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Exosomes-Based Nanomedicine for Neurodegenerative Diseases: Current Insights and Future Challenges

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Recent Advances on Extracellular Vesicles in Central Nervous System Diseases

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Exosome-based approaches in the management of Alzheimer’s disease

Kandimalla, R., Saeed, M., Tyagi, N., Gupta, R. C., & Aqil, F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104974 · Cited by 43 · see citing works

The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial

Nishihira, J., Nishimura, M., Kurimoto, M., Kagami‐Katsuyama, H., Hattori, H., Nakagawa, T., Muro, T., & Kobori, M. (2021) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.21-17 · Cited by 43 · see citing works

Multi-targeted engineered hybrid exosomes as Aβ nanoscavengers and inflammatory modulators for multi-pathway intervention in Alzheimer's disease

Du, B., Zou, Q., Wang, X., Wang, H., Yang, X., Wang, Q., & Wang, K. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123403 · Cited by 42 · see citing works

Current Overview on the Use of Nanosized Drug Delivery Systems in the Treatment of Neurodegenerative Diseases

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Design strategies of polysaccharide, protein and lipid-based nano-delivery systems in improving the bioavailability of polyphenols and regulating gut homeostasis

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Unveiling the Complex Role of Exosomes in Alzheimer’s Disease

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Recent progress of nanomedicine in the treatment of Alzheimer’s disease

Hu, L., Tao, Y., Jiang, Y., & Qin, F. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1228679 · Cited by 40 · see citing works

The emerging role of exosomes in communication between the periphery and the central nervous system

Han, W., Zhang, H., Feng, L., Dang, R., Wang, J., Cui, C., & Jiang, P. (2023) · MedComm · doi:10.1002/mco2.410 · Cited by 38 · see citing works

To re-examine the intersection of microglial activation and neuroinflammation in neurodegenerative diseases from the perspective of pyroptosis

Li, Y., Li, Y., & Zhu, Z. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1284214 · Cited by 41 · see citing works

Bioengineered microglia-targeted exosomes facilitate Aβ clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer's disease

Hao, Y., Su, C., Liu, X., Sui, H., Shi, Y., & Zhao, L. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212770 · Cited by 39 · see citing works

Exosome-based drug delivery systems for enhanced neurological therapeutics

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M1 Microglia Induced Neuronal Injury on Ischemic Stroke via Mitochondrial Crosstalk between Microglia and Neurons

Liu, W., Qi, Z., Li, W., Liang, J., Zhao, L., & Shi, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4335272 · Cited by 37 · see citing works

Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders

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Recent Progress in Nanomedicine for the Diagnosis and Treatment of Alzheimer’s Diseases

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Peripheral extracellular vesicles in neurodegeneration: pathogenic influencers and therapeutic vehicles

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Nano-based drug delivery systems for active ingredients from traditional Chinese medicine: Harnessing the power of nanotechnology

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Overcoming the Blood–Brain Barrier: Multifunctional Nanomaterial‐Based Strategies for Targeted Drug Delivery in Neurological Disorders

McLoughlin, C. D., Nevins, S., Stein, J. B., Khakbiz, M., & Lee, K. (2024) · Small Science · doi:10.1002/smsc.202400232 · Cited by 38 · see citing works

Fabrication and In Vitro/Vivo Evaluation of Drug Nanocrystals Self-Stabilized Pickering Emulsion for Oral Delivery of Quercetin

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Quercetin-Loaded Nanostructured Lipid Carrier In Situ Gel for Brain Targeting Through Intranasal Route: Formulation, In Vivo Pharmacokinetic and Pharmacodynamic Studies

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Latest Perspectives on Alzheimer’s Disease Treatment: The Role of Blood-Brain Barrier and Antioxidant-Based Drug Delivery Systems

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The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation

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Exosomes: Biological Pharmaceutical Nanovectors for Theranostics

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Applications of Extracellular Vesicles in Nervous System Disorders: An Overview of Recent Advances

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Exploring the potential of quercetin in Alzheimer's Disease: Pharmacodynamics, Pharmacokinetics, and Nanodelivery systems

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Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease

Woon, C. K., Hui, W. K., Abas, R., Haron, M. H., Das, S., & Lin, T. S. (2021) · Current Neuropharmacology · doi:10.2174/1570159x20666211217163540 · Cited by 34 · see citing works

What we know on the potential use of exosomes for nanodelivery

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Exosomes in Parkinson: Revisiting Their Pathologic Role and Potential Applications

Ouerdane, Y., Hassaballah, M. Y., Nagah, A., Ibrahim, T. M., Mohamed, H. A. H., El-Baz, A., & Attia, M. S. (2022) · Pharmaceuticals · doi:10.3390/ph15010076 · Cited by 31 · see citing works

