The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway
Abstract
Alzheimer's disease (AD) is the progressive development of fatal neurodegenerative diseases. Owing to the unclearness of the pathogenesis of AD and the failure of the drug to cross the blood-brain barrier (BBB), there is currently a lack of effective diagnostic and therapeutic approaches in the treatment of AD. The aim of this study was to design exosomes (Exo) as a specifically designed carrier able to carry curcumin (cur) to prevent neuronal death in vitro and in vivo to alleviate the AD symptoms. Our results demonstrated that Exo improved the solubility and bioavailability of cur and increased drug penetration across the BBB by specific active targeting between Exo, inheriting the lymphocyte function-associated antigen 1 (LFA-1) and endothelial intercellular adhesion molecule 1 (ICAM-1). Exosomes derived from curcumin-treated (primed) cells (Exo-cur) can better prevent the death of neurons in vitro and in vivo to relieve the symptoms of AD by inhibiting phosphorylation of the Tau protein through activating the AKT/GSK-3β pathway. Our results suggested that Exo-cur featured highly effective BBB-crossing via receptor-mediated transcytosis to access brain tissues and inhibited Tau phosphorylation, holding great potential in improving targeted drug delivery and the recovery of neuronal function in AD therapy.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, it enhanced curcumin solubility, stability, and bioavailability, and curcumin exhibited a slow and smooth release profile.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [116]
In the citing paper
“Enhanced brain penetration via RMT was also observed, with a 6.5 times higher brain concentration compared to free curcumin.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [116]
In the citing paper
“Western plot analysis confirmed the inheritance of lymphocyte function-associated antigen 1 (LFA-1) from their parental cells, a protein that interacts with the endothelial intercellular adhesion molecule 1 (ICAM-1), used for BBB crossing.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [116]
In the citing paper
“No significant cytotoxicity was reported; in vivo, higher hippocampus accumulation was observed, and a reduction in OA-induced neuronal injury, cytotoxicity, and tau phosphorylation was confirmed.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [116]
In the citing paper
“The MWM test revealed an amelioration of learning and memory abilities by presenting shorter escape latencies, spatially oriented swimming behavior, and more time in the targeted quadrant.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [116]
In the citing paper
“Finally, naïve exosomes also reduced OA-induced consequences and inhibited microglia activation and neuronal cell apoptosis.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [116]
Citations
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Extracellular vesicles: biology and emerging therapeutic opportunities
EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,571
Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., Sabbagh, M., Honig, L. S., Porsteinsson, A. P., Ferris, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1304839 · Cited by 1,960
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312889 · Cited by 1,668
A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
Doody, R. S., Raman, R., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., He, F., Sun, X., Thomas, R. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1210951 · Cited by 1,224
Using exosomes, naturally-equipped nanocarriers, for drug delivery
Batrakova, E. V., & Kim, M. S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.030 · Cited by 1,041
(2016) · London School of Economics and Political Science Research Online (London School of Economics and Political Science) · Cited by 874
Flagged first, then by citations
Research works printed but not linked: 3
- M. Prince , A.Comas-Herrera , M.Knapp , M.Guerchet and M.Karagiannidou , in Proceedings of the World Alzheimer Report at Alzheimer's Disease International , London, UK , September, 2016
- Holtzman, 2011, Sci. Transl. Med., 3, 77sr1
- Johnsen, 2014, Biochim. Biophys. Acta, 1846, 75
Cited by
Sorted by citations
Items 201–300 of 326
Neurovascular glial unit: A target of phytotherapy for cognitive impairments
Chen, L., Zhen, Y., Wang, X., Wang, J., & Zhu, G. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155009 · Cited by 19
Lai, G., Wu, H., Yang, K., Hu, K., Zhao, W., Chen, X., Li, J., Haifeng, W., Lv, Z., Xie, G., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s525960 · Cited by 19
Overcoming the Blood-Brain Barrier for Drug Delivery to the Brain
Katz, J. S., Slika, H., Sattari, S. A., Malla, A. P., Xia, Y., Antar, A., Ran, K. R., & Tyler, B. (2025) · ACS Omega · doi:10.1021/acsomega.5c00364 · Cited by 19
Liu, M.-M., Liu, H., Li, S., Zhong, Y., Chen, Y., Guo, Z.-Z., Chen, W., Lin, X., Lei, Y., & Liu, A. (2020) · Talanta · doi:10.1016/j.talanta.2020.121738 · Cited by 17
Can Soluble Immune Checkpoint Molecules on Exosomes Mediate Inflammation?
