Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing
Open accessAbstract
We fabricated a micropump for reciprocating, zero-net-volume intracochlear drug delivery.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The battery had a stretchability of 300% with a capacity density of approximately 1.1 mAh cm−2.
“The battery had a stretchability of 300% with a capacity density of ≈1.1 mAh cm−2 (Figure 8 a).”
From Wearables in Medicine (2018) · cites this paper as [187]
The Methods (§2.1) describe a flexible membrane and fluidic capacitors in a micropump; the Results (§3.1) report fluid-delivery performance. Searches for battery stretchability, 300%, and capacity density found no passage in our copy addressing the claimed battery measurements. (LLM, conf=0.77)
Experimental — accuracy not yet measuredA wireless charging system was designed with 1 mm spaced coils, where the received power by the receiving coil was 9.2 mW, showing a DC output of 3.0 V with an efficiency of 4.9%.
“A wireless charging system was designed with 1 mm spaced coils, where the received power by the receiving coil was 9.2 mW, showing a DC output of 3.0 V with an efficiency of 4.9%.187”
From Wearables in Medicine (2018) · cites this paper as [187]
Methods §2.3 says the experimental controller was connected by cable and powered from a wall outlet. Our copy does not address a wireless charging system or report the claimed coil spacing, received power, DC output, or efficiency (searched for wireless charging, receiving coils, and those values). (LLM, conf=0.76)
Experimental — accuracy not yet measuredA rechargeable Li-ion battery has been fabricated from low-modulus silicone elastomers as substrates, segmented active components, and interconnected structures.
“A rechargeable Li‐ion battery has been fabricated from low‐modulus silicone elastomers as substrates, segmented active components, and interconnected structures.187”
From Wearables in Medicine (2018) · cites this paper as [187]
The Methods (sections 2.2–2.3; page unavailable) describe materials and fabrication of a drug-delivery micropump, not a rechargeable Li-ion battery. Searches for Li-ion batteries, silicone elastomer substrates, and segmented active components found no passage addressing the claimed battery fabrication. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cochlear implants: A remarkable past and a brilliant future
Wilson, B. S., & Dorman, M. F. (2008) · Hearing Research · doi:10.1016/j.heares.2008.06.005 · Cited by 875 · see citing works
Mizutari, K., Fujioka, M., Hosoya, M., Bramhall, N. F., Okano, H. J., Okano, H., & Edge, A. S. B. (2013) · Neuron · doi:10.1016/j.neuron.2012.10.032 · Cited by 398 · see citing works
Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons
Richardson, R. T., Wise, A. K., Thompson, B. C., Flynn, B. O., Atkinson, P. J., Fretwell, N. J., Fallon, J. B., Wallace, G. G., Shepherd, R. K., Clark, G. M., et al. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.015 · Cited by 304 · see citing works
Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy
Haynes, D. S., O'Malley, M., Cohen, S., Watford, K., & Labadie, R. F. (2007) · The Laryngoscope · doi:10.1097/01.mlg.0000245058.11866.15 · Cited by 289 · see citing works
Thorne, M. C., Salt, A. N., DeMott, J. E., Henson, M. M., Henson, O. W., & Gewalt, S. L. (1999) · The Laryngoscope · doi:10.1097/00005537-199910000-00021 · Cited by 251 · see citing works
Sound Strategies for Hearing Restoration
Géléoc, G. S. G., & Holt, J. R. (2014) · Science · doi:10.1126/science.1241062 · Cited by 240 · see citing works
Inner ear drug delivery for auditory applications
Swan, E. E. L., Mescher, M. J., Sewell, W. F., Tao, S. L., & Borenstein, J. T. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.08.001 · Cited by 217 · see citing works
Self-citationNew treatment options for hearing loss
Müller, U., & Gillespie, P. G. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4533 · Cited by 189 · see citing works
Local inner-ear drug delivery and pharmacokinetics
Salt, A. N., & Plontke, S. K. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03574-9 · Cited by 180 · see citing works
Labyrinthine Barriers and Cochlear Homeostasis
Juhn, S. K., & Rybak, L. P. (1981) · Acta Oto-Laryngologica · doi:10.3109/00016488109138538 · Cited by 169 · see citing works
Plontke, S. K., Löwenheim, H., Mertens, J., Engel, C., Meisner, C., Weidner, A., Zimmermann, R., Preyer, S., Koitschev, A., & Zenner, H. (2009) · The Laryngoscope · doi:10.1002/lary.20074 · Cited by 162 · see citing works
Blood-labyrinth barrier and fluid dynamics of the inner ear.
