Chlorogenic Acids from Green Coffee Extract Are Highly Bioavailable in Humans
Open accessAbstract
Chlorogenic acids (CGA) are cinnamic acid derivatives with biological effects mostly related to their antioxidant and antiinflammatory activities. Caffeoylquinic acids (CQA) and dicaffeoylquinic acids (diCQA) are the main CGA found in nature. Because green coffee is a major source of CGA, it has been used for production of nutraceuticals. However, data on the bioavailability of CGA from green coffee in humans are inexistent. The present study evaluated the pharmacokinetic profile and apparent bioavailability of CGA in plasma and urine of 10 healthy adults for 8 h after the consumption of a decaffeinated green coffee extract containing 170 mg of CGA. Three CQA, 3 diCQA, and caffeic, ferulic, isoferulic, and p-coumaric acids were identified in plasma by HPLC-Diode Array Detector-MS after treatment. Over 30% (33.1 +/- 23.1%) of the ingested cinnamic acid moieties were recovered in plasma, including metabolites, with peak levels from 0.5 to 8 h after treatment. CGA and metabolites identified in urine after treatment were 4-CQA, 5-CQA, and sinapic, p-hydroxybenzoic, gallic, vanillic, dihydrocaffeic, caffeic, ferulic, isoferulic, and p-coumaric acids, totaling 5.5 +/- 10.6% urinary recovery of the ingested cinnamic and quinic acid moiteties. This study shows that the major CGA compounds present in green coffee are highly absorbed and metabolized in humans.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Coffee is a source of CGA, which has antioxidant, antibacterial, and anti-inflammatory activities.
“Coffee is also a source of CGA (Table 1), a hydroxycinnamic acid with health-promoting properties such as antioxidant, antibacterial, and anti-inflammatory activities, among others [212].”
From Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis (2020) · cites this paper as [212]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085 · see citing works
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175 · see citing works
Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261 · see citing works
Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
Olthof, M. R., Katan, M. B., & Hollman, P. C. H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.1.66 · Cited by 975 · see citing works
Farah, A., & Donangelo, C. M. (2006) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202006000100003 · Cited by 840 · see citing works
Self-citationEffect of Roasting on the Formation of Chlorogenic Acid Lactones in Coffee
Farah, A., de Paulis, T., Trugo, L. C., & Martin, P. R. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048701t · Cited by 540 · see citing works
Self-citationdos Santos, M. D., Almeida, M. C., Lopes, N. P., & de Souza, G. E. P. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.2236 · Cited by 513 · see citing works
The Physiology and Pathophysiology of Gastric Emptying in Humans
Minami, H., & McCallum, R. W. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80178-x · Cited by 511 · see citing works
Chlorogenic Acid, Quercetin-3-Rutinoside and Black Tea Phenols Are Extensively Metabolized in Humans
Olthof, M. R., Hollman, P. C. H., Buijsman, M. N. C. P., van Amelsvoort, J. M. M., & Katan, M. B. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.6.1806 · Cited by 468 · see citing works
Coffee consumption and risk for type 2 diabetes mellitus
Salazar-Martinez, E., Willett, W. C., Ascherio, A., Manson, J. E., Leitzmann, M. F., Stampfer, M. J., & Hu, F. B. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-1-200401060-00005 · Cited by 462 · see citing works
The small intestine can both absorb and glucuronidate luminal flavonoids
Spencer, J. P. E., Chowrimootoo, G., Choudhury, R., Debnam, E. S., Srai, S. K., & Rice-Evans, C. A. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01160-6 · Cited by 405 · see citing works
Disposition of quercetin in man after single oral and intravenous doses
Gugler, R., Leschik, M., & Dengler, H. J. (1975) · European Journal of Clinical Pharmacology · doi:10.1007/bf00614022 · Cited by 405 · see citing works
Absorption of Phenolic Acids in Humans after Coffee Consumption
Nardini, M., Cirillo, E., Natella, F., & Scaccini, C. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0257547 · Cited by 386 · see citing works
Estimation of creatinine by the Jaffe reaction. A comparison of three methods.
