One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

3D bioprinting of tissues and organs

Murphy, S. V., & Atala, A. (2014) · Nature Biotechnology · doi:10.1038/nbt.2958 · Cited by 7,034 · see citing works

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250 · see citing works

Microfluidic organs-on-chips

Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305 · see citing works

3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs

Kolesky, D. B., Truby, R. L., Gladman, A. S., Busbee, T. A., Homan, K. A., & Lewis, J. A. (2014) · Advanced Materials · doi:10.1002/adma.201305506 · Cited by 2,102 · see citing works

From 3D cell culture to organs-on-chips

Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.005 · Cited by 1,834 · see citing works

3D Printing of Interdigitated Li‐Ion Microbattery Architectures

Sun, K., Wei, T., Ahn, B. Y., Seo, J. Y., Dillon, S. J., & Lewis, J. A. (2013) · Advanced Materials · doi:10.1002/adma.201301036 · Cited by 1,342 · see citing works

A microfluidic culture platform for CNS axonal injury, regeneration and transport

Taylor, A. M., Blurton-Jones, M. M., Rhee, S. W., Cribbs, D. H., Cotman, C. W., & Jeon, N. L. (2005) · Nature Methods · doi:10.1038/nmeth777 · Cited by 1,138 · see citing works

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

Halldorsson, S., Lucumi, E., Gómez-Sjöberg, R., & Fleming, R. M. T. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.07.029 · Cited by 1,027 · see citing works

Advances in Microfluidic Materials, Functions, Integration, and Applications

Nge, P. N., Rogers, C. I., & Woolley, A. T. (2013) · Chemical Reviews · doi:10.1021/cr300337x · Cited by 960 · see citing works

Engineering of functional, perfusable 3D microvascular networks on a chip

Kim, S., Lee, H., Chung, M., & Jeon, N. L. (2013) · Lab on a Chip · doi:10.1039/c3lc41320a · Cited by 872 · see citing works

Rapid prototyping in tissue engineering: challenges and potential

Yeong, W. Y., Chua, C. K., Leong, K. F., & Chandrasekaran, M. (2004) · Trends in biotechnology · doi:10.1016/j.tibtech.2004.10.004 · Cited by 805 · see citing works

3D‐Printed Microfluidics

Au, A. K., Huynh, W., Horowitz, L. F., & Folch, A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201504382 · Cited by 792 · see citing works

A Simple, Low-Cost Conductive Composite Material for 3D Printing of Electronic Sensors

Leigh, S. J., Bradley, R. J., Purssell, C. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049365 · Cited by 786 · see citing works

A liver-on-a-chip platform with bioprinted hepatic spheroids

Bhise, N. S., Manoharan, V., Massa, S., Tamayol, A., Ghaderi, M., Miscuglio, M., Lang, Q., Shrike Zhang, Y., Shin, S. R., Calzone, G., et al. (2016) · Biofabrication · doi:10.1088/1758-5090/8/1/014101 · Cited by 615 · see citing works

An artificial liver sinusoid with a microfluidic endothelial‐like barrier for primary hepatocyte culture

Lee, P. J., Hung, P. J., & Lee, L. P. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21360 · Cited by 507 · see citing works

Cost-Effective Three-Dimensional Printing of Visibly Transparent Microchips within Minutes

Shallan, A. I., Šmejkal, P., Corban, M., et al. (2014) · Analytical Chemistry · doi:10.1021/ac4041857 · Cited by 501 · see citing works

Revisiting lab-on-a-chip technology for drug discovery

Neužil, P., Giselbrecht, S., Länge, K., Huang, T. J., & Manz, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3799 · Cited by 490 · see citing works

Microfluidic cell culture systems for drug research

Wu, M.-H., Huang, S.-B., & Lee, G.-B. (2010) · Lab on a Chip · doi:10.1039/b921695b · Cited by 432 · see citing works

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

Sin, A., Chin, K. C., Jamil, M. F., Kostov, Y. V., Rao, G., & Shuler, M. L. (2004) · Biotechnology Progress · doi:10.1021/bp034077d · Cited by 369 · see citing works

Three-dimensional print of a liver for preoperative planning in living donor liver transplantation

Zein, N. N., Hanouneh, I. A., Bishop, P. D., et al. (2013) · Liver Transplantation · doi:10.1002/lt.23729 · Cited by 327 · see citing works

Rapid heterogeneous liver-cell on-chip patterning via the enhanced field-induced dielectrophoresis trap

Ho, C.-T., Lin, R., Chang, W.-Y., Chang, H., & Liu, C. (2006) · Lab on a Chip · doi:10.1039/b602036d · Cited by 283 · see citing works