Joseph, J., Rahmani, B., Cole, Y., Puttagunta, N., Lin, E., Khan, Z. K., & Jain, P. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10018-3 · Cited by 16
Non-pharmacological treatment of Alzheimer’s disease: an update
Wang, S., Xu, H., Liu, G., & Chen, L.-M. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1527242 · Cited by 19
Tang, X., He, Y., Liu, J., Xu, J., & Peng, Q. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113938 · Cited by 17
Pramoda, G., Verma, R. K., Kesharwani, P., & Shukla, R. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.127938 · Cited by 15
Cell primitive-based biomimetic nanomaterials for Alzheimer's disease targeting and therapy
Yin, T., Liu, Y., He, B., Gong, B., Chu, J., Gao, C., Liang, W., Hao, M., Sun, W., Zhuang, J., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100789 · Cited by 16
Ashique, S., Kumar, N., Mishra, N., Muthu, S., Rajendran, R. L., Chandrasekaran, B., Obeng, B. F., Hong, C. M., Krishnan, A., Ahn, B., et al. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155451 · Cited by 16
Gao, L., Yang, X.-N., Dong, Y., Han, Y., Zhang, X., Zhou, X.-L., Liu, Y., Liu, F., Fang, J., Ji, J., et al. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108751 · Cited by 16
Ke, J., Ding, J., Xu, Y., Yu, C., Hong, Y., Li, S., Meng, T., Yuan, P., Yuan, H., & Hu, F. (2025) · Biomaterials Science · doi:10.1039/d5bm01080b · Cited by 17
Gao, C., Liu, Y., Zhang, T., Luo, Y., Gao, J., Chu, J., Gong, B., Chen, X., Yin, T., Zhang, J., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s436774 · Cited by 16
Bibliometric and visualized analysis of the applications of exosomes based drug delivery
Wei, B., Huang, H., Cao, Q., Song, X., & Zhang, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116803 · Cited by 14
Exosome-based therapies for mucosal delivery
Sajnani, S. L. P., Zhang, Y., & Vllasaliu, D. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121087 · Cited by 15
Therapeutic potential of extracellular vesicles in neurodegenerative disorders
Roudi, S., Rädler, J., & Andaloussi, S. E. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-85555-6.00017-5 · Cited by 14
Zhang, N., Yan, C., Yin, C., Hu, X., Guan, P., & Cheng, Y. (2022) · ACS Omega · doi:10.1021/acsomega.2c05995 · Cited by 15
Nutritional neurology: Unraveling cellular mechanisms of natural supplements in brain health
Kumar, S., Malviya, R., & Sundram, S. (2023) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2023.200232 · Cited by 16
Ke, J., Yu, C., Li, S., Hong, Y., Xu, Y., Wang, K., Meng, T., Yuan, P., Fu, Q., Yuan, H., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302939 · Cited by 16
Wang, X., Gong, W., Li, R., Li, L., & Wang, J. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1329388 · Cited by 14
Drug Delivery Systems Based on Dendritic-Cell-Derived Exosomes
Chen, L., Zhang, J., Huang, Y., Zhang, X., Zhang, G., Kong, S., Gao, J., Zhang, X., & Ding, B. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030326 · Cited by 15
Jearjaroen, P., Pakdeepak, K., Tocharus, C., Chaichompoo, W., Suksamrarn, A., & Tocharus, J. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00269-y · Cited by 13
Deng, Z., Chen, H., Chen, J., Du, Z., Zhou, W., & Yuan, Z. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167960 · Cited by 14
Nanocarrier-mediated curcumin delivery: An adjuvant strategy for CNS disease treatment