Husdan, H., & Rapoport, A. (1968) · PubMed · Cited by 367 · see citing works
Almeida, A. A. P., Farah, A., Silva, D. A. M., Nunan, E. A., & Glória, M. B. A. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0617317 · Cited by 343 · see citing works
Self-citationAbsorption of Chlorogenic Acid and Caffeic Acid in Rats after Oral Administration
Azuma, K., Ippoushi, K., Nakayama, M., Ito, H., Higashio, H., & Terao, J. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000483q · Cited by 339 · see citing works
Chlorogenic Acid Compounds from Coffee Are Differentially Absorbed and Metabolized in Humans ,
Monteiro, M., Farah, A., Perrone, D., Trugo, L. C., & Donangelo, C. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.10.2196 · Cited by 324 · see citing works
Self-citationEstimation of Creatinine by the Jaffe Reaction
Husdan, H., & Rapoport, A. (1968) · Clinical Chemistry · doi:10.1093/clinchem/14.3.222 · Cited by 296 · see citing works
Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice
Shimoda, H., Seki, E., & Aitani, M. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-9 · Cited by 277 · see citing works
Bioavailability of Ferulic Acid
Bourne, L., & Rice-Evans, C. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9681 · Cited by 275 · see citing works
Chlorogenic Acid Is Absorbed in Its Intact Form in the Stomach of Rats
Lafay, S., Gil‐Izquierdo, Á., Manach, C., Morand, C., Besson, C., & Scalbert, A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.5.1192 · Cited by 256 · see citing works
Self-citationNovel biomarkers of the metabolism of caffeic acid derivatives in vivo
Rechner, A. R., Spencer, J. P. E., Kuhnle, G., Hahn, U., & Rice-Evans, C. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00506-8 · Cited by 255 · see citing works
Ranheim, T., & Halvorsen, B. L. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200400109 · Cited by 251 · see citing works
Chlorogenic Acids and Lactones in Regular and Water-Decaffeinated Arabica Coffees
Farah, A., de Paulis, T., Moreira, D. P., Trugo, L. C., & Martin, P. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0518305 · Cited by 243 · see citing works
Self-citationGastric emptying of varying meal weight and composition in man
Moore, J. G., Christian, P. E., & Coleman, R. E. (1981) · Digestive Diseases and Sciences · doi:10.1007/bf01307971 · Cited by 217 · see citing works
In vitro modulation of inflammatory cytokine and IgG levels by extracts of Perna canaliculus
Mani, S., & Lawson, J. W. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-1 · Cited by 211 · see citing works
Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats
Lafay, S., Morand, C., Manach, C., Besson, C., & Scalbert, A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061714 · Cited by 199 · see citing works
Self-citationURINARY METABOLITES OF CAFFEIC AND CHLOROGENIC ACIDS
Booth, A. N., Emerson, O. H., Jones, F. T., & DeEds, F. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70592-9 · Cited by 181 · see citing works
Antihypertensive Effect of Green Coffee Bean Extract on Mildly Hypertensive Subjects
Kozuma, K., TSUCHIYA, S., Kohori, J., Hase, T., & Tokimitsu, I. (2005) · Hypertension Research · doi:10.1291/hypres.28.711 · Cited by 180 · see citing works
Suzuki, A., Kagawa, D., OCHIAI, R., Tokimitsu, I., & Saito, I. (2002) · Hypertension Research · doi:10.1291/hypres.25.99 · Cited by 175 · see citing works
Quinides of roasted coffee enhance insulin action in conscious rats
Shearer, J., Farah, A., de Paulis, T., Bracy, D. P., Pencek, R. R., Graham, T. E., & Wasserman, D. H. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.11.3529 · Cited by 154 · see citing works
