Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system
Abstract
We have constructed a mechanism-based pharmacokinetic model for triazolam and its metabolites in the entero-hepatic two-organ MPS, and extrapolated the kinetic information obtained with the MPS to the plasma concentration profiles in humans.
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GLA regulates the absorption/prevention of exogenous agents at the gut barrier and metabolic processes in the liver.
“that regulates the absorption/prevention of exogenous agents at the gut barrier and metabolic processes in the liver.2,3”
From Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction (2022) · cites this paper as [2]
Cites
Maschmeyer, I., Lorenz, A. K., Schimek, K., Hasenberg, T., Ramme, A. P., Hübner, J., Lindner, M., Drewell, C., Bauer, S., Thomas, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00392j · Cited by 861 · see citing works
Jones, H., Chen, Y., Gibson, C., Heimbach, T., Parrott, N., Peters, S., Snoeys, J., Upreti, V., Zheng, M., & Hall, S. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.37 · Cited by 488 · see citing works
Marx, U. (2016) · ALTEX · doi:10.14573/altex.1603161 · Cited by 295 · see citing works
On being the right size: scaling effects in designing a human-on-a-chip
Moraes, C., Labuz, J. M., Leung, B. M., Inoue, M., Chun, T.-H., & Takayama, S. (2013) · Integrative Biology · doi:10.1039/c3ib40040a · Cited by 134 · see citing works
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Yang, J., Hirai, Y., Imamura, S., Tsuchiya, T., Tabata, O., & Kamei, K.-I. (2022) · doi:10.1101/2022.01.31.478467 · Cited by 21 · see citing works
- Authors
- Arakawa, H., Sugiura, S., Kawanishi, T., Shin, K., Toyoda, H., Satoh, T., Sakai, Y., Kanamori, T., & Kato, Y.
- Affiliations
- Faculty of Pharmacy
- Biotechnology Research Institute for Drug Discovery
- Department of Chemical System Engineering
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 20
- Issue
- 3
- Pages
- 537-547
- ISSN
- 1473-0197
- 1473-0189
- Cited by
- 49
- References
- 4
- Language
- en
- Funders
- Japan Agency for Medical Research and Development (19be0304101h0003, 19be0304201h0002)
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