Short-chain fatty acids: ready for prime time?

Roy, Claude C.; Kien, C. Lawrence; Bouthillier, Lise; Levy, Emile

doi:10.1177/0115426506021004351

Cited by 443Microbial Metabolites in Food BiotechnologyGut microbiota and healthProbiotics and Fermented Foods

Short-chain fatty acids: ready for prime time?

Roy, Claude C., Kien, C. Lawrence, Bouthillier, Lise, Levy, Emile·2006·Nutrition in Clinical Practice

DOI 10.1177/0115426506021004351

Open this paper in CoChat — free account

Abstract

The concept of colonic health has become a major target for the development of functional foods such as probiotics, prebiotics, and synbiotics. These bioactive agents have a profound effect on the composition of the microflora, as well as on the physiology of the colon, and display distinct health benefits. Dietary carbohydrates escaping digestion/absorption in the small bowel and prebiotics undergo fermentation in the colon and give rise to short‐chain fatty acids (SCFA). As the main anions of the colon and the major source of energy for colonocytes, SCFA are rapidly absorbed by nonionic diffusion mostly but also by active transport mediated by a sodium‐coupled transporter, thereby fostering the absorption of sodium and water. SCFA in general and butyrate in particular enhance the growth of lactobacilli and bifidobacteria and play a central role on the physiology and metabolism of the colon. The effect of prebiotics on cell proliferation, differentiation, apoptosis, mucin production, immune function, mineral absorption, lipid metabolism, and gastrointestinal (GI) peptides has been well documented experimentally. These effects seem to be largely mediated by SCFA, but evidence from human studies remains inconsistent. The food industry is making a leap of faith in their efforts to commercialize prebiotics and exploit potential health benefits. The future lies with the design of studies to further explore basic mechanisms, and gene expression in particular, but emphasis should be placed on human intervention trials.

Integrity signals

Registry

Crossref · 10.1177/0115426506021004351

Cites

133 of 133 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

SCFAs are produced by gut bacterial fermentation of dietary starches or complex carbohydrates.
“SCFAs are produced by fermentation of dietary starches or complex carbohydrates by gut bacteria54”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [54]

Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Cancer Statistics, 2003
Jemal, A., Murray, T., Samuels, A., Ghafoor, A., Ward, E., & Thun, M. J. (2003) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.53.1.5 · Cited by 3,275 · see citing works
Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091 · see citing works
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750 · see citing works
The effect of infections on susceptibility to autoimmune and allergic diseases.
Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,714 · see citing works
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362 · see citing works
Inhibition of Histone Deacetylase Activity by Butyrate
Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515 · see citing works
Analysis of Intestinal Flora Development in Breast-Fed and Formula-Fed Infants by Using Molecular Identification and Detection Methods
Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Raangs, G. C., Wagendorp, A. A., Klijn, N., BINDELS, J. G., & Welling, G. W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00019 · Cited by 1,326 · see citing works
Antibiotic-Associated Diarrhea
Bartlett, J. G. (2002) · New England Journal of Medicine · doi:10.1056/nejmcp011603 · Cited by 1,206 · see citing works
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study
Bingham, S. A., Day, N., Luben, R., Ferrari, P., Slimani, N., Norat, T., Clavel‐Chapelon, F., Kesse‐Guyot, E., Nieters, A., Boeing, H., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13174-1 · Cited by 1,109 · see citing works
Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics
Sartor, R. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.024 · Cited by 1,053 · see citing works
Phylogenetic Relationships of Butyrate-Producing Bacteria from the Human Gut
Barcenilla, A., Pryde, S. E., Martin, J. C., Duncan, S. H., Stewart, C. S., Henderson, C., & Flint, H. J. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.4.1654-1661.2000 · Cited by 996 · see citing works
Calcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer
Wactawski‐Wende, J., Kotchen, J. M., Anderson, G. L., Assaf, A. R., Brunner, R. L., O’Sullivan, M. J., Margolis, K. L., Ockene, J. K., Phillips, L. S., Pottern, L. M., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055222 · Cited by 980 · see citing works
Introducing inulin-type fructans
Roberfroid, M. B. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041350 · Cited by 799 · see citing works
Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation
Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 748 · see citing works
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M., & Yanagisawa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2637002100 · Cited by 731 · see citing works
Applications of inulin and oligofructose in health and nutrition
Kaur, N., & Gupta, A. K. (2002) · Journal of Biosciences · doi:10.1007/bf02708379 · Cited by 673 · see citing works
Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis in Very Low Birth Weight Infants
Lin, H.-C., Su, B.-H., Chen, A.-C., Lin, T.-W., Tsai, C.-H., Yeh, T.-F., & Oh, W. (2005) · Pediatrics · doi:10.1542/peds.2004-1463 · Cited by 660 · see citing works
Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43
Hong, Y.-H., Nishimura, Y., Hishikawa, D., Tsuzuki, H., Miyahara, H., Gotoh, C., Choi, K.-C., Feng, D. D., Chen, C., Lee, H.-G., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0545 · Cited by 613 · see citing works
LactobacillusTherapy for Acute Infectious Diarrhea in Children: A Meta-analysis
Niel, C. W. V., Feudtner, C., Garrison, M. M., & Christakis, D. (2002) · PEDIATRICS · doi:10.1542/peds.109.4.678 · Cited by 599 · see citing works
THE MICROBIAL CONTRIBUTION TO HUMAN FAECAL MASS
Stephen, A. M., & Cummings, J. H. (1980) · Journal of Medical Microbiology · doi:10.1099/00222615-13-1-45 · Cited by 545 · see citing works
Nondigestible Oligo‐ and Polysaccharides (Dietary Fiber): Their Physiology and Role in Human Health and Food
Tungland, B. C., & Meyer, D. (2002) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2002.tb00009.x · Cited by 525 · see citing works
Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E 1 and E 2 production by intestinal myofibroblasts
Willemsen, L. E. M., Koetsier, M. A., van Deventer, S. J. H., & van Tol, E. A. F. (2003) · Gut · doi:10.1136/gut.52.10.1442 · Cited by 518 · see citing works
Methane, a Gas Produced by Enteric Bacteria, Slows Intestinal Transit and Augments Small Intestinal Contractile Activity
Pimentel, M., Lin, H. C., Enayati, P., van den Burg, B., Lee, H.-R., Chen, J. H., Park, S., Kong, Y., & Conklin, J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00574.2004 · Cited by 508 · see citing works
Dietary Fiber Intake and Risk of Colorectal Cancer
Park, Y., Hunter, D. J., Spiegelman, D. L., Bergkvist, L., Berrino, F., van den Brandt, P. A., Buring, J. E., Colditz, G. A., Freudenheim, J. L., Fuchs, C. S., et al. (2005) · JAMA · doi:10.1001/jama.294.22.2849 · Cited by 489 · see citing works
Prebiotics
Manning, T. S., & Gibson, G. R. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2003.10.008 · Cited by 480 · see citing works
Comparison of Compositions and Metabolic Activities of Fecal Microbiotas in Young Adults and in Antibiotic-Treated and Non-Antibiotic-Treated Elderly Subjects
Woodmansey, E. J., McMurdo, M. E. T., Macfarlane, G. T., & Macfarlane, S. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.6113-6122.2004 · Cited by 418 · see citing works
Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?
Sonnenburg, J. L., Angenent, L. T., & Gordon, J. I. (2004) · Nature Immunology · doi:10.1038/ni1079 · Cited by 406 · see citing works
The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study
Bouhnik, Y., Raskine, L., Simoneau, G., Vicaut, É., Neut, C., Flourié, B., Brouns, F. J. P. H., & Bornet, F. R. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1658 · Cited by 402 · see citing works
Give us this day our daily germs
Rook, G. A. W., & Stanford, J. L. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)80008-x · Cited by 402 · see citing works
The Effects of Glyceride Structure on Absorption and Metabolism
SMALL, D. M. (1991) · Annual Review of Nutrition · doi:10.1146/annurev.nu.11.070191.002213 · Cited by 365 · see citing works
Stool microflora in extremely low birthweight infants
Gewolb, I. H., Schwalbe, R. S., Taciak, V. L., Harrison, T. S., & Panigrahi, P. (1999) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.80.3.f167 · Cited by 355 · see citing works
Prebiotics and synbiotics: concepts and nutritional properties
Roberfroid, M. B. (1998) · British Journal Of Nutrition · doi:10.1017/s0007114500006024 · Cited by 347 · see citing works
Colon as a digestive organ in patients with short bowel
Nordgaard, I., Hansen, B. S., & Mortensen, P. B. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91220-3 · Cited by 343 · see citing works
Antibiotic-Associated Diarrhea Accompanied by Large-Scale Alterations in the Composition of the Fecal Microbiota
