On being the right size: scaling effects in designing a human-on-a-chip
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Developing a human-on-a-chip by connecting multiple model organ systems would provide an intermediate screen for therapeutic efficacy and toxic side effects of drugs prior to conducting expensive clinical trials. However, correctly designing individual organs and scaling them relative to each other to make a functional microscale human analog is challenging, and a generalized approach has yet to be identified. In this work, we demonstrate the importance of rational design of both the individual organ and its relationship with other organs, using a simple two-compartment system simulating insulin-dependent glucose uptake in adipose tissues. We demonstrate that inter-organ scaling laws depend on both the number of cells and the spatial arrangement of those cells within the microfabricated construct. We then propose a simple and novel inter-organ 'metabolically supported functional scaling' approach predicated on maintaining in vivo cellular basal metabolic rates by limiting resources available to cells on the chip. This approach leverages findings from allometric scaling models in mammals that limited resources in vivo prompt cells to behave differently than in resource-rich in vitro cultures. Although applying scaling laws directly to tissues can result in systems that would be quite challenging to implement, engineering workarounds may be used to circumvent these scaling issues. Specific workarounds discussed include the limited oxygen carrying capacity of cell culture media when used as a blood substitute and the ability to engineer non-physiological structures to augment organ function, to create the transport-accessible, yet resource-limited environment necessary for cells to mimic in vivo functionality. Furthermore, designing the structure of individual tissues in each organ compartment may be a useful strategy to bypass scaling concerns at the inter-organ level.
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Cites
Textbook of Medical Physiology
Guyton, A. C., & Hall, J. E. (1966) · Annals of Internal Medicine · doi:10.7326/0003-4819-64-6-1363_2 · Cited by 9,760 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)
Duffy, D. C., McDonald, J. C., Schueller, O. J. A., & Whitesides, G. M. (1998) · Analytical Chemistry · doi:10.1021/ac980656z · Cited by 5,301 · see citing works
A General Model for the Origin of Allometric Scaling Laws in Biology
West, G. B., Brown, J. H., & Enquist, B. J. (1997) · Science · doi:10.1126/science.276.5309.122 · Cited by 5,016 · see citing works
Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250 · see citing works
Thompson, D. W. (2019) · Princeton University Press eBooks · doi:10.1515/9780691183978-018 · Cited by 4,179 · see citing works
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005 · see citing works
Todaro, G. J., & Green, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.299 · Cited by 2,725 · see citing works
Kleiber, M. (1947) · Physiological Reviews · doi:10.1152/physrev.1947.27.4.511 · Cited by 1,817 · see citing works
Kim, H. J., Huh, D., Hamilton, G., & Ingber, D. E. (2012) · Lab on a Chip · doi:10.1039/c2lc40074j · Cited by 1,734 · see citing works
The Fourth Dimension of Life: Fractal Geometry and Allometric Scaling of Organisms
West, G. B., Brown, J. H., & Enquist, B. J. (1999) · Science · doi:10.1126/science.284.5420.1677 · Cited by 1,718 · see citing works
Recent advances in three‐dimensional multicellular spheroid culture for biomedical research
Lin, R., & Chang, H. (2008) · Biotechnology Journal · doi:10.1002/biot.200700228 · Cited by 1,264 · see citing works
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
Trayhurn, P., & Beattie, J. H. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200194 · Cited by 1,259 · see citing works
High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array
Tung, Y.-C., Hsiao, A. Y., Allen, S. G., Torisawa, Y.-S., Ho, M., & Takayama, S. (2011) · The Analyst · doi:10.1039/c0an00609b · Cited by 969 · see citing works
Self-citationSize and form in efficient transportation networks
Banavar, J. R., Maritan, A., & Rinaldo, A. (1999) · Nature · doi:10.1038/20144 · Cited by 856 · see citing works
Engineers are from PDMS-land, Biologists are from Polystyrenia
Berthier, E., Young, E. W. K., & Beebe, D. J. (2012) · Lab on a Chip · doi:10.1039/c2lc20982a · Cited by 800 · see citing works
West, G. B., & Brown, J. H. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01589 · Cited by 795 · see citing works
The predominance of quarter‐power scaling in biology
Savage, V. M., Gillooly, J. F., Woodruff, W. H., West, G. B., Allen, A. P., Enquist, B. J., & Brown, J. H. (2004) · Functional Ecology · doi:10.1111/j.0269-8463.2004.00856.x · Cited by 713 · see citing works
Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals
West, G. B., Woodruff, W. H., & Brown, J. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012579799 · Cited by 679 · see citing works
Rubin, C. S., Hirsch, A. H., Fung, C. K., & Rosen, O. M. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34541-6 · Cited by 670 · see citing works