Juhn, S. K., Hunter, B. A., & Odland, R. M. (2001) · PubMed · Cited by 140 · see citing works
Intratympanic Steroid Treatment: A Review
Doyle, K. J., Bauch, C. D., Battista, R. A., Beatty, C. W., Hughes, G. B., Mason, J., Maw, J., & Musiek, F. E. (2004) · Otology & Neurotology · doi:10.1097/00129492-200411000-00031 · Cited by 104 · see citing works
The AMPA receptors of auditory neurons
Parks, T. N. (2000) · Hearing Research · doi:10.1016/s0378-5955(00)00122-2 · Cited by 101 · see citing works
Keynote review: The auditory system, hearing loss and potential targets for drug development
Holley, M. C. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03595-6 · Cited by 83 · see citing works
Inner ear drug delivery via a reciprocating perfusion system in the guinea pig
Chen, Z., Kujawa, S. G., McKenna, M. J., Fiering, J. O., Mescher, M. J., Borenstein, J. T., Swan, E. E. L., & Sewell, W. F. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.003 · Cited by 78 · see citing works
Self-citationComparing octaves, frequency ranges, and cochlear-map curvature across species
Greenwood, D. D. (1996) · Hearing Research · doi:10.1016/0378-5955(95)00229-4 · Cited by 71 · see citing works
Morphometric Comparison of Endolymphatic and Perilymphatic Spaces in Human Temporal Bones
Igarashi, M., �Ohashi, K., & Ishii, M. (1986) · Acta Oto-Laryngologica · doi:10.3109/00016488609132823 · Cited by 65 · see citing works
Quantitative anatomy of the round window and cochlear aqueduct in guinea pigs
Ghiz, A. F., Salt, A. N., DeMott, J. E., Henson, M. M., Henson, O. W., & Gewalt, S. L. (2001) · Hearing Research · doi:10.1016/s0378-5955(01)00375-6 · Cited by 61 · see citing works
Development of a Microfluidics-Based Intracochlear Drug Delivery Device
Sewell, W. F., Borenstein, J. T., Chen, Z., Fiering, J., Handzel, O., Holmboe, M., Kim, E. S., Kujawa, S. G., McKenna, M. J., Mescher, M. M., et al. (2009) · Audiology and Neurotology · doi:10.1159/000241898 · Cited by 57 · see citing works
Self-citationBuckingham, R. A., & Valvassori, G. E. (2001) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348940111000204 · Cited by 56 · see citing works
Littman, T. A., Bobbin, R. P., Fallon, M., & Puel, J. (1989) · Hearing Research · doi:10.1016/0378-5955(89)90098-1 · Cited by 54 · see citing works
Bobbin, R. P., & Ceasar, G. (1987) · Hearing Research · doi:10.1016/0378-5955(87)90081-5 · Cited by 51 · see citing works
Inner Ear Therapy for Neural Preservation
Richardson, R. T., Noushi, F., & O’Leary, S. J. (2006) · Audiology and Neurotology · doi:10.1159/000095896 · Cited by 51 · see citing works
The measurement and manipulation of intralabyrinthine pressure in experimental endolymphatic hydrops
Andrews, J. C., Böhmer, A. B., & Hoffman, L. F. (1991) · The Laryngoscope · doi:10.1288/00005537-199106000-00015 · Cited by 50 · see citing works
Kim, E. S., Gustenhoven, E., Mescher, M. J., Swan, E. E. L., Smith, K. A., Spencer, A. J., Tandon, V., Borenstein, J. T., & Fiering, J. O. (2013) · Lab on a Chip · doi:10.1039/c3lc51105g · Cited by 49 · see citing works
Self-citationHydrostatic pressure measurement of endolymph and perilymph in the guinea pig cochlea
Yoshida, M., & Lowry, L. D. (1984) · American Journal of Otolaryngology · doi:10.1016/s0196-0709(84)80007-1 · Cited by 44 · see citing works
Local drug delivery with a self-contained, programmable, microfluidic system
Fiering, J. O., Mescher, M. J., Swan, E. E. L., Holmboe, M. E., Murphy, B. A., Chen, Z., Peppi, M., Sewell, W. F., McKenna, M. J., Kujawa, S. G., et al. (2008) · Biomedical Microdevices · doi:10.1007/s10544-008-9265-5 · Cited by 43 · see citing works
