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Protective effects of different Bacteroides vulgatus strains against lipopolysaccharide-induced acute intestinal injury, and their underlying functional genes

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Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation

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Acetic acid and butyric acid released in large intestine play different roles in the alleviation of constipation

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Lactic acid bacteria reduce diabetes symptoms in mice by alleviating gut microbiota dysbiosis and inflammation in different manners

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Lactobacillus casei CCFM1074 Alleviates Collagen-Induced Arthritis in Rats via Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota

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A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation

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Probiotics modulate the gut microbiota composition and immune responses in patients with atopic dermatitis: a pilot study

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A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of the gut microbiota and relief from chronic constipation

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The gut microbiota alteration and the key bacteria in Astragalus polysaccharides (APS)-improved osteoporosis

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Lactobacillus paracasei 24 Attenuates Lipid Accumulation in High-Fat Diet-Induced Obese Mice by Regulating the Gut Microbiota

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Lactobacillus rhamnosus Strains Relieve Loperamide-Induced Constipation via Different Pathways Independent of Short-Chain Fatty Acids

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Lactobacillus plantarum CCFM1143 Alleviates Chronic Diarrhea via Inflammation Regulation and Gut Microbiota Modulation: A Double-Blind, Randomized, Placebo-Controlled Study

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Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice

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Bamboo shavings derived O-acetylated xylan alleviates loperamide-induced constipation in mice

Huang, J., Lin, B., Zhang, Y., Xie, Z., Zheng, Y., Wang, Q., & Xiao, H. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118761 · Cited by 67

Pediococcus pentosaceus B49 from human colostrum ameliorates constipation in mice

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Identification of the key physiological characteristics of Lactobacillus plantarum strains for ulcerative colitis alleviation

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Bifidobacteria attenuate the development of metabolic disorders, with inter- and intra-species differences

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Adhesive Bifidobacterium Induced Changes in Cecal Microbiome Alleviated Constipation in Mice

Wang, L., Chen, C., Cui, S., Lee, Y. K., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01721 · Cited by 65

Protective effects of Bifidobacterium adolescentis on collagen-induced arthritis in rats depend on timing of administration

Fan, Z., Yang, B. K., Ross, R. P., Stanton, C., Shi, G., Zhao, J., Zhang, H., & Chen, W. (2020) · Food & Function · doi:10.1039/d0fo00077a · Cited by 82

Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation

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The Constipation-Relieving Property of d-Tagatose by Modulating the Composition of Gut Microbiota

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Efficacy of Probiotic Compounds in Relieving Constipation and Their Colonization in Gut Microbiota

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Effect of Bifidobacterium animalis subsp. lactis MN-Gup on constipation and the composition of gut microbiota

Wang, R., Sun, J. G., Li, G., Zhang, M., Niu, T., Kang, X., Zhao, H., Chen, J., Sun, E., & Li, Y. (2020) · Beneficial Microbes · doi:10.3920/bm2020.0023 · Cited by 49

Bifidobacterium inhibits the progression of colorectal tumorigenesis in mice through fatty acid isomerization and gut microbiota modulation

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A High-Fat, High-Cholesterol Diet Promotes Intestinal Inflammation by Exacerbating Gut Microbiome Dysbiosis and Bile Acid Disorders in Cholecystectomy

Xu, F., Yu, Z., Liu, Y., Du, T., Yu, L., Tian, F., Chen, W., & Zhai, Q. (2023) · Nutrients · doi:10.3390/nu15173829 · Cited by 49

The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats

Fan, Z., Yang, B. K., Ross, R. P., Stanton, C., Zhao, J., Zhang, H., & Chen, W. (2020) · Food & Function · doi:10.1039/c9fo02556a · Cited by 44

Ligilactobacillus acidipiscis YJ5 modulates the gut microbiota and produces beneficial metabolites to relieve constipation by enhancing the mucosal barrier

Shen, F., Wang, Q., Ullah, S., Pan, Y., Zhao, M., Wang, J., Chen, M., Feng, F., & Zhong, H. (2023) · Food & Function · doi:10.1039/d3fo03259k · Cited by 46

Lactobacillus plantarum Ameliorates Colorectal Cancer by Ameliorating the Intestinal Barrier through the CLA-PPAR-γ Axis

