Extrinsic plasmalogens suppress neuronal apoptosis in mouse neuroblastoma Neuro-2A cells: importance of plasmalogen molecular species
Abstract
Plasmalogen, especially those having 22:6, suppressed neuronal apoptosis via death receptor and mitochondrial pathways. These mechanisms of action of plasmalogen may be responsible for regulation of membrane functions and second messenger production.
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In murine cell lines, plasmalogens counteract neuronal death elicited by serum starvation via a process involving AKT signaling.
“Furthermore, in murine cell lines, plasmalogens seem to counteract neuronal death elicited by serum starvation [223,224] by utilizing a process, which has been reported to involve protein kinase B (AKT) signaling [224].”
From Peroxisomes in brain development and function (2016) · cites this paper as [223]
Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524 · see citing works
Oberhammer, F., Wilson, J. W., Dive, C., Morris, I. D., Hickman, J. A., Wakeling, A. E., Walker, P. R., & Sikorska, M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06042.x · Cited by 1,130 · see citing works
The Distribution and Function of Phosphatidylserine in Cellular Membranes
Leventis, P. A., & Grinstein, S. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.093008.131234 · Cited by 996 · see citing works
Calcium-dependent phospholipid scrambling by TMEM16F
Suzuki, J., Umeda, M., Sims, P. J., & Nagata, S. (2010) · Nature · doi:10.1038/nature09583 · Cited by 982 · see citing works
Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.
Sellins, K. S., & Cohen, J. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.10.3199 · Cited by 919 · see citing works
Lukiw, W. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25420 · Cited by 873 · see citing works
Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
Busciglio, J., & Yankner, B. A. (1995) · Nature · doi:10.1038/378776a0 · Cited by 741 · see citing works
Ishiyama, M., Tominaga, H., Shiga, M., Sasamoto, K., Ohkura, Y., & Ueno, K. (1996) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.19.1518 · Cited by 737 · see citing works
Colangelo, V., Schurr, J., Ball, M. J., Pelaez, R. P., Bazan, N. G., & Lukiw, W. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10351 · Cited by 517 · see citing works
Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival
Akbar, M. D., Calderón, F. H., Wen, Z., & Kim, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502903102 · Cited by 466 · see citing works
Plasmalogens the neglected regulatory and scavenging lipid species
Wallner, S., & Schmitz, G. (2011) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2011.06.008 · Cited by 324 · see citing works
Hofmann, K., Tomiuk, S., Wolff, G., & Stoffel, W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.5895 · Cited by 309 · see citing works
Inhibition of Neuronal Apoptosis by Docosahexaenoic Acid (22:6n-3)
Kim, H., Akbar, M. D., Lau, A. O. T., & Edsall, L. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004446200 · Cited by 308 · see citing works
Boissonneault, V., Plante, I., Rivest, S., & Provost, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807530200 · Cited by 301 · see citing works
Phospholipase A₂-Generated Lipid Mediators in the Brain: The Good, the Bad, and the Ugly
Farooqui, A. A., & Horrocks, L. A. (2006) · The Neuroscientist · doi:10.1177/1073858405285923 · Cited by 273 · see citing works
Diano, S., Liu, Z.-W., Jeong, J. K., Dietrich, M. O., Ruan, H., Kim, E., Suyama, S., Kelly, K., Gyengési, E., Arbiser, J. L., et al. (2011) · Nature Medicine · doi:10.1038/nm.2421 · Cited by 268 · see citing works
Goodenowe, D. B., Cook, L. L., Liu, J., Lu, Y., Jayasinghe, D., Ahiahonu, P. W. K., Heath, D., Yamazaki, Y., Flax, J., Krenitsky, K. F., et al. (2007) · Journal of Lipid Research · doi:10.1194/jlr.p700023-jlr200 · Cited by 253 · see citing works
Disease and anatomic specificity of ethanolamine plasmalogen deficiency in Alzheimer's disease brain
Ginsberg, L., Rafique, S., Xuereb, J. H., Rapoport, S. I., & Gershfeld, N. L. (1995) · Brain Research · doi:10.1016/0006-8993(95)00931-f · Cited by 248 · see citing works