Self-citationFridberger, A., van Maarseveen, J. T. P. W., Scarfone, E., Ulfendahl, M., Flock, B., & Flock, Å. (1997) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1997.00214.x · Cited by 42 · see citing works
Tandon, V., Kang, W. S., Spencer, A. J., Kim, E. S., Pararas, E. E. L., McKenna, M. J., Kujawa, S. G., Mescher, M. J., Fiering, J. O., Sewell, W. F., et al. (2015) · Biomedical Microdevices · doi:10.1007/s10544-014-9923-8 · Cited by 34 · see citing works
Self-citationMescher, M. J., Swan, E. E. L., Fiering, J. O., Holmboe, M. E., Sewell, W. F., Kujawa, S. G., McKenna, M. J., & Borenstein, J. T. (2009) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2009.2015484 · Cited by 33 · see citing works
Self-citationKinetics of reciprocating drug delivery to the inner ear
Swan, E. E. L., Chen, Z., Fiering, J. O., Mescher, M. J., Kim, E. S., McKenna, M. J., Kujawa, S. G., Borenstein, J. T., & Sewell, W. F. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.02.021 · Cited by 32 · see citing works
Self-citationDefourny, J., Sánchez, S. M., Schoonaert, L., Robberecht, W., Davy, A., Nguyen, L., & Malgrange, B. (2015) · Nature Communications · doi:10.1038/ncomms8017 · Cited by 30 · see citing works
Tracing neurotrophin-3 diffusion and uptake in the guinea pig cochlea
Richardson, R. T., Wise, A. K., O’Leary, S. J., Hardman, J., CASLEY, D. J., & Clark, G. M. (2004) · Hearing Research · doi:10.1016/j.heares.2004.02.012 · Cited by 29 · see citing works
Dynamics of Inner Ear Pressure Change Caused by Intracranial Pressure Manipulation in the Guinea Pig
Laurens-Thalen, E. O., Wit, H. P., Segenhout, J. M., & Albers, F. W. J. (2001) · Acta Oto-Laryngologica · doi:10.1080/00016480117641 · Cited by 28 · see citing works
Non-Ototoxic Local Delivery of Bisphosphonate to the Mammalian Cochlea
Kang, W. S., Sun, S., Nguyen, K., Kashemirov, B. A., McKenna, C. E., Hacking, S. A., Quesnel, A. M., Sewell, W. F., McKenna, M. J., & Jung, D. H. (2015) · Otology & Neurotology · doi:10.1097/mao.0000000000000786 · Cited by 27 · see citing works
Self-citationMaintenance of hydrostatic pressure gradients in the membranous labyrinth
B�hmer, A., & Andrews, J. C. (1989) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/bf00454138 · Cited by 27 · see citing works
Handzel, O., Wang, H., Fiering, J. O., Borenstein, J. T., Mescher, M. J., Swan, E. E. L., Murphy, B. A., Chen, Z., Peppi, M., Sewell, W. F., et al. (2009) · Audiology and Neurotology · doi:10.1159/000212110 · Cited by 25 · see citing works
Self-citationPharmacodynamics of adenovector distribution within the inner ear tissues of the mouse
Praetorius, M., Baker, K. B., Brough, D. E., Plinkert, P. K., & Staecker, H. (2006) · Hearing Research · doi:10.1016/j.heares.2006.07.002 · Cited by 19 · see citing works
Methods for Providing Therapeutic Agents to Treat Damaged Spiral Ganglion Neurons
Bianchi, L. M., & Raz, Y. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337454 · Cited by 19 · see citing works
On the pathomechanism of cochlear dysfunction in experimental perilymph fistulas
Böhmer, A. B. (1991) · The Laryngoscope · doi:10.1002/lary.5541011209 · Cited by 15 · see citing works
Cytochalasin D suppresses sound evoked potentials in the guinea pig cochlea
Barron, S. E., Bobbin, R. P., Guth, P. S., & Norris, C. H. (1987) · Hearing Research · doi:10.1016/0378-5955(87)90120-1 · Cited by 9 · see citing works
Neurotransmitters and synaptic transmission.