Microengineered physiological biomimicry: Organs-on-Chips
Huh, D., Torisawa, Y., Hamilton, G. A., Kim, H. J., & Ingber, D. E. (2012) · Lab on a Chip · doi:10.1039/c2lc40089h · Cited by 667 · see citing works
Engineering microscale topographies to control the cell–substrate interface
Nikkhah, M., Edalat, F., Manoucheri, S., & Khademhosseini, A. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.079 · Cited by 640 · see citing works
Universal scaling of respiratory metabolism, size and nitrogen in plants
Reich, P. B., Tjoelker, M. G., Machado, J., & Oleksyn, J. (2006) · Nature · doi:10.1038/nature04282 · Cited by 581 · see citing works
To Scale or Not to Scale: The Principles of Dose Extrapolation
Sharma, V., & McNeill, J. H. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00267.x · Cited by 544 · see citing works
Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats
DeSesso, J. M., & Jacobson, C. F. (2001) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(00)00136-8 · Cited by 528 · see citing works
Huh, D., Fujioka, H., Tung, Y., Futai, N., Paine, R., Grotberg, J. B., & Takayama, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610868104 · Cited by 496 · see citing works
Self-citationA microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip
Sung, J. H., Kam, C., & Shuler, M. L. (2010) · Lab on a Chip · doi:10.1039/b917763a · Cited by 485 · see citing works
Shear stress and the endothelium
Ballermann, B. J., Dardik, A., Eng, E., & Liu, A. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.06720.x · Cited by 441 · see citing works
The role of shear stress in Blood-Brain Barrier endothelial physiology
Cucullo, L., Hossain, M., Puvenna, V., Marchi, N., & Janigro, D. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-40 · Cited by 437 · see citing works
Sung, J. H., & Shuler, M. L. (2009) · Lab on a Chip · doi:10.1039/b901377f · Cited by 431 · see citing works
Engineering microscale cellular niches for three-dimensional multicellular co-cultures
Huang, C. P., Lu, J., Seon, H., Lee, A. P., Flanagan, L. A., Kim, H.-Y., Putnam, A. J., & Jeon, N. L. (2009) · Lab on a Chip · doi:10.1039/b818401a · Cited by 384 · see citing works
Glucolipotoxicity of the pancreatic beta cell
Poitout, V., Amyot, J., Semache, M., Zarrouki, B., Hagman, D., & Fontés, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.08.006 · Cited by 382 · see citing works
A Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue
Chun, T.-H., Hotary, K. B., Sabeh, F., Saltiel, A. R., Allen, E. D., & Weiss, S. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.050 · Cited by 378 · see citing works
Self-citationSin, A., Chin, K. C., Jamil, M. F., Kostov, Y. V., Rao, G., & Shuler, M. L. (2004) · Biotechnology Progress · doi:10.1021/bp034077d · Cited by 369 · see citing works
Reference values for resting blood flow to organs of man
Williams, L. R., & Leggett, R. W. (1989) · Clinical Physics and Physiological Measurement · doi:10.1088/0143-0815/10/3/001 · Cited by 358 · see citing works
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
Inoue, M., Chang, L. C., Hwang, J., Chiang, S.-H., & Saltiel, A. R. (2003) · Nature · doi:10.1038/nature01533 · Cited by 351 · see citing works
Self-citationHerculano-Houzel, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017514 · Cited by 343 · see citing works
Zhang, C., Zhao, Z., Abdul Rahim, N. A., van Noort, D., & Yu, H. (2009) · Lab on a Chip · doi:10.1039/b915147h · Cited by 340 · see citing works
The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies
Esch, M. B., King, T. L., & Shuler, M. L. (2011) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124629 · Cited by 333 · see citing works
Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells
Song, J. W., Cavnar, S. P., Walker, A. C., Luker, K. E., Gupta, M., Tung, Y.-C., Luker, G. D., & Takayama, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005756 · Cited by 317 · see citing works
Self-citationScaling of number, size, and metabolic rate of cells with body size in mammals
Savage, V. M., Allen, A. P., Brown, J. H., Gillooly, J. F., Herman, A. B., Woodruff, W. H., & West, G. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611235104 · Cited by 312 · see citing works
Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity
Viravaidya‐Pasuwat, K., Sin, A., & Shuler, M. L. (2004) · Biotechnology Progress · doi:10.1021/bp0341996 · Cited by 306 · see citing works
Sizing Up Allometric Scaling Theory
Savage, V. M., Deeds, E. J., & Fontana, W. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000171 · Cited by 273 · see citing works
Hyder, F., Rothman, D. L., & Bennett, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214912110 · Cited by 271 · see citing works
Current Methods of Adipogenic Differentiation of Mesenchymal Stem Cells
Scott, M., Nguyen, V. T., Lévi, B., & James, A. W. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0040 · Cited by 265 · see citing works
Sung, J. H., Esch, M. B., Prot, J. M., Long, C. J., Smith, A. S. T., Hickman, J. J., & Shuler, M. L. (2013) · Lab on a Chip · doi:10.1039/c3lc41017j · Cited by 232 · see citing works
