Human stomach-on-a-chip with luminal flow and peristaltic-like motility
Open accessAbstract
We created a human stomach-on-a-chip by using an innovative microfluidic imaging platform housing human gastric organoids (hGOs) with peristaltic luminal flow.
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OoC devices have improved the characteristics of hPSC-derived pancreatic islets, intestinal, stomach, and liver organoids by supporting physiological flow rates.
“OoC devices have improved the characteristics of hPSC-derived pancreatic islets104, intestinal105, stomach106, and liver77 organoids by supporting physiological flow rates.”
From Organoids (2022) · cites this paper as [105]
The Introduction and Conclusions describe a chip that supports robust growth of hPSC-derived gastric organoids with controllable luminal flow that mimics in vivo flow. This supports the stomach-organoid portion of the sentence, but the paper does not establish that flow improved the organoids’ characteristics relative to a comparator. (LLM, conf=0.84)
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- Authors
- Lee, K. K., McCauley, H. A., Broda, T. R., Kofron, M. J., Wells, J. M., & Hong, C. I.
- Affiliations
- University of Cincinnati (US)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Lee, Kang Kug
- Hong, Christian I.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 18
- Issue
- 20
- Pages
- 3079-3085
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- PMC
- PMC6364752
- OpenAlex
- W2891700335
- Cited by
- 129
- References
- 21
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 27 · 2023: 22 · 2022: 11 · 2021: 21 · 2020: 11 · 2019: 5
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (U19AI116491)
- National Institutes of Health (U01DK103117)
- Defense Advanced Research Projects Agency (D12AP00005)
- National Institute of Child Health and Human Development (P01HD093363)
- American Diabetes Association (ADA-1-17-PDF-102)
- University of Cincinnati
- Cincinnati Children's Hospital Medical Center
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- gastric organoids, human pluripotent stem cells, organ-on-a-chip, luminal flow, gastric motility, fluorescent dextran, gastric physiology, drug screening
- MeSH terms
- Gastrointestinal Motility, Humans, Organoids, Stomach, Tissue Array Analysis
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