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Cited by 47Phytoestrogen effects and researchBlood Pressure and Hypertension StudiesSodium Intake and Health

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Effect of soybean protein on blood pressure in postmenopausal women: a meta-analysis of randomized controlled trials

Kou, Tingyan, Wang, Qiuzhen, Cai, Jing, Song, Jiaqi, Du, Baoli, Zhao, Kun, Ma, Yan, Geng, Bo, Zhang, Yu, Han, Xiaohong, Jiang, Menglu, Guo, Haiyan, Hu, Baocui, Li, Zhaoying, Zhai, Yaoyao, Zhang, Chuan·2017·Food & Function
DOI 10.1039/c6fo01845a
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Abstract

The effect of soybean protein on blood pressure (BP) in postmenopausal women is controversial, so we aimed to conduct a systematic review and a meta-analysis of published randomized controlled trials (RCTs) to investigate whether supplementation with soy protein improves their blood pressure. PubMed and Embase were searched up to February 2016. Weighted mean differences were calculated for net changes in BP by using fixed-effect or random-effect models. Subgroup and meta-regression analyses were performed to clarify heterogeneity among the trials. A total of twelve trials (1551 postmenopausal women participants) were included in the present meta-analysis. The overall pooled estimates of the effect of soy protein indicated a significant effect on systolic blood pressure (SBP) (mean difference: -3.03 mmHg; 95% CI: -5.03, -1.02; P = 0.003) and diastolic blood pressure (DBP) (mean difference: -0.71 mmHg; 95% CI: -1.26, -0.16; P = 0.012). Subgroup analyses further demonstrated that soy protein intake ≥25 g d -1 significantly reduced BP, and the mean difference in SBP and DBP was -4.62 mmHg (95% CI: -8.42, -0.81; P = 0.04) and -1.63 mmHg (95% CI: -2.85, -0.41; P = 0.009), respectively. Soy isoflavone intake ≥100 mg d -1 had a better reduction effect both in SBP (-5.47 mmHg; 95% CI: -8.42, -2.51; P = 0.00) and DBP (-2.03 mmHg; 95% CI: -3.35, -0.72; P = 0.002). However, soy protein intake -1 or soy isoflavone intake -1 had no such effects (P > 0.05). This meta-analysis suggests that…

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  • Systematic reviews and meta-analyses of randomized controlled trials of viscous fibre, total dietary fibre, and sources of plant protein including dietary pulses and soy protein have shown reductions in SBP/DBP.

    “Systematic reviews and meta-analyses of randomized controlled trials of viscous fibre 48,49 as well as total dietary fibre (inclusive of viscous fibre) 50 and sources of plant protein including dietary pulses and soy protein, have shown reductions in SBP/DBP 51,52 .”

    From Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials (2018) · cites this paper as [52]

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Research works printed but not linked: 52