Chen, Y., Ma, W., Zhao, J., Stanton, C., Ross, R. P., Zhang, H., Chen, W., & Yang, B. K. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02824 · Cited by 42

The Different Ways Multi-Strain Probiotics with Different Ratios of Bifidobacterium and Lactobacillus Relieve Constipation Induced by Loperamide in Mice

Zhang, C., Wang, L., Liu, X., Wang, G., Guo, X., Liu, X., Zhao, J., & Chen, W. (2023) · Nutrients · doi:10.3390/nu15194230 · Cited by 42

Physiological Characteristics of Lactobacillus casei Strains and Their Alleviation Effects against Inflammatory Bowel Disease

Liu, Y., Li, Y., Yu, X., Yu, L., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2003.03041 · Cited by 39

Comparative study on alleviating effect of kiwi berry (Actinidia arguta) polysaccharide and polyphenol extracts on constipated mice

Zhang, J., Gao, N., Jiang, H., Li, H., Cui, X., Tang, S., Jin, C., Tian, J., & Li, B. (2022) · Food Research International · doi:10.1016/j.foodres.2022.112037 · Cited by 39

Regulatory effects of Poria cocos polysaccharides on gut microbiota and metabolites: evaluation of prebiotic potential

Zhou, X., Li, Y., Yang, Y., Li, W., Wang, C., Xu, J., Song, J., Liu, S., Bai, J., & Suo, H. (2025) · npj Science of Food · doi:10.1038/s41538-025-00416-9 · Cited by 39

Precise probiotic therapy: Advances, bottlenecks, and the road to microbiome-informed nutrition

Jiang, Y., Jiang, S., Wang, Z., Zhu, P., Zhang, J., Teng, F., & Huang, S. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2623359 · Cited by 41

Regulatory mechanisms of the gut microbiota-short chain fatty acids signaling axis in slow transit constipation and progress in multi-target interventions

Liu, S. H., Yang, X., Liang, L., Song, B. B., Song, X. M., Yang, Y., & Alhoot, M. A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1689597 · Cited by 39

Effects of Bacteroides-Based Microecologics against Antibiotic-Associated Diarrhea in Mice

Guo, H., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2021) · Microorganisms · doi:10.3390/microorganisms9122492 · Cited by 36

Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice

Tang, T., Wang, J., Jiang, Y., Zhu, X., Zhang, Z., Wang, Y., Shu, X., Deng, Y., & Zhang, F. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.890314 · Cited by 35

Effect of water-soluble polysaccharides from Morchella esculenta on high-fat diet-induced obese mice: changes in gut microbiota and metabolic functions

Liu, B., Yu, L., Zhai, Q., Li, M., Li, L., Tian, F., & Chen, W. (2023) · Food & Function · doi:10.1039/d3fo00574g · Cited by 34

In vitro fermentation characteristics of fucoidan and its regulatory effects on human gut microbiota and metabolites

Zhou, X., Zhang, Y., Li, W., Yang, Y., Wang, B., Liu, C., Bai, J., & Wang, C. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.141998 · Cited by 34

Structural characteristics, digestion properties, fermentation properties, and biological activities of butyrylated starch: A review

Zhang, Y., Li, L., Sun, S., Cheng, L., Gu, Z., & Hong, Y. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.121825 · Cited by 32

In vitro batch fermentation demonstrates variations in the regulation of gut microbiota and metabolic functions by β-glucans of differing structures

Gao, Y., Yu, L., Ye, Z., Zhang, C., Gong, Y., Zhang, Q., Zhang, C., Zhao, J., Narbad, A., Chen, W., et al. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114287 · Cited by 30

Soluble and insoluble dietary fiber at different ratios: Hydration characteristics, rheological properties, and ameliorative effects on constipation

Wang, L., Wang, J., Wang, J., Guo, Z., Li, Z., Qiu, J., & Wang, L. (2024) · Food Chemistry X · doi:10.1016/j.fochx.2024.101996 · Cited by 30

Strain-specific regulative effects of Lactobacillus plantarum on intestinal barrier dysfunction are associated with their capsular polysaccharides

Liu, Y., Liu, Q., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.136 · Cited by 29

The roles of different Bacteroides uniformis strains in alleviating DSS-induced ulcerative colitis and related functional genes

Wang, C., Guo, H., Bai, J., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2024) · Food & Function · doi:10.1039/d3fo04863b · Cited by 29

In vitro fermentation of heparin by the human gut microbiota: Changes in the microbiota community and metabolic functions

Zhang, C., Yu, L., Zhai, Q., Zhao, R., Zhao, J., Zhang, H., Chen, W., & Tian, F. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135010 · Cited by 29

Lactic acid bacteria in relieving constipation: mechanism, clinical application, challenge, and opportunity

Zhang, T., Liu, W., Lu, H., Cheng, T., Wang, L., Wang, G., Zhang, H., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2278155 · Cited by 30

How do probiotics alleviate constipation? A narrative review of mechanisms

Huang, Y.-P., Shi, J.-Y., Luo, X.-T., Luo, S.-C., Cheung, P. C. K., Corke, H., Yang, Q.-Q., & Zhang, B. (2024) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2024.2336531 · Cited by 28

Beneficial effects of lactitol on the composition of gut microbiota in constipated patients

Li, X. Q., Zhang, X. M., Wu, X., Lan, Y., Xu, L., Meng, X. C., & Li, J. (2020) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12912 · Cited by 27

Torreya grandis Kernel Oil Alleviates Loperamide‐Induced Slow Transit Constipation via Up‐Regulating the Colonic Expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R in BALB/c Mice

Wang, X., Guo, R., Yu, Z., Zikela, L., Li, J., Li, S., & Han, Q. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300615 · Cited by 28

Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review

Fu, L., Wang, M., Li, D., Ma, S., Zhang, F.-L., & Zheng, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1624415 · Cited by 25

Bifidobacterium bifidum CCFM1163 Alleviated Cathartic Colon by Regulating the Intestinal Barrier and Restoring Enteric Nerves

Tang, N., Yu, Q., Mei, C., Wang, J., Wang, L., Wang, G., Zhao, J., & Chen, W. (2023) · Nutrients · doi:10.3390/nu15051146 · Cited by 27

Role of folic acid in regulating gut microbiota and short-chain fatty acids based on an in vitro fermentation model

Zheng, X., Xia, C., Liu, M., Wu, H., Yan, J., Zhang, Z., Huang, Y., Gu, Q., & Li, P. (2024) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12825-5 · Cited by 23

Consumption of Wheat Peptides Improves Functional Constipation: A Translational Study in Humans and Mice

Wang, Q., Shen, F., Zhang, J., Cai, H., Pan, Y., Sun, T., Gong, Y., Du, J., Zhong, H., & Feng, F. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200313 · Cited by 20

Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice

Li, L., Fang, Z., Liu, Z., Zhao, J., Zhang, H., Wang, S., He, J., Lu, W., & Chen, W. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104286 · Cited by 21

Compendium of Bifidobacterium-based probiotics: characteristics and therapeutic impact on human diseases

Bocchio, F., Mancabelli, L., Milani, C., Lugli, G. A., Tarracchini, C., Longhi, G., Conto, F. D., Turroni, F., & Ventura, M. (2024) · Microbiome Research Reports · doi:10.20517/mrr.2024.52 · Cited by 28

Novel Phocaeicola Strain Ameliorates Dextran Sulfate Sodium-induced Colitis in Mice

Sun, Z., Jiang, X., Wang, B., Tian, F., Zhang, H., & Yu, L. (2022) · Current Microbiology · doi:10.1007/s00284-022-03054-6 · Cited by 20

Alleviating effects of gut micro-ecologically regulatory treatments on mice with constipation

Zhao, Y., Liu, Q., Hou, Y., & Zhao, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.956438 · Cited by 18

Strain-specific ameliorating effect of Bifidobacterium longum on atopic dermatitis in mice

Fang, Z., Li, L., Liu, X., Lu, W., Zhao, J., Zhang, H., & Chen, W. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103426 · Cited by 19

Perinatal transmission of a probiotic Bifidobacterium strain protects against early life stress-induced mood and gastrointestinal motility disorders

Zhu, H., Tian, P., Qian, X., Gu, L., Zhao, J., Wang, G., & Chen, W. (2022) · Food & Function · doi:10.1039/d2fo01164f · Cited by 19

Bifidobacterium Treated by Electrostatic Spray Drying Relieved Constipation by Changing the Relative Abundance of Bacteria Associated With Gastrointestinal Regulatory Peptides

Jiang, T., Lu, W., Fang, Z., Wang, H., Zhu, J., Zhang, H., & Zhao, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.894216 · Cited by 18

Therapeutic effects ofBombax ceibaflower aqueous extracts against loperamide-induced constipation in mice

Wang, L., Xie, S., Jiang, X., Xu, C., Wang, Y., Feng, J., & Yang, B. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2157841 · Cited by 18

Milk fermented by combined starter cultures comprising three Lactobacillus strains exerts an alleviating effect on loperamide-induced constipation in BALB/c mice

Jiang, Y. L., Guo, H., Sun, M., Jiang, C., Jiang, S., Mu, G., Tuo, Y., & Gao, P. (2023) · Food & Function · doi:10.1039/d3fo00222e · Cited by 18

Bifidobacterium longum S3 alleviates loperamide-induced constipation by modulating intestinal acetic acid and stearic acid levels in mice

Zhang, T., Lu, H., Cheng, T., Wang, L., Wang, G., Zhang, H., & Chen, W. (2024) · Food & Function · doi:10.1039/d4fo00695j · Cited by 18

Effects of Lactiplantibacillus plantarum GUANKE on Diphenoxylate-Induced Slow Transit Constipation and Gut Microbiota in Mice

Huang, Y., Guo, Y., Li, X., Xiao, Y., Wang, Z., Song, L., & Ren, Z. (2023) · Nutrients · doi:10.3390/nu15173741 · Cited by 20

Hemp seeds attenuate loperamide-induced constipation in mice

Huang, H., Yongtong, W., Ding, X., Fang, L., Jing, G., Fumao, Z., Jie, J., & Ji, L. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1353015 · Cited by 16

Arecoline alleviated loperamide induced constipation by regulating gut microbes and the expression of colonic genome

Xu, M. Y., Wang, W., Su, S., Li, W., Hu, X., & Zhang, J. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115423 · Cited by 16

Gastrointestinal Fermentable Polysaccharide Is Beneficial in Alleviating Loperamide-Induced Constipation in Mice

Liu, B., Zhang, Z., Liu, X., Hu, W., & Wu, W. (2023) · Nutrients · doi:10.3390/nu15204364 · Cited by 15

The Anti-Constipation Effects of Raffino-Oligosaccharide on Gut Function in Mice Using Neurotransmitter Analyses, 16S rRNA Sequencing and Targeted Screening

Liang, Y., Wang, Y., Wen, P., Chen, Y., Ouyang, D., Wang, D., Zhang, B., Deng, J., Chen, Y., Sun, Y., et al. (2022) · Molecules · doi:10.3390/molecules27072235 · Cited by 15

Fecal fermentation behaviors of Konjac glucomannan and its impacts on human gut microbiota

Tan, X., Wang, B., Zhou, X., Liu, C., Wang, C., & Bai, J. (2024) · Food Chemistry X · doi:10.1016/j.fochx.2024.101610 · Cited by 14

Gut microbiota: The pivotal conduit in the onset of constipation and its alleviation by tea flower polysaccharides (TFP) in a mouse model

Wu, T., Song, F., Huang, J., Cui, S., Wang, L., Yang, Q., Wu, Y., Li, B., Tu, Y., Wan, X., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140808 · Cited by 14

Potential Targets in Constipation Research: A Review

Ravichandiran, V., Arumugam, S., Bisht, P., Dagar, N., & Kumar, N. (2022) · Current Drug Targets · doi:10.2174/1389450124666221209123541 · Cited by 16

Different effects of Bacillus coagulans vegetative cells and spore isolates on constipation-induced gut microbiota dysbiosis in mice

Li, L., Liu, B., Cao, J., Zhang, H., Tian, F., Yu, L., Chen, W., & Zhai, Q. (2022) · Food & Function · doi:10.1039/d2fo01668k · Cited by 13

Alleviation effects of Lactobacillus plantarum in colitis aggravated by a high-salt diet depend on intestinal barrier protection, NF-κB pathway regulation, and oxidative stress improvement

Chen, Y., Liu, N., Chen, F., Liu, M., Yang, M., Wang, C., Xia, L., Peng, M., & Zhou, M. (2025) · Food & Function · doi:10.1039/d4fo06377e · Cited by 13

Preventive effect of kiwi berry ( Actinidia arguta ) on loperamide-induced constipation

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