The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

Design and studies of multiple mechanism of anti-Candida activity of a new potent Trp-rich peptide dendrimers

Zielińska, P., Staniszewska, M., Bondaryk, M., Koronkiewicz, M., & Urbańczyk-Lipkowska, Z. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.10.013 · Cited by 40

Peptide Targeting of an Antibiotic Prodrug toward Phagosome-Entrapped Mycobacteria

Pereira, M. P., Shi, J., & Kelley, S. O. (2015) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5b00099 · Cited by 40

Positional effects of click cyclization on β-hairpin structure, stability, and function

Park, J. H., & Waters, M. L. (2012) · Organic & Biomolecular Chemistry · doi:10.1039/c2ob26445e · Cited by 39

Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2

Migoń, D., Jaśkiewicz, M., Neubauer, D., Bauer, M., Sikorska, E., Kamysz, E., & Kamysz, W. (2018) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-018-9501-0 · Cited by 39

Design, crystal structure and atomic force microscopy study of thioether ligated d , l -cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa

He, R., Bonaventura, I. D., Visini, R., Gan, B., Fu, Y., Probst, D., Lüscher, A., Köhler, T., van Delden, C., Stocker, A., et al. (2017) · Chemical Science · doi:10.1039/c7sc01599b · Cited by 38

Antibiotic resilience: a necessary concept to complement antibiotic resistance?

Carvalho, G., Forestier, C., & Mathias, J. (2019) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2408 · Cited by 38

β-Lactam-host defence peptide conjugates as antibiotic prodrug candidates targeting resistant bacteria

Desgranges, S., Ruddle, C. C., Burke, L. P., McFadden, T. M., O’Brien, J. E., Fitzgerald‐Hughes, D., Humphreys, H., Smyth, T. P., & Devocelle, M. C. (2012) · RSC Advances · doi:10.1039/c2ra01351g · Cited by 37

Antiplasmodial Activity of Lauryl-Lysine Oligomers

Radzishevsky, I. S., Krugliak, M., Ginsburg, H., & Mor, A. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01288-06 · Cited by 37

An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria

Bonaventura, I. D., Baeriswyl, S., Capecchi, A., Gan, B., Jin, X., Siriwardena, T. N., He, R., Köhler, T., Pompilio, A., Bonaventura, G. D., et al. (2018) · Chemical Communications · doi:10.1039/c8cc02412j · Cited by 37

Extracorporeal Removal of Endotoxin: The Polymyxin B-Immobilized Fiber Cartridge

Tani, T., Shoji, H., Guadagni, G., & Perego, A. F. (2010) · Contributions to nephrology · doi:10.1159/000315917 · Cited by 36

Novel Miniature Membrane Active Lipopeptidomimetics against Planktonic and Biofilm Embedded Methicillin-Resistant Staphylococcus aureus

Joshi, S., Mumtaz, S., Singh, J., Pasha, S., & Mukhopadhyay, K. (2018) · Scientific Reports · doi:10.1038/s41598-017-17234-z · Cited by 36

Key Residues in Octyl‐Tridecaptin A1 Analogues Linked to Stable Secondary Structures in the Membrane

Cochrane, S. A., Findlay, B., Vederas, J. C., & Ratemi, E. (2014) · ChemBioChem · doi:10.1002/cbic.201402024 · Cited by 35

Site-specific pegylation of an antimicrobial peptide increases resistance to Pseudomonas aeruginosa elastase

Falciani, C., Lozzi, L., Scali, S., Brunetti, J., Bracci, L., & Pini, A. (2014) · Amino Acids · doi:10.1007/s00726-014-1686-2 · Cited by 35

Put a Bow on It: Knotted Antibiotics Take Center Stage

Tan, S., Moore, G., & Nodwell, J. (2019) · Antibiotics · doi:10.3390/antibiotics8030117 · Cited by 35

Design of Salt-Insensitive Glycine-Rich Antimicrobial Peptides with Cyclic Tricystine Structures

Tam, J. P., Lu, Y., & Yang, J. (2000) · Biochemistry · doi:10.1021/bi0003487 · Cited by 33