  1. Lopez, 2006, Lancet, 367, 1747, 10.1016/S0140-6736(06)68770-9 · DOI · Paper page
  2. Roger, 2014, Circulation, 131, 29
  3. Lewington, 2002, Lancet, 360, 1903, 10.1016/S0140-6736(02)11911-8 · DOI · Paper page
  4. Kannel, 1976, Ann. Intern. Med., 85, 447, 10.7326/0003-4819-85-4-447 · DOI
  5. Jones, 2004, Hypertension, 43, 1, 10.1161/01.HYP.0000110061.06674.ca · DOI
  6. Sarrafzadegan, 2011, J. Hum. Hypertens., 25, 545, 10.1038/jhh.2010.99 · DOI
  7. Yanes, 2011, Am. J. Hypertens., 24, 740, 10.1038/ajh.2011.71 · DOI
  8. Taddei, 2009, Climacteric, 12, 36, 10.1080/13697130903004758 · DOI
  9. Ong, 2008, Hypertension, 51, 1142, 10.1161/HYPERTENSIONAHA.107.105205 · DOI
  10. Coylewright, 2008, Hypertension, 51, 952, 10.1161/HYPERTENSIONAHA.107.105742 · DOI
  11. Mosca, 2007, J. Am. Coll. Cardiol., 49, 1230, 10.1016/j.jacc.2007.02.020 · DOI
  12. Appel, 2006, Hypertension, 47, 296, 10.1161/01.HYP.0000202568.01167.B6 · DOI · Paper page
  13. Administration, 1999, Fed. Regist., 64, 57699
  14. Cuevas, 2003, Eur. J. Clin. Nutr., 57, 889, 10.1038/sj.ejcn.1601622 · DOI
  15. Nasca, 2008, Am. J. Cardiol., 102, 84, 10.1016/j.amjcard.2008.02.100 · DOI · Paper page
  16. Matthan, 2007, Am. J. Clin. Nutr., 85, 960, 10.1093/ajcn/85.4.960 · DOI · Paper page
  17. Kreijkamp-Kaspers, 2005, Am. J. Clin. Nutr., 81, 189, 10.1093/ajcn/81.1.189 · DOI
  18. Rivas, 2002, J. Nutr., 132, 1900, 10.1093/jn/132.7.1900 · DOI
  19. Teede, 2006, J. Am. Coll. Nutr., 25, 533, 10.1080/07315724.2006.10719569 · DOI
  20. Xiao, 2008, J. Nutr., 138, 1244s, 10.1093/jn/138.6.1244S · DOI
  21. Liu, 2012, Nutr. Metab. Cardiovasc. Dis., 22, 463, 10.1016/j.numecd.2010.09.006 · DOI
  22. Hermansen, 2001, Diabetes Care, 24, 228, 10.2337/diacare.24.2.228 · DOI
  23. Jayagopal, 2002, Diabetes Care, 25, 1709, 10.2337/diacare.25.10.1709 · DOI
  24. Puska, 2004, Br. J. Nutr., 91, 393, 10.1079/BJN20031074 · DOI
  25. Hermansen, 2005, Eur. J. Clin. Nutr., 59, 843, 10.1038/sj.ejcn.1602151 · DOI
  26. Llaneza, 2010, Menopause, 17, 372, 10.1097/gme.0b013e3181ba56fa · DOI
  27. Jadad, 1996, Controlled Clin. Trials, 17, 1, 10.1016/0197-2456(95)00134-4 · DOI · Paper page
  28. Higgins, 2003, Br. Med. J., 327, 557, 10.1136/bmj.327.7414.557 · DOI · Paper page
  29. Pickering, 2005, Hypertension, 45, 142, 10.1161/01.HYP.0000150859.47929.8e · DOI · Paper page
  30. Egger, 1997, Br. Med. J., 315, 629, 10.1136/bmj.315.7109.629 · DOI · Paper page
  31. Begg, 1994, Biometrics, 50, 1088, 10.2307/2533446 · DOI · Paper page
  32. Lukaczer, 2006, Nutrition, 22, 104, 10.1016/j.nut.2005.05.007 · DOI
  33. Welty, 2007, Arch. Intern. Med., 167, 1060, 10.1001/archinte.167.10.1060 · DOI
  34. Bakhtiary, 2012, Arch. Iran. Med., 15, 462
  35. Liu, 2013, J. Hypertens., 31, 384, 10.1097/HJH.0b013e32835c0905 · DOI
  36. Acharjee, 2015, Metabolism, 64, 236, 10.1016/j.metabol.2014.09.005 · DOI
  37. Liu, 2015, Eur. J. Clin. Nutr., 69, 1161, 10.1038/ejcn.2015.24 · DOI
  38. M. Borenstein , L. V.Hedges, J. P. T.Higgins and H. R.Rothstein, Introduction to Meta-Analysis, 2009 · DOI · Paper page
  39. Franklin, 2001, Circulation, 103, 1245, 10.1161/01.CIR.103.9.1245 · DOI · Paper page
  40. Taku, 2010, J. Hypertens., 28, 1971, 10.1097/HJH.0b013e32833c6edb · DOI
  41. L. Hooper , P. A.Kroon, E. B.Rimm, J. S.Cohn, I.Harvey, K. A. L.Cornu, J. J.Ryder, W. L.Hall and A.Cassidy, Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials, Centre for Reviews and Dissemination, UK, 2008
  42. Vegalópez, 2005, Am. J. Clin. Nutr., 81, 43, 10.1093/ajcn/81.1.43 · DOI
  43. Anderson, 1999, Am. J. Clin. Nutr., 70, 464S, 10.1093/ajcn/70.3.464s · DOI
  44. Wang, 1994, J. Agric. Food Chem., 42, 1666, 10.1021/jf00044a016 · DOI
  45. Wiseman, 2000, Am. J. Clin. Nutr., 72, 395, 10.1093/ajcn/72.2.395 · DOI
  46. Nasca, 2008, Am. J. Cardiol., 102, 84, 10.1016/j.amjcard.2008.02.100 · DOI · Paper page
  47. Squadrito, 2002, Atherosclerosis, 163, 339, 10.1016/S0021-9150(02)00013-8 · DOI
  48. Nestel, 1997, Arterioscler., Thromb., Vasc. Biol., 17, 3392, 10.1161/01.ATV.17.12.3392 · DOI
  49. Teede, 2001, J. Clin. Endocrinol. Metab., 86, 3053
  50. Dong, 2011, Br. J. Nutr., 106, 317, 10.1017/S0007114511000262 · DOI
  51. Krisetherton, 2009, J. Am. Coll. Nutr., 28, 103S, 10.1080/07315724.2009.10719804 · DOI
  52. Soedamah-Muthu, 2012, Hypertension, 60, 1131, 10.1161/HYPERTENSIONAHA.112.195206 · DOI · Paper page

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Metadata

Authors
Kou, T., Wang, Q., Cai, J., Song, J., Du, B., Zhao, K., Ma, Y., Geng, B., Zhang, Y., Han, X., Jiang, M., Guo, H., Hu, B., Li, Z., Zhai, Y., & Zhang, C.
Affiliations
Qingdao University (CN)
Corresponding author
Wang, Qiuzhen
ORCID
Venue
Food & Function
Publisher
Royal Society of Chemistry (RSC)
Published
2017
Volume
8
Issue
8
Pages
2663-2671
ISSN
  • 2042-6496 (ISSN-L)
  • 2042-650X
DOI
10.1039/c6fo01845a
OpenAlex
W2626174246
Cited by
47
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 3 · 2017: 2
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Locations
  • Food & Function (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81472983)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
soy protein, blood pressure, postmenopausal women, isoflavones, hypertension, protein intake
MeSH terms
Blood Pressure, Female, Humans, Middle Aged, Randomized Controlled Trials as Topic, Postmenopause, Soybean Proteins

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