Liver-Specific Functional Studies in a Microfluidic Array of Primary Mammalian Hepatocytes

Kane, B. J., Zinner, M. J., Yarmush, M. L., & Toner, M. (2006) · Analytical Chemistry · doi:10.1021/ac051856v · Cited by 265 · see citing works

Biofabrication of a three-dimensional liver micro-organ as an in vitro drug metabolism model

Chang, R. C., Emami, K., Wu, H., & Sun, W. (2010) · Biofabrication · doi:10.1088/1758-5082/2/4/045004 · Cited by 249 · see citing works

A 3D Printed Fluidic Device that Enables Integrated Features

Anderson, K. B., Lockwood, S. Y., Martin, R. S., & Spence, D. M. (2013) · Analytical Chemistry · doi:10.1021/ac4009594 · Cited by 229 · see citing works

Direct Cell Writing of 3D Microorgan for In Vitro Pharmacokinetic Model

Chang, R. C., Nam, J., & Sun, W. (2008) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2007.0392 · Cited by 204 · see citing works

Liver development in zebrafish (Danio rerio)

Tao, T., & Peng, J. (2009) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(08)60121-6 · Cited by 165 · see citing works

Low cost lab-on-a-chip prototyping with a consumer grade 3D printer

Cómina, G., Suska, A., & Filippini, D. (2014) · Lab on a Chip · doi:10.1039/c4lc00394b · Cited by 136 · see citing works

Solid freeform fabrication technology applied to tissue engineering with various biomaterials

Seol, Y., Kang, T.-Y., & Cho, D. (2011) · Soft Matter · doi:10.1039/c1sm06863f · Cited by 128 · see citing works

3D Hepatic Cultures Simultaneously Maintain Primary Hepatocyte and Liver Sinusoidal Endothelial Cell Phenotypes

Kim, Y.-H., & Rajagopalan, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015456 · Cited by 125 · see citing works

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

van Midwoud, P. M., Verpoorte, E., & Groothuis, G. M. M. (2011) · Integrative Biology · doi:10.1039/c0ib00119h · Cited by 115 · see citing works

Organs-on-a-chip for drug discovery

Selimović, Š., Dokmeci, M. R., & Khademhosseini, A. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.06.005 · Cited by 114 · see citing works

Chip-based liver equivalents for toxicity testing – organotypicalness versus cost-efficient high throughput

Dehne, E., Tonevitsky, A., & Marx, U. (2013) · Lab on a Chip · doi:10.1039/c3lc50240f · Cited by 108 · see citing works

Analyzing shear stress-induced alignment of actin filaments in endothelial cells with a microfluidic assay

van der Meer, A. D., Poot, A. A., Feijén, J., & Vermes, I. (2010) · Biomicrofluidics · doi:10.1063/1.3366720 · Cited by 108 · see citing works

Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications

Gomez-Sjoberg, R., Leyrat, A. A., Houseman, B. T., Shokat, K., & Quake, S. R. (2010) · Analytical Chemistry · doi:10.1021/ac101870s · Cited by 104 · see citing works

Microfluidic Technology in Vascular Research

van der Meer, A. D., Poot, A. A., Duits, M. H. G., Feijén, J., & Vermes, I. (2009) · BioMed Research International · doi:10.1155/2009/823148 · Cited by 103 · see citing works

Protein adsorption and macrophage activation on polydimethylsiloxane and silicone rubber

Anderson, J. M., Ziats, N. P., Azeez, A., Brunstedt, M. R., Stack, S., & Bonfield, T. L. (1996) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856295x00670 · Cited by 97 · see citing works

Organ-on-a-chip technology and microfluidic whole-body models for pharmacokinetic drug toxicity screening

Lee, J. B., & Sung, J. H. (2013) · Biotechnology Journal · doi:10.1002/biot.201300086 · Cited by 92 · see citing works

3D printing of cell-laden constructs for heterogeneous tissue regeneration

Pati, F., Shim, J., Lee, J., et al. (2013) · Manufacturing Letters · doi:10.1016/j.mfglet.2013.09.004 · Cited by 61 · see citing works

Evaluation of antiretrovirals in animal models of HIV infection

Rompay, K. K. A. V. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.07.008 · Cited by 58 · see citing works

Metabolic Control Through Hepatocyte and Adipose Tissue Cross-Talk in a Multicompartmental Modular Bioreactor

Guzzardi, M. A., Domenici, C., & Ahluwalia, A. D. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0541 · Cited by 30 · see citing works

Three dimensional plotted extracellular matrix scaffolds using a rapid prototyping for tissue engineering application

Song, B. R., Yang, S. S., Jin, H., et al. (2015) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-015-0107-2 · Cited by 19 · see citing works