Godse, S., Zhou, L., Sakshi, S., Singla, B., Singh, U. P., & Kumar, S. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702231211863 · Cited by 13
Yusof, N. I. S. M., & Fauzi, F. M. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105738 · Cited by 13
Ma, Y., You, T., Wang, J., Jiang, Y. J., & Niu, J. (2022) · Coatings · doi:10.3390/coatings12101449 · Cited by 12
Self-citationFan, L., & Zhang, Z. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-02946-7 · Cited by 12
Shahlaei, M., Afkhami, H., Ahmadieh-Yazdi, A., Mirmazloumi, S. H., Sahraei, S. S., Akbari, M., Yang, P., Manoochehri, H., Tanzadehpanah, H., Mahaki, H., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118548 · Cited by 11
Chen, Z., Li, Z., Zong, Y., Xia, B., Luo, S., Deng, G., & Gao, J. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18097 · Cited by 11
Liu, K., Ding, Q., Cao, D., Xi, E., Zhao, Y. S., Gao, N., Yang, Y., & Yuan, Y. (2024) · Communications Chemistry · doi:10.1038/s42004-024-01299-9 · Cited by 12
Exosomes transport trace amounts of (poly)phenols
Arola‐Arnal, A., Hazas, M. L. D. L., Iglesias‐Carres, L., Mantilla-Escalante, D. C., Suárez, M., Busto, R., Visioli, F., Bladé, C., & Dávalos, A. (2020) · Food & Function · doi:10.1039/d0fo01824d · Cited by 11
Li, F., Wu, L., Feng, X., Li, Y., & Fan, H. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18010070 · Cited by 10
Advancing Alzheimer’s disease therapy through engineered exosomal Macromolecules
Jain, S., Murmu, A., & Chauhan, A. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149590 · Cited by 10
Yang, D., Deng, Z., Zhou, H., Zhang, Q., Zhang, X., & Gong, J. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1562565 · Cited by 11
Liu, G., & Sun, Y. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251374149 · Cited by 11
Afzal, A., Khawar, M. B., Habiba, U., Shahzaman, S., Hamid, S. E., Rafiq, M., Abbasi, M. H., & Sheikh, N. (2023) · OpenNano · doi:10.1016/j.onano.2023.100130 · Cited by 10
Mazahir, F., Rahi, V., Kaundal, R. K., Alam, M. I., & Yadav, A. K. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.158197 · Cited by 9
Dhapola, R., Kumari, S., Sharma, P., Paidlewar, M., Medhi, B., Vellingiri, B., & HariKrishnaReddy, D. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05216-6 · Cited by 9
Kehinde, S. A., Lin, W. P., Lay, B. B., Phyo, K. Y., San, M. M., Pattanayaiying, R., & Chusri, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26147026 · Cited by 10
Extracellular vesicles as the drug delivery vehicle for gene-based therapy
Aquino, A. D., Rubinstein, A., Кудрявцев, И. В., Yakovlev, A. A., & Головкин, А. С. (2025) · Applied Physics Reviews · doi:10.1063/5.0255519 · Cited by 9
Emerging Role of Plant-Derived Nanostructures in Nanomedicine
Xing, H., Li, G., Qi, C., Zhang, M., Ding, N., & Zhang, X. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s547550 · Cited by 9
Senousy, M. A., Eid, A. H., Zaki, M. B., Abd‐Elmawla, M. A., Ghaiad, H. R., El‐Shiekh, R. A., Ahmed, S., & Khalifa, H. O. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1794983 · Cited by 9
Tailored Extracellular Vesicles: Novel Tool for Tissue Regeneration
Li, L., Wu, P., Qian, H., Xu, W., Shi, H., & Jiang, J. (2022) · Stem Cells International · doi:10.1155/2022/7695078 · Cited by 9
Nanovesicles for delivery of central nervous system drugs