Bw, A. (1975) · PubMed · Cited by 8 · see citing works
Frontiers of auditory prosthesis research: Implications for clinical practice
Pfingst, B. E. (2008) · Hearing Research · doi:10.1016/j.heares.2008.06.006 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [2]Juhn SK Hunter BA Odland RM Int Tinnitus J 2001 7 72 83 14689642
- [18]Pararas EEL Chen Z Fiering J Mescher MJ Kim ES McKenna MJ Kujawa SG Borenstein JT Sewell WF J Control Release 2011 152 270 277 21385596 PMC3114251
- [35]Agranoff BW Fed Proc 1975 34 1911 1914 239869
- [38]Böhmer A Andrews JC Arch Otorhinolaryngol 1989 246 65 66 2735833
Cited by
Sorted by citations
Yetisen, A. K., Martinez‐Hurtado, J. L., Ünal, B., Khademhosseini, A., & Butt, H. (2018) · Advanced Materials · doi:10.1002/adma.201706910 · Cited by 569 · see citing works
Narayanamurthy, V., Jeroish, Z. E., Bhuvaneshwari, K. S., Bayat, P., Premkumar, R., Samsuri, F., & Yusoff, M. M. (2020) · RSC Advances · doi:10.1039/d0ra00263a · Cited by 237 · see citing works
Azizgolshani, H., Coppeta, J. R., Vedula, E. M., Marr, E. E., Cain, B. P., Luu, R. J., Lech, M. P., Kann, S. H., Mulhern, T. J., Tandon, V., et al. (2021) · Lab on a Chip · doi:10.1039/d1lc00067e · Cited by 227 · see citing works
Self-citationMicrofluidics for Drug Development: From Synthesis to Evaluation
Liu, Y., Sun, L., Zhang, H., Shang, L., & Zhao, Y. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01289 · Cited by 209 · see citing works
Recent Advances in Intelligent Wearable Medical Devices Integrating Biosensing and Drug Delivery
Tan, M., Xu, Y., Gao, Z., Yuan, T., Liu, Q., Yang, R., Zhang, B., & Peng, L. (2022) · Advanced Materials · doi:10.1002/adma.202108491 · Cited by 187 · see citing works
Inner ear drug delivery: Recent advances, challenges, and perspective
Hao, J., & Li, S. K. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.05.020 · Cited by 114 · see citing works
Coppeta, J. R., Mescher, M. J., Isenberg, B. C., Spencer, A. J., Kim, E., Lever, A., Mulhern, T. J., Prantil‐Baun, R., Comolli, J. C., & Borenstein, J. T. (2016) · Lab on a Chip · doi:10.1039/c6lc01236a · Cited by 101 · see citing works
Self-citationApplication of Microfluidics in Wearable Devices
Chen, G., Zheng, J., Liu, L., & Xu, L. (2019) · Small Methods · doi:10.1002/smtd.201900688 · Cited by 88 · see citing works
Mohseni‐Dargah, M., Falahati, Z., Pastras, C. J., Khajeh, K., Mukherjee, P., Razmjou, A., Stefani, S. P., & Asadnia, M. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116972 · Cited by 83 · see citing works
Inner Ear Drug Delivery for Sensorineural Hearing Loss: Current Challenges and Opportunities
Liu, S. S., & Yang, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.867453 · Cited by 74 · see citing works
Shroff, T., Aina, K. O., Maaß, C., Cipriano, M., Lambrecht, J., Tacke, F., Mosig, A. S., & Loskill, P. (2022) · Open Biology · doi:10.1098/rsob.210333 · Cited by 69 · see citing works
Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss
Xu, K., Xu, B., Gu, J., Wang, X., Chen, Y., & Chen, Y. (2023) · Theranostics · doi:10.7150/thno.83383 · Cited by 64 · see citing works
A nanoliter resolution implantable micropump for murine inner ear drug delivery
Forouzandeh, F., Zhu, X., Alfadhel, A., Ding, B., Walton, J. P., Cormier, D., Frisina, R. D., & Borkholder, D. A. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.032 · Cited by 61 · see citing works
