Effect of polyethylene glycol on properties and drug encapsulation-release performance of biodegradable/cytocompatible agarose-polyethylene glycol-polycaprolactone amphiphilic Co-network gels
Abstract
We synthesized agarose-polycaprolactone (Agr-PCL) bicomponent and Agr-polyethylene glycol-PCL (Agr-PEG-PCL) tricomponent amphiphilic co-network (APCN) gels by the sequential nucleophilic substitution reaction between amine-functionalized Agr and activated halide terminated PCL or PCL-b-PEG-b-PCL copolymer for the sustained and localized delivery of hydrophilic and hydrophobic drugs. The biodegradability of the APCNs was confirmed using lipase and by hydrolytic degradation. These APCN gels displayed good cytocompatibility and blood compatibility. Importantly, these APCN gels exhibited remarkably high drug loading capacity coupled with sustained and triggered release of both hydrophilic and hydrophobic drugs. PEG in the APCNs lowered the degree of phase separation and enhanced the mechanical property of the APCN gels. The drug loading capacity and the release kinetics were also strongly influenced by the presence of PEG, the nature of release medium, and the nature of the drug. Particularly, PEG in the APCN gels significantly enhanced the 5-fluorouracil loading capacity and lowered its release rate and burst release. Release kinetics of highly water-soluble gemcitabine hydrochloride and hydrophobic prednisolone acetate depended on the extent of water swelling of the APCN gels. Cytocompatibility/blood compatibility and pH and enzyme-triggered degradation together with sustained release of drugs show great promise for the use of these APCN gels in localized drug delivery and tissue engineering applications.
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Grafting techniques and copolymerization with other natural or synthetic molecules can open novel facets in pH-responsive drug delivery.
“In addition, grafting techniques and copolymerization with other natural or synthetic molecules can open novel facets in the fields of pH responsive drug delivery (Bera et al., 2015; Chandel et al., 2016; Singh Chandel and Jewrajka, 2020).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Chandel et al., 2016
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- Authors
- Chandel, A. K. S., Kumar, C. U., & Jewrajka, S. K.
- Affiliations
- Central Salt and Marine Chemicals Research Institute (IN)
- Corresponding author
- Jewrajka, Suresh K.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-01-27
- Volume
- 8
- Issue
- 5
- Pages
- 3182-3192
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2239611926
- Cited by
- 98
- References
- 49
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 24 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 5 · 2017: 7 · 2016: 4
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research
- Department of Science and Technology, Ministry of Science and Technology (EMR/2015/000843)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- polyethylene glycol, drug encapsulation, sustained drug release, triggered release, 5-fluorouracil, gemcitabine hydrochloride, prednisolone acetate, biodegradability, lipase degradation, hydrolytic degradation, cytocompatibility, hemocompatibility, phase separation, mechanical properties, tissue engineering scaffolds, local drug delivery
- MeSH terms
- Drug Carriers, Ethylene Glycols, Fluorouracil, Humans, Neoplasms, Polyesters, Polyethylene Glycols, Sepharose, Drug Delivery Systems, Hydrogels, Hydrophobic and Hydrophilic Interactions, Drug Liberation
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