Young, V. B., & Schmidt, T. M. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.3.1203-1206.2004 · Cited by 337 · see citing works
Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats
Femia, A. P. (2002) · Carcinogenesis · doi:10.1093/carcin/23.11.1953 · Cited by 330 · see citing works
The Effects Of Glyceride Structure On Absorption And Metabolism
SMALL, D. M. (1991) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.11.1.413 · Cited by 327 · see citing works
Impact of inulin and oligofructose on gastrointestinal peptides
Delzenne, N. M., Cani, P. D., Daubioul, C., & Neyrinck, A. M. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041342 · Cited by 314 · see citing works
Physiological and Clinical Aspects of Short-Chain Fatty Acids
Cummings, J. H., Rombeau, J. L., & 坂田, 隆. (2004) · Medical Entomology and Zoology · Cited by 313 · see citing works
The role of gut-associated lymphoid tissues and mucosal defence
Forchielli, M. L., & Walker, W. A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041356 · Cited by 305 · see citing works
Effect of Dietary Inulin Supplementation on Inflammation of Pouch Mucosa in Patients With an Ileal Pouch-Anal Anastomosis
Welters, C. F. M., Heineman, E., Thunnissen, E., van den Bogaard, A. E. J. M., Soeters, P. B., & Baeten, C. G. M. I. (2002) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6257-2 · Cited by 294 · see citing works
Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus rhamnosus and Bifidobacterium lactis Modulates Intestinal Immune Functions in Rats
Roller, M., Rechkemmer, G., & Watzl, B. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.153 · Cited by 281 · see citing works
Prebiotics and resistance to gastrointestinal infections
Gibson, G. R., McCartney, A. L., & Rastall, R. A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041343 · Cited by 276 · see citing works
Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data
Pool-Zobel, B. L. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041349 · Cited by 267 · see citing works
Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera
Ramakrishna, B., Venkataraman, S., Srinivasan, P., Dash, P., Young, G. P., & Binder, H. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002033420502 · Cited by 249 · see citing works
Estimation of the fermentability of dietary fibrein vitro: a European interlaboratory study
Barry, J.-L., Hoebler, C., Macfarlane, G. T., Macfarlane, S., Mathers, J. C., Reed, K. A., Mortensen, P. B., Nordgaard, I., Rowland, I. R., & Rumney, C. J. (1995) · British Journal Of Nutrition · doi:10.1079/bjn19950137 · Cited by 242 · see citing works
Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease
Piche, T., Varannes, S. B. D., Sacher‐Huvelin, S., Holst, J. J., Cuber, J. C., & Galmiche, J. P. (2003) · Gastroenterology · doi:10.1053/gast.2003.50159 · Cited by 232 · see citing works
Reduction of Colitis by Prebiotics in HLA-B27 Transgenic Rats Is Associated with Microflora Changes and Immunomodulation
Hoentjen, F., Welling, G. W., Harmsen, H. J. M., Zhang, X., Snart, J., Tannock, G. W., Lien, K. A., Churchill, T. A., Lupicki, M., & Dieleman, L. A. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000183421.02316.d5 · Cited by 218 · see citing works
Effects of inulin-type fructans on lipid metabolism in man and in animal models
Beylot, M. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041339 · Cited by 212 · see citing works
The influence of a preserved colon on the absorption of medium chain fat in patients with small bowel resection
Jeppesen, P. B., & Mortensen, P. B. (1998) · Gut · doi:10.1136/gut.43.4.478 · Cited by 212 · see citing works
The First Prebiotics in Humans
Coppa, G. V., Bruni, S., Morelli, L., Soldi, S., & Gabrielli, O. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128926.14285.25 · Cited by 202 · see citing works
Physiological and Clinical Aspects of Short-Chain Fatty Acids
Kris‐Etherton, P. M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1293a · Cited by 202 · see citing works
Inulin, Oligofructose and Intestinal Function
Jenkins, D., Kendall, C. W. C., & Vuksan, V. V. V. (1999) · Journal of Nutrition · doi:10.1093/jn/129.7.1431s · Cited by 200 · see citing works
Substrate‐induced regulation of the human colonic monocarboxylate transporter, MCT1
Cuff, M. A., Lambert, D., & Shirazi‐Beechey, S. P. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.014241 · Cited by 195 · see citing works
Effect of high performance chicory inulin on constipation
Hond, E. D., Geypens, B. J., & Ghoos, Y. F. (2000) · Nutrition Research · doi:10.1016/s0271-5317(00)00162-7 · Cited by 193 · see citing works
Importance of colonic support for energy absorption as small-bowel failure proceeds
Nordgaard, I., Hansen, B. S., & Mortensen, P. B. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.2.222 · Cited by 192 · see citing works
Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets
Bartholome, A. L., Albin, D. M., BAKER, D. H., et al. (2004) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607104028004210 · Cited by 189 · see citing works
Effects of inulin-type fructans of different chain length and type of branching on intestinal absorption and balance of calcium and magnesium in rats
Coudray, C., Tressol, J. C., Gueux, E., et al. (2003) · European Journal of Nutrition · doi:10.1007/s00394-003-0390-x · Cited by 181 · see citing works
Functional foods: concepts and application to inulin and oligofructose
M.B.*, R. (2002) · British Journal Of Nutrition · doi:10.1079/bjnbjn/2002529 · Cited by 181 · see citing works
On defining dietary fibre
DeVries, J. W. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2002234 · Cited by 181 · see citing works
Functional foods: concepts and application to inulin and oligofructose
Roberfroid, M. B. (2002) · British Journal Of Nutrition · doi:10.1079/bjn/2002529 · Cited by 179 · see citing works
Colonic fermentation and proximal gastric tone in humans
Ropert, A., Cherbut, C., Rozé, C., Quellec, A. L., Holst, J. J., Fu–Cheng, X., Varannes, S. B. D., & Jp, G. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690193 · Cited by 165 · see citing works
Effect of short-chain fructooligosaccharides on intestinal calcium absorption and calcium status in postmenopausal women: a stable-isotope study
Tahiri, M., Tressol, J. C., Arnaud, J., et al. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.449 · Cited by 153 · see citing works
Enteral nutrition and microflora in pediatric Crohn's disease
Lionetti, P., Callegari, M. L., Ferrari, S., Cavicchi, M. C., Pozzi, E., de Martino, M., & Morelli, L. (2005) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/01486071050290s4s173 · Cited by 150 · see citing works
Fecal Short-Chain Fatty Acids in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: In Vitro Studies of Carbohydrate Fermentation
Treem, W. R., Ahsan, N., Kastoff, G., & Hyams, J. S. (1996) · Journal of Pediatric Gastroenterology &amp Nutrition · doi:10.1097/00005176-199610000-00013 · Cited by 146 · see citing works
SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells
Musch, M. W., Bookstein, C., Xie, Y., Sellin, J. H., & Chang, E. B. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.4.g687 · Cited by 144 · see citing works
Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome
Olesen, M., & Gudmand-Höyer, E. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.6.1570 · Cited by 140 · see citing works
Butyrate inhibits cytokine-induced VCAM-1 and ICAM-1 expression in cultured endothelial cells: the role of NF-κB and PPARα
Zapolska‐Downar, D., Siennicka, A., Kaczmarczyk, M., Kołodziej, B., & Naruszewicz, M. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.11.008 · Cited by 140 · see citing works
Biological Effects of Short-Chain Fatty Acids in Nonruminant Mammals
Bugaut, M., & Bentéjac, M. (1993) · Annual Review of Nutrition · doi:10.1146/annurev.nu.13.070193.001245 · Cited by 136 · see citing works
Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa
Borruel, N., Casellas, F., Antolı́n, M., Llopis, M., Carol, M., Espín, E., Naval, J., Guarner, F., & Malagelada, J. R. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07384.x · Cited by 135 · see citing works
Prebiotic Effect Of Fructo-Oligosaccharide Supplemented Term Infant Formula at Two Concentrations Compared with Unsupplemented Formula and Human Milk
Euler, A. R., Mitchell, D. K., Kline, R., & Pickering, L. K. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200502000-00014 · Cited by 135 · see citing works
Reversal by short-chain fatty acids of colonic fluid secretion induced by enteral feeding
Bowling, T. E., Raimundo, A. H., GRIMBLE, G. K., & Silk, D. B. A. (1993) · The Lancet · doi:10.1016/0140-6736(93)92360-6 · Cited by 133 · see citing works
Acidic Oligosaccharides from Pectin Hydrolysate as New Component for Infant Formulae: Effect on Intestinal Flora, Stool Characteristics, and pH
Fanaro, S., Jelínek, J., Stahl, B., Boehm, G., Kock, R., & Vigi, V. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000172747.64103.d7 · Cited by 133 · see citing works
Enriched chicory inulin increases calcium absorption mainly in girls with lower calcium absorption
Griffin, I. J., Hicks, P. D., Heaney, R. P., et al. (2003) · Nutrition Research · doi:10.1016/s0271-5317(03)00085-x · Cited by 131 · see citing works
Gastrointestinal Satiety Signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide
Stanley, S. A., Wynne, K., & Bloom, S. R. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00536.2003 · Cited by 131 · see citing works
Dietary fibre-rich oat-based products affect serum lipids, microbiota, formation of short-chain fatty acids and steroids in rats
Drzikova, B., Dongowski, G., & Gebhardt, E. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051577 · Cited by 127 · see citing works
Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72
Arvans, D. L., Vavricka, S. R., Ren, H., Musch, M. W., Kang, L. H., Rocha, F. G., Lucioni, A., Turner, J. R., Alverdy, J. C., & Chang, E. B. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00206.2004 · Cited by 126 · see citing works
Defining and reporting diarrhea in tube-fed patients— what a mess!
Bliss, D., Guenter, P., & Settle, R. G. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.3.753 · Cited by 124 · see citing works
Prebiotics in Infant Formulas
Boehm, G., Jelínek, J., Stahl, B., et al. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128927.91414.93 · Cited by 122 · see citing works
Modulation of gut mucosal biofilms
Kleessen, B., & Blaut, M. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041346 · Cited by 122 · see citing works
Effects ofSaccharomyces boulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition
Schneider, S. M. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i39.6165 · Cited by 120 · see citing works
Fructooligosaccharides and fiber partially prevent the alterations in fecal microbiota and short-chain fatty acid concentrations caused by standard enteral formula in healthy humans
Whelan, K., Judd, P. A., Preedy, V. R., Simmering, R., Jann, A., & Taylor, M. A. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.8.1896 · Cited by 118 · see citing works
Short Chain Fatty Acid Regulation of Signaling Genes Expressed by the Intestinal Epithelium
Sanderson, I. R. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2450s · Cited by 115 · see citing works
Short-chain fatty acid–supplemented total parenteral nutrition alters intestinal structure, glucose transporter 2 (GLUT2) mRNA and protein, and proglucagon mRNA abundance in normal rats
Tappenden, K. A., Drozdowski, L. A., Thomson, A. B. R., & McBurney, M. I. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.1.118 · Cited by 112 · see citing works
Modulation of lipid synthesis, apolipoprotein biogenesis, and lipoprotein assembly by butyrate
Marcil, V., DELVIN, E. E., Seidman, E. G., Poitras, L., Zoltowska, M., Garofalo, C., & Levy, E. H. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00440.2001 · Cited by 109 · see citing works
Self-citation
Butyrate is only one of several growth inhibitors produced during gut flora-mediated fermentation of dietary fibre sources
Beyer-Sehlmeyer, G., Glei, M., Hartmann, E., Hughes, R., Persin, C., Böhm, V., Schubert, R., Jahreis, G., & Pool-Zobel, B. L. (2003) · British Journal Of Nutrition · doi:10.1079/bjn20031003 · Cited by 108 · see citing works
Impaired colonic fermentation of carbohydrate after ampicillin
Rao, S. S. C., Edwards, C. A., Austen, C. J., Bruce, C., & Read, N. W. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90549-5 · Cited by 104 · see citing works
Short-chain fatty acids induce reversible injury of porcine colon
Argenzio, R. A., & Meuten, D. J. (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01296816 · Cited by 104 · see citing works
Isotonic Tube Feeding Formula Induces Liquid Stool in Normal Subjects: Reversal by Pectina
Zimmaro, D. M., Rolandelli, R. H., Koruda, M. J., Settle, R. G., Stein, T. P., & Rombeau, J. L. (1989) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607189013002117 · Cited by 102 · see citing works
Inulin and oligofructose: impact on intestinal diseases and disorders
Guarner, F. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041345 · Cited by 100 · see citing works
Glucagon-Like Peptide-2 and Short-Chain Fatty Acids: A New Twist to an Old Story
Tappenden, K. A., Albin, D. M., Bartholome, A. L., & Mangian, H. F. (2003) · Journal of Nutrition · doi:10.1093/jn/133.11.3717 · Cited by 97 · see citing works
Nonionic diffusion of short-chain fatty acids across rat colon
Charney, A. N., Micic, L., & Egnor, R. W. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.3.g518 · Cited by 96 · see citing works
Total artificial nutrition is associated with major changes in the fecal flora
Schneider, S. M., Gall, P. L., Girard-Pipau, F., et al. (2000) · European Journal of Nutrition · doi:10.1007/s003940070003 · Cited by 89 · see citing works
Prebiotics Promote Good Health
Loo, J. V. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128928.99037.e6 · Cited by 88 · see citing works