Self-citationUrinary excretion of hydroxycinnamates and flavonoids after oral and intravenous administration
Choudhury, R., Srai, S. K., Debnam, E. S., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00054-4 · Cited by 152 · see citing works
Kern, S. M., Bennett, R. N., Needs, P. W., Mellon, F. A., Kroon, P. A., & García‐Conesa, M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030470n · Cited by 147 · see citing works
Phenolic Acids Are Absorbed from the Rat Stomach with Different Absorption Rates
Konishi, Y., Zhao, Z., & Shimizu, M. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061554+ · Cited by 143 · see citing works
Polyphenols from Alcoholic Apple Cider Are Absorbed, Metabolized and Excreted by Humans
DuPont, M. S., Bennett, R. N., Mellon, F. A., & Williamson, G. (2002) · Journal of Nutrition · doi:10.1093/jn/132.2.172 · Cited by 136 · see citing works
Green Coffee Bean Extract Improves Human Vasoreactivity
OCHIAI, R., JOKURA, H., Suzuki, A., Tokimitsu, I., Ohishi, M., Komai, N., Rakugi, H., & Ogihara, T. (2004) · Hypertension Research · doi:10.1291/hypres.27.731 · Cited by 133 · see citing works
Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds
Baer‐Dubowska, W., Szaefer, H., & Krajka‐Kuźniak, V. (1998) · Xenobiotica · doi:10.1080/004982598239155 · Cited by 132 · see citing works
The Metabolic Fate of Gallic Acid and Related Compounds
Booth, A. N., Masri, M. S., ROBBINS, D. J., Emerson, O. H., Jones, F. T., & DeEds, F. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69715-7 · Cited by 124 · see citing works
Dupas, C., Marsset‐Baglieri, A., Ordonaud, C. S., Tomé, D., & Maillard, M. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600034 · Cited by 105 · see citing works
LC/ES−MS Detection of Hydroxycinnamates in Human Plasma and Urine
Cremin, P. A., Kasim-Karakas, S. E., & Waterhouse, A. L. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000764y · Cited by 104 · see citing works
Release of substituents from phenolic compounds during oxidative coupling reactions
Dec, J., Haider, K., & Bollag, J. (2003) · Chemosphere · doi:10.1016/s0045-6535(03)00236-4 · Cited by 90 · see citing works
Absorption of isoflavones in humans: effects of food matrix and processing
de Pascual‐Teresa, S., Hallund, J., Talbot, D. C. S., Schroot, J. H., Williams, C. M., Bügel, S., & Cassidy, A. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.04.008 · Cited by 84 · see citing works
Masukawa, Y., Matsui, Y., Shimizu, N., Kondou, N., Endou, H., Kuzukawa, M., & Hase, T. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.02.008 · Cited by 66 · see citing works
Urinary Detection of Hydroxycinnamates and Flavonoids in Humans after High Dietary Intake of Fruit
Bourne, L., & Rice-Evans, C. A. (1998) · Free Radical Research · doi:10.3109/10715769809070812 · Cited by 65 · see citing works
Dellalibera, O., Lemaire, B., & Lafay, S. (2006) · Phytothérapie · doi:10.1007/s10298-006-0181-7 · Cited by 64 · see citing works
Self-citationAn Analysis of Methods for the Prediction of Normal Erythrocyte Mass
Frenkel, E. P., McCall, M. S., Reisch, J., & Minton, P. D. (1972) · American Journal of Clinical Pathology · doi:10.1093/ajcp/58.3.260 · Cited by 14 · see citing works
Geotz, P. (2006) · Phytothérapie · doi:10.1007/bf02763540 · Cited by 6 · see citing works
Chlorogenic acids from coffee are absorbed and excreted in human digested fluids.
Farah, A., Monteiro, M. S., Guigon, F., Perrone, D., Calado, V. M. D. A., Donangelo, C. M., & Trugo, L. C. (2007) · Cited by 5 · see citing works
Self-citationThe effect of human digestive fluids on chlorogenic acid isomers from coffee.
