The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy
Abstract
Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal-organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free "green" post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.
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Cited by
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
Zhou, J., Yu, G., & Huang, F. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00898d · Cited by 677
Metal-organic frameworks: mechanisms of antibacterial action and potential applications
Wyszogrodzka, G., Marszałek, B., Gil, B., & Dorożyński, P. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.04.009 · Cited by 543
Deng, X., Liang, S., Cai, X., Huang, S., Cheng, Z., Shi, Y., Pang, M., Ma, P., & Lin, J. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b01716 · Cited by 319
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Metadata
- Authors
- Wang, X.-G., Dong, Z.-Y., Cheng, H., Wan, S.-S., Chen, W.-H., Zou, M.-Z., Huo, J.-W., Deng, H.-X., & Zhang, X.-Z.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 7
- Issue
- 38
- Pages
- 16061-16070
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W1778497012
- Cited by
- 291
- References
- 65
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, X.-G., Dong, Z.-Y., Cheng, H., Wan, S.-S., Chen, W.-H., Zou, M.-Z., Huo, J.-W., Deng, H.-X., & Zhang, X.-Z. (2015). A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy. Nanoscale. https://doi.org/10.1039/c5nr04045k
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