Identification of the more complex triacylglycerols in bovine milk fat by gas chromatography—mass spectrometry using polar capillary columns
Myher, J. J., Kuksis, A., Marai, L., et al. (1988) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)81440-0 · Cited by 87 · see citing works
Research Communication: Butyrate Impairs Lipid Transport by Inhibiting Microsomal Triglyceride Transfer Protein in Caco-2 Cells
Marcil, V., Garofalo, C., Levy, E. H., & DELVIN, E. E. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2180 · Cited by 83 · see citing works
Self-citation
Digestion, Absorption, and Fermentation of Carbohydrates in the Newborn
Kien, C. L. (1996) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30239-2 · Cited by 80 · see citing works
Self-citation
The Colon in Carbohydrate Malabsorption: Short-Chain Fatty Acids, pH, and Osmotic Diarrhoea
Holtug, K., Clausen, M. R., Hove, H., et al. (1992) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529209000118 · Cited by 77 · see citing works
The SYNCAN project: goals, set-up, first results and settings of the human intervention study
Loo, J. V., Clune, Y., Bennett, M. F., & Collins, J. K. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041353 · Cited by 74 · see citing works
The Role of Enteric Microflora in Inflammatory Bowel Disease: Human and Animal Studies with Probiotics and Prebiotics
Rioux, K. P., Madsen, K. L., & Fedorak, R. N. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.05.005 · Cited by 73 · see citing works
Glucagon-like peptide-2 acutely increases proximal small intestinal blood flow in TPN-fed neonatal piglets
Stephens, J. E., Stoll, B., Cottrell, J. J., Chang, X., Helmrath, M. A., & Burrin, D. G. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00588.2005 · Cited by 72 · see citing works
Probiotics and Prebiotics: Role in Clinical Disease States
Chen, C.-C., & Walker, W. A. (2005) · Advances in Pediatrics · doi:10.1016/j.yapd.2005.03.001 · Cited by 72 · see citing works
Fecal Microbial Community in Preterm Infants
Magne, F., Suau, A., Pochart, P., & Desjeux, J. F. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000179855.38543.85 · Cited by 69 · see citing works
Oligofructose contributes to the protective role of bifidobacteria in experimental necrotising enterocolitis in quails
Catala, I., Butel, M. J., Bensaada, M., Popot, F., Tessèdre, A., Rimbault, A., & Szylit, O. (1999) · Journal of Medical Microbiology · doi:10.1099/00222615-48-1-89 · Cited by 65 · see citing works
Enteral feeding: The effect on faecal output, the faecal microflora and SCFA concentrations
Whelan, K., Judd, P. A., Preedy, V. R., & Taylor, M. A. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2003317 · Cited by 65 · see citing works
Role of short-chain fatty acids in colonic HCO<sub>3</sub>secretion
Vidyasagar, S., Barmeyer, C., Geibel, J., Binder, H. J., & Rajendran, V. M. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00415.2004 · Cited by 63 · see citing works
The Delivery of Probiotics and Prebiotics to Infants
Kullen, M. J., & Bettler, J. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382359 · Cited by 60 · see citing works
Influence of luminal pH on rat large bowel epithelial cell cycle
Lupton, J. R., Coder, D. M., & Jacobs, L. R. (1985) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1985.249.3.g382 · Cited by 56 · see citing works
Short-Chain Fatty Acids Inhibit Fluid and Electrolyte Loss Induced by Cholera Toxin in Proximal Colon of Rabbit In Vivo
Rabbani, G. H., Albert, M. J., Rahman, H., & Chowdhury, A. K. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1026650624193 · Cited by 55 · see citing works
Characterization of the inhibitory effect of boiled rice on intestinal chloride secretion in guinea pig crypt cells☆, ☆☆, ★
Mathews, C. J., MACLEOD, R., ZHENG, S., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70498-1 · Cited by 55 · see citing works
Application of prebiotics in infant foods
Veereman‐Wauters, G. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041354 · Cited by 49 · see citing works
Famine, Fiber, Fatty Acids, and Failed Colonic Absorption: Does Fiber Fermentation Ameliorate Diarrhea?
Roediger, W. E. W. (1994) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719401800104 · Cited by 48 · see citing works
Diet, length of gestation, and fecal short chain fatty acids in healthy premature neonates
Favre, A., Szylit, O., Popot, F., Catala, I., Rondeau, C., Maurage, C., Gold, F., Borderon, J. C., & Butel, M. J. (2002) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860710202600151 · Cited by 47 · see citing works
Inhibition of intestinal secretion by rice
Macleod, J., Hamilton, J. R., & Bennett, H. P. J. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92115-x · Cited by 46 · see citing works
Zonation of acetate labeling across the liver: implications for studies of lipogenesis by MIDA
Puchowicz, M. A., Bederman, I. R., Comte, B., Yang, D., David, F., Stone, E. C., Jabbour, K., Wasserman, D. H., & Brunengraber, H. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1022 · Cited by 42 · see citing works
Short‐chain fatty acids and total parenteral nutrition affect intestinal gene expression
Drozdowski, L. A., Dixon, W. T., McBurney, M. I., & Thomson, A. (2002) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607102026003145 · Cited by 41 · see citing works
Sodium Butyrate‐Mediated Sp3 Acetylation Represses Human Insulin‐Like Growth Factor Binding Protein‐3 Expression in Intestinal Epithelial Cells
White, N. R., Mulligan, P., King, P., & Sanderson, I. R. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000189345.31010.89 · Cited by 41 · see citing works
Digestion, absorption, and fermentation of carbohydrates.
Kien, C. L., Heitlinger, L. A., Li, B. U. K., et al. (1989) · PubMed · Cited by 36 · see citing works
Self-citation
Effects of lactose intake on lactose digestion and colonic fermentation in preterm infants
Kien, C. L., McClead, R. E., & Cordero, L. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70278-1 · Cited by 36 · see citing works
Self-citation
The place of short chain fatty acids in colonocyte metabolism in health and in ulcerative colitis: the impaired colonocyte barrier.
Roediger, W. E. W. (1995) · Adelaide Research & Scholarship (AR&S) (University of Adelaide) · Cited by 36 · see citing works
Stable isotope model for estimating colonic acetate production in premature infants
Kien, C. L., Kepner, J., Grotjohn, K. A., et al. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91702-6 · Cited by 35 · see citing works
Self-citation
Diversion colitis in children with severe gastrointestinal motility disorders.
Ordein, J. J., Lorenzo, C. D., Flores, A., et al. (1992) · PubMed · Cited by 33 · see citing works
Sodium Butyrate Inhibits Cell Growth and Stimulates p21WAF1/CIP1 Protein in Human Colonic Adenocarcinoma Cells Independently of p53 Status
Kobayashi, H., Tan, E. M., & Fleming, S. E. (2003) · Nutrition and Cancer · doi:10.1207/s15327914nc4602_14 · Cited by 30 · see citing works
Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity
Resta‐Lenert, S. C., Truong, F., Barrett, K. E., et al. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.6.c1837 · Cited by 30 · see citing works
Short‐Chain Fatty Acid Induces Intestinal Mucosal Injury in Newborn Rats and Down‐Regulates Intestinal Trefoil Factor Gene Expression In Vivo and In Vitro
Lin, J., Peng, L., Itzkowitz, S. H., Holzman, I. R., & Babyatsky, M. W. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000179659.09210.ff · Cited by 26 · see citing works
New lipids in enteral feeding
ROY, C. C., Bouthillier, L., Seidman, E. G., & Levy, M. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200403000-00003 · Cited by 24 · see citing works
Self-citation
Stable Isotope Model for Assessing Production of Short Chain Fatty Acids from Colon-Derived Sugar: Application in Pigs
Kien, C. L., Murray, R. D., Ailabouni, A. H., et al. (1996) · Journal of Nutrition · doi:10.1093/jn/126.12.3069 · Cited by 22 · see citing works
Self-citation
Increased Colonic Luminal Synthesis of Butyric Acid Is Associated with Lowered Colonic Cell Proliferation in Piglets ,
Kien, C. L., Schmitz-Brown, M., Solley, T. N., et al. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.64 · Cited by 21 · see citing works
Self-citation
Contribution of low-molecular-weight compounds to the fecal excretion of carbohydrate energy in premature infants
Kien, C. L., Liechty, E. A., & Mullett, M. D. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91244-z · Cited by 19 · see citing works
Self-citation
Effects of prefeeding a prebiotic on diarrhea and colonic cell proliferation in piglets fed lactulose
Kien, C. L., Chang, J. C., Cooper, J., et al. (2004) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860710402800122 · Cited by 18 · see citing works
Self-citation
Butyric Acid Is Synthesized by Piglets
Kien, C. L., Chang, J., & Cooper, J. R. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.234 · Cited by 16 · see citing works
Self-citation
Diarrhea in Severely Burned Children
Thakkar, K. M., Kien, C. L., Rosenblatt, J. I., et al. (2005) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860710502900108 · Cited by 9 · see citing works
Self-citation
Diarrhea in Severely Burned Children
Thakkar, K. H., Kien, C. L., Rosenblatt, J. I., et al. (2005) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/j.1941-2444.2005.tb04839.x · Cited by 6 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048 · see citing works
The role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425 · see citing works
Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204 · see citing works
Strains, functions and dynamics in the expanded Human Microbiome Project
Lloyd-Price, J., Mahurkar, A., Rahnavard, G., Crabtree, J., Orvis, J., Hall, A. B., Brady, A., Creasy, H. H., McCracken, C., Giglio, M. G., et al. (2017) · Nature · doi:10.1038/nature23889 · Cited by 1,267 · see citing works
The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis
Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891 · see citing works
Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells
Belcheva, A., Irrazabal, T., Robertson, S. J., Streutker, C., Maughan, H., Rubino, S., Moriyama, E. H., Copeland, J. K., Surendra, A., Kumar, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.051 · Cited by 473 · see citing works
Butyrate and other short-chain fatty acids as modulators of immunity: What relevance for health?
Meijer, K., de Vos, P., & Priebe, M. G. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833eebe5 · Cited by 443 · see citing works
A Diet High in Resistant Starch Modulates Microbiota Composition, SCFA Concentrations, and Gene Expression in Pig Intestine
Haenen, D., Zhang, J., Souza da Silva, C., Bosch, G., van der Meer, I. M., van Arkel, J., van den Borne, J. J. G. C., Pérez Gutiérrez, O., Smidt, H., Kemp, B., et al. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.169672 · Cited by 341 · see citing works
Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host
Ganapathy, V., Thangaraju, M., Prasad, P. D., Martin, P. M., & Singh, N. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.08.006 · Cited by 290 · see citing works
Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?
Brahe, L. K., Astrup, A., & Larsen, L. H. (2013) · Obesity Reviews · doi:10.1111/obr.12068 · Cited by 264 · see citing works
Soluble Corn Fiber Increases Calcium Absorption Associated with Shifts in the Gut Microbiome: A Randomized Dose-Response Trial in Free-Living Pubertal Females
Whisner, C. M., Martin, B. R., Nakatsu, C. H., Story, J. A., MacDonald-Clarke, C. J., McCabe, L. D., McCabe, G. P., & Weaver, C. M. (2016) · The Journal of Nutrition · doi:10.3945/jn.115.227256 · Cited by 169 · see citing works
The gut Microbiome in adult and pediatric functional gastrointestinal disorders
Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163 · see citing works
NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer
Lin, Y., Ma, C., Liu, C., Wang, Z., Yang, J., Liu, X., Shen, Z., & Wu, R. (2016) · Oncotarget · doi:10.18632/oncotarget.8762 · Cited by 126 · see citing works
The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
Aydin, Ö., Nieuwdorp, M., & Gerdes, V. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1020-6 · Cited by 124 · see citing works
The Interplay of Dietary Fibers and Intestinal Microbiota Affects Type 2 Diabetes by Generating Short-Chain Fatty Acids
Mazhar, M., Zhu, Y., & Qin, L. (2023) · Foods · doi:10.3390/foods12051023 · Cited by 119 · see citing works
Bifidobacteria exert species-specific effects on constipation in BALB/c mice
Wang, L., Hu, L., Xu, Q., Jiang, T., Fang, S., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2017) · Food & Function · doi:10.1039/c6fo01641c · Cited by 115 · see citing works
Butyrate production from high-fiber diet protects against lymphoma tumor
Wei, W., Sun, W., Yu, S., Yang, Y., & Ai, L. (2016) · Leukemia & Lymphoma · doi:10.3109/10428194.2016.1144879 · Cited by 102 · see citing works
Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH
Kang, G. G., Trevaskis, N. L., Murphy, A. J., & Febbraio, M. A. (2023) · iScience · doi:10.1016/j.isci.2022.105905 · Cited by 94 · see citing works
The Emerging Role of Polyphenols in the Management of Type 2 Diabetes
Wang, Y., Alkhalidy, H., & Liu, D. (2021) · Molecules · doi:10.3390/molecules26030703 · Cited by 88 · see citing works
Evaluation of the probiotic characteristics and prophylactic potential of Weissella cibaria strains isolated from kimchi
Yu, H.-S., Jang, H. J., Lee, N.-K., & Paik, H.-D. (2019) · LWT · doi:10.1016/j.lwt.2019.05.127 · Cited by 63 · see citing works
<sup>1</sup>H NMR‐based metabolomics reveal overlapping discriminatory metabolites and metabolic pathway disturbances between colorectal tumor tissues and fecal samples
Lin, Y., Ma, C., Bezabeh, T., Wang, Z., Liang, J., Huang, Y., Zhao, J., Liu, X., Ye, W., Tang, W., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32190 · Cited by 57 · see citing works

