An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging
Open accessAbstract
Conventional X-ray mammography has low diagnostic sensitivity for women with dense breasts. As a result, alternative contrast-enhanced screening tools such as dual energy mammography (DEM), computed tomography (CT), magnetic resonance imaging (MRI), and near-infrared fluorescence (NIRF) imaging are being used or investigated for these women. However, currently available contrast agents are non-ideal, have safety issues, and each imaging technique requires a different contrast agent. We therefore sought to develop a multimodal contrast agent that is functional for each breast imaging modality to simplify the diagnosis process and address the issues of existing contrast agents. Herein, we present a novel "all-in-one" nanoparticle (AION) multimodal imaging probe that has potent DEM, CT, MRI, and NIRF contrast properties and improved biocompatibility. AION were formed by co-encapsulation of a near-infrared fluorophore (DiR), silver sulfide nanoparticles (Ag2S-NP), and iron oxide nanoparticles (IO-NP) in PEGylated micelles. AION showed negligible cytotoxicity, which was in agreement with its minimal silver ion release profiles. AION generated strong contrast with all imaging modalities as demonstrated in phantom imaging. AION allowed in vivo tumor imaging as evidenced by the increase in contrast after injection. This study indicates the potential of AION as an effective multimodal contrast agent for breast cancer diagnosis with a range of imaging methods.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
For achieving multiscale imaging evidence, optical imaging and MSI have been harmonized with clinical imaging.
“For achieving multiscale imaging evidence, optical imaging and MSI have been harmonized with clinical imaging [141].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [141]
The Materials and methods section (In vivo imaging; page unavailable) describes NIRF optical imaging alongside mammography, CT, and MRI in tumor-bearing mice, supporting the integration of optical and other imaging modalities. Our copy does not describe MSI or show that optical imaging and MSI were harmonized with clinical imaging to produce multiscale evidence. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Breast Density and Parenchymal Patterns as Markers of Breast Cancer Risk: A Meta-analysis
McCormack, V., & dos‐Santos‐Silva, I. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0034 · Cited by 2,148 · see citing works
Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement
Siu, A. L., & on behalf of the U.S. Preventive Services Task Force (2016) · Annals of Internal Medicine · doi:10.7326/m15-2886 · Cited by 2,094 · see citing works
Ion Release Kinetics and Particle Persistence in Aqueous Nano-Silver Colloids
Liu, J.-Y., & Hurt, R. H. (2010) · Environmental Science & Technology · doi:10.1021/es9035557 · Cited by 1,657 · see citing works
Environmental Transformations of Silver Nanoparticles: Impact on Stability and Toxicity
Levard, C., Hotze, E. M., Lowry, G. V., & Brown, G. E. (2012) · Environmental Science & Technology · doi:10.1021/es2037405 · Cited by 1,527 · see citing works
Intracranial gadolinium deposition after contrast-enhanced MR imaging
McDonald, R. J., McDonald, J. S., Kallmes, D. F., Jentoft, M. E., Murray, D. L., Thielen, K. R., Williamson, E. E., & Eckel, L. J. (2015) · Radiology · doi:10.1148/radiol.15150025 · Cited by 1,358 · see citing works
Kanda, T., Ishii, K., Kawaguchi, H., Kitajima, K., & Takenaka, D. (2013) · Radiology · doi:10.1148/radiol.13131669 · Cited by 1,341 · see citing works
Carney, P. A., Miglioretti, D. L., Yankaskas, B. C., Kerlikowske, K. M., Rosenberg, R., Rutter, C. M., Geller, B. M., Abraham, L., Taplin, S. H., Dignan, M., et al. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-3-200302040-00008 · Cited by 1,144 · see citing works
Multimodality Imaging Probes: Design and Challenges
Louie, A. (2010) · Chemical Reviews · doi:10.1021/cr9003538 · Cited by 1,044 · see citing works
Mandelson, M. T. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.13.1081 · Cited by 1,032 · see citing works
Kanda, T., Fukusato, T., Matsuda, M., Toyoda, K., Oba, H., Kotoku, J., Haruyama, T., Kitajima, K., & Furui, S. (2015) · Radiology · doi:10.1148/radiol.2015142690 · Cited by 877 · see citing works
Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms
Rogosnitzky, M., & Branch, S. (2016) · BioMetals · doi:10.1007/s10534-016-9931-7 · Cited by 769 · see citing works
Zhang, Y., Hong, G., Zhang, Y., Chen, G., Li, F., Dai, H., & Wang, Q. (2012) · ACS Nano · doi:10.1021/nn301218z · Cited by 765 · see citing works
Superparamagnetic iron oxide based MRI contrast agents: Current status of clinical application.