Virmani, R., Virmani, T., & Pathak, K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91865-7.00004-3 · Cited by 9
Extracellular Vesicles for the Treatment of Alzheimer's Disease: A Systematic Review
Phelps, J., Orr, A., Elvira, K. S., & Willerth, S. M. (2025) · Journal of Extracellular Biology · doi:10.1002/jex2.70077 · Cited by 10
Mazahir, F., Alam, M. I., & Yadav, A. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102318 · Cited by 9
Liang, F., You, Q., Wang, H., Liu, J., Yang, Q., Lu, D., Ma, X., Wang, C., He, Z., Yang, Y., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202408006 · Cited by 8
Self-citationRay, R., Chowdhury, S. G., & Karmakar, P. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.109906 · Cited by 8
Zhang, C., Liu, Y., Bai, T., Shao, H., Xiong, Z., Epstein, M. M., Li, X., & Chen, H. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108637 · Cited by 9
Current trends in exosomes as therapeutic drug delivery systems
Alsaidan, O. A. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04615-9 · Cited by 7
Exosomes: A Cellular Communication Medium That Has Multiple Effects On Brain Diseases
Fang, X., Zhou, D., Wang, X., Ma, Y., Zhong, G., Jing, S., Huang, S., & Wang, Q. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03957-4 · Cited by 7
Rieux, A. D. (2021) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2021.101460 · Cited by 7
Bioengineering extracellular vesicles as novel nanocarriers towards brain disorders
Wu, J., Ma, L., Sun, D., Zhang, X., Cui, J., Du, Y., Guo, Y., Wang, X., Di, L., & Wang, R. (2022) · Nano Research · doi:10.1007/s12274-022-4913-2 · Cited by 8
Meng, X., Gong, Y., Xiao, F., Cao, Z., Zhuang, Z., Yi, X., Wang, J., Feng, R., Gong, C., & Ni, P. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251344188 · Cited by 6
Research progress of exosomes used in the Alzheimer's disease treatment
Gao, X., Yang, K., Yuan, X., Song, M., Wang, T., & Shen, C. (2025) · Discover Nano · doi:10.1186/s11671-025-04361-0 · Cited by 6
A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases
Zhang, L., Srinivasarao, S., Ansari, A. J., Kao, G., Kim, S. H., Zhang, Z., Shen, K., Hoang, T. M. L., Xinping, D., Cheng, Q., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67661-0 · Cited by 7
Rajkumar, M., Kirubakaran, D., Govindaraj, P., Shanmugarathinam, A., Deepak, P., Rajkumar, P., Uvarajan, D., Uddandrao, V. V. S., Rajendran, M., & Balamurugan, P. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.115612 · Cited by 6
Anti-aging effect of polyphenols: possibilities and challenges
Chaiwangyen, W., Chumphukam, O., Kangwan, N., Pintha, K., & Suttajit, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90581-7.00022-0 · Cited by 7
Kawiková, I., Špička, V., Lai, J. C. K., Askenase, P. W., Li, W., Kejík, Z., Jakubek, M., Valeš, K., & Španiel, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1454306 · Cited by 6
Exosomes-incorporated biomaterials boost cancer immunotherapy
Li, Y., Yang, J.-Z., Shen, S., & Ding, J. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102805 · Cited by 6
Kodidela, S., Godse, S., Kumar, A., Nguyen, X. H., Cernasev, A., Zhou, L., Singh, A. K., Bhat, H. K., & Kumar, S. (2022) · Biology · doi:10.3390/biology11020177 · Cited by 6
Roy, R., Bhattacharya, P., & Borah, A. (2022) · Current Drug Metabolism · doi:10.2174/1389200223666220526094802 · Cited by 6