High throughput methods applied in biomaterial development and discovery
Hook, A. L., Anderson, D. G., Langer, R., Williams, P. M., Davies, M. C., & Alexander, M. R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.037 · Cited by 228 · see citing works
Wu, Y., Carballo‐Jane, E., McLaren, D. G., Mendoza, V., Gagen, K., Geoghagen, N. S. M., McNamara, L. A., Gorski, J. N., Eiermann, G. J., Petrov, A., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m019927 · Cited by 220 · see citing works
Douville, N. J., Zamankhan, P., Tung, Y.-C., Li, R., Vaughan, B. L., Tai, C.-F., White, J., Christensen, P. J., Grotberg, J. B., & Takayama, S. (2011) · Lab Chip · doi:10.1039/c0lc00251h · Cited by 216 · see citing works
Self-citationA general basis for quarter-power scaling in animals
Banavar, J. R., Moses, M. E., Brown, J. H., Damuth, J. D., Rinaldo, A., Sibly, R. M., & Maritan, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009974107 · Cited by 212 · see citing works
Die Abhängigkeit des Hirngewichtes von dem Körpergewicht und den geistigen Fähigkeiten
Snell, O. (1892) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf01843462 · Cited by 211 · see citing works
van Midwoud, P. M., Merema, M. T., Verpoorte, E., & Groothuis, G. M. M. (2010) · Lab on a Chip · doi:10.1039/c0lc00043d · Cited by 203 · see citing works
Organs-on-a-Chip: A Focus on Compartmentalized Microdevices
Moraes, C., Mehta, G., Lesher‐Pérez, S. C., & Takayama, S. (2011) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0455-6 · Cited by 200 · see citing works
Self-citationOlefsky, J. M. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108360 · Cited by 184 · see citing works
Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems
Wikswo, J. P., Block, F. E., Cliffel, D. E., Goodwin, C. R., Marasco, C. C., Markov, D. A., McLean, D. L., MCLEAN, J. A. J., McKenzie, J. R., Reiserer, R. S., et al. (2013) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2013.2244891 · Cited by 176 · see citing works
Rapid Prototyping of Arrayed Microfluidic Systems in Polystyrene for Cell-Based Assays
Young, E. W. K., Berthier, E., Guckenberger, D. J., Sackmann, E. K., Lamers, C., Meyvantsson, I., Anna Huttenlocher, A., & Beebe, D. J. (2011) · Analytical Chemistry · doi:10.1021/ac102897h · Cited by 172 · see citing works
Daquinag, A. C., Souza, G. R., & Kolonin, M. G. (2012) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2012.0198 · Cited by 169 · see citing works
Oxygen gradients for open well cellular cultures via microfluidic substrates
Lo, J. F., Sinkala, E., & Eddington, D. (2010) · Lab on a Chip · doi:10.1039/c004660d · Cited by 127 · see citing works
Li, A. P., Bode, C., & Sakai, Y. (2004) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2004.09.010 · Cited by 113 · see citing works
Noujaim (2004) · doi:10.1161/01.cir.0000146785.15995.67 · Cited by 110 · see citing works
A low shear stress modular bioreactor for connected cell culture under high flow rates
Mazzei, D., Guzzardi, M. A., Giusti, S., & Ahluwalia, A. D. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.22671 · Cited by 97 · see citing works
(Micro)managing the mechanical microenvironment
Moraes, C., Sun, Y., & Simmons, C. A. (2011) · Integrative Biology · doi:10.1039/c1ib00056j · Cited by 87 · see citing works
Self-citationA cell culture analogue of rodent physiology: Application to naphthalene toxicology
Sweeney, L. M., Shuler, M. L., Babish, J. G., & Ghanem, A. (1995) · Toxicology in Vitro · doi:10.1016/0887-2333(95)00007-u · Cited by 84 · see citing works
Wu-Wong, J. R., Berg, C. E., Wang, J., Chiou, W. J. H., & Fissel, B. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8103 · Cited by 74 · see citing works
Imura, Y., Yoshimura, E., & Sato, K. (2012) · Analytical Sciences · doi:10.2116/analsci.28.197 · Cited by 70 · see citing works
Guzzardi, M. A., Vozzi, F., & Ahluwalia, A. D. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0695 · Cited by 62 · see citing works
Microtechnology for Mimicking In Vivo Tissue Environment
Sung, J. H., & Shuler, M. L. (2012) · Annals of Biomedical Engineering · doi:10.1007/s10439-011-0491-2 · Cited by 61 · see citing works
Iori, E., Vinci, B., Murphy, E. G., Marescotti, M. C., Avogaro, A., & Ahluwalia, A. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034704 · Cited by 56 · see citing works
Vozzi, F., Heinrich, J., Bader, A., & Ahluwalia, A. D. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0066 · Cited by 53 · see citing works
Vishwanath, D., Srinivasan, H., Patil, M. S., Seetarama, S., Agrawal, S. K., Dixit, M. N., & Dhar, K. (2013) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-012-0188-9 · Cited by 53 · see citing works
Hepatology Principles and Practice
Taylor-Robinson, S. D. (2003) · Gut · doi:10.1136/gut.52.7.1074 · Cited by 49 · see citing works
In vitro liver model using microfabricated scaffolds in a modular bioreactor
Vinci, B., Cavallone, D., Vozzi, G., Mazzei, D., Domenici, C., Brunetto, M. R., & Ahluwalia, A. D. (2009) · Biotechnology Journal · doi:10.1002/biot.200900074 · Cited by 41 · see citing works
Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology
Toussaint, O., Weemaels, G., Debacq‐Chainiaux, F., Scharffetter‐Kochanek, K., & Wlaschek, M. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22416 · Cited by 38 · see citing works
New Technologies for Toxicity Testing
Balls, M., Bhogal, N., & Combes, R. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3055-1 · Cited by 36 · see citing works
Hepatology, Principles and Practice: History, Morphology, Biochemistry, Diagnostics, Clinic, Therapy
Kuntz, E., & Kuntz, H.-D. (2001) · Springer eBooks · doi:10.1007/3-540-28977-1 · Cited by 36 · see citing works
Human glomerular structure under normal conditions and in isolated glomerular disease
Bohle, A., Aeikens, B., Eenboom, A., Fronholt, L., Plate, W. R., Xiao, J., Greschniok, A., & Wehrmann, M. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.06742.x · Cited by 31 · see citing works
Guzzardi, M. A., Domenici, C., & Ahluwalia, A. D. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0541 · Cited by 30 · see citing works
Sinkala, E., & Eddington, D. (2010) · Lab on a Chip · doi:10.1039/c0lc00244e · Cited by 28 · see citing works
Zuber, M. X., Wang, S. M., Thammavaram, K. V., Reed, D. K., & Reed, B. C. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38682-9 · Cited by 26 · see citing works
Torii, T., Miyazawa, M., & Koyama, I. (2005) · Transplantation Proceedings · doi:10.1016/j.transproceed.2005.10.118 · Cited by 24 · see citing works
Allometry of the mammalian intracellular pulmonary surfactant system
Wirkes, A., Jung, K., Ochs, M., & Mühlfeld, C. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00674.2010 · Cited by 18 · see citing works
Artificial Oxygen Carriers: Renewed Commercial Interest and Scientific/Technological Advances
Simoni, J. M. (2012) · Artificial Organs · doi:10.1111/j.1525-1594.2011.01430.x · Cited by 9 · see citing works
Balaban, R. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221313110 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 86 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- [73]Lo JF Sinkala E Eddington DT Lab Chip 2010 10 3291 3295 20938500
- [77]Ross SM Journal of Engineering Technology 2003 38 41
- [81]Peterson DR eLS John Wiley & Sons, Ltd 2001
Cited by
Sorted by citations
Advances in organ-on-a-chip engineering
Zhang, B., Korolj, A., Lai, B. F. L., & Radisic, M. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0034-7 · Cited by 1,017 · see citing works
Maschmeyer, I., Lorenz, A. K., Schimek, K., Hasenberg, T., Ramme, A. P., Hübner, J., Lindner, M., Drewell, C., Bauer, S., Thomas, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00392j · Cited by 861 · see citing works
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825 · see citing works
A liver-on-a-chip platform with bioprinted hepatic spheroids
Bhise, N. S., Manoharan, V., Massa, S., Tamayol, A., Ghaderi, M., Miscuglio, M., Lang, Q., Shrike Zhang, Y., Shin, S. R., Calzone, G., et al. (2016) · Biofabrication · doi:10.1088/1758-5090/8/1/014101 · Cited by 615 · see citing works
Engineered In Vitro Disease Models
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554 · see citing works
Organ-on-a-chip devices advance to market
Zhang, B., & Radisic, M. (2017) · Lab on a Chip · doi:10.1039/c6lc01554a · Cited by 437 · see citing works
Organ-on-a-chip platforms for studying drug delivery systems
Bhise, N. S., Ribas, J., Manoharan, V., Zhang, Y. S., Polini, A., Massa, S., Dokmeci, M. R., & Khademhosseini, A. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.004 · Cited by 381 · see citing works
Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication
Picollet-D’hahan, N., Żuchowska, A., Lemeunier, I., & Gac, S. L. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.11.014 · Cited by 384 · see citing works
Marx, U. (2016) · ALTEX · doi:10.14573/altex.1603161 · Cited by 295 · see citing works
Recent Advances in Body-on-a-Chip Systems
Sung, J. H., Wang, Y. I., Narasimhan Sriram, N., Jackson, M., Long, C., Hickman, J. J., & Shuler, M. L. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05293 · Cited by 258 · see citing works
The relevance and potential roles of microphysiological systems in biology and medicine
Wikswo, J. P. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214542068 · Cited by 248 · see citing works
Abaci, H. E., & Shuler, M. L. (2015) · Integrative Biology · doi:10.1039/c4ib00292j · Cited by 243 · see citing works
Organs-on-a-chip: a new tool for drug discovery
Polini, A., Prodanov, L., Bhise, N. S., Manoharan, V., Dokmeci, M. R., & Khademhosseini, A. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.886562 · Cited by 223 · see citing works
Microfluidic Organ‐on‐a‐Chip Technology for Advancement of Drug Development and Toxicology
Caplin, J. D., Granados, N. G., James, M. R., Montazami, R., & Hashemi, N. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500040 · Cited by 195 · see citing works
Microfluidic Gut-liver chip for reproducing the first pass metabolism
Choe, A., Ha, S. K., Choi, I., Choi, N., & Sung, J. H. (2017) · Biomedical Microdevices · doi:10.1007/s10544-016-0143-2 · Cited by 188 · see citing works