Farah, A., Guigon, F., & Trugo, L. C. (2007) · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 6
- [5]5. Santos MD, Almeida MC, Lopes NP, Souza GEP. Evaluation of the antiinflamatory, analgesic and antypiretic activity of the natural poly- phenol chlorogenic acid. Biol Pharm Bull. 2006;29:2236-40.
- [13]13. Blum J, Lemaire B, Lafay S. Effect of a green decaffeinated coffee extract on glycaemia. NutraFoods Res. 2007;6:13-7.
- [19]19. Farah A. Distribuic xa ˜o nos gra ˜os, importa ˆncia na qualidade da bebida e biodisponibilidade dos a ´cidos cloroge ˆncios do cafe ´[PhD thesis]. Rio de Janeiro: Universidade Federal do Rio de Janeiro; 2004.
- [22]22. Baer-Dubowska W, Szaefer H. Inhibition of murine hepatic cytochrome p-450 acitivies by natural and synthetic compounds. Xenobiotica. 1998; 28:735-43.
- [24]24. Farah A, Trugo LC. Chlorogenic acid isomers from coffee are differ- entially uptaken by HEPG2 human hepatocite cell line. Proceedings of the 21 st International Conference on Coffee Science. 2006:101-4.
- [32]32. IUPAC. Nomenclature of cyclitols. Biochem J. 1976;153:23-31.
Cited by
Sorted by citations
Functional Properties of Coffee and Coffee By-Products
Esquivel, P., & Jiménez, V. M. (2012) · Food Research International · doi:10.1016/j.foodres.2011.05.028 · Cited by 847 · see citing works
Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions
Liang, N., & Kitts, D. D. (2015) · Nutrients · doi:10.3390/nu8010016 · Cited by 824 · see citing works
Bioavailability of dietary flavonoids and phenolic compounds
Crozier, A., Rio, D. D., & Clifford, M. N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.007 · Cited by 550 · see citing works
Lu, H., Tian, Z., Cui, Y., Liu, Z., & Ma, X. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12620 · Cited by 454 · see citing works
The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota
Makarewicz, M., Drożdż, I., Tarko, T., & Duda‐Chodak, A. (2021) · Antioxidants · doi:10.3390/antiox10020188 · Cited by 444 · see citing works
Clifford, M. N., Jaganath, I. B., Ludwig, I. A., & Crozier, A. (2017) · Natural Product Reports · doi:10.1039/c7np00030h · Cited by 418 · see citing works
Stalmach, A., Mullen, W., Barron, D., Uchida, K., Yokota, T., Cavin, C., Steiling, H., Williamson, G., & Crozier, A. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.028019 · Cited by 401 · see citing works
Arscott, S. A., & Tanumihardjo, S. A. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2009.00103.x · Cited by 323 · see citing works
Centella asiatica: Phytochemistry and mechanisms of neuroprotection and cognitive enhancement
Gray, N. E., Alcazar Magana, A., Lak, P., Wright, K. M., Quinn, J., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-017-9528-y · Cited by 299 · see citing works
Recovery of Natural Antioxidants from Spent Coffee Grounds
Panusa, A., Zuorro, A., Lavecchia, R., Marrosu, G., & Petrucci, R. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4005719 · Cited by 289 · see citing works
Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy
Stalmach, A., Steiling, H., Williamson, G., & Crozier, A. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.03.005 · Cited by 284 · see citing works
Klingel, T., Kremer, J. I., Gottstein, V., Rajcic de Rezende, T., Schwarz, S., & Lachenmeier, D. W. (2020) · Foods · doi:10.3390/foods9050665 · Cited by 264 · see citing works
Influence of genotype and environment on coffee quality
Cheng, B., Furtado, A., Smyth, H. E., & Henry, R. J. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.09.003 · Cited by 263 · see citing works
Jacobo‐Velázquez, D. A., Martínez–Hernández, G. B., Rodríguez, S., Cao, C.-M., & Cisneros‐Zevallos, L. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2006529 · Cited by 257 · see citing works
Neuroprotective Effects of Coffee Bioactive Compounds: A Review
Socała, K., Szopa, A., Serefko, A., Poleszak, E., & Właź, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010107 · Cited by 263 · see citing works
Nallamuthu, I., Devi, A. T., & Khanum, F. (2014) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2014.09.005 · Cited by 238 · see citing works
Onakpoya, I., Terry, R. H., & Ernst, E. (2010) · Gastroenterology Research and Practice · doi:10.1155/2011/382852 · Cited by 238 · see citing works
Revalorization of coffee by-products. Prebiotic, antimicrobial and antioxidant properties
Jiménez-Zamora, A., Pastoriza, S., & Rufián‐Henares, J. Á. (2014) · LWT · doi:10.1016/j.lwt.2014.11.031 · Cited by 231 · see citing works
Antioxidant Properties of Hydroxycinnamic Acids: A Review of Structure- Activity Relationships
Razzaghi‐Asl, N., Garrido, J., Khazraei, H., Borges, F., & Firuzi, O. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990141 · Cited by 227 · see citing works
Genaro‐Mattos, T. C., Maurı́cio, A. Q., Rettori, D., Alonso, A., & Hermes‐Lima, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129963 · Cited by 206 · see citing works
Palafox-Carlos, H., Yahia, E. M., & González-Aguilar, G. A. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.04.103 · Cited by 202 · see citing works
The influence of beverage composition on delivery of phenolic compounds from coffee and tea
Ferruzzi, M. G. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.01.035 · Cited by 198 · see citing works
Coffee consumption and disease correlations
Gökcen, B. B., & Şanlıer, N. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1369391 · Cited by 188 · see citing works
Bioavailability and metabolism of chlorogenic acids (acyl‐quinic acids) in humans
Clifford, M. N., Kerimi, A., & Williamson, G. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12518 · Cited by 183 · see citing works
Perrone, D., Farah, A., & Donangelo, C. M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205388x · Cited by 179 · see citing works
Self-citationConsumption of Chlorogenic Acids through Coffee and Health Implications
Farah, A., & Lima, J. D. P. (2019) · Beverages · doi:10.3390/beverages5010011 · Cited by 177 · see citing works
Self-citationPotential health enhancing properties of edible flowers from Thailand
Kaisoon, O., Konczak, I., & Siriamornpun, S. (2011) · Food Research International · doi:10.1016/j.foodres.2011.06.016 · Cited by 176 · see citing works
Mills, C. E., Tzounis, X., Oruña-Concha, M. J., Mottram, D. S., Gibson, G. R., & Spencer, J. P. E. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514003948 · Cited by 173 · see citing works
Antioxidative mechanisms in chlorogenic acid
Tošović, J., Marković, S., Marković, J. M. D., Mojović, M., & Milenković, D. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.05.080 · Cited by 172 · see citing works
Phenolic compounds in agri-food by-products, their bioavailability and health effects
Shahidi, F., Vamadevan, V., Oh, W. Y., & Peng, H. (2019) · Journal of Food Bioactives · doi:10.31665/jfb.2019.5178 · Cited by 166 · see citing works
Chen, L., Gnanaraj, C., Arulselvan, P., El-Seedi, H. R., & Teng, H. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.11.026 · Cited by 163 · see citing works
Gupta, A., Atanasov, A. G., Li, Y., Kumar, N., & Bishayee, A. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106505 · Cited by 163 · see citing works
Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols
Feliciano, R. P., Boeres, A., Massacessi, L., Istas, G., Ventura, M. R., dos Santos, C. N., Heiß, C., & Rodriguez‐Mateos, A. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.01.014 · Cited by 162 · see citing works
Cardozo, E. L., & Morand, C. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2015.12.010 · Cited by 160 · see citing works
Ncube, E. N., Mhlongo, M. I., Piater, L. A., Steenkamp, P. A., Dubery, I. A., & Madala, N. E. (2014) · Chemistry Central Journal · doi:10.1186/s13065-014-0066-z · Cited by 159 · see citing works
Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine
Nabavi, S. F., Tejada, S., Setzer, W. N., Gortzi, O., Sureda, A., Braidy, N., Daglia, M., Manayi, A., & Nabavi, S. M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160325120625 · Cited by 152 · see citing works
Mubarak, A., Bondonno, C. P., Liu, A. H., Considine, M. J., Rich, L., Mas, E., Croft, K. D., & Hodgson, J. M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf303440j · Cited by 157 · see citing works
Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review
Rojas-González, A., Figueroa-Hernández, C. Y., González-Ríos, Ó., Suárez-Quiroz, M. L., González‐Amaro, R. M., Hernández‐Estrada, Z. J., & Rayas‐Duarte, P. (2022) · Molecules · doi:10.3390/molecules27113400 · Cited by 157 · see citing works
Hydroxycinnamic acids and human health: recent advances
Coman, V., & Vodnar, D. C. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10010 · Cited by 155 · see citing works
Anticancer Properties of Hydroxycinnamic Acids -A Review
Rocha, L. D., Monteiro, M. C., & Teodoro, A. J. (2012) · Cancer and Clinical Oncology · doi:10.5539/cco.v1n2p109 · Cited by 148 · see citing works
Self-citationChait, Y. A., Gunenc, A., Bendali, F., & Hosseinian, F. S. (2019) · LWT · doi:10.1016/j.lwt.2019.108623 · Cited by 148 · see citing works
Onakpoya, I., Spencer, E. A., Thompson, M., & Heneghan, C. J. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2014.46 · Cited by 146 · see citing works
Çinkılıç, N., Çetintaş, S., Zorlu, T., Vatan, Ö., Yılmaz, D., Çavaş, T., TUNÇ, S. G., Özkan, L., & Bilaloğlu, R. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.12.008 · Cited by 139 · see citing works
Pimpley, V. A., Patil, S. A., Srinivasan, K., Desai, N. M., & Murthy, P. S. (2020) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2020.1786699 · Cited by 139 · see citing works
Renouf, M., Guy, P. A., Marmet, C., Fraering, A.-L., Longet, K., Moulin, J., Enslen, M., Barron, D., Dionisi, F., Cavin, C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900056 · Cited by 137 · see citing works
Coffee, caffeine, chlorogenic acid, and the purinergic system.
Stefanello, N., Spanevello, R., Passamonti, S., Porciúncula, L., Bonan, C., Olabiyi, A., da Rocha, J. B. T., Assmann, C., Morsch, V., & Schetinger, M. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.10.005 · Cited by 108 · see citing works
Guertin, K. A., Loftfield, E., Boca, S. M., Sampson, J. N., Moore, S. C., Xiao, Q., Huang, W.-Y., Xiong, X., Freedman, N. D., Cross, A. J., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.096099 · Cited by 134 · see citing works
Choy, Y. Y., Quifer‐Rada, P., Holstege, D. M., Frese, S. A., Calvert, C. C., Mills, D. A., Lamuela-Raventós, R. M., & Waterhouse, A. L. (2014) · Food & Function · doi:10.1039/c4fo00325j · Cited by 133 · see citing works
Williamson, G., Dionisi, F., & Renouf, M. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000631 · Cited by 131 · see citing works
Intestinal transit and systemic metabolism of apple polyphenols
Kahle, K., Kempf, M. A., Schreier, P. H., Scheppach, W. M., Schrenk, D., Kautenburger, T., Hecker, D. C., Hümmer, W., Ackermann, M., & Richling, E. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0157-0 · Cited by 128 · see citing works
Cheng, B., Liu, X., Gong, H., Huang, L., Chen, H., Zhang, X., Li, C., Yang, M., Ma, B., Jiao, L., et al. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201702h · Cited by 127 · see citing works
Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis
Iriondo-DeHond, A., Uranga, J. A., del Castillo, M. D., & Abalo, R. (2020) · Nutrients · doi:10.3390/nu13010088 · Cited by 126 · see citing works
“Coffee is also a source of CGA (Table 1), a hydroxycinnamic acid with health-promoting properties such as antioxidant, antibacterial, and anti-inflammatory activities, among others [212].”