Wáng, Y. X. J. (2011) · PubMed Central · doi:10.3978/j.issn.2223-4292.2011.08.03 · Cited by 679 · see citing works
Tepel, M., Aspelin, P., & Lameire, N. H. (2006) · Circulation · doi:10.1161/circulationaha.105.595090 · Cited by 505 · see citing works
Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents
Ni, D., Bu, W., Ehlerding, E. B., Cai, W., & Shi, J. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00316a · Cited by 485 · see citing works
Klibanov, A. L., Maruyama, K., Beckerleg, A. M., Torchilin, V. P., & Huang, L. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90385-l · Cited by 480 · see citing works
Levard, C., Reinsch, B. C., Michel, F. M., Oumahi, C., Lowry, G. V., & Brown, G. E. (2011) · Environmental Science & Technology · doi:10.1021/es2007758 · Cited by 478 · see citing works
PEG-based micelles as carriers of contrast agents for different imaging modalities
Torchilin, V. P. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00019-4 · Cited by 470 · see citing works
Sulfidation of Silver Nanoparticles: Natural Antidote to Their Toxicity
Levard, C., Hotze, E. M., Colman, B. P., Dale, A. L., Truong, L., Yang, X., Bone, A. J., Brown, G. E., Tanguay, R. L., Giulio, R. T. D., et al. (2013) · Environmental Science & Technology · doi:10.1021/es403527n · Cited by 434 · see citing works
Li, C., Zhang, Y., Wang, M., Zhang, Y., Chen, G., Li, L., Wu, D., & Wang, Q. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.010 · Cited by 428 · see citing works
Jochelson, M. S., Dershaw, D. D., Sung, J. S., Heerdt, A. S., Thornton, C. M., Moskowitz, C. S., Ferrara, J., & Morris, E. A. (2012) · Radiology · doi:10.1148/radiol.12121084 · Cited by 424 · see citing works
Errante, Y., Cirimele, V., Mallio, C. A., Lazzaro, V. D., Zobel, B. B., & Quattrocchi, C. C. (2014) · Investigative Radiology · doi:10.1097/rli.0000000000000072 · Cited by 421 · see citing works
The dissolution and biological effects of silver nanoparticles in biological media
Loza, K., Diendorf, J., Sengstock, C., Ruiz‐González, L., González-Calbet, J. M., Vallet‐Regí, M., Köller, M., & Epple, M. (2014) · Journal of Materials Chemistry B · doi:10.1039/c3tb21569e · Cited by 371 · see citing works
Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cells
Greulich, C., Diendorf, J., Simon, T., Eggeler, G., Epple, M., & Köller, M. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.08.003 · Cited by 362 · see citing works
Artemov, D., Mori, N., Okollie, B., & Bhujwalla, Z. M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10406 · Cited by 351 · see citing works
Dedicated Breast CT: Initial Clinical Experience
Lindfors, K. K., Boone, J. M., Nelson, T. R., Yang, K., Kwan, A. L. C., & Miller, D. F. (2008) · Radiology · doi:10.1148/radiol.2463070410 · Cited by 350 · see citing works
Current status of gadolinium toxicity in patients with kidney disease
Perazella, M. A. (2009) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06011108 · Cited by 275 · see citing works
Claustrophobia during magnetic resonance imaging: Cohort study in over 55,000 patients
Dewey, M., Schink, T., & Dewey, C. F. (2007) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21147 · Cited by 271 · see citing works
Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice
Zhang, Y., Zhang, Y., Hong, G., Wei, H., Zhou, K., Yang, K., Li, F., Chen, G., Liu, Z., Dai, H., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.089 · Cited by 254 · see citing works
