Synergizing artificial intelligence and probiotics: A comprehensive review of emerging applications in health promotion and industrial innovation
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Whole-genome sequencing-based genomic screening allows in silico detection of antibiotic resistance genes, virulence-associated factors, and mobile genetic elements, providing a basis for modern probiotic safety evaluation.
“Whole-genome sequencing-based genomic screening allows for the in silico detection of antibiotic resistance genes, virulence-associated factors, and mobile genetic elements, thus providing a basis for modern probiotic safety evaluation [20,133,155,156].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]
Genomic risk screening can be accelerated using AI algorithms such as DeepMicro, CARD, ResFinder, and machine-learning models identifying specific tRNAs that distinguish safe probiotics from dangerous intestinal pathogens.
“Thus, genomic risk screening can be accelerated through rapid identification using artificial intelligence (AI) algorithms (in particular, DeepMicro, which analyzes sequencing data at high speed to identify bacterial species and potential pathogens with greater speed and accuracy than cultivation-based methods); identification of ARG and virulence detection (for example, using a big data platform”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]
AI can analyze big data from omics technologies to create a safety profile for probiotics based on metabolomics, evaluating metabolite production to ensure strains do not produce harmful substances associated with health risks.
“AI can be used to analyze big data from various omics technologies to create a safety profile for probiotics based on, for example, metabolomics, where AI evaluates metabolite production to ensure that strains do not produce harmful substances associated with various health risks [156,164].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]
AI plays a major role in predictive toxicology, where microbial metabolites and their physiological functions can be predicted using machine learning and potential toxic activity identified before in vivo testing.
“AI plays a major role in the development of predictive toxicology, in which microbial metabolites and their physiological functions can be predicted using a machine learning (ML) model, and potential toxic activity can be identified before in vivo testing [21,156].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]
AI assessment of safety for vulnerable groups analyzes large data and identifies specific risk factors for side effects such as impaired intestinal barrier function or immunocompromised conditions, allowing safer probiotic use.
“The assessment of the degree of safety for vulnerable groups using AI is conducted by analyzing large amounts of data and identifying specific “risk factors” for side effects, such as impaired intestinal barrier function or immunocompromised conditions, which allows for safer use of probiotics [21,156].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]
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Parkinson's Disease and Its's Stage Classification using Artificial Intelligence
Uma Rani, M., Rithikasri, R. P., SakthiPraba, V., et al. (2022) · International Conference on Advanced Technologies in Intelligent Control, Environment, Computing & Communication Engineering (ICATIECE) · doi:10.1109/icatiece56365.2022.10046891 · Cited by 2 · see citing works
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Understanding the Functionality of Probiotics on the Edge of Artificial Intelligence (AI) Era
Asar, R., Erenler, S., Devecioglu, D., Ispirli, H., Karbancioglu-Guler, F., Ozturk, H. I., & Dertli, E. (2025) · Fermentation · doi:10.3390/fermentation11050259 · Cited by 37 · see citing works
Current Concepts in Probiotic Safety and Efficacy
Churin, A. A., Sokolyanskaya, L. O., Lukina, A. P., & Karnachuk, O. V. (2026) · Nutrients · doi:10.3390/nu18040696 · Cited by 31 · see citing works
“…genes and virulence factors at the genomic level); and prediction based on a machine learning model with the identification of specific tRNAs that distinguish safe probiotics against dangerous intestinal pathogens, which helps to carry out screening at an early stage [156,165,166].”
InfluentialJo, D.-M., Ko, S.-C., Kim, K. W., Yang, D., Kim, J.-Y., Oh, G.-W., Choi, G., Lee, D.-S., Tabassum, N., Kim, Y.-M., et al. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105309 · Cited by 20 · see citing works
- Authors
- Han, X., Liu, Q., Li, Y., Zhang, M., Liu, K., Kwok, L.-Y., Zhang, H., & Zhang, W.
- Affiliations
- Inner Mongolia Agricultural University (CN)
- Corresponding author
- Zhang, Meng
- Venue
- Trends in Food Science & Technology
- Publisher
- Elsevier BV
- Published
- 2025-05
- Volume
- 159
- Pages
- 104938
- ISSN
- 0924-2244 (ISSN-L)
- OpenAlex
- W4407923135
- Cited by
- 64
- References
- 203
- Citations by year
- 2026: 43 · 2025: 21
- FWCI
- 30.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 337 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Trends in Food Science & Technology (acceptedVersion)
- Funders
- National Natural Science Foundation of China (32372304)
- Government of Inner Mongolia Autonomous Region
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Computer Science › Artificial Intelligence › Artificial Intelligence Applications
- Keywords
- artificial intelligence, probiotics, machine learning, biomarker prediction, probiotic metabolites, antimicrobial peptides, exopolysaccharides, phenolic compounds, personalized nutrition, inflammatory bowel disease, irritable bowel syndrome, gut microbiota, functional foods, personalized medicine, fermentation technology, bacterial identification
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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