Satoh, T., Sugiura, S., Shin, K., Onuki-Nagasaki, R., Ishida, S., Kikuchi, K., Kakiki, M., & Kanamori, T. (2018) · Lab on a Chip · doi:10.1039/c7lc00952f · Cited by 181 · see citing works
Prantil-Baun, R., Novak, R., Das, D., Somayaji, M. R., Przekwas, A., & Ingber, D. E. (2018) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104748 · Cited by 176 · see citing works
Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk
Chen, W. L. K., Edington, C., Suter, E., Yu, J., Velazquez, J. J., Velazquez, J. G., Shockley, M., Large, E. M., Venkataramanan, R., Hughes, D. J., et al. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26370 · Cited by 171 · see citing works
Shaegh, S. A. M., Ferrari, F. D., Zhang, Y. S., Nabavinia, M., Mohammad, N. B., Ryan, J., Pourmand, A., Laukaitis, E., Sadeghian, R. B., Nadhman, A., et al. (2016) · Biomicrofluidics · doi:10.1063/1.4955155 · Cited by 160 · see citing works
Perspective: The promise of multi-cellular engineered living systems
Kamm, R. D., Bashir, R., Arora, N., Dar, R. D., Gillette, M. U., Griffith, L. G., Kemp, M. L., Kinlaw, K., Levin, M. G., Martin, A. C., et al. (2018) · APL Bioengineering · doi:10.1063/1.5038337 · Cited by 152 · see citing works
Self-citationSung, J. H., Srinivasan, B., Esch, M. B., McLamb, W., Bernabini, C., Shuler, M. L., & Hickman, J. J. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214529397 · Cited by 132 · see citing works
Sticker, D., Rothbauer, M., Lechner, S., Hehenberger, M.-T., & Ertl, P. (2015) · Lab on a Chip · doi:10.1039/c5lc01028d · Cited by 130 · see citing works
Organ‐on‐a‐Chip Technology for Reproducing Multiorgan Physiology
Lee, S. H., & Sung, J. H. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700419 · Cited by 128 · see citing works
A pumpless multi‐organ‐on‐a‐chip (MOC) combined with a pharmacokinetic–pharmacodynamic (PK–PD) model
Lee, H., Kim, D. S., Ha, S. K., Choi, I., Lee, J. M., & Sung, J. H. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26087 · Cited by 126 · see citing works
Human-Derived Organ-on-a-Chip for Personalized Drug Development
Jodat, Y. A., Kang, M., Kiaee, K., Kim, G. J., Martinez, A. F. H., Rosenkranz, A., Bae, H., & Shin, S. R. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190308150055 · Cited by 118 · see citing works
Approaching the in vitro clinical trial: engineering organs on chips
Capulli, A. K., Tian, K., Mehandru, N., Bukhta, A., Choudhury, S. F., Suchyta, M., & Parker, K. K. (2014) · Lab on a Chip · doi:10.1039/c4lc00276h · Cited by 111 · see citing works
Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation
Park, D., Lee, J., Chung, J. J., Jung, Y., & Kim, S. H. (2020) · Trends in Biotechnology · doi:10.1016/j.tibtech.2019.06.006 · Cited by 105 · see citing works
2021 update on thyroid-associated ophthalmopathy
Neag, E. J., & Smith, T. J. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01663-9 · Cited by 104 · see citing works
Coppeta, J. R., Mescher, M. J., Isenberg, B. C., Spencer, A. J., Kim, E., Lever, A., Mulhern, T. J., Prantil‐Baun, R., Comolli, J. C., & Borenstein, J. T. (2016) · Lab on a Chip · doi:10.1039/c6lc01236a · Cited by 101 · see citing works
Next generation human skin constructs as advanced tools for drug development
Abaci, H., Guo, Z., Doucet, Y., Jacków, J., & Christiano, A. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217712690 · Cited by 104 · see citing works
Organ-on-a-chip and the kidney
Kim, S., & Takayama, S. (2015) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2015.08.001 · Cited by 92 · see citing works
Self-citationJoint-on-chip platforms: entering a new era of in vitro models for arthritis
Paggi, C. A., Teixeira, L. M., Gac, S. L., & Karperien, M. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00736-6 · Cited by 90 · see citing works
Zheng, F., Xiao, Y., Liu, H., Fan, Y., & Dao, M. (2021) · Advanced Biology · doi:10.1002/adbi.202000024 · Cited by 92 · see citing works
Microphysiological Systems: Design, Fabrication, and Applications
Wang, K., Man, K., Liu, J., Liu, Y., Chen, Q., Zhou, Y., & Yang, Y. S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01667 · Cited by 83 · see citing works
In vitromicrofluidic models of tumor microenvironment to screen transport of drugs and nanoparticles
Özçelikkale, A., Moon, H., Linnes, M. P., & Han, B. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1460 · Cited by 88 · see citing works
HIF2A–LOX Pathway Promotes Fibrotic Tissue Remodeling in Thyroid-Associated Orbitopathy
Hikage, F., Atkins, S., Kahana, A., Smith, T. J., & Chun, T. (2018) · Endocrinology · doi:10.1210/en.2018-00272 · Cited by 86 · see citing works
Self-citation3D gut-liver chip with a PK model for prediction of first-pass metabolism
Lee, D. W., Ha, S. K., Choi, I., & Sung, J. H. (2017) · Biomedical Microdevices · doi:10.1007/s10544-017-0242-8 · Cited by 83 · see citing works
Stem-cell based organ-on-a-chip models for diabetes research
Rogal, J., Zbinden, A., Schenke‐Layland, K., & Loskill, P. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.010 · Cited by 83 · see citing works
Integration Concepts for Multi-Organ Chips: How to Maintain Flexibility?!