Diagnostic and therapeutic potential of exosomal miRNAs in Alzheimer’s disease
Manna, I., Benedittis, S. D., Iaccino, E., Quattrone, A., & Quattrone, A. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.310674 · Cited by 6
Potential Protective Effects of Pungent Flavor Components in Neurodegenerative Diseases
Guo, F., Qin, X., Mao, J., Xu, Y. C., & Xie, J. (2024) · Molecules · doi:10.3390/molecules29235700 · Cited by 4
Olasehinde, T. A., Olisah, C., & Olaniran, A. O. (2024) · Studies in natural products chemistry · doi:10.1016/b978-0-443-15628-1.00004-0 · Cited by 5
Roles of exosomes in regenerative periodontology: a narrative review
Ünsal, R. B. K., & Chaurasia, A. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08010-y · Cited by 7
Li, J., Zhao, C., Guan, D.-H., & Liu, C. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s482362 · Cited by 4
Işık, M., Sari, H. K., Çağlayan, M. G., Yılmaz, R., & Derkuş, B. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70090 · Cited by 4
Therapeutic potential of extracellular vesicle-polyphenol nanoplatform in regenerative medicine
Ma, M., Wu, Q., Wang, T., Ma, Y., Le, F., Wang, Y., Jiang, L., Gu, Z., & Hao, Z. (2025) · Nano Materials Science · doi:10.1016/j.nanoms.2025.05.008 · Cited by 5
Unveiling Exosome Potential: Transforming Treatments for Neurodegeneration
Tiwari, A. K., Singh, B. K., Singh, G. K., Meena, J., Agrawal, A. K., Kumar, S., & Modi, G. P. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00096 · Cited by 4
Chakravarty, S., Revi, N., & Bijukumar, D. R. (2026) · Biomedical Materials · doi:10.1088/1748-605x/ae6164 · Cited by 4
Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease
QUAN, X., MA, X., LI, G., FU, X., LI, J., & ZENG, L. (2023) · Biocell · doi:10.32604/biocell.2023.031226 · Cited by 4
Extracellular Vesicles: The Invisible Heroes and Villains of COVID‐19 Central Neuropathology
Chang, H., Chen, E., Hu, Y., Wu, L., Deng, L., Ye, S., Mao, X., Zhu, T., Liu, J., & Chen, C. (2023) · Advanced Science · doi:10.1002/advs.202305554 · Cited by 4
Exosome-Based Drug Delivery Systems
Huang, R., Zhou, J., & Chen, S. (2025) · Physiology · doi:10.5772/intechopen.1009138 · Cited by 4
Pandey, P., Chaturvedi, S., Gumathannavar, R., Shirolkar, M. M., Kanuru, V. K., Kulkarni, A., & Moh, S.-H. (2023) · ChemistryOpen · doi:10.1002/open.202200200 · Cited by 4
Bone-Derived Factors: Regulating Brain and Treating Alzheimer’s Disease
Guan, Q., Cao, Y., Zou, J., & Zhang, L. (2025) · Biology · doi:10.3390/biology14091112 · Cited by 3
Shi, J., Liu, Z., Xie, J., Zhao, Z., Huang, X., & Cao, Z. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.11.060 · Cited by 4
Chen, H., Zhang, J., Huang, J., Wu, Z., Tang, L., Tian, Y., Gao, S., Huang, S., Cao, J., Chen, J., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07470-7 · Cited by 3
Zhou, J., Pu, Y., Ren, X., Li, L., Chen, Z., Lo, E. H., & Li, W. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x251348816 · Cited by 3
Shi, Y., Bao, Q., Chen, W., Wang, L., Peng, D., Liu, J., Liu, Q., Zhang, Y., Ji, Z., & Shen, A. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215666 · Cited by 3
Self-citationSilva, R., Monteiro, J., Ramalho, M. J., Andrade, S., Loureiro, J. A., & Pereira, M. C. (2026) · Pharmaceuticals · doi:10.3390/ph19050685 · Cited by 2
“[116] BBB-Blood-brain barrier; OA-osteoarthritis; Qc-quercetin; SD-Sprague Dawley.”
