Augmented peripheral nerve regeneration through elastic nerve guidance conduits prepared using a porous PLCL membrane with a 3D printed collagen hydrogel
Abstract
Longitudinally oriented, 3D printed collagen hydrogel-grafted elastic nerve guidance conduits to promote nerve regeneration in peripheral nerve defects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Introducing collagen, gelatin and fibroin into PLCL significantly improves cell adhesion ability of PLCL nerve conduit and promotes migration adhesion and growth of nerve cells.
“By introducing collagen, gelatin and fibroin into PLCL, the cell adhesion ability of PLCL nerve conduit can be significantly improved, and the migration adhesion and growth of nerve cells can be promoted [183, 184].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [183]
Cites
3D bioprinting of collagen to rebuild components of the human heart
Lee, A., Hudson, A. R., Shiwarski, D. J., Tashman, J. W., Hinton, T. J., Yerneni, S., Bliley, J. M., Campbell, P. G., & Feinberg, A. W. (2019) · Science · doi:10.1126/science.aav9051 · Cited by 1,782 · see citing works
Neural tissue engineering options for peripheral nerve regeneration
Gu, X., Ding, F., & Williams, D. F. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.064 · Cited by 630 · see citing works
DiameterJ: A validated open source nanofiber diameter measurement tool
Hotaling, N. A., Bharti, K., Kriel, H., & Simon, C. G. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.05.015 · Cited by 531 · see citing works
Biomaterials for the Development of Peripheral Nerve Guidance Conduits
Nectow, A. R., Marra, K. G., & Kaplan, D. L. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2011.0240 · Cited by 395 · see citing works
3D Bioprinting of Spatially Heterogeneous Collagen Constructs for Cartilage Tissue Engineering
Rhee, S., Puetzer, J. L., Mason, B. N., Reinhart‐King, C. A., & Bonassar, L. J. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00288 · Cited by 367 · see citing works
Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit
Carvalho, C. R., Oliveira, J. M., & Reis, R. L. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00337 · Cited by 297 · see citing works
Diamantides, N., Wang, L., Pruiksma, T., Siemiatkoski, J., Dugopolski, C., Shortkroff, S., Kennedy, S. M., & Bonassar, L. J. (2017) · Biofabrication · doi:10.1088/1758-5090/aa780f · Cited by 254 · see citing works
Jeong, S. I., Kim, B., Kang, S., Kwon, J. H., Lee, Y. M., Kim, S. H., & Kim, Y. H. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.01.057 · Cited by 247 · see citing works
Self-citationChemical insights into bioinks for 3D printing
Valot, L., Martínez, J., Mehdi, A., & Subra, G. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00718c · Cited by 223 · see citing works
Peripheral Nerve Conduit: Materials and Structures
Houshyar, S., Bhattacharyya, A., & Shanks, R. A. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00203 · Cited by 216 · see citing works
Park, J. Y., Choi, J., Shim, J., Lee, J., Park, H., Kim, S. W., Doh, J., & Cho, D. (2014) · Biofabrication · doi:10.1088/1758-5082/6/3/035004 · Cited by 214 · see citing works
Self-citationSarker, M. D., Naghieh, S., McInnes, A. D., Schreyer, D. J., & Chen, D. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.07.002 · Cited by 199 · see citing works
GelMA-collagen blends enable drop-on-demand 3D printablility and promote angiogenesis
Stratesteffen, H., Köpf, M., Kreimendahl, F., Blaeser, A., Jockenhoevel, S., & Fischer, H. (2017) · Biofabrication · doi:10.1088/1758-5090/aa857c · Cited by 197 · see citing works
Manufacture of elastic biodegradable PLCL scaffolds for mechano-active vascular tissue engineering
Jeong, S. I., Kim, S. H., Kim, Y. H., Jung, Y., Kwon, J. H., Kim, B.-S., & Lee, Y. M. (2004) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856204323046906 · Cited by 181 · see citing works