Semi-synthesis of Polymyxin B (2-10) and Colistin (2-10) Analogs Employing the Trichloroethoxycarbonyl (Troc) Group for Side Chain Protection of .ALPHA.,.GAMMA.-Diaminobutyric Acid Residues

Okimura, K., Ohki, K., Sato, Y., Ohnishi, K., & Sakura, N. (2007) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.55.1724 · Cited by 32

Designing Hybrid Antibiotic Peptide Conjugates To Cross Bacterial Membranes

Deshayes, S., Xian, W., Schmidt, N. W., Kordbacheh, S., Lieng, J., Wang, J. P., Zarmer, S., Germain, S. S., Voyen, L., Thulin, J., et al. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00725 · Cited by 32

Magainin 2 and PGLa in Bacterial Membrane Mimics II: Membrane Fusion and Sponge Phase Formation

Kabelka, I., Pachler, M., Prévost, S. F., Letofsky‐Papst, I., Lohner, K., Pabst, G., & Vácha, R. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2019.12.019 · Cited by 32

Defense peptides: recent developments

Cytryńska, M., & Zdybicka‐Barabas, A. (2015) · BioMolecular Concepts · doi:10.1515/bmc-2015-0014 · Cited by 31

A heterodimer comprised of two bovine lactoferrin antimicrobial peptides exhibits powerful bactericidal activity against Burkholderia pseudomallei

Puknun, A., Bolscher, J. G. M., Nazmi, K., Veerman, E. C. I., Tungpradabkul, S., Wongratanacheewin, S., Kanthawong, S., & Taweechaisupapong, S. (2013) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-013-1284-6 · Cited by 31

Association between vision-specific quality of life and falls in community-dwelling older adults: LOHAS

Niihata, K., Fukuma, S., Hiratsuka, Y., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195806 · Cited by 31

The Skin Secretion of the Amphibian Phyllomedusa nordestina: A Source of Antimicrobial and Antiprotozoal Peptides

Brand, G. D., Santos, R. M. R., de Tacca, L. A., et al. (2013) · Molecules · doi:10.3390/molecules18067058 · Cited by 30

Selection and redesign for high selectivity of membrane-active antimicrobial peptides from a dedicated sequence/function database

Rončević, T., Vukičević, D., Krce, L., Benincasa, M., Aviani, I., Maravić, A., & Tossi, A. (2019) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2019.01.017 · Cited by 30

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling

Robertson, N., Walsh, S. J., Fowler, E., Yoshida, M., Rowe, S. M., Wu, Y., Sore, H. F., Parker, J. S., & Spring, D. R. (2019) · Chemical Communications · doi:10.1039/c9cc05042f · Cited by 30

Efficacy of Voriconazole against Aspergillus fumigatus Infection Depends on Host Immune Function

Rosowski, E. E., He, J., Huisken, J., Keller, N. P., & Huttenlocher, A. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00917-19 · Cited by 29

Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides

Rubin, G. M., & Ding, Y. (2020) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-020-02289-1 · Cited by 29

Increased potency of a novel d-β-naphthylalanine-substituted antimicrobial peptide against fluconazole-resistant fungal pathogens

Wang, C., Yip, B., Cheng, H.-T., Wang, A.-H., Chen, H., Cheng, J., & Lo, H. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00531.x · Cited by 28

Pharmacokinetics and Pharmacodynamics of Murepavadin in Neutropenic Mouse Models

Melchers, M. J. B., Teague, J., Warn, P. A., Hansen, J. U., Bernardini, F., Wach, A., Obrecht, D., Dale, G. E., & Mouton, J. W. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01699-18 · Cited by 28

Efficacy and toxicity of the antimicrobial peptide M33 produced with different counter-ions

Pini, A., Lozzi, L., Bernini, A., Brunetti, J., Falciani, C., Scali, S., Bindi, S., Maggio, T. D., Rossolini, G. M., Niccolai, N., et al. (2011) · Amino Acids · doi:10.1007/s00726-011-1103-z · Cited by 27

Using chemical synthesis to optimise antimicrobial peptides in the fight against antimicrobial resistance

Li, F. F., & Brimble, M. A. (2019) · Pure and Applied Chemistry · doi:10.1515/pac-2018-0704 · Cited by 27

