Turning double hydrophilic into amphiphilic: IR825-conjugated polymeric nanomicelles for near-infrared fluorescence imaging-guided photothermal cancer therapy
Abstract
(abbreviated as PEG-PLD) via amine-carboxyl reaction. The as-designed PEG-PLD(IR825) was amphiphilic and could self-assemble into polymeric nanomicelles in aqueous solutions. Benefiting from the chemical conjugation strategy, PEG-PLD(IR825) nanomicelles realized a considerably high drug loading rate (∼21.0%) and substantially avoided the premature release of IR825 during systemic circulation. Confocal imaging revealed that the nanomicelles mainly located at mitochondria and endoplasmic reticulum after cellular internalization. In vitro photothermal therapy demonstrated the excellent cancer killing efficiency of PEG-PLD(IR825) nanomicelles due to their high light-to-heat conversion efficiency upon NIR laser irradiation. In addition, PEG-PLD(IR825) nanomicelles showed polarity-sensitive fluorescence at ∼610 nm (under 552 nm excitation) and 830 nm (under 780 nm excitation), which was especially useful for both in vitro visible fluorescence imaging and in vivo near-infrared fluorescence imaging-guided photothermal therapy (PTT). At the in vivo level, PEG-PLD(IR825) nanomicelles exhibited an excellent tumor-homing ability and a long retention time in tumor tissues as evidenced by the in vivo fluorescence imaging results. The desirable properties of PEG-PLD(IR825) nanomicelles ensured their effective tumor ablation during PTT treatment. More importantly, the PEG-PLD(IR825) nanomicelles underwent degradation after laser irradiation, which ensured their post-treatment biosafety. Therefore, the nanomicelles are promising to serve as an efficient and safe PTA for imaging-guided photothermal cancer therapy.
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These nanomicelles possess good drug loading efficiency (~21%) and in vivo studies demonstrated their long circulation half-life, suitable EPR effect, a minor release of cyanine, and notable accumulation in the mitochondrion.
“Studies showed that these nanomicelles possess good drug loading efficiency (~21%) while in vivo studies demonstrated their long circulation half-life, suitable EPR effect, a minor release of cyanine, and notable accumulation in the mitochondrion.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [188]
Pan et al. studied the fabrication of smart nanomicelles produced from the self-assembly of IR825 with methoxy poly(ethylene glycol)-block-poly(l-aspartic acid sodium salt) (PEG-PLD-IR825).
“Pan et al. [188] recently studied the fabrication of smart nanomicelles produced from the self-assembly of IR825 with methoxy poly(ethylene glycol)-block-poly(l-aspartic acid sodium salt) (PEG-PLD-IR825).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [188]
The only drawback observed was the tendency of IR825 to photobleaching when color disappeared during the laser irradiation in sample solutions.
“The only drawback observed was the tendency of IR825 to photobleaching when color disappeared during the laser irradiation in sample solutions.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [188]
The nanomicelles bolstered significant photothermal response upon NIR irradiation at a concentration of drug as low as 50 μg/mL, as revealed in vitro studies in HeLa cells.
“The latter bolstered significant photothermal response upon NIR irradiation at a concentration of drug as low as 50 µg/mL, which was revealed in vitro studies in HeLa cells.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [188]
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Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“[188] recently studied the fabrication of smart nanomicelles produced from the self-assembly of IR825 with methoxy poly(ethylene glycol)-block-poly(L-aspartic acid sodium salt) (PEG-PLD-IR825).”
Background
- Authors
- Pan, G.-Y., Jia, H.-R., Zhu, Y.-X., & Wu, F.-G.
- Affiliations
- State Key Laboratory of Digital Medical Engineering (CN)
- Corresponding author
- Wu, Fu-Gen
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 10
- Issue
- 4
- Pages
- 2115-2127
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2777514926
- Cited by
- 74
- References
- 90
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 9 · 2018: 9
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21673037)
- Natural Science Foundation of Jiangsu Province (BK20170078)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- polymeric micelles, near-infrared fluorescence imaging, photothermal cancer therapy, amphiphilic polymers, drug loading, tumor homing, photothermal conversion, biosafety
- MeSH terms
- Animals, Female, HeLa Cells, Humans, Hyperthermia, Induced, Mice, Inbred BALB C, Mice, Nude, Micelles, Mitochondria, Neoplasms, Polymers, Xenograft Model Antitumor Assays, Nanoparticles, Hydrophobic and Hydrophilic Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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