Zhao, Y., Calon, F., Julien, C., Winkler, J. W., Petasis, N. A., Lukiw, W. J., & Bazan, N. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015816 · Cited by 243 · see citing works
Rouser, G., Kritchevsky, G., Simon, G., et al. (1967) · Lipids · doi:10.1007/bf02531998 · Cited by 241 · see citing works
Book Review: Plasmalogens: Workhorse Lipids of Membranes in Normal and Injured Neurons and Glia
Farooqui, A. A., & Horrocks, L. A. (2001) · The Neuroscientist · doi:10.1177/107385840100700308 · Cited by 237 · see citing works
Glaser, P. E. A., & Gross, R. W. (1994) · Biochemistry · doi:10.1021/bi00185a019 · Cited by 229 · see citing works
Peroxisomal alterations in Alzheimer’s disease
Kou, J., Kovacs, G. G., Höftberger, R., Kulik, W., Brodde, A., Forss-Petter, S., Hönigschnabl, S., Gleiss, A., Brügger, B., Wanders, R., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0836-9 · Cited by 227 · see citing works
Astarita, G., Jung, K.-M., Berchtold, N. C., Nguyen, V. Q., Gillen, D. L., Head, E., Cotman, C. W., & Piomelli, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012538 · Cited by 218 · see citing works
Yamatsuji, T., Matsui, T., Okamoto, T., Komatsuzaki, K., Takeda, S., Fukumoto, H., Iwatsubo, T., Suzuki, N., Asami-Odaka, A., Ireland, S., et al. (1996) · Science · doi:10.1126/science.272.5266.1349 · Cited by 210 · see citing works
Igarashi, M., Ma, K., Gao, F., Kim, H., Rapoport, S. I., & Rao, J. S. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101608 · Cited by 200 · see citing works
Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems
Broniec, A., Klosinski, R., Pawlak, A. M., Wrona, M., Thompson, D. H., & Sarna, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.002 · Cited by 159 · see citing works
The role of intranuclear lipids
Albi, E., & Magni, M. P. V. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2004.05.004 · Cited by 156 · see citing works
Kriem, B., Sponne, I., Fifre, A., Malaplate, C., Lozac'h‐Pillot, K., Koziel, V., Yen, F. T., Bihain, B. E., Oster, T., Olivier, J. L., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-1807fje · Cited by 152 · see citing works
NADPH oxidase is required for NMDA receptor‐dependent activation of ERK in hippocampal area CA1
Kishida, K. T., Pao, M., Holland, S. M., & Klann, E. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03189.x · Cited by 135 · see citing works
Xu, J., Weng, Y., Simonyi, Á., Krugh, B. W., Liao, Z., Weisman, G. A., & Sun, G. Y. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01145.x · Cited by 127 · see citing works
Phuyal, S., Skotland, T., Hessvik, N. P., Simolin, H., Øverbye, A., Brech, A., Parton, R. G., Ekroos, K., Sandvig, K., & Llorente, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.593962 · Cited by 126 · see citing works
Fatty acids of serine, ethanolamine, and choline plasmalogens in some marine bivalves
Kraffe, E., Soudant, P., & Marty, Y. (2004) · Lipids · doi:10.1007/s11745-004-1202-x · Cited by 122 · see citing works
Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling
Hossain, M. S., Ifuku, M., Take, S., Kawamura, J., Miake, K., & Katafuchi, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083508 · Cited by 116 · see citing works
Sun, G. Y., Xu, J., Jensen, M. D., et al. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:027 · Cited by 104 · see citing works
Park, J., Choi, H., Min, J., Kim, B., Lee, S., Yun, J. W., Choi, M., Chang, K., & Lee, D. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.12984 · Cited by 93 · see citing works
Fonteh, A. N., Chiang, J., Cipolla, M., Hale, J., Diallo, F., Chirino, A., Arakaki, X., & Harrington, M. G. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m037622 · Cited by 91 · see citing works
Docosahexaenoic acid neurolipidomics
Niemoller, T. D., & Bazan, N. G. (2009) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2009.09.005 · Cited by 89 · see citing works
Provost, P. (2010) · Aging · doi:10.18632/aging.100131 · Cited by 76 · see citing works
Plasmalogens Inhibit APP Processing by Directly Affectingγ-Secretase Activity in Alzheimer’s Disease
Rothhaar, T. L., Grösgen, S., Haupenthal, V. J., Burg, V. K., Hundsdörfer, B., Mett, J., Riemenschneider, M. J., Grimm, H. S., Hartmann, T., & Grimm, M. O. W. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/141240 · Cited by 74 · see citing works
Studies on Plasmalogen-Selective Phospholipase A2 in Brain
Farooqui, A. A. (2010) · Molecular Neurobiology · doi:10.1007/s12035-009-8091-y · Cited by 72 · see citing works
Honsho, M., Yagita, Y., Kinoshita, N., & Fujiki, Y. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.05.018 · Cited by 71 · see citing works
Strokin, M., Sergeeva, M. G., & Reiser, G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04663.x · Cited by 65 · see citing works
Ong, W.-Y., Farooqui, T., & Farooqui, A. A. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791859289 · Cited by 58 · see citing works
Plasmalogens, Docosahexaenoic Acid and Neurological Disorders
Farooqui, A. A., Ong, W., & Horrocks, L. A. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9072-3_45 · Cited by 57 · see citing works
Arachidonic acid induces both Na+ and Ca2+ entry resulting in apoptosis
Fang, K., Chang, W., Wang, S., Su, M., & Wu, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05022.x · Cited by 52 · see citing works
Preparation of Marine Plasmalogen and Selective Identification of Molecular Species by LC-MS/MS
Yamashita, S., Honjo, A., Aruga, M., et al. (2014) · Journal of Oleo Science · doi:10.5650/jos.ess13188 · Cited by 43 · see citing works
Self-citationOnodera, T., Futai, E., Kan, E., Abe, N., Uchida, T., Kamio, Y., & Kaneko, J. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu074 · Cited by 40 · see citing works
Plasmalogen-selective phospholipase A2 and its role in signal transduction
Yang, H., Farooqui, A. A., & Horrocks, L. A. (1996) · Journal of Lipid Mediators and Cell Signalling · doi:10.1016/0929-7855(96)01502-7 · Cited by 39 · see citing works
Dembitsky, V. M. (1988) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)94606-5 · Cited by 38 · see citing works
Yamashita, S., Abe, A., Nakagawa, K., et al. (2014) · Lipids · doi:10.1007/s11745-014-3957-9 · Cited by 27 · see citing works
Self-citationTNFα‐induced glutathione depletion lies downstream of cPLA2 in L929 cells
Hayter, H., Pettus, B. J., Ito, F., et al. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02967-2 · Cited by 24 · see citing works
Serrano, F., Chang, A., Hernandez, C. M., Pautler, R. G., Sweatt, J. D., & Klann, E. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-31 · Cited by 24 · see citing works
Hack, M. H., & Helmy, F. M. (1977) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)86326-8 · Cited by 23 · see citing works
Dietary Fats and Risk of Chronic Disease
Yanagita, Y., Knapp, H. R., & Huang, Y. S. (2006) · AOCS Publishing eBooks · doi:10.1201/9781439822418 · Cited by 17 · see citing works
Separation and Determination of Functional Complex Lipids from Chicken Skin
Yunoki, K., Kukino, O., Nadachi, Y., et al. (2008) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-008-1228-8 · Cited by 12 · see citing works
?2-integrins mediate a novel form of chemoresistance in cycloheximide-induced U937 apoptosis
Wu, R.-C., Wang, Z., Liu, M.-J., et al. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4165-1 · Cited by 12 · see citing works
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Peroxisomes in brain development and function
Berger, J., Dorninger, F., Forss-Petter, S., & Kunze, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.005 · Cited by 194 · see citing works
“starvation [223,224] by utilizing a process, which has been reported to involve protein kinase B (AKT) signaling [224].”
Background
- Authors
- Yamashita, S., Kanno, S., Nakagawa, K., Kinoshita, M., & Miyazawa, T.
- Affiliations
- Tohoku University (JP)
- Obihiro University of Agriculture and Veterinary Medicine (JP)
- Corresponding author
- Miyazawa, Teruo
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 5
- Issue
- 75
- Pages
- 61012-61020
- ISSN
- 2046-2069 (ISSN-L)
- OpenAlex
- W1954397360
- Cited by
- 22
- References
- 59
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- RSC Advances (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- plasmalogens, neuronal apoptosis, N2a cells, docosahexaenoic acid, death receptor signaling, mitochondrial pathway, membrane function, second messenger signaling
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