Mortality associated with Blastomyces dermatitidis infection: A systematic review of the literature and meta-analysis

Carignan, A., Denis, M., & Chakra, C. N. A. (2019) · Medical Mycology · doi:10.1093/mmy/myz048 · Cited by 27

In Vitro Efficacies, ADME, and Pharmacokinetic Properties of Phenoxazine Derivatives Active against Mycobacterium tuberculosis

Tanner, L., Evans, J. C., Seldon, R., et al. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01010-19 · Cited by 27

The relationship of eosinophil granule proteins to ions in the sputum of patients with cystic fibrosis

Halmerbauer, G., Arri, S., Schierl, M., Strauch, E., & Koller, D. Y. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00988.x · Cited by 26

Bioinspired Amphiphilic Peptide Dendrimers as Specific and Effective Compounds against Drug Resistant Clinical Isolates of E. coli

Sowińska, M., Laskowska, A. K., Guśpiel, A., Solecka, J., Bochyńska-Czyż, M., Lipkowski, A. W., Trzeciak, K., & Urbańczyk-Lipkowska, Z. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00544 · Cited by 25

Synergistic Effect of Propidium Iodide and Small Molecule Antibiotics with the Antimicrobial Peptide Dendrimer G3KL against Gram-Negative Bacteria

Gan, B., Cai, X., Javor, S., Köhler, T., & Reymond, J. (2020) · Molecules · doi:10.3390/molecules25235643 · Cited by 25

De Novo Design and Their Antimicrobial Activity of Stapled Amphipathic Helices of Heptapeptides

Dinh, T. T. T., Kim, D., Lee, B., et al. (2014) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2014.35.12.3632 · Cited by 24

A potent antibacterial activity of new short d-enantiomeric lipopeptide against multi drug resistant bacteria

Lee, J. H., Kim, S., Sim, J.-Y., Lee, D., Kim, H. H., Hwang, J. S., Lee, D. G., Park, Z., & Kim, J. I. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.10.014 · Cited by 24

Antimicrobial peptides in the real world: implications for cystic fibrosis

Hiemstra, P. S. (2007) · European Respiratory Journal · doi:10.1183/09031936.00017007 · Cited by 23

Induced expression of cathelicidins in trout ( Oncorhynchus mykiss ) challenged with four different bacterial pathogens

Furlan, M., Rosani, U., Gambato, S., Irato, P., Manfrin, A., Mardirossian, M., Venier, P., Pallavicini, A., & Scocchi, M. (2018) · Journal of Peptide Science · doi:10.1002/psc.3089 · Cited by 23

A systems biological view of intracellular pathogens

Beiting, D. P., & Roos, D. S. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00998.x · Cited by 22

Evolution and Impact of Bacterial Drug Resistance in the Context of Cystic Fibrosis Disease and Nosocomial Settings

Sriramulu, D. D. (2013) · Microbiology Insights · doi:10.4137/mbi.s10792 · Cited by 22

Effect of Selectively Introducing Arginine and D-Amino Acids on the Antimicrobial Activity and Salt Sensitivity in Analogs of Human Beta-Defensins

Olli, S., Rangaraj, N., & Nagaraj, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077031 · Cited by 22

Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides

Mitchell, S. A., Truscott, F., Dickman, R., Ward, J., & Tabor, A. B. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.10.015 · Cited by 22

Antifungal activity of a de novo synthetic peptide and derivatives against fungal food contaminants

Thery, T. L. C., Shwaiki, L. N., O’Callaghan, Y. C., O’Brien, N. M., & Arendt, E. K. (2018) · Journal of Peptide Science · doi:10.1002/psc.3137 · Cited by 21

Peptidomimetics and their Applications in Antifungal Drug Design

Moradi, S., Soltani, S., Ansari, A. M., & Sardari, S. (2009) · Anti-Infective Agents · doi:10.2174/187152109789760216 · Cited by 20

Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment

Slootweg, J. C., Peters, N., van Ufford, H. C. Q., Breukink, E. J., Liskamp, R. M. J., & Rijkers, D. T. S. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.07.046 · Cited by 17