Self-citationEngland, S., Rajaram, A., Schreyer, D. J., & Chen, D. (2016) · Bioprinting · doi:10.1016/j.bprint.2016.12.001 · Cited by 127 · see citing works
Bridging the gap in peripheral nerve repair with 3D printed and bioprinted conduits
Dixon, A. R., Jariwala, S. H., Bilis, Z., Loverde, J. R., Pasquina, P. F., & Alvarez, L. M. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.010 · Cited by 110 · see citing works
Mitochondrial dysfunction and neuromuscular disease
Nardin, R. A., & Johns, D. R. (2001) · Muscle & Nerve · doi:10.1002/1097-4598(200102)24:2 · Cited by 100 · see citing works
Manoukian, O. S., Baker, J. T., Rudraiah, S., Arul, M. R., Vella, A. T., Domb, A. J., & Kumbar, S. G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.11.021 · Cited by 97 · see citing works
Singh, A., Shiekh, P. A., Das, M., Seppälä, J. V., & Kumar, A. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b01308 · Cited by 95 · see citing works
Singh, A., Asikainen, S., Teotia, A. K., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b11677 · Cited by 91 · see citing works
Zhang, D., Yao, Y., Duan, Y.-Y., Yu, X., Shi, H.-F., Nakkala, J. R., Zuo, X., Hong, L., Mao, Z.-W., & Gao, C.-Y. (2020) · ACS Applied Materials and Interfaces · doi:10.1021/acsami.9b20321 · Cited by 89 · see citing works
Meyer, C., Wróbel, S., Raimondo, S., Rochkind, S., Heimann, C., Shahar, A., Ziv‐Polat, O., Geuna, S., Grothe, C., & Haastert‐Talini, K. (2016) · Cell Transplantation · doi:10.3727/096368915x688010 · Cited by 84 · see citing works
Dense fibrillar collagen matrices: A model to study myofibroblast behaviour during wound healing
Hélary, C., Ovtracht, L., Coulomb, B., Godeau, G., & Giraud‐Guille, M. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.04.005 · Cited by 84 · see citing works
Isometric tetanic force measurement method of the tibialis anterior in the rat
Shin, R. H., Vathana, T., Giessler, G. A., et al. (2008) · Microsurgery · doi:10.1002/micr.20520 · Cited by 83 · see citing works
Yang, Y., Zhao, W., He, J., Zhao, Y., Ding, F., & Gu, X. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.06.008 · Cited by 74 · see citing works
Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction
Sierra-Fonseca, J. A., Najera, O., Martinez-Jurado, J., Walker, E. M., Varela-Ramı́rez, A., Khan, A. M., Miranda, M., Lamango, N. S., & Roychowdhury, S. (2014) · BMC Neuroscience · doi:10.1186/s12868-014-0132-4 · Cited by 60 · see citing works
Functional Evaluation in the Rat Sciatic Nerve Defect Model
Lee, J.-Y., Giusti, G., Wang, H., et al. (2013) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3182a3bfeb · Cited by 60 · see citing works
Kim, T. H., Jung, Y., & Kim, S. H. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0318 · Cited by 60 · see citing works
Self-citationApplication of peripheral nerve conduits in clinical practice: A literature review
Chrząszcz, P., Derbisz, K., Suszyńśki, K., Miodoński, J., Trybulski, R., Lewin‐Kowalik, J., & Marcol, W. (2018) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2018.06.003 · Cited by 57 · see citing works
Shafiq, M., Jung, Y., & Kim, S. H. (2015) · European Cells and Materials · doi:10.22203/ecm.v030a20 · Cited by 51 · see citing works
Self-citationOh, S. H., Kang, J. G., Kim, T. H., Namgung, U., Song, K. S., Jeon, B. H., & Lee, J. H. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36216 · Cited by 46 · see citing works
Saltzman, E. B., Villa, J. C., Doty, S. B., Feinberg, J. H., Lee, S. K., & Wolfe, S. W. (2018) · The Journal Of Hand Surgery · doi:10.1016/j.jhsa.2018.10.008 · Cited by 46 · see citing works
The critical chemical and mechanical regulation of folic acid on neural engineering