Microdosing for drug delivery application—A review
Bußmann, A. B., Grünerbel, L., Durasiewicz, C. P., Thalhofer, T., Wille, A., & Richter, M. (2021) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2021.112820 · Cited by 59 · see citing works
Advances in Valveless Piezoelectric Pumps
Yan, Q., Yin, Y., Sun, W., & Fu, J. (2021) · Applied Sciences · doi:10.3390/app11157061 · Cited by 56 · see citing works
Vaisbuch, Y., & Maria, P. L. S. (2018) · Otolaryngologic Clinics of North America · doi:10.1016/j.otc.2018.03.002 · Cited by 45 · see citing works
Inner Ear Therapeutics: An Overview of Middle Ear Delivery
Patel, J. J., Szczupak, M., Rajguru, S. M., Balaban, C. D., & Hoffer, M. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00261 · Cited by 40 · see citing works
Schneider, S., Bubeck, M., Rogal, J., Weener, H. J., Rojas, C., Weiß, M., Heymann, M., van der Meer, A. D., & Loskill, P. (2021) · Lab on a Chip · doi:10.1039/d1lc00494h · Cited by 40 · see citing works
Soenksen, L. R., Kassis, T., Noh, M., Griffith, L. G., & Trumper, D. L. (2018) · Lab on a Chip · doi:10.1039/c7lc01223c · Cited by 36 · see citing works
A 3D Microscaffold Cochlear Electrode Array for Steroid Elution
Jang, J., Kim, J., Kim, Y. C., Kim, S., Chou, N., Lee, S., Choung, Y., Kim, S., Brügger, J., Choi, H., et al. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900379 · Cited by 34 · see citing works
Performance analysis of valveless piezoelectric pump with dome composite structures
He, L., Zhao, D. Z., Li, W., Xu, Q., & Cheng, G. (2019) · Review of Scientific Instruments · doi:10.1063/1.5084307 · Cited by 30 · see citing works
Performance evaluation and comparison of a serial–parallel hybrid multichamber piezoelectric pump
Zhang, Z., Chen, S., Wang, S., Kan, J., Wen, J., & Yang, C. (2018) · Journal of Intelligent Material Systems and Structures · doi:10.1177/1045389x18758181 · Cited by 30 · see citing works
Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials
Dash, S., Zuo, J., & Steyger, P. S. (2022) · Pharmaceuticals · doi:10.3390/ph15091115 · Cited by 28 · see citing works
Park, S. M., Eom, S., Hong, H., Yoon, J., Lee, S. J., Kim, B. C., Kim, H. W., & Kim, D. S. (2018) · Microelectronic Engineering · doi:10.1016/j.mee.2018.10.010 · Cited by 28 · see citing works
Biomaterial-based drug delivery systems in the treatment of inner ear disorders
Cheng, H., Zhang, B., Jiang, P., Liao, M., Gao, X., Xu, D., Wang, Y., Hu, Y., Wang, H., Liu, T., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03368-0 · Cited by 27 · see citing works
Intracochlear drug delivery systems: a novel approach whose time has come
Peppi, M., Marie, A., Belline, C., & Borenstein, J. T. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1444026 · Cited by 25 · see citing works
Self-citationLehner, E., Menzel, M., Gündel, D., Plontke, S. K., Mäder, K., Klehm, J., Kielstein, H., & Liebau, A. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00914-9 · Cited by 23 · see citing works
Mansouri, M., Ahmed, A., Ahmad, S. D., McCloskey, M. C., Joshi, I. M., Gaborski, T. R., Waugh, R. E., McGrath, J. L., Day, S. W., & Abhyankar, V. V. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200802 · Cited by 19 · see citing works
Rational Design of Inner Ear Drug Delivery Systems
Maimaitikelimu, X., Xuan, Z., Ren, H., Chen, K., Zhang, H., & Wang, H. (2025) · Advanced Science · doi:10.1002/advs.202410568 · Cited by 18 · see citing works