Synbiotics: a New Route of Self-production and Applications to Human and Animal Health
Nguyen, T.-T., Nguyen, P.-T., Pham, M.-N., Razafindralambo, H. L., Hoang, Q.-K., & Nguyen, H. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09960-2 · Cited by 20 · see citing works
Effects of dietary prebiotics, probiotic and synbiotics on performance, caecal bacterial populations and caecal fermentation concentrations of broiler chickens
Saminathan, M., Sieo, C. C., Ramasamy, K., Abdullah, N., & Ho, Y. W. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6365 · Cited by 273 · see citing works
Probiotics, prebiotics, and synbiotics: Current status and future uses for human health
Kumari, R., Singh, A., Yadav, A. N., Mishra, S. K., Sachan, A., & Sachan, S. G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820528-0.00012-0 · Cited by 24 · see citing works
Biotherapeutic microbial supplementation for ameliorating fish health: developing trends in probiotics, prebiotics, and synbiotics use in finfish aquaculture
Puri, P., Sharma, J. G., & Singh, R. (2022) · Animal Health Research Reviews · doi:10.1017/s1466252321000165 · Cited by 45 · see citing works
Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review
Ferro, L. E., Crowley, L. N., Bittinger, K. L., Friedman, E. S., Decker, J. E., Russel, K., Katz, S. E., Kim, J. K., & Trabulsi, J. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.2022595 · Cited by 51 · see citing works

