Cited by 62Hydrogels: synthesis, properties, applicationsBlock Copolymer Self-AssemblyAdvanced Polymer Synthesis and Characterization

Degradable/cytocompatible and pH responsive amphiphilic conetwork gels based on agarose-graft copolymers and polycaprolactone

Bera, Anupam, Singh Chandel, Arvind K., Uday Kumar, Chinta, Jewrajka, Suresh K.·2015·Journal of Materials Chemistry B

Abstract

Amphiphilic conetwork (APCN) gels have emerged as an important class of biomaterials due to their diverse applications. APCN gels based on biocompatible/biodegradable polymers are useful for controlled release and tissue engineering applications. Herein, we report a facile synthesis of APCN gel films by click type sequential nucleophilic substitution reaction between pendent tertiary amine groups of agarose-g-poly(methyl methacrylate)-b(co)-poly(2-dimethylamino)ethyl methacrylate [Agr-g-PMMA-b(co)-PDMA] copolymers and activated benzyl chloride groups of polychloromethyl styrene or benzyl methyl chloride terminated polycaprolactone. A linear triblock copolymer (PDMA-b-PMMA-b-PDMA) containing a central PMMA block and end PDMA blocks was also employed for the synthesis of APCN gels for comparison purposes. These APCN gels exhibit co-continuous nanophase morphology, pH responsive water swelling and pH triggered release of hydrophobic and hydrophilic drugs. These gels are biodegradable/cytocompatible as confirmed by MTT assay and hemolysis experiment. The degraded species undergo micellization in aqueous environment and display a low critical micelle concentration. Milled APCN gel particles are injectable through a hypodermic syringe. This synthesis approach is extremely useful for the preparation of a library of APCN gels of diverse architectures and compositions for biomedical applications.

Integrity signals

Registry

Crossref · 10.1039/c5tb01251a

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Grafting techniques and copolymerization with other natural or synthetic molecules can open novel facets in pH-responsive drug delivery.

    “In addition, grafting techniques and copolymerization with other natural or synthetic molecules can open novel facets in the fields of pH responsive drug delivery (Bera et al., 2015; Chandel et al., 2016; Singh Chandel and Jewrajka, 2020).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Bera, A., Singh Chandel, A. K., Uday Kumar, C., & Jewrajka, S. K.
Affiliations
  • Central Salt and Marine Chemicals Research Institute (IN)
  • Reverse Osmosis Membrane Division
Corresponding author
Jewrajka, Suresh K.
Venue
Journal of Materials Chemistry B
Published
2015
Volume
3
Issue
43
Pages
8548-8557
ISSN
  • 2050-750X (ISSN-L)
  • 2050-7518
OpenAlex
W1749181809
Cited by
62
References
39
Citations by year
2026: 4 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 16 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 6
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Materials Chemistry B (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Keywords
polycaprolactone, pH-responsive gels, click chemistry, nucleophilic substitution, drug release, biodegradable polymers, cytocompatibility, micellization, tissue engineering, controlled release

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review