Astor, T. L., & Borenstein, J. T. (2022) · Artificial Organs · doi:10.1111/aor.14266 · Cited by 18 · see citing works
Self-citationElectronically powered drug delivery devices: considerations and challenges
Liu, G., Lu, Y., Zhang, F., & Liu, Q. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2141709 · Cited by 18 · see citing works
A Wirelessly Controlled Scalable 3D-Printed Microsystem for Drug Delivery
Forouzandeh, F., Ahamed, N. N. N., Zhu, X., Bazard, P., Goyal, K., Walton, J. P., Frisina, R. D., & Borkholder, D. A. (2021) · Pharmaceuticals · doi:10.3390/ph14060538 · Cited by 16 · see citing works
Zhang, G., Chen, Y., Zhou, W., Chen, C., & Liu, Y. (2023) · Small Science · doi:10.1002/smsc.202300043 · Cited by 15 · see citing works
Animal model studies yield translational solutions for cochlear drug delivery
Frisina, R. D., Budzevich, M. M., Zhu, X., Martinez, G. V., Walton, J. P., & Borkholder, D. A. (2018) · Hearing Research · doi:10.1016/j.heares.2018.05.002 · Cited by 14 · see citing works
Fused deposition modelling 3D printing proof-of-concept study for personalised inner ear therapy
Haddow, O., Mathew, E., & Lamprou, D. A. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab147 · Cited by 13 · see citing works
State-of-the-art methods in clinical intracochlear drug delivery
Chin, O. Y., & Diaz, R. C. (2019) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/moo.0000000000000566 · Cited by 13 · see citing works
Microtechnologies for inner ear drug delivery
Forouzandeh, F., & Borkholder, D. A. (2020) · Current Opinion in Otolaryngology & Head & Neck Surgery · doi:10.1097/moo.0000000000000648 · Cited by 13 · see citing works
A passive Stokes flow rectifier for Newtonian fluids
Mehboudi, A., & Yeom, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-89699-y · Cited by 11 · see citing works
Bhushan, B. M., Yoon, J. Y., Griffith, L. G., & Trumper, D. L. (2020) · IEEE/ASME Transactions on Mechatronics · doi:10.1109/tmech.2020.3038885 · Cited by 10 · see citing works
Jackler, R. K., & Jan, T. A. (2019) · The Journal of Laryngology & Otology · doi:10.1017/s0022215119001531 · Cited by 9 · see citing works
Zhou, J., Sun, W., Fu, J., Liu, H., Wang, H., & Yan, Q. (2022) · Micromachines · doi:10.3390/mi13101621 · Cited by 7 · see citing works
A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery
Ayoob, A. M., Peppi, M., Tandon, V., Langer, R., & Borenstein, J. T. (2018) · Hearing Research · doi:10.1016/j.heares.2018.03.026 · Cited by 7 · see citing works
Self-citationEmerging trends in biosensor and microfluidics integration for inner ear theragnostics
Aghajanloo, B., Nazarnezhad, S., Arshadi, F., Kottapalli, A. G. P., Pastras, C. J., & Asadnia, M. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.117588 · Cited by 6 · see citing works
Hwang, S. H., Gonzalez‐Suarez, A. M., Stybayeva, G., & Revzin, A. (2020) · Clinical and Experimental Otorhinolaryngology · doi:10.21053/ceo.2020.00626 · Cited by 6 · see citing works
Ayoob, A. M., Peppi, M., Tandon, V., Langer, R., & Borenstein, J. T. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.09.007 · Cited by 6 · see citing works
Self-citationProspection of Microfluidics for Local Drug Delivery
Naveen, N. R., Dornadula, G., Prakash Goudanavar, S. O. P., Chagaleti, B. K., & Gunturu, L. N. (2022) · Current Drug Targets · doi:10.2174/1389450123666220404154710 · Cited by 5 · see citing works
