author
- FitzGerald, Richard J.
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 6
- Issue
- 7
- Pages
- 2115-2127
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W2145870957
- Cited by
- 83
- References
- 128
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 3
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- University of Limerick Institutional Repository (University of Limerick) (acceptedVersion, cc-by-nc-sa)
- University of Limerick Institutional Repository (University of Limerick) (acceptedVersion, other-oa)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Figshare (submittedVersion, cc-by-nc-sa)
- University of Limerick Institutional Repository (University of Limerick)
- Funders
- Enterprise Ireland (TC2013-0001)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
- Keywords
- tryptophan, milk protein, bioactive peptides, tryptophan-containing peptides, free tryptophan, proteolytic enzymes, angiotensin-converting enzyme inhibition, antioxidant activity, antidiabetic activity, satiety, thermolability, food processing, health-promoting peptides, serotonin precursor
- MeSH terms
- Animals, Humans, Hydrolysis, Milk Proteins, Peptides, Tryptophan
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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