Cheheltani, R., Ezzibdeh, R. M., Chhour, P., Kumidini, P., Kim, J., Jurcova, M., Hsu, J. C., Blundell, C., Litt, H. I., Ferrari, V. A., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.015 · Cited by 240 · see citing works
Self-citationKinsella, J. M., Jimenez, R. E., Karmali, P. P., Rush, A. M., Kotamraju, V. R., Gianneschi, N. C., Ruoslahti, E. I., Stupack, D. G., & Sailor, M. J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201104507 · Cited by 224 · see citing works
Contrast-enhanced Dedicated Breast CT: Initial Clinical Experience
Prionas, N. D., Lindfors, K. K., Ray, S., Huang, S.-Y., Beckett, L. A., Monsky, W. L., & Boone, J. M. (2010) · Radiology · doi:10.1148/radiol.10092311 · Cited by 205 · see citing works
Cheung, Y., Lin, Y., Wan, Y., Yeow, K., Huang, P.-C., Lo, Y., Tsai, H.-P., Ueng, S., & Chang, C. (2014) · European Radiology · doi:10.1007/s00330-014-3271-1 · Cited by 198 · see citing works
Adverse reactions to intravenous iodinated contrast media: a primer for radiologists
Namasivayam, S., Kalra, M. K., Torres, W. E., & Small, W. C. (2006) · Emergency Radiology · doi:10.1007/s10140-006-0488-6 · Cited by 194 · see citing works
Zhang, J., Li, C., Zhang, X., Huo, S., Jin, S., An, F., Wang, X., Xue, X., Okeke, C., Duan, G., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.11.053 · Cited by 179 · see citing works
Comparison between Breast MRI and Contrast-Enhanced Spectral Mammography
Jakubowicz, J. (2015) · Medical Science Monitor · doi:10.12659/msm.893018 · Cited by 173 · see citing works
Effect of the Lipid Chain Melting Transition on the Stability of DSPE-PEG(2000) Micelles
Kastantin, M. J., Ananthanarayanan, B., Karmali, P. P., Ruoslahti, E. I., & Tirrell, M. (2009) · Langmuir · doi:10.1021/la900310k · Cited by 129 · see citing works
Breast Density and Breast Cancer Risk: A Practical Review
Wang, A. T., Vachon, C. M., Brandt, K. R., & Ghosh, K. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.12.014 · Cited by 116 · see citing works
Enders, J., Zimmermann, E., Rief, M., Martus, P., Klingebiel, R., Asbach, P., Klessen, C., Diederichs, G., Bengner, T., Teichgräber, U. K.-M., et al. (2011) · BMC Medical Imaging · doi:10.1186/1471-2342-11-4 · Cited by 116 · see citing works
Effect of Computed Tomography Scanning Parameters on Gold Nanoparticle and Iodine Contrast
Galper, M. W., Saung, M. T., Fuster, V., Roessl, E., Thran, A., Proksa, R., Fayad, Z. A., & Cormode, D. P. (2012) · Investigative Radiology · doi:10.1097/rli.0b013e3182562ab9 · Cited by 111 · see citing works
Self-citationJarzyna, P. A., Skajaa, T., Gianella, A., Cormode, D. P., Samber, D. D., Dickson, S. D., Chen, W., Griffioen, A. W., Fayad, Z. A., & Mulder, W. J. M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.004 · Cited by 109 · see citing works
Self-citationNaha, P. C., Lau, K. C., Hsu, J. C., Hajfathalian, M., Mian, S., Chhour, P., Uppuluri, L., McDonald, E. S., Maidment, A. D. A., & Cormode, D. P. (2016) · Nanoscale · doi:10.1039/c6nr02618d · Cited by 94 · see citing works
Self-citationKumar, R., Ohulchanskyy, T. Y., Roy, I., Gupta, S., Borek, C., Thompson, M. E., & Prasad, P. N. (2009) · ACS Applied Materials & Interfaces · doi:10.1021/am9001293 · Cited by 92 · see citing works
Delayed adverse reactions to iodinated contrast media and their risk factors.