Li, H., Chen, J., Zhang, J., Zhang, J., Zhao, G., & Wang, L. (2018) · Micromachines · doi:10.3390/mi9040182 · Cited by 5 · see citing works
Research on output performance of valve-less piezoelectric pump with multi-cone-shaped tubes
He, L., Wu, X., Hu, D., Zhang, Z., Yu, B., & Cheng, G. (2020) · Microsystem Technologies · doi:10.1007/s00542-020-05009-y · Cited by 5 · see citing works
Energy-efficient self-locking micropump system using single bi-stable electromagnetic actuator
Kim, E. K., Kang, B. M., Lee, H. G., Yoon, H. M., Kim, J. H., Jung, J. W., & Yoon, J. Y. (2023) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2023.114173 · Cited by 4 · see citing works
Self-citationManipulating fluid with vibrating 3D-printed paddles for applications in micropump
Tang, Z., Shao, X., Huang, J., Yao, J., & Ding, G. (2019) · Nanotechnology and Precision Engineering · doi:10.1016/j.npe.2019.08.001 · Cited by 3 · see citing works
Forouzandeh, F., Alfadhel, A., Zhu, X., Walton, J. P., Cormier, D., Frisina, R. D., & Borkholder, D. A. (2018) · Solid-State Sensors, Actuators, and Microsystems Workshop (Hilton Head Workshop) · doi:10.31438/trf.hh2018.11 · Cited by 3 · see citing works
ALZET pump implantation in mice for chronic drug delivery to the cochlea
Depreux, F. F. S., Whitlon, D. S., & Richter, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-20395-x · Cited by 2 · see citing works
Deep Volumetric Segmentation of Murine Cochlear Compartments from Micro-Computed Tomography Images
Moudgalya, S. S., Cahill, N. D., & Borkholder, D. A. (2020) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc44109.2020.9176596 · Cited by 2 · see citing works
Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss
Frisina, R. D., Cruz, C. J., Williamson, T. T., Zhu, X., & Ding, B. (2020) · Springer handbook of auditory research · doi:10.1007/978-3-030-49367-7_12 · Cited by 2 · see citing works
Outer hair cells stir cochlear fluidsPreprint
Lee, C., Shokrian, M., Henry, K. S., Carney, L. H., Holt, J. C., & Nam, J.-H. (2024) · eLife · doi:10.7554/elife.101943 · Cited by 2 · see citing works
Hovev, Z., Moverman, D. J., Quesnel, A. M., & Handzel, O. (2025) · Audiology and Neurotology · doi:10.1159/000548540 · Cited by 1 · see citing works
Otic Drug Delivery Systems: Current and Future Perspectives
Yapar, E. A., Esentürk‐Güzel, İ., Özdemir, M. N., & Abdo, L. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128373749251002102552 · Cited by 1 · see citing works
Engineered Inner Ear Drug Delivery Systems for Hearing Loss Treatment
Xuan, Z., Maimaitikelimu, X., Zhan, J., Li, M., Gan, J., & Wang, H. (2026) · Research · doi:10.34133/research.1396 · Cited by 1 · see citing works
Sound-induced drug distribution in the cochlea, how close are we? A PRISMA scoping review
Gargula, S., Ebode, D., Meister, L., Radulesco, T., & Michel, J. (2024) · International Journal of Audiology · doi:10.1080/14992027.2024.2389465 · Cited by 1 · see citing works
Wearable Sensors for Wound Diagnosis and Close‐Loop Therapeutics
Peng, L., Zhao, J., & Tan, M. (2024) · Wiley eBooks · doi:10.1002/9783527841080.ch9 · Cited by 1 · see citing works
Li, H., Chen, J., Zhang, J., & Wang, L. (2018) · IEEE International Conference on Nano/Micro Engineered and Molecular Systems · doi:10.1109/nems.2018.8557017
Controlled Drug Delivery via the Otic Route
Hao, J., & Li, S. K. (2021) · Wiley eBooks · doi:10.1002/9781119769644.ch15