InfluentialHao, M., Tao, B., Luan, Y., Li, Y., Li, X., Shi, H., Wu, H., Li, Q., Liu, D., Hu, Y., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157088 · Cited by 2
Exosomes as Emerging Therapeutic Platforms in Neurological and Psychiatric Disorders
Kumar, R. M. R., Logesh, R., & Chidambaram, S. B. (2025) · Pharmaceutical Medicine · doi:10.1007/s40290-025-00584-9 · Cited by 4
Bacterial infection hypothesis-based therapies for Alzheimer's disease
Teng, M., Ma, R., Liu, S., Zhang, G., Zou, J., & Fu, Q. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169535 · Cited by 3
Liu, X., Wei, X., Zheng, X., Xu, L., Wu, G., & Feng, K. (2026) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2026.127573 · Cited by 2
Zhao, Y., Pan, M., He, S., & Zhou, X. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05794-z · Cited by 2
Genomics of aging: Reactive oxidation and inefficient mitochondria
Wysocki, K., & Heuer, B. (2023) · Journal of the American Association of Nurse Practitioners · doi:10.1097/jxx.0000000000000880 · Cited by 2
Potential Roles of Exosomes in Aging and Age-Related Diseases
Hosseini, L., & Abolhasanpour, N. (2023) · International Journal of Aging · doi:10.34172/ija.2023.e22 · Cited by 2
Medicinal and Nutritional Importance of Curcuma longa in Human Health
Shoaib, S., Jahan, R., Rehman, A. S., Shadab, M., Chauhan, W., Alomary, M. N., Ansari, M. A., & Islam, N. (2024) · Springer eBooks · doi:10.1007/978-981-97-6895-0_1 · Cited by 2
Exosomes as nanocarrier for Neurotherapy: Journey from application to challenges
Ale, Y., & Nainwal, N. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106312 · Cited by 2
Extracellular Vesicles: Therapeutic Delivery
Ma, R., Chen, L., & Hu, G. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_47 · Cited by 2
DNA methylation signatures in autism spectrum disorders
Banerjee, N., & Adak, P. (2021) · The Nucleus · doi:10.1007/s13237-021-00370-3 · Cited by 2
Xie, J., Zhong, C., Wang, T., He, D., Lu, L., Yang, J., Yuan, Z., & Zhang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.937075 · Cited by 2
Li, J., Xu, R., Zhao, C., & Liu, C. (2023) · Research Square · doi:10.21203/rs.3.rs-2485896/v1 · Cited by 2
Recent advances on the role of exosomes in neurodegenerative diseases
Bu, C.-T., Zhu, X., Zhang, Q., & Wenya, S. H. A. O. (2025) · Chinese Journal of Chromatography · doi:10.3724/sp.j.1123.2024.10035 · Cited by 1
Tiny Messengers, Huge Consequences: Extracellular Vesicles and mTOR Signaling in Neuroinflammation
Garcia‐Segura, P., Chicote‐González, A., Espasa‐Marco, A., Garcia‐Alcaraz, M., Mora‐Bernabé, L., Abelló‐Fernández, M., & Malagelada, C. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70256 · Cited by 2
Cao, Y., Wang, R., Ni, Z., Luo, T., & Zhang, X. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c08992 · Cited by 2
Mazahir, F., Rahi, V., Kumar, A., Kaundal, R. K., & Yadav, A. K. (2026) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2026.102934 · Cited by 1
Wang, Y., Yin, J., Wang, W., Song, M., Shen, X., Wu, T., Sun, R., Liu, M., Han, X., Yong, J., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152468 · Cited by 1
Zhang, C., Long, W., Ni, J., Chen, Z., Wu, X., Li, M., Du, F., Zhao, Y., Shen, J., Cho, C. H., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06002-8 · Cited by 1
Metadata
- Authors
- Wang, H., Sui, H., Zheng, Y., Jiang, Y., Shi, Y., Liang, J., & Zhao, L.
- Affiliations
- Jinzhou Medical University (CN)
- Corresponding author
- Shi, Yijie
- Liang, Jia
- Zhao, Liang
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2019
- Volume
- 11
- Issue
- 15
- Pages
- 7481-7496
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2923362583
- Cited by
- 324
- References
- 48
- Citations by year
- 2026: 26 · 2025: 51 · 2024: 48 · 2023: 63 · 2022: 45 · 2021: 51 · 2020: 32 · 2019: 8
- FWCI
- 23.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81501017, 81502484)
- Natural Science Foundation of Liaoning Province (201602337)
- Department of Education of Liaoning Province (JYTQN201719)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Keywords
- curcumin, exosomes, Alzheimer's disease, tau hyperphosphorylation, blood-brain barrier penetration, transcytosis, drug delivery, neuronal cell death, cognitive function
- MeSH terms
- RAW 264.7 Cells, Glycogen Synthase Kinase 3 beta, Alzheimer Disease, Animals, Cognition, Curcumin, Disease Models, Animal, Drug Carriers, Male, Phosphorylation, tau Proteins, Rats, Sprague-Dawley, Proto-Oncogene Proteins c-akt, Mice, Rats, Exosomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