Hosoya, T., Yamaguchi, K., Akutsu, T., Mitsuhashi, Y., Kondo, S., Sugai, Y., & Adachi, M. (2000) · PubMed · Cited by 86 · see citing works
Dual-energy contrast-enhanced digital breast tomosynthesis – a feasibility study
Carton, A.-K., Gavenonis, S. C., Currivan, J. A., Conant, E. F., Schnall, M. D., & Maidment, A. D. A. (2010) · British Journal of Radiology · doi:10.1259/bjr/80279516 · Cited by 73 · see citing works
Self-citationQin, M., Yang, X., Wang, K., Zhang, X., Song, J., Yao, M., Yan, D., Liu, B., & Zhao, Y. (2015) · Nanoscale · doi:10.1039/c5nr05620a · Cited by 53 · see citing works
Zhang, Y., Zhang, B., Luo, J., Bai, J., & Liu, F. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s52492 · Cited by 52 · see citing works
Molecular photoacoustic imaging of breast cancer using an actively targeted conjugated polymer
Balasundaram, G., Ho, C. J. H., Li, K., Driessen, W. H. P., Dinish, U. S., Wong, C. L., Ntziachristos, V., Liu, B., & Olivo, M. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s73558 · Cited by 49 · see citing works
Hyaluronic Acid-Coated Silver Nanoparticles As a Nanoplatform for in Vivo Imaging Applications
Zhang, X., Yao, M., Chen, M., Li, L., Dong, C., Hou, Y., Zhao, H., Jia, B., & Wang, F. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b08166 · Cited by 46 · see citing works
Cormode, D. P., Skajaa, T., Delshad, A., Parker, N., Jarzyna, P. A., Calcagno, C., Galper, M. W., Skajaa, T., Briley-Saebo, K. C., Bell, H. M., et al. (2011) · Bioconjugate Chemistry · doi:10.1021/bc1003179 · Cited by 42 · see citing works
Self-citationKarunamuni, R. A., Naha, P. C., Lau, K. C., Al-Zaki, A., Popov, A. V., Delikatny, E. J., Tsourkas, A., Cormode, D. P., & Maidment, A. D. A. (2016) · European Radiology · doi:10.1007/s00330-015-4152-y · Cited by 35 · see citing works
Self-citationCarton, A.-K., Ullberg, C. K., Lindman, K., Acciavatti, R. J., Francke, T., & Maidment, A. D. A. (2010) · Medical Physics · doi:10.1118/1.3490556 · Cited by 31 · see citing works
Self-citationExploring silver as a contrast agent for contrast-enhanced dual-energy X-ray breast imaging
Karunamuni, R. A., Tsourkas, A., & Maidment, A. D. A. (2014) · British Journal of Radiology · doi:10.1259/bjr.20140081 · Cited by 31 · see citing works
Self-citationFarrell, Z. J., Shelton, C. K., Dunn, C., & Green, D. (2013) · Langmuir · doi:10.1021/la305133d · Cited by 25 · see citing works
Measurement of breast-tissue x-ray attenuation by spectral mammography: solid lesions
Fredenberg, E., Kilburn-Toppin, F., Willsher, P., Moa, E., Danielsson, M. E., Dance, D. R., Young, K. C., & Wallis, M. G. (2016) · Physics in Medicine and Biology · doi:10.1088/0031-9155/61/7/2595 · Cited by 22 · see citing works
Characterization of Cystic Lesions by Spectral Mammography
Erhard, K., Kilburn‐Toppin, F., Willsher, P., Moa, E., Fredenberg, E., Wieberneit, N., Buelow, T., & Wallis, M. (2016) · Investigative Radiology · doi:10.1097/rli.0000000000000246 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Magnetic Nanoparticles as MRI Contrast Agents
Avasthi, A., Caro, C., Pozo-Torres, E., Leal, M. P., & García‐Martín, M. L. (2020) · Topics in Current Chemistry · doi:10.1007/s41061-020-00302-w · Cited by 269 · see citing works
Naha, P. C., Hsu, J. C., Kim, J., Shah, S., Bouché, M., Si-Mohamed, S. A., Rosario‐Berríos, D. N., Douek, P., Hajfathalian, M., Yasini, P., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c03457 · Cited by 178 · see citing works
Self-citationNanoparticle contrast agents for X‐ray imaging applications
Hsu, J. C., Nieves, L. M., Betzer, O., Sadan, T., Noël, P. B., Popovtzer, R., & Cormode, D. P. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1642 · Cited by 143 · see citing works