Treating Sensorineural Hearing Loss: Recent Advances in Inner Ear Drug Delivery
Vachheta, D. N., Shah, Y. D., Athalye, M., Kakkad, D. K., & Darji, M. J. (2023) · Drug Delivery Letters · doi:10.2174/2210303113666230407082515
Design and Control of PM-biased Bi-stable Latching Actuator for Low-power Micropump
Kim, E. K., Kang, B. M., Lee, H. G., Yoon, H. M., Kim, J. H., Jung, J. W., & Yoon, J. Y. (2023) · IEEE/ASME International Conference on Advanced Intelligent Mechatronics · doi:10.1109/aim46323.2023.10196203
Self-citationCharacteristic study of valveless pump with dual outlet composite drainage structures
Li, W., Zhao, D. Z., Huang, Y., Xie, J., Li, J., & Wang, D. (2024) · Journal of Physics Conference Series · doi:10.1088/1742-6596/2787/1/012027
Outer hair cells stir cochlear fluids
Lee, C., Shokrian, M., Henry, K. S., Carney, L. H., Holt, J. C., & Nam, J.-H. (2025) · eLife · doi:10.7554/elife.101943.4
Outer hair cells stir cochlear fluidsPreprint
Lee, C., Shokrian, M., Henry, K. S., Carney, L. H., Holt, J. C., & Nam, J.-H. (2024) · eLife · doi:10.7554/elife.101943.1
Outer hair cells stir cochlear fluidsPreprint
Lee, C., Shokrian, M., Henry, K. S., Carney, L. H., Holt, J. C., & Nam, J.-H. (2024) · eLife · doi:10.7554/elife.101943.2
Outer hair cells stir cochlear fluidsPreprint
Lee, C., Shokrian, M., Henry, K. S., Carney, L. H., Holt, J. C., & Nam, J.-H. (2024) · eLife · doi:10.7554/elife.101943.3
Wearable Nanoelectronic Devices for Skin Wound Healing
Liu, Y., Jia, Z., Huang, Y., Gao, Y., Yang, L., & Zhang, D. (2025) · Journal of Nanoelectronics and Optoelectronics · doi:10.1166/jno.2025.3709
Park, J., Yun, J. H., Jang, J. H., Brügger, J., & Jang, J. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.138496
Flexible fish-tail piezoelectric pump with bidirectional pumping characteristic
Wang, N., Chen, Z., Mai, J., Li, W., Wen, Y., Zhang, J., & Zhang, F. (2025) · Review of Scientific Instruments · doi:10.1063/5.0270329
Microfabrication techniques for making organ-on-a-chip and body-on-a-chip devices
Azizgolshani, H., & Borenstein, J. T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-16110-0.00021-2
Self-citation
- Authors
- Tandon, V., Kang, W. S., Robbins, T. A., Spencer, A. J., Kim, E. S., McKenna, M. J., Kujawa, S. G., Fiering, J., Pararas, E. E. L., Mescher, M. J., Sewell, W. F., & Borenstein, J. T.
- Affiliations
- Massachusetts Eye and Ear Infirmary (US)
- Materials Engineering and Microfabrication Directorate
- Corresponding author
- Borenstein, Jeffrey T.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 16
- Issue
- 5
- Pages
- 829-846
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC4766044
- OpenAlex
- W2205058162
- Cited by
- 73
- References
- 44
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 8 · 2018: 13 · 2016: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (5 R01 DC006848-08)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Physical Sciences › Engineering › Biomedical Engineering › Intravenous Infusion Technology and Safety
- Keywords
- intracochlear drug delivery, cochlear fluid, hair cell regeneration, implantable drug delivery, DNQX, compound action potential, glutamate receptor antagonists, guinea pig model, hearing disorders
- MeSH terms
- Animals, Cochlea, Guinea Pigs, Humans, Infusion Pumps, Drug Delivery Systems, Microfluidic Analytical Techniques, Lab-On-A-Chip Devices
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