BackgroundEffect of Chlorogenic Acid Supplementation in MPTP-Intoxicated Mouse
Singh, S. S., Rai, S. N., Birla, H., Zahra, W., Kumar, G., Gedda, M. R., Tiwari, N., Patnaik, R., Singh, R. K., & Singh, S. P. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00757 · Cited by 125 · see citing works
Jacobo‐Velázquez, D. A., & Cisneros‐Zevallos, L. (2012) · Agriculture · doi:10.3390/agriculture2030259 · Cited by 125 · see citing works
Impact of potato processing on nutrients, phytochemicals, and human health
Furrer, A., Chegeni, M., & Ferruzzi, M. G. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1139542 · Cited by 131 · see citing works
Li, L., Su, C., Chen, X., Wang, Q., Jiao, W., Luo, H., Tang, J., Wang, W., Li, S., & Guo, S. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01554 · Cited by 124 · see citing works
Villarreal-García, D., Nair, V., Cisneros‐Zevallos, L., & Jacobo‐Velázquez, D. A. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00045 · Cited by 123 · see citing works
Bioavailability of Coffee Chlorogenic Acids and Green Tea Flavan-3-ols
Rio, D. D., Stalmach, A., Calani, L., & Crozier, A. (2010) · Nutrients · doi:10.3390/nu2080820 · Cited by 122 · see citing works
Wang, Z., Ma, L., Zhang, X., Xu, L., Cao, J., & Jiang, W. (2014) · Scientia Horticulturae · doi:10.1016/j.scienta.2014.10.055 · Cited by 119 · see citing works
Acidri, R., Sawai, Y., Sugimoto, Y., Handa, T., Sasagawa, D., Masunaga, T., Yamamoto, S., & Nishihara, E. (2020) · Antioxidants · doi:10.3390/antiox9020093 · Cited by 120 · see citing works
Impact of dose on the bioavailability of coffee chlorogenic acids in humans
Stalmach, A., Williamson, G., & Crozier, A. (2014) · Food Funct. · doi:10.1039/c4fo00316k · Cited by 118 · see citing works
Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential
Singh, A. K., Singla, R. K., & Pandey, A. K. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220816154634 · Cited by 118 · see citing works
5-O-Caffeoylquinic acid: A spectroscopic study and biological screening for antimicrobial activity
Bajko, E., Kalinowska, M., Borowski, P., Siergiejczyk, L., & Lewandowski, W. (2015) · LWT · doi:10.1016/j.lwt.2015.08.024 · Cited by 117 · see citing works
Bioavailability of hydroxycinnamates: a brief review of in vivo and in vitro studies
Zhao, Z., & Moghadasian, M. H. (2009) · Phytochemistry Reviews · doi:10.1007/s11101-009-9145-5 · Cited by 117 · see citing works
Duarte, G. S., & Farah, A. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201906p · Cited by 117 · see citing works
Self-citationPham, N. M., Nanri, A., Kurotani, K., Kuwahara, K., Kume, A., Sato, M., Hayabuchi, H., & Mizoue, T. (2013) · Public Health Nutrition · doi:10.1017/s1368980013000360 · Cited by 115 · see citing works
Mullen, W., Nemzer, B. V., Ou, B., Stalmach, A., Hunter, J., Clifford, M. N., & Combet, E. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200122m · Cited by 113 · see citing works
Abbasi, A. M., Guo, X., Fu, X., Zhou, L. M., Chen, Y., Zhu, Y., Yan, H., & Liu, R. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160613507 · Cited by 109 · see citing works
Massaya, J., Pereira, A. P., Mills-Lamptey, B., Jack, B., & Chuck, C. J. (2019) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2019.08.010 · Cited by 110 · see citing works
Liang, N., Xue, W., Kennepohl, P., & Kitts, D. D. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.