Cited by 578Coffee research and impactsPhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

Chlorogenic Acids from Green Coffee Extract Are Highly Bioavailable in Humans

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Farah, Adriana, Monteiro, Mariana, Donangelo, Carmen M., Lafay, Sophie·2008·The Journal of Nutrition

Abstract

Chlorogenic acids (CGA) are cinnamic acid derivatives with biological effects mostly related to their antioxidant and antiinflammatory activities. Caffeoylquinic acids (CQA) and dicaffeoylquinic acids (diCQA) are the main CGA found in nature. Because green coffee is a major source of CGA, it has been used for production of nutraceuticals. However, data on the bioavailability of CGA from green coffee in humans are inexistent. The present study evaluated the pharmacokinetic profile and apparent bioavailability of CGA in plasma and urine of 10 healthy adults for 8 h after the consumption of a decaffeinated green coffee extract containing 170 mg of CGA. Three CQA, 3 diCQA, and caffeic, ferulic, isoferulic, and p-coumaric acids were identified in plasma by HPLC-Diode Array Detector-MS after treatment. Over 30% (33.1 +/- 23.1%) of the ingested cinnamic acid moieties were recovered in plasma, including metabolites, with peak levels from 0.5 to 8 h after treatment. CGA and metabolites identified in urine after treatment were 4-CQA, 5-CQA, and sinapic, p-hydroxybenzoic, gallic, vanillic, dihydrocaffeic, caffeic, ferulic, isoferulic, and p-coumaric acids, totaling 5.5 +/- 10.6% urinary recovery of the ingested cinnamic and quinic acid moiteties. This study shows that the major CGA compounds present in green coffee are highly absorbed and metabolized in humans.

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  1. [5]5. Santos MD, Almeida MC, Lopes NP, Souza GEP. Evaluation of the antiinflamatory, analgesic and antypiretic activity of the natural poly- phenol chlorogenic acid. Biol Pharm Bull. 2006;29:2236-40.
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Authors
Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S.
Affiliations
  • Universidade Federal do Rio de Janeiro (BR)
  • Naturex (France) (FR)
Corresponding author
Farah, Adriana
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2008-12
Volume
138
Issue
12
Pages
2309-2315
ISSN
0022-3166 (ISSN-L)
OpenAlex
W2127688626
Cited by
578
References
50
Citations by year
2026: 18 · 2025: 16 · 2024: 20 · 2023: 33 · 2022: 29 · 2021: 40 · 2020: 43 · 2019: 42 · 2018: 49 · 2017: 52 · 2016: 48 · 2015: 39 · 2014: 35 · 2013: 28 · 2012: 32
FWCI
12.42
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords
chlorogenic acid, green coffee bean extract, bioavailability, pharmacokinetics, caffeoylquinic acids, dicaffeoylquinic acids, cinnamic acid derivatives, urinary excretion, plasma absorption, metabolites, nutraceuticals, decaffeinated coffee
MeSH terms
Adult, Biological Availability, Caffeic Acids, Caffeine, Chlorogenic Acid, Cinnamates, Coffee, Coumaric Acids, Female, Humans, Male, Middle Aged, Propionates, Quinic Acid, Young Adult

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