Rogal, J., Probst, C., & Loskill, P. (2017) · Future Science OA · doi:10.4155/fsoa-2016-0092 · Cited by 80 · see citing works
Maass, C., Stokes, C. L., Griffith, L. G., & Cirit, M. (2017) · Integrative Biology · doi:10.1039/c6ib00243a · Cited by 72 · see citing works
Shroff, T., Aina, K. O., Maaß, C., Cipriano, M., Lambrecht, J., Tacke, F., Mosig, A. S., & Loskill, P. (2022) · Open Biology · doi:10.1098/rsob.210333 · Cited by 69 · see citing works
High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model
Conant, G., Lai, B. F. L., Lu, R. X. Z., Korolj, A., Wang, E. Y., & Radisic, M. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9736-2 · Cited by 67 · see citing works
Sung, J. H., Wang, Y., & Shuler, M. L. (2019) · APL Bioengineering · doi:10.1063/1.5097675 · Cited by 66 · see citing works
Microfluidic trends in drug screening and drug delivery
Feng, J., Neužil, J., Manz, A., Iliescu, C., & Neužil, P. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116821 · Cited by 66 · see citing works
Li, X., Brooks, J. C., Hu, J., Ford, K. I., & Easley, C. J. (2016) · Lab on a Chip · doi:10.1039/c6lc01201a · Cited by 63 · see citing works
Self-contained, low-cost Body-on-a-Chip systems for drug development
Wang, Y. I., Oleaga, C., Long, C. J., Esch, M. B., McAleer, C. W., Miller, P. G., Hickman, J. J., & Shuler, M. L. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217694101 · Cited by 59 · see citing works
Fat-On-A-Chip Models for Research and Discovery in Obesity and Its Metabolic Comorbidities
McCarthy, M. E., Brown, T., Alarcon, A., Williams, C., Wu, X., Abbott, R. D., Gimble, J. M., & Frazier, T. P. (2020) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2019.0261 · Cited by 57 · see citing works
Parrish, J., Lim, K. S., Baer, K., Hooper, G. J., & Woodfield, T. B. F. (2018) · Lab on a Chip · doi:10.1039/c8lc00485d · Cited by 57 · see citing works
Hydrogel Mechanics Influence the Growth and Development of Embedded Brain Organoids
Cassel de Camps, C., Aslani, S., Stylianesis, N., Nami, H., Mohamed, N.-V., Durcan, T. M., & Moraes, C. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c01047 · Cited by 55 · see citing works
Self-citationMicrofluidic-Based Multi-Organ Platforms for Drug Discovery
Kolahchi, A. R., Mohtaram, N. K., Modarres, H. P., Mohammadi, M., Geraili, A., Jafari, P., Akbari, M., & Sanati‐Nezhad, A. (2016) · Micromachines · doi:10.3390/mi7090162 · Cited by 56 · see citing works
Multi-organ-on-a-chip for pharmacokinetics and toxicokinetic study of drugs
Sung, J. H. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1908996 · Cited by 53 · see citing works
Ahluwalia, A. D. (2017) · Scientific Reports · doi:10.1038/srep42113 · Cited by 50 · see citing works
Sizing it up: The mechanical feedback hypothesis of organ growth regulation
Buchmann, A., Alber, M., & Zartman, J. J. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.06.018 · Cited by 49 · see citing works
Stokes, C., Cirit, M., & Lauffenburger, D. A. (2015) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12042 · Cited by 49 · see citing works
Mimicking the Kidney: A Key Role in Organ-on-Chip Development
Paoli, R., & Samitier, J. (2016) · Micromachines · doi:10.3390/mi7070126 · Cited by 49 · see citing works
Allometric Scaling and Cell Ratios in Multi-Organ in vitro Models of Human Metabolism
Ucciferri, N., Sbrana, T., & Ahluwalia, A. D. (2014) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00074 · Cited by 46 · see citing works
Emerging In Vitro Liver Technologies for Drug Metabolism and Inter-Organ Interactions
Bale, S. S., Moore, L., Yarmush, M. L., & Jindal, R. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0031 · Cited by 46 · see citing works
Arakawa, H., Sugiura, S., Kawanishi, T., Shin, K., Toyoda, H., Satoh, T., Sakai, Y., Kanamori, T., & Kato, Y. (2020) · Lab on a Chip · doi:10.1039/c9lc00884e · Cited by 49 · see citing works
Bringing 3D tumor models to the clinic – predictive value for personalized medicine
Halfter, K., & Mayer, B. (2017) · Biotechnology Journal · doi:10.1002/biot.201600295 · Cited by 45 · see citing works
Organ‐on‐a‐Chip Systems for Women's Health Applications
Nawroth, J. C., Rogal, J., Weiß, M., Brucker, S. Y., & Loskill, P. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700550 · Cited by 44 · see citing works
Engineering living systems on chips: from cells to human on chips
Sei, Y. J., Justus, K., LeDuc, P. R., & Kim, Y. (2014) · Microfluidics and Nanofluidics · doi:10.1007/s10404-014-1341-y · Cited by 42 · see citing works
Lang, Q., Ren, Y., Hobson, D., Tao, Y., Hou, L., Jia, Y., Hu, Q., Liu, J., Zhao, X., & Jiang, H. (2016) · Biomicrofluidics · doi:10.1063/1.4967455 · Cited by 42 · see citing works
Microtechnology-Based Multi-Organ Models
Lee, S. H., & Sung, J. H. (2017) · Bioengineering · doi:10.3390/bioengineering4020046 · Cited by 42 · see citing works