Kim, G. B., Chen, Y., Kang, W., Guo, J., Payne, R. A., Li, H., Wei, Q., Baker, J., Dong, C., Zhang, S., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.059 · Cited by 45 · see citing works
Ezra, M., Bushman, J. S., Shreiber, D. I., et al. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0354 · Cited by 44 · see citing works
Mohamadi, F., Ebrahimi‐Barough, S., Nourani, M. R., Ahmadi, A., & Ai, J. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1451339 · Cited by 40 · see citing works
Wang, J., Qu, Y., Chen, C., Sun, J., Pan, H., Shao, C., Tang, R., & Gu, X. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109959 · Cited by 39 · see citing works
Tidu, A., Ghoubay, D., Teulon, C., Asnacios, S., Grieve, K. F., Portier, F., Schanne‐Klein, M., Borderie, V. M., & Mosser, G. (2018) · Biomaterials Science · doi:10.1039/c7bm01163f · Cited by 33 · see citing works
Drug‐delivering nerve conduit improves regeneration in a critical‐sized gap
Labroo, P., Hilgart, D., Davis, B., Lambert, C. J., Sant, H. J., Gale, B. K., Shea, J., & Agarwal, J. P. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26837 · Cited by 30 · see citing works
Evaluation of two biodegradable nerve guides for the reconstruction of the rat sciatic nerve.
Luís, A. L., Rodrigues, J. M., Lobato, J. V., et al. (2007) · PubMed · Cited by 29 · see citing works
Vigier, S., Catania, C., Baroukh, B., Jl, S., Giraud‐Guille, M., & Colombier, M. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0336 · Cited by 18 · see citing works
Liu, Y., Yu, S., Gu, X., Cao, R., & Cui, S. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab17a0 · Cited by 17 · see citing works
Enhanced Cartilaginous Tissue Formation with a Cell Aggregate-Fibrin-Polymer Scaffold Complex
Lee, S., Lee, K., Kim, S. H., & Jung, Y. (2017) · Polymers · doi:10.3390/polym9080348 · Cited by 14 · see citing works
Self-citationKim, J. P., Hundepool, C. A., Friedrich, P. F., et al. (2017) · Microsurgery · doi:10.1002/micr.30211 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Structure-property relationships in 3D-printed poly(l-lactide-co-ε-caprolactone) degradable polymer
Bachtiar, E. O., Ritter, V. C., & Gall, K. (2021) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2021.104650 · Cited by 27 · see citing works
Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works
“By introducing collagen, gelatin and fi broin into PLCL, the cell adhesion ability of PLCL nerve conduit can be signi fi cantly improved, and the migration adhesion and growth of nerve cells can be promoted [183, 184].”
- Authors
- Yoo, J., Park, J. H., Kwon, Y. W., Chung, J. J., Choi, I. C., Nam, J. J., Lee, H. S., Jeon, E. Y., Lee, K., Kim, S. H., Jung, Y., & Park, J. W.
- Affiliations
- Korea Institute of Science and Technology (KR)
- Korea University Guro Hospital (KR)
- Eulji Medical Center (KR)
- Korea University Anam Hospital (KR)
- Seoul National University (KR)
- Korea University (KR)
- Yonsei University (KR)
- Corresponding author
- Jung, Youngmee
- Park, Jong Woong
- ORCID
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 8
- Issue
- 22
- Pages
- 6261-6271
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W3090628389
- Cited by
- 86
- References
- 43
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 17 · 2023: 12 · 2022: 24 · 2021: 10
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (NRF2018M3A7B4071106)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- peripheral nerve regeneration, nerve conduits, sciatic nerve defect, collagen gel, 3D printing, electrospinning, nanoporous membranes, axon regeneration, remyelination, functional recovery
- MeSH terms
- Animals, Collagen, Nerve Regeneration, Porosity, Rats, Sprague-Dawley, Hydrogels, Rats, Printing, Three-Dimensional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review