Self-citationMetallic nanoparticles as X-Ray computed tomography (CT) contrast agents: A review
Aslan, N., Ceylan, B., Koç, M. M., & Fındık, F. (2020) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2020.128599 · Cited by 134 · see citing works
Nanomaterial-based contrast agents
Hsu, J. C., Tang, Z., Eremina, O. E., Sofias, A. M., Lammers, T., Lovell, J. F., Zavaleta, C. L., Cai, W., & Cormode, D. P. (2023) · Nature Reviews Methods Primers · doi:10.1038/s43586-023-00211-4 · Cited by 132 · see citing works
Self-citationSilver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo
Cunningham, B. E., Engstrom, A. M., Harper, B. J., Harper, S. L., & Mackiewicz, M. R. (2021) · Nanomaterials · doi:10.3390/nano11061516 · Cited by 102 · see citing works
Soufi, G. J., & Iravani, S. (2020) · Green Chemistry · doi:10.1039/d0gc00734j · Cited by 99 · see citing works
Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis
Subhan, M. A., Parveen, F., Filipczak, N., Yalamarty, S. S. K., & Torchilin, V. P. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13030389 · Cited by 98 · see citing works
“For achieving multiscale imaging evidence, optical imaging and MSI have been harmonized with clinical imaging [141].”
MethodCT and X-ray contrast agents: Current clinical challenges and the future of contrast
Owens, T. C., Anton, N., & Attia, M. F. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.09.027 · Cited by 93 · see citing works
NIRF Nanoprobes for Cancer Molecular Imaging: Approaching Clinic
Hu, Z., Chen, W., Tian, J., & Cheng, Z. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.02.003 · Cited by 86 · see citing works
Hou, Z., Liu, Y., Xu, J., & Zhu, J. (2020) · Nanoscale · doi:10.1039/d0nr03346d · Cited by 83 · see citing works
de Maar, J. S., Sofias, A. M., Porta Siegel, T., Vreeken, R. J., Moonen, C., Bos, C., & Deckers, R. (2020) · Theranostics · doi:10.7150/thno.38625 · Cited by 71 · see citing works
Silver chalcogenide nanoparticles: a review of their biomedical applications
Nieves, L. M., Mossburg, K. J., Hsu, J. C., Maidment, A. D. A., & Cormode, D. P. (2021) · Nanoscale · doi:10.1039/d0nr03872e · Cited by 68 · see citing works
Self-citationWang, S., You, Q., Wang, J., Song, Y., Cheng, Y. S., Wang, Y., Yang, S., Yang, L., Li, P., Lu, Q., et al. (2019) · Nanoscale · doi:10.1039/c9nr00918c · Cited by 66 · see citing works
Lipid-Encapsulated Fe3O4 Nanoparticles for Multimodal Magnetic Resonance/Fluorescence Imaging
Zhang, L., Tong, S., Zhang, Q., & Bao, G. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c01193 · Cited by 57 · see citing works
Iron Oxide Nanoparticles for Breast Cancer Theranostics
Shakil, M. S., Hasan, M. A., & Sarker, S. R. (2018) · Current Drug Metabolism · doi:10.2174/1389200220666181122105043 · Cited by 55 · see citing works
Hsu, J. C., Cruz, E. D., Lau, K. C., Bouché, M., Kim, J., Maidment, A. D. A., & Cormode, D. P. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b01750 · Cited by 51 · see citing works
Self-citationNano-Based Theranostic Platforms for Breast Cancer: A Review of Latest Advancements
Arshad, R., Kiani, M. H., Rahdar, A., Sargazi, S., Barani, M., Shojaei, S., Bilal, M., Kumar, D., & Pandey, S. (2022) · Bioengineering · doi:10.3390/bioengineering9070320 · Cited by 50 · see citing works
Horizons of nanotechnology applications in female specific cancers
Rajitha, B., Malla, R. R., Vadde, R., Kasa, P., Prasad, G. L. V., Farran, B., Kumari, S., Pavitra, E., Kamal, M. A., Raju, G. S. R., et al. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.005 · Cited by 47 · see citing works