Authors: Roy, C. C., Kien, C. L., Bouthillier, L., & Levy, E.
Affiliations: Centre Hospitalier Universitaire Sainte-Justine (CA)
University of Vermont (US)
Corresponding author: Roy, Claude C.
ORCID: Kien, C. Lawrence
Levy, Emile
Venue: Nutrition in Clinical Practice
Publisher: Wiley
Published: 2006-08
Volume: 21
Issue: 4
Pages: 351-366
ISSN: 0884-5336 (ISSN-L)
1941-2452
DOI: 10.1177/0115426506021004351
OpenAlex: W2170348331
Cited by: 443
References: 133
Citations by year: 2026: 7 · 2025: 22 · 2024: 20 · 2023: 29 · 2022: 34 · 2021: 34 · 2020: 26 · 2019: 34 · 2018: 29 · 2017: 24 · 2016: 34 · 2015: 22 · 2014: 23 · 2013: 27 · 2012: 17
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Nutrition in Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (R01 DK61775 (C.L.K.))
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: short-chain fatty acids, butyrate, colonic health, prebiotics, probiotics, synbiotics, colonic fermentation, sodium uptake, lactobacilli, Bifidobacterium, gut microbiota, functional foods
MeSH terms: Animals, Colon, Dietary Fiber, Fatty Acids, Volatile, Fermentation, Gastrointestinal Diseases, Gastrointestinal Transit, Humans, Intestinal Absorption, Probiotics, Carbohydrate Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Short-chain fatty acids: ready for prime time?

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks