Cited by 64Probiotics and Fermented FoodsGut microbiota and healthArtificial Intelligence Applications

Synergizing artificial intelligence and probiotics: A comprehensive review of emerging applications in health promotion and industrial innovation

Open access
Han, Xin, Liu, Qingqiu, Li, Yun, Zhang, Meng, Liu, Kaiyang, Kwok, Lai-Yu, Zhang, Heping, Zhang, Wenyi·2025·Trends in Food Science & Technology

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Registry

Crossref · 10.1016/j.tifs.2025.104938

Cites

203 of 203 references verified0 citation errors · 0 not checkable

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  • Whole-genome sequencing-based genomic screening allows in silico detection of antibiotic resistance genes, virulence-associated factors, and mobile genetic elements, providing a basis for modern probiotic safety evaluation.

    “Whole-genome sequencing-based genomic screening allows for the in silico detection of antibiotic resistance genes, virulence-associated factors, and mobile genetic elements, thus providing a basis for modern probiotic safety evaluation [20,133,155,156].”

    From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]

  • Genomic risk screening can be accelerated using AI algorithms such as DeepMicro, CARD, ResFinder, and machine-learning models identifying specific tRNAs that distinguish safe probiotics from dangerous intestinal pathogens.

    “Thus, genomic risk screening can be accelerated through rapid identification using artificial intelligence (AI) algorithms (in particular, DeepMicro, which analyzes sequencing data at high speed to identify bacterial species and potential pathogens with greater speed and accuracy than cultivation-based methods); identification of ARG and virulence detection (for example, using a big data platform”

    From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]

  • AI can analyze big data from omics technologies to create a safety profile for probiotics based on metabolomics, evaluating metabolite production to ensure strains do not produce harmful substances associated with health risks.

    “AI can be used to analyze big data from various omics technologies to create a safety profile for probiotics based on, for example, metabolomics, where AI evaluates metabolite production to ensure that strains do not produce harmful substances associated with various health risks [156,164].”

    From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]

  • AI plays a major role in predictive toxicology, where microbial metabolites and their physiological functions can be predicted using machine learning and potential toxic activity identified before in vivo testing.

    “AI plays a major role in the development of predictive toxicology, in which microbial metabolites and their physiological functions can be predicted using a machine learning (ML) model, and potential toxic activity can be identified before in vivo testing [21,156].”

    From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]

  • AI assessment of safety for vulnerable groups analyzes large data and identifies specific risk factors for side effects such as impaired intestinal barrier function or immunocompromised conditions, allowing safer probiotic use.

    “The assessment of the degree of safety for vulnerable groups using AI is conducted by analyzing large amounts of data and identifying specific “risk factors” for side effects, such as impaired intestinal barrier function or immunocompromised conditions, which allows for safer use of probiotics [21,156].”

    From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [156]

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Authors
Han, X., Liu, Q., Li, Y., Zhang, M., Liu, K., Kwok, L.-Y., Zhang, H., & Zhang, W.
Affiliations
Inner Mongolia Agricultural University (CN)
Corresponding author
Zhang, Meng
Venue
Trends in Food Science & Technology
Publisher
Elsevier BV
Published
2025-05
Volume
159
Pages
104938
ISSN
0924-2244 (ISSN-L)
OpenAlex
W4407923135
Cited by
64
References
203
Citations by year
2026: 43 · 2025: 21
FWCI
30.21
Type
journal article
Language
en
Open access
Locations
Trends in Food Science & Technology (acceptedVersion)
Funders
  • National Natural Science Foundation of China (32372304)
  • Government of Inner Mongolia Autonomous Region
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Physical Sciences › Computer Science › Artificial Intelligence › Artificial Intelligence Applications
Keywords
artificial intelligence, probiotics, machine learning, biomarker prediction, probiotic metabolites, antimicrobial peptides, exopolysaccharides, phenolic compounds, personalized nutrition, inflammatory bowel disease, irritable bowel syndrome, gut microbiota, functional foods, personalized medicine, fermentation technology, bacterial identification

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