Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?: The Framingham Heart Study
Abstract
Background —We examined the relative importance of diastolic (DBP), systolic (SBP) and pulse pressure (PP) as predictors of coronary heart disease (CHD) risk in different age groups of Framingham Heart Study participants. Methods and Results —We studied 3060 men and 3479 women between 20 and 79 years of age who were free of CHD and were not on antihypertensive drug therapy at baseline. Cox regression adjusted for age, sex, and other risk factors was used to assess the relations of BP indexes to CHD risk over a 20-year follow-up. In the group <50 years of age, DBP was the strongest predictor of CHD risk (hazard ratio [HR] per 10 mm Hg increment, 1.34; 95% CI, 1.18 to 1.51) rather than SBP (HR, 1.14; 95% CI, 1.06 to 1.24) or PP (HR, 1.02; 95% CI, 0.89 to 1.17). In the group 50 to 59 years of age, risks were comparable for all 3 BP indexes. In the older age group, the strongest predictor of CHD risk was PP (HR, 1.24; 95% CI, 1.16 to 1.33). When both SBP and DBP were considered jointly, the former was directly and the latter was inversely related to CHD risk in the oldest age group Conclusions —With increasing age, there was a gradual shift from DBP to SBP and then to PP as predictors of CHD risk. In patients <50 years of age, DBP was the strongest predictor. Age 50 to 59 years was a transition period when all 3 BP indexes were comparable predictors, and from 60 years of age on, DBP was negatively related to CHD risk so that PP became superior to SBP.
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Some studies show wide pulse pressure is a better predictor of adverse cardiovascular outcomes than SBP or DBP individually, and identifies patients with systolic hypertension at particularly high risk.
“A wide pulse pressure (SBP minus DBP) has been shown in some studies to be a better predictor of adverse cardiovascular outcomes than either SBP or DBP individually, 413 and to identify patients with systolic hypertension who are at particularly high risk.414”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [413]
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- Authors
- Franklin, S. S., Larson, M. G., Khan, S. A., Wong, N. D., Leip, E. P., Kannel, W. B., & Levy, D.
- Affiliations
- Boston University (US)
- Venue
- Circulation
- Published
- 2001-03-06
- Volume
- 103
- Issue
- 9
- Pages
- 1245-1249
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2170831516
- Cited by
- 1,390
- References
- 32
- Citations by year
- 2026: 33 · 2025: 22 · 2024: 35 · 2023: 39 · 2022: 55 · 2021: 43 · 2020: 43 · 2019: 44 · 2018: 40 · 2017: 59 · 2016: 47 · 2015: 55 · 2014: 71 · 2013: 63 · 2012: 73
- FWCI
- 47.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- National Institutes of Health (n01hc038038-022)
- National Heart, Lung, and Blood Institute (N01-HC-38038)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- blood pressure, coronary heart disease risk, diastolic blood pressure, systolic blood pressure, pulse pressure, aging, Framingham Heart Study, cardiovascular risk prediction
- MeSH terms
- Adult, Aged, Aging, Blood Pressure, Coronary Disease, Diastole, Female, Follow-Up Studies, Heart Rate, Humans, Male, Middle Aged, Predictive Value of Tests, Pulse, Risk Factors, Systole, Proportional Hazards Models
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