New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development
Parrish, J., Lim, K. S., Zhang, B., Radisic, M., & Woodfield, T. B. F. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.04.009 · Cited by 41 · see citing works
<i>In vitro</i> functional models for human liver diseases and drug screening: beyond animal testing
Paradiso, A., Volpi, M., Rinoldi, C., Celikkin, N., Contessi Negrini, N., Bilgen, M., Dallera, G., Pierini, F., Costantini, M., Święszkowski, W., et al. (2023) · Biomaterials Science · doi:10.1039/d1bm01872h · Cited by 40 · see citing works
Lee, D. W., Lee, S. H., Choi, N., & Sung, J. H. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27151 · Cited by 38 · see citing works
Allometric Scaling of physiologically-relevant organoids
Magliaro, C., Rinaldo, A., & Ahluwalia, A. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-48347-2 · Cited by 35 · see citing works
Liver-on-chips for drug discovery and development
Mehta, V., Karnam, G., & Madgula, V. L. M. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101143 · Cited by 40 · see citing works
Engineering cell heterogeneity into organs-on-a-chip
Mertz, D. R., Ahmed, T., & Takayama, S. (2018) · Lab on a Chip · doi:10.1039/c8lc00413g · Cited by 33 · see citing works
Self-citationManufacturing of Microfluidic Sensors Utilizing 3D Printing Technologies: A Production System
Khorsandi, D., Nodehi, M., Waqar, T., Shabani, M., Kamare, B., Zare, E. N., Ersoy, S., Annabestani, M., Çelebi, M. F., & Kafadenk, A. (2021) · Journal of Nanomaterials · doi:10.1155/2021/5537074 · Cited by 33 · see citing works
Bajaj, P., Harris, J. F., Huang, J., Nath, P., & Iyer, R. S. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00480 · Cited by 31 · see citing works
Mimicking the Human Physiology with Microphysiological Systems (MPS)
Sung, J. H., Koo, J., & Shuler, M. L. (2019) · BioChip Journal · doi:10.1007/s13206-019-3201-z · Cited by 31 · see citing works
Microphysiological systems: What it takes for community adoption
Hargrove-Grimes, P., Low, L. A., & Tagle, D. A. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211008872 · Cited by 31 · see citing works
Cook, S. R., Ball, A. G., Mohammad, A., & Pompano, R. R. (2024) · Lab on a Chip · doi:10.1039/d4lc00489b · Cited by 29 · see citing works
Circadian hormone control in a human-on-a-chip: In vitro biology’s ignored component?
Cyr, K. J., Avaldi, O. M., & Wikswo, J. P. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217732766 · Cited by 29 · see citing works
Optical glucose sensor for microfluidic cell culture systems
Fuchs, S., Rieger, V., Tjell, A. Ø., Spitz, S., Brandauer, K., Schaller‐Ammann, R., Feiel, J., Ertl, P., Klimant, I., & Mayr, T. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115491 · Cited by 29 · see citing works
Microfluidic systems for studying dynamic function of adipocytes and adipose tissue
Li, X., & Easley, C. J. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0741-8 · Cited by 26 · see citing works
Microtechnology‐based organ systems and whole‐body models for drug screening
Lee, S. H., Ha, S. K., Choi, I., Choi, N., Park, T. H., & Sung, J. H. (2016) · Biotechnology Journal · doi:10.1002/biot.201500551 · Cited by 24 · see citing works
Barnes, R. H., Akama, T., Öhman, M. K., Woo, M., Bahr, J. C., Weiss, S. J., Eitzman, D. T., & Chun, T. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.003693 · Cited by 23 · see citing works
Self-citationFarshidfar, N., Assar, S., Amiri, M. A., Sahmeddini, S., Hamedani, S., Zarei, M., & Tayebi, L. (2023) · Bio-Design and Manufacturing · doi:10.1007/s42242-023-00235-5 · Cited by 23 · see citing works
Hu, J., Li, X., Judd, R. L., & Easley, C. J. (2020) · Lab on a Chip · doi:10.1039/d0lc00103a · Cited by 23 · see citing works
Microfluidics and Lab-on-a-Chip Devices: History and Challenges
Castillo-León, J. (2014) · Springer eBooks · doi:10.1007/978-3-319-08687-3_1 · Cited by 24 · see citing works
Microfabricated Physiological Models for In Vitro Drug Screening Applications
Ugolini, G. S., Cruz‐Moreira, D., Visone, R., Redaelli, A. C. L., & Rasponi, M. (2016) · Micromachines · doi:10.3390/mi7120233 · Cited by 22 · see citing works
Zhang, H., Whalley, R. D., Ferreira, A. M., & Dalgarno, K. W. (2020) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ab7cc4 · Cited by 22 · see citing works
Sumit, M., Takayama, S., & Linderman, J. J. (2016) · Integrative Biology · doi:10.1039/c6ib00178e · Cited by 20 · see citing works
Self-citationStudying Adipose Tissue in the Breast Tumor Microenvironment In Vitro: Progress and Opportunities
Mertz, D. R., Sentosa, J., Luker, G. D., & Takayama, S. (2020) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-020-00299-9 · Cited by 20 · see citing works
Self-citationHave microfluidics delivered for drug discovery?
