A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of the gut microbiota and relief from chronic constipation
Abstract
CCFM16 raises Firmicutes and Clostridia then SCFAs levels to relieve constipation. Several taxa in Clostridiales prevent CCFM16 from properly functioning.
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In α diversity, three of four studies showed no significant change or difference.
“In α diversity, three of four studies showed that there was no significant change/difference,21 26 30”
Cites
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256 · see citing works
Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S., Kotler, E., Zur, M., Regev-Lehavi, D., Brik, R. B.-Z., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.041 · Cited by 1,695 · see citing works
Vandeputte, D., Falony, G., Vieira-Silva, S., Tito, R. Y., Joossens, M., & Raes, J. (2016) · Gut · doi:10.1136/gutjnl-2015-309618 · Cited by 1,028 · see citing works
Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.202 · Cited by 747 · see citing works
Management of functional constipation in children and adults
Vriesman, M. H., Koppen, I. J. N., Camilleri, M., Di Lorenzo, C., & Benninga, M. A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0222-y · Cited by 457 · see citing works
Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.10.005 · Cited by 396 · see citing works
Dimidi, E., Christodoulides, S., Fragkos, K. C., Scott, S. M., & Whelan, K. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.089151 · Cited by 316 · see citing works
Zhang, C., Jiang, J., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.01.005 · Cited by 131 · see citing works
Self-citationOjetti, V., Ianiro, G., Tortora, A., D‘Angelo, G., Di Rienzo, T. A., Bibbò, S., Migneco, A., & Gasbarrini, A. (2014) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld.2014.1121.234.elr · Cited by 125 · see citing works
Bifidobacteria exert species-specific effects on constipation in BALB/c mice
Wang, L., Hu, L., Xu, Q., Jiang, T., Fang, S., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2017) · Food & Function · doi:10.1039/c6fo01641c · Cited by 115 · see citing works
Self-citationDimidi, E., Zdanaviciene, A., Christodoulides, S., Taheri, S., Louis, P., Duncan, P. I., Emami, N., Crabbé, R., De Castro, C. A., McLean, P., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15073 · Cited by 80 · see citing works
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Lai, H., Li, Y., He, Y., Chen, F., Mi, B., Li, J., Xie, J., Ma, G., Yang, J., Xu, K., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2197837 · Cited by 208 · see citing works
Pan, R., Wang, L., Xu, X., Chen, Y., Wang, H., Wang, G., Zhao, J., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14183704 · Cited by 149 · see citing works
Self-citationvan der Schoot, A., Helander, C., Whelan, K., & Dimidi, E. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.10.015 · Cited by 60 · see citing works
Ding, F., Hu, M., Ding, Y., Meng, Y., & Zhao, Y. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-074557 · Cited by 22 · see citing works
“Bacillus-containing formula exhibits promising but non-significant efficacy, and requires further validation; the multistrains formula displays satisfactory and credible efficacy, while synbiotics demonstrates superior efficacy compared with probiotics.”
BackgroundResultInfluential
- Authors
- Wang, L., Wang, L., Tian, P., Wang, B., Cui, S., Zhao, J., Zhang, H., Qian, L., Wang, Q., Chen, W., & Wang, G.
- Affiliations
- Jiangnan University (CN)
- The Tinghu People's Hospital, Yancheng 224002, P. R. China
- Corresponding author
- Wang, Gang
- ORCID
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 13
- Issue
- 3
- Pages
- 1628-1640
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W4205765264
- Cited by
- 81
- References
- 11
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 25 · 2023: 20 · 2022: 8
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2019YFF0217601)
- Fundamental Research Funds for the Central Universities (JUSRP22006, JUSRP51501)
- National Natural Science Foundation of China (31820103010, 31972052, 32021005, 81800469)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- chronic constipation, gut microbiota, short-chain fatty acids, butyrate, acetic acid, Firmicutes/Bacteroidetes ratio, Clostridiales, stool consistency, probiotic therapy, Chinese adults
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium bifidum, Administration, Oral, Constipation, Double-Blind Method, Female, Humans, Male, Middle Aged, Quality of Life, Treatment Outcome, Probiotics
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