Exosome‐Based Therapeutics: A Natural Solution to Overcoming the Blood–Brain Barrier in Neurodegenerative Diseases

Sun, M., Qin, F., Bu, Q., Zhao, Y., Yang, X., Zhang, D., & Cen, X. (2025) · MedComm · doi:10.1002/mco2.70386 · Cited by 33 · see citing works

Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair

McKay, T. B., Emmitte, K. A., German, C., & Karamichos, D. (2023) · Bioengineering · doi:10.3390/bioengineering10101127 · Cited by 29 · see citing works

Exploring potential of exosomes drug delivery system in the treatment of cancer: Advances and prospective

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Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape

Sugandhi, V. V., Gadhave, D. G., Ugale, A. R., Kulkarni, N. N., Nangare, S., Patil, H. P., Rath, S., Saxena, R., Lavate, A., Patel, A. T., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102775 · Cited by 31 · see citing works

Role of exosomes and its emerging therapeutic applications in the pathophysiology of non-infectious diseases

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Synthesis and evaluation of glycosylated quercetin to enhance neuroprotective effects on cerebral ischemia-reperfusion

Wang, S., Chen, Y., Chen, X., Yang, C., Chen, J., Li, H., Wu, Y., & Yang, Z. (2022) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2022.117008 · Cited by 26 · see citing works

Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders

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Engineered Extracellular Vesicles for Drug Delivery in Therapy of Stroke

Ahmed, W., Kuniyan, M. S., Jawed, A., & Chen, L. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092173 · Cited by 26 · see citing works

Living Cells and Cell-Derived Vesicles: A Trojan Horse Technique for Brain Delivery

Ou, A., Wang, Y., Zhang, J., & Huang, Y. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041257 · Cited by 25 · see citing works

Exosomes as a therapeutic tool to promote neurorestoration and cognitive function in neurological conditions: Achieve two ends with a single effort

Fallahi, S., Zangbar, H. S., Farajdokht, F., Rahbarghazi‬, R., Mohaddes, G., & Ghiasi, R. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14752 · Cited by 25 · see citing works

Advances in Neurodegenerative Disease Therapy: Stem Cell Clinical Trials and Promise of Engineered Exosomes

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Expanding Arsenal against Neurodegenerative Diseases Using Quercetin Based Nanoformulations: Breakthroughs and Bottlenecks

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Engineered extracellular vesicles: an emerging nanomedicine therapeutic platform

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery

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Exosomes: A novel insight into traditional Chinese medicine

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Extracellular vesicle–based drug delivery system boosts phytochemicals’ therapeutic effect for neurodegenerative diseases

Zhu, Z., Liao, L., & Qiao, H. (2022) · Acupuncture and Herbal Medicine · doi:10.1097/hm9.0000000000000039 · Cited by 23 · see citing works

HIV Neuroinflammation: The Role of Exosomes in Cell Signaling, Prognostic and Diagnostic Biomarkers and Drug Delivery

Mahajan, S. D., Ordain, N. S., Kutscher, H. L., Karki, S., & Reynolds, J. L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637192 · Cited by 23 · see citing works

Single and Multitarget Systems for Drug Delivery and Detection: Up-to-Date Strategies for Brain Disorders

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Drug-Loaded Extracellular Vesicle-Based Drug Delivery: Advances, Loading Strategies, Therapeutic Applications, and Clinical Challenges

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Recent Advances in Nanocrystals Heralding Greater Potential in Brain Delivery

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Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

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Exosome-mediated dual drug delivery of curcumin and methylene blue for enhanced cognitive function and mechanistic elucidation in Alzheimer’s disease therapy

Yang, D., Deng, Z., Zhou, H., Zhang, Q., Zhang, X., & Gong, J. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1562565 · Cited by 10 · see citing works

Plasma Exosomes as a Therapeutic Approach Prevent the Cognitive Decline by Inhibiting Tau Protein Hyperphosphorylation in Alzheimer’s Disease Mice

Huang, L., Wang, H., Sui, H., Shi, Y., & Zhao, L. (2021) · Journal of Biomaterials and Tissue Engineering · doi:10.1166/jbt.2021.2558

Exosome-Based Drug Delivery in Alzheimer’s Disease: Current Advances and Emerging Strategies

Studer, M. (2026) · Open Access Journal of Gerontology & Geriatric Medicine · doi:10.19080/oajggm.2026.09.555770

Trace Metal Imbalances and Their Association with Malnutrition in Children with Febrile Seizures in Interior Sindh, Pakistan

Abbasi, M. A. (2025) · Nutrition & Food Science International journal · doi:10.19080/nfsij.2025.15.555907