Miesen, T. J., Engstrom, A. M., Frost, D. C., Ajjarapu, R., Ajjarapu, R., Lira, C. N., & Mackiewicz, M. R. (2020) · RSC Advances · doi:10.1039/d0ra01727b · Cited by 45 · see citing works
Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review
Soufi, G. J., Hekmatnia, A., Iravani, S., & Varma, R. S. (2022) · ACS Applied Nano Materials · doi:10.1021/acsanm.2c03297 · Cited by 44 · see citing works
Nieves, L. M., Hsu, J. C., Lau, K. C., Maidment, A. D. A., & Cormode, D. P. (2020) · Nanoscale · doi:10.1039/d0nr05489e · Cited by 40 · see citing works
Self-citationde la Torre, C. M., Grossman, J. H., Bobko, A. A., & Bennewitz, M. F. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239034 · Cited by 36 · see citing works
Iron Oxide-Based Magneto-Optical Nanocomposites for In Vivo Biomedical Applications
Lamichhane, N., Sharma, S., Parul, Verma, A. K., Roy, I., & Sen, T. (2021) · Biomedicines · doi:10.3390/biomedicines9030288 · Cited by 36 · see citing works
Magneto-silver core–shell nanohybrids for theragnosis
Haribabu, V., Girigoswami, K., & Girigoswami, A. (2020) · Nano-Structures & Nano-Objects · doi:10.1016/j.nanoso.2020.100636 · Cited by 35 · see citing works
Radiolabeled Human Protein-Functionalized Upconversion Nanoparticles for Multimodal Cancer Imaging
Akhtar, N., Wu, P., Chen, C. L., Chang, W.-Y., Liu, R.-S., Wu, C., Girigoswami, A., & Chattopadhyay, S. (2022) · ACS Applied Nano Materials · doi:10.1021/acsanm.2c01016 · Cited by 32 · see citing works
Ag2S nanoparticles as an emerging single-component theranostic agent
Han, R., Peng, J., Xiao, Y., Hao, Y., Jia, Y., & Qian, Z. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.03.038 · Cited by 29 · see citing works
IFPTML mapping of nanoparticle antibacterial activity vs. pathogen metabolic networks
Ortega-Tenezaca, B., & González‐Díaz, H. (2020) · Nanoscale · doi:10.1039/d0nr07588d · Cited by 29 · see citing works
Sharma, S., Lamichhane, N., Parul, Sen, T., & Roy, I. (2021) · Nanomedicine · doi:10.2217/nnm-2020-0442 · Cited by 29 · see citing works
Li, L., Wu, C., Pan, L., Li, X., Kuang, A., Cai, H., & Tian, R. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s211476 · Cited by 27 · see citing works
Akakuru, O. U., Zhang, Z., Iqbal, M. Z., Zhu, C., Zhang, Y., & Wu, A. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.02.016 · Cited by 27 · see citing works
Kim, J., Silva, A. B., Hsu, J. C., Maidment, P. S. N., Shapira, N., Noël, P. B., & Cormode, D. P. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b03931 · Cited by 26 · see citing works
Self-citationRenally Excretable Silver Telluride Nanoparticles as Contrast Agents for X-ray Imaging
Nieves, L. M., Dong, Y. C., Rosario‐Berríos, D. N., Mossburg, K. J., Hsu, J. C., Cramer, G. M., Busch, T. M., Maidment, A. D. A., & Cormode, D. P. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c06190 · Cited by 23 · see citing works
Self-citationMotiei, M., Dreifuss, T., Sadan, T., Omer, N., Blumenfeld‐Katzir, T., Fragogeorgi, E. A., Loudos, G. K., Popovtzer, R., & Ben‐Eliezer, N. (2019) · Chemistry Letters · doi:10.1246/cl.180780 · Cited by 23 · see citing works
Song, J., Zhang, L., Yi, H., Huang, J., Zhang, N., Zhong, Y., Hao, L., Yang, K., Wang, Z., Wang, D., et al. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102020 · Cited by 21 · see citing works
Yang, S.-D., Chen, W., Li, W., Song, J., Gao, Y., & Li, X. (2021) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2021.1884085 · Cited by 19 · see citing works
Hsu, J. C., Barragan, D., Tward, A. E., Hajfathalian, M., Amirshaghaghi, A., Mossburg, K. J., Rosario‐Berríos, D. N., Bouché, M., Andrianov, A. K., Delikatny, E. J., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202303018 · Cited by 16 · see citing works