Biofabrication strategies for 3D in vitro models and regenerative medicine

Moroni, L., Burdick, J. A., Highley, C., Lee, S. J., Morimoto, Y., Takeuchi, S., & Yoo, J. J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0006-y · Cited by 753 · see citing works

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

Yi, H.-G., Jeong, Y. H., Kim, Y., Choi, Y.-J., Moon, H. E., Park, S. H., Kang, K. S., Bae, M., Jang, J., Youn, H., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0363-x · Cited by 634 · see citing works

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H.-W., Seol, Y.-J., Shrike Zhang, Y., Shin, S.-R., Zhao, L., Aleman, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08879-x · Cited by 623 · see citing works

Tumor-on-a-chip: from bioinspired design to biomedical application

Liu, X., Fang, J., Huang, S., Wu, X., Xie, X., Wang, J., Liu, F., Zhang, M., Peng, Z., & Hu, N. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00277-8 · Cited by 246 · see citing works

Emerging organoid models: leaping forward in cancer research

Fan, H., Demirci, U., & Chen, P. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0832-4 · Cited by 199 · see citing works

The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors

Trujillo-de Santiago, G., Flores-Garza, B. G., Tavares-Negrete, J. A., Lara-Mayorga, I. M., González-Gamboa, I., Zhang, Y. S., Rojas-Martínez, A., Ortiz-López, R., & Álvarez, M. M. (2019) · Materials · doi:10.3390/ma12182945 · Cited by 184 · see citing works

In Vitro Models for Non-Alcoholic Fatty Liver Disease: Emerging Platforms and Their Applications

Ramos, M. J., Bandiera, L., Menolascina, F., & Fallowfield, J. A. (2022) · iScience · doi:10.1016/j.isci.2021.103549 · Cited by 127 · see citing works

Human stomach-on-a-chip with luminal flow and peristaltic-like motility

Lee, K. K., McCauley, H. A., Broda, T. R., Kofron, M. J., Wells, J. M., & Hong, C. I. (2018) · Lab on a Chip · doi:10.1039/c8lc00910d · Cited by 129 · see citing works

3D Bioprinting of Tumor Models for Cancer Research

Kang, Y., Datta, P., Shanmughapriya, S., & Ozbolat, I. T. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00791 · Cited by 112 · see citing works

Flat and microstructured polymeric membranes in organs-on-chips

Pasman, T., Grijpma, D., Stamatialis, D., & Poot, A. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0351 · Cited by 98 · see citing works

Perspective: Fabrication of integrated organ-on-a-chip via bioprinting

Yang, Q., Lian, Q., & Xu, F. (2017) · Biomicrofluidics · doi:10.1063/1.4982945 · Cited by 95 · see citing works

Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine

Huang, D. (., Gibeley, S. B., Xu, C., Xiao, Y., Celik, O., Ginsberg, H. N., & Leong, K. W. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909553 · Cited by 65 · see citing works

Constructing biomimetic liver models through biomaterials and vasculature engineering

Lv, W., Zhou, H., Aazmi, A., Yu, M., Xu, X., Yang, H., Huang, Y. Y. S., & Ma, L. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac079 · Cited by 45 · see citing works

Expanding Embedded 3D Bioprinting Capability for Engineering Complex Organs with Freeform Vascular Networks

Fang, Y., Guo, Y., Wu, B., Liu, Z., Ye, M., Xu, Y., Ji, M., Chen, L., Lu, B., Nie, K., et al. (2023) · Advanced Materials · doi:10.1002/adma.202205082 · Cited by 155 · see citing works

3D Bioprinting: A Short Overview and Future Prospects in Healthcare Engineering

Read, S. A., & Domingos, M. A. N. (2022) · Springer eBooks · doi:10.1007/978-981-16-4566-2_6

Three-dimensional bioprinting and tissue fabrication: prospects for drug discovery and regenerative medicine

Dai, G., & Lee, V. (2015) · Advanced Health Care Technologies · doi:10.2147/ahct.s69191 · Cited by 38 · see citing works

Recent advances in biofabrication strategies based on bioprinting for vascularized tissue repair and regeneration

Xing, F., Xu, J., Yu, P., Zhou, Y., Zhe, M., Luo, R., Liu, M., Xiang, Z., Duan, X., & Ritz, U. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.111885 · Cited by 46 · see citing works

The Art of Building Living Tissues: Exploring the Frontiers of Biofabrication with 3D Bioprinting

Verma, S., Khanna, V., Kumar, S., & Kumar, S. (2023) · ACS Omega · doi:10.1021/acsomega.3c02600 · Cited by 14 · see citing works