Chandrasekaran, A., Abduljawad, M. M., & Moraes, C. (2016) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2016.1193485 · Cited by 19 · see citing works
Self-citationLab-on-a-chip workshop activities for secondary school students
Esfahani, M. M., Tarn, M. D., Choudhury, T. A., Hewitt, L. C., Mayo, A. J., Rubin, T. A., Waller, M. R., Christensen, M. G., Dawson, A., & Pamme, N. (2016) · Biomicrofluidics · doi:10.1063/1.4940884 · Cited by 18 · see citing works
Application of chemical reaction engineering principles to “body‐on‐a‐chip” systems
Sung, J. H., Wang, Y. I., Kim, J. H., Lee, J. M., & Shuler, M. L. (2018) · AIChE Journal · doi:10.1002/aic.16448 · Cited by 17 · see citing works
Lee, J., Choi, J., Ha, S. K., Choi, I., Lee, S. H., Kim, D., Choi, N., & Sung, J. H. (2014) · Lab on a Chip · doi:10.1039/c4lc00332b · Cited by 18 · see citing works
Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes in vitro
Pope, B. D., Warren, C. R., Dahl, M. O., Pizza, C. V., Henze, D. E., Sinatra, N. R., Gonzalez, G. M., Chang, H., Liu, Q., Glieberman, A. L., et al. (2020) · Lab on a Chip · doi:10.1039/d0lc00508h · Cited by 18 · see citing works
Frost, T. S., Jiang, L., & Zohar, Y. (2020) · Micromachines · doi:10.3390/mi11050536 · Cited by 16 · see citing works
Akalın, A. A., Dedekargınoğlu, B., Choi, S. R., Han, B., & Özçelikkale, A. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03298-8 · Cited by 16 · see citing works
Culture and Sampling of Primary Adipose Tissue in Practical Microfluidic Systems
Brooks, J. C., Judd, R. L., & Easley, C. J. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6820-6_18 · Cited by 15 · see citing works
3D engineered tissue models for studying human-specific infectious viral diseases
Hwang, K. S., Seo, E. U., Choi, N., Kim, J., & Kim, H. N. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.010 · Cited by 13 · see citing works
Designing 3-D Adipospheres for Quantitative Metabolic Study
Akama, T., Leung, B. M., Labuz, J., Takayama, S., & Chun, T. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6820-6_17 · Cited by 14 · see citing works
Self-citationA similarity scaling approach for organ-on-chip devices
Feng, J. J., & Hedtrich, S. (2022) · Lab on a Chip · doi:10.1039/d2lc00641c · Cited by 13 · see citing works
Shahin‐Shamsabadi, A., & Selvaganapathy, P. R. (2020) · Materials Today Bio · doi:10.1016/j.mtbio.2020.100070 · Cited by 13 · see citing works
(Bio)fabrication of microfluidic devices and organs-on-a-chip
Hrynevich, A., Li, Y., Cedillo‐Servín, G., Malda, J., & Castilho, M. D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89831-7.00001-8 · Cited by 11 · see citing works
Targeted Cancer Therapy‐on‐A‐Chip
Abed, H., Radha, R., Anjum, S., Paul, V., AlSawaftah, N., Pitt, W. G., Ashammakhi, N. A., & Husseini, G. A. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400833 · Cited by 11 · see citing works
- Authors
- Moraes, C., Labuz, J. M., Leung, B. M., Inoue, M., Chun, T.-H., & Takayama, S.
- Affiliations
- University of Michigan (US)
- Michigan Medicine (US)
- Corresponding author
- Takayama, Shuichi
- Venue
- Integrative Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013
- Volume
- 5
- Issue
- 9
- Pages
- 1149
- ISSN
- 1757-9694 (ISSN-L)
- 1757-9708
- PMC
- PMC3787867
- OpenAlex
- W2038998535
- Cited by
- 134
- References
- 86
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 12 · 2019: 9 · 2018: 11 · 2017: 24 · 2016: 19 · 2015: 7 · 2014: 14 · 2013: 1
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Integrative Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R21HL106332)
- National Cancer Institute (CA 170198, R01CA170198)
- National Institute of General Medical Sciences (GM 096040, R01GM096040)
- National Institute of Diabetes and Digestive and Kidney Diseases (R03DK091433, R01DK095137, P30DK020572)
- National Institute of Biomedical Imaging and Bioengineering (T32EB005582)
- National Institute of Dental and Craniofacial Research (T32DE007057)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- human-on-a-chip, allometric scaling, adipose tissue, basal metabolic rate, resource constraints, oxygen-carrying capacity, blood substitutes, tissue engineering, drug screening, organ-on-a-chip
- MeSH terms
- Adipose Tissue, Basal Metabolism, Computer Simulation, Glucose, Humans, Tissue Engineering, Biomimetics
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