Self-citationKumar, P. P. P., Nafiujjaman, M., Makela, A. V., Hadrick, K., Hill, M. L., Lee, M., & Kim, T. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c00332 · Cited by 16 · see citing works
Yaghoobi, F., Shervedani, R. K., Torabi, M., Kefayat, A., Ghahremani, F. H., & Farzadniya, A. (2019) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2019.123917 · Cited by 13 · see citing works
Hsu, J. C., Du, Y. M., Sengupta, A., Dong, Y. C., Mossburg, K. J., Bouché, M., Maidment, A. D. A., Weljie, A. M., & Cormode, D. P. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c18941 · Cited by 13 · see citing works
Self-citationRouffiac, V., Roux, K. S., Salomé‐Desnoulez, S., Leguerney, I., Ginéfri, J., Sebrié, C., Jourdain, L., Lécluse, Y., & Laplace‐Builhé, C. (2019) · Journal of Biophotonics · doi:10.1002/jbio.201900217 · Cited by 13 · see citing works
Ilosvai, Á. M., Forgách, L., Kovács, N., Heydari, F., Szigeti, K., Máthé, D., Kristály, F., Daróczi, L., Kaleta, Z., Viskolcz, B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216203 · Cited by 12 · see citing works
Maksimova, E. A., Nozdriukhin, D. V., Kalva, S. K., Lyu, S., Lafci, B., Augath, M., Rudakovskaya, P. G., Solovev, A. A., Mei, Y., Deán‐Ben, X. L., et al. (2023) · Laser & Photonics Review · doi:10.1002/lpor.202300137 · Cited by 11 · see citing works
Core/Shell Iron Oxide@Gold nanoparticles for dual-modal CT/MRI imaging
Betzer, O., Motiei, M., Dreifuss, T., Sadan, T., Omer, N., Blumenfeld‐Katzir, T., Liu, Z., Ben‐Eliezer, N., & Popovtzer, R. (2020) · Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications · doi:10.1117/12.2548430 · Cited by 9 · see citing works
Mossburg, K. J., Shepherd, S. J., Barragan, D., O, N. H., Berkow, E. K., Maidment, P. S. N., Rosario‐Berríos, D. N., Hsu, J. C., Siedlik, M. J., Yadavali, S., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06967-5 · Cited by 8 · see citing works
Self-citationNanoparticles as a Tool in Neuro-Oncology Theranostics
Klein, A. L., Nugent, G., Cavendish, J. Z., Geldenhuys, W. J., Sriram, K., Porter, D. W., Fladeland, R. A., Lockman, P. R., & Sherman, J. H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070948 · Cited by 7 · see citing works
Nieves, L. M., Berkow, E. K., Mossburg, K. J., O, N. H., Lau, K. C., Rosario‐Berríos, D. N., Singh, P., Zhong, X., Maidment, A. D. A., & Cormode, D. P. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00508 · Cited by 6 · see citing works
Self-citationSynergy between nanoparticles and breast cancer theranostics
Kandasamy, G., & Kumar, K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820016-2.00005-7 · Cited by 6 · see citing works
Metal Graphitic Nanocapsules for Theranostics in Harsh Conditions
Yang, Y., Li, S., Bu, H., Xia, X., Chen, L., Xu, Y., & Chen, Z. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.909110 · Cited by 6 · see citing works
An update on nanoparticle usage in breast cancer imaging
Waller, J., DeStefano, K., Chiu, B., Jang, I., Cole, Y., Agyemang, C. O., Miao, T., Shah, J., Martin, C., & Umair, M. (2022) · Nano Select · doi:10.1002/nano.202100320 · Cited by 5 · see citing works
Jung, H.-S., Hou, M., Kang, B., Wang, Z., Choi, H., Lee, H. W., Lee, Y., Lee, D., Lee, P., Aviv, D., et al. (2023) · Advanced Sustainable Systems · doi:10.1002/adsu.202300253 · Cited by 3 · see citing works
Beyond Conventional Approaches: The Revolutionary Role of Nanoparticles in Breast Cancer
Liu, M., Wang, Y., Li, Y., Zhang, Y., Zhou, B., Yang, L., Yan, X., & Yang, L. (2025) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.70012 · Cited by 3 · see citing works
Lau, K. C., Hsu, J. C., Cederström, B., Cormode, D. P., & Maidment, A. D. A. (2019) · SPIE Medical Imaging: Physics of Medical Imaging · doi:10.1117/12.2511757 · Cited by 3 · see citing works
Self-citationPreparation and in vivo imaging of a novel potential αvβ3 targeting PET/MRI dual-modal imaging agent
Shi, X., Sun, Y., & Langtao, S. (2022) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-022-08431-w · Cited by 3 · see citing works
Emerging nanoparticle-based x-ray imaging contrast agents for breast cancer screening
Mossburg, K. J., Barragan, D., O, N. H., Kian, A. C., Maidment, A. D. A., & Cormode, D. P. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2496129 · Cited by 2 · see citing works
Self-citationSurface Chemistry and Properties of Magnetic Nanoparticles
Mayeen, A., Sajan, A. K., & Kalarikkal, N. (2021) · Gels horizons: from science to smart materials · doi:10.1007/978-981-16-1260-2_2 · Cited by 2 · see citing works
Applications of Colloidal Nanocrystals
(2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781788016568-00209 · Cited by 1 · see citing works
Hsu, J. C., Lau, K. C., Barragan, D., Mossburg, K. J., Cormode, D. P., & Maidment, A. D. A. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c05431 · Cited by 1 · see citing works
Self-citationPreclinical Imaging for Laboratory Rodents
Chaudhari, P. R. (2021) · Springer eBooks · doi:10.1007/978-981-16-0987-9_25 · Cited by 1 · see citing works
Inorganic Nanocrystals and Biointerfaces
(2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781788016568-00161 · Cited by 1 · see citing works
Inorganic imaging nanoprobes for breast cancer diagnosis
Guo, Q. K., Hong, M., Wu, T., Chen, L., Duan, G., Zeng, J., Wang, X., Wen, L., & Hu, C. (2023) · Radiation Medicine and Protection · doi:10.1016/j.radmp.2023.05.004 · Cited by 1 · see citing works
Guzmán, C., Soria-Martínez, R., & Urresta, J. D. (2022) · Applied Sciences · doi:10.3390/app12199969
Nanoteknolojinin Tıp ve Mühendislik Uygulamaları
Nas, M. S., Gür, F., Oğul, H., Naldemir, İ. F., Sezer, C. V., Cengiz, M., Selimoğlu, F., Akın, İ., & Ayhan, M. E. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.2942
- Authors
- Hsu, J. C., Naha, P. C., Lau, K. C., Chhour, P., Hastings, R., Moon, B. F., Stein, J. M., Witschey, W. R. T., McDonald, E. S., Maidment, A. D. A., & Cormode, D. P.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Cormode, David P.
- ORCID
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 10
- Issue
- 36
- Pages
- 17236-17248
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- PMC
- PMC6148383
- OpenAlex
- W2889288998
- Cited by
- 63
- References
- 57
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 17 · 2019: 10 · 2018: 1
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Division of Graduate Education (1321851)
- National Institutes of Health (R01 CA227142, R01 HL131557)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Digital Radiography and Breast Imaging
- Physical Sciences › Engineering › Biomedical Engineering › Advanced X-ray and CT Imaging
- Keywords
- multimodal contrast agents, breast cancer screening, dual-energy mammography, CT contrast, MRI contrast, near-infrared fluorescence imaging, silver sulfide nanoparticles, iron oxide nanoparticles, silver ion release, cytotoxicity, dense breasts, tumor imaging
- MeSH terms
- Animals, Breast Neoplasms, Cell Line, Contrast Media, Female, Ferric Compounds, Humans, Magnetic Resonance Imaging, Mammography, Mice, Nude, Neoplasms, Experimental, Tomography, X-Ray Computed, Silver Compounds, Phantoms, Imaging, Nanoparticles, Early Detection of Cancer, Hep G2 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review