Random mixtures of antimicrobial peptides inhibit bacteria associated with pasteurized bovine milk

Bauer, T. S., & Hayouka, Z. (2018) · Journal of Peptide Science · doi:10.1002/psc.3088 · Cited by 16

Antibacterial AZT derivative regulates metastasis of breast cancer cells

Chirumarry, S., Soung, N., Han, J., Kim, E. Y., Ryu, E. K., Lee, Y., Shin, S. Y., Gunasekaran, P., & Bang, J. K. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112233 · Cited by 15

Antimicrobial peptide cocktail activity in minced turkey meat

Palman, Y., Leo, R. D., Pulvirenti, A., Green, S. J., & Hayouka, Z. (2020) · Food Microbiology · doi:10.1016/j.fm.2020.103580 · Cited by 15

Antimicrobial activity of levofloxacin – M33 peptide conjugation or combination

Ceccherini, F., Falciani, C., Onori, M., et al. (2015) · MedChemComm · doi:10.1039/c5md00392j · Cited by 14

Self-assembling Lipopeptides with a Potent Activity Against Gram-Positive Bacteria, Including Multidrug Resistant Strains

Azmi, F., Elliott, A. G., Khalil, Z. G., Hussein, W. M., Kavanagh, A. M., Huang, J. X., Quezada, M., Blaskovich, M. A. T., Capon, R. J., Cooper, M. A., et al. (2015) · Nanomedicine · doi:10.2217/nnm.15.137 · Cited by 12

CB 1 cannabinoid receptor‐phosphorylated fourth intracellular loop structure‐function relationships

Eldeeb, K., Ganjiwale, A. D., Chandrashekaran, I. R., et al. (2018) · Peptide Science · doi:10.1002/pep2.24104 · Cited by 11

A QSAR modeling approach for predicting myeloid antimicrobial peptides with high sequence similarity

Waghu, F. H., Gawde, U., Gomatam, A., Coutinho, E. C., & Idicula‐Thomas, S. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13749 · Cited by 10

There’s plenty of room at the top

(2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0532-9 · Cited by 10

Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin

Ptaszyńska, N., Gucwa, K., Łęgowska, A., Dębowski, D., Gitlin‐Domagalska, A., Lica, J. J., Heldt, M., Martynow, D., Olszewski, M., Milewski, S., et al. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00440 · Cited by 9

Antimicrobial activity of POL7306 tested against clinical isolates of Gram-negative bacteria collected worldwide

Sader, H. S., Rhomberg, P. R., Duncan, L. R., Locher, H. H., Dale, G. E., & Flamm, R. K. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa020 · Cited by 9

Solution Structure and Model Membrane Interactions of P‐113, a Clinically Active Antimicrobial Peptide Derived from Human Saliva

Yip, B., Chen, H., Cheng, H.-T., Wu, J., & Cheng, J. (2009) · Journal of the Chinese Chemical Society · doi:10.1002/jccs.200900140 · Cited by 6

Antimicrobial peptides for combating drug-resistant bacterial infections

Xuan, J., Feng, W., Wang, J., Wang, R., Zhang, B., Bo, L., Chen, Z.-S., Yang, H., & Sun, L. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100954 · Cited by 665

Antimicrobial Peptides—Mechanisms of Action, Antimicrobial Effects and Clinical Applications

Talapko, J., Meštrović, T., Juzbašić, M., Tomas, M., Erić, S., Horvat Aleksijević, L., Bekić, S., Schwarz, D., Matić, S., Neuberg, M., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11101417 · Cited by 281

Synergizing artificial intelligence and probiotics: A comprehensive review of emerging applications in health promotion and industrial innovation

Han, X., Liu, Q., Li, Y., Zhang, M., Liu, K., Kwok, L.-Y., Zhang, H., & Zhang, W. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.104938 · Cited by 64

Antimicrobial peptides in green coconut water: from nutritional benefits to multifunctional applications for human health

Ngan, H. D., Huy, B. L., Uyen, C. L., Phuong, H. B. T., & Xuan, H. L. (2025) · European Food Research and Technology · doi:10.1007/s00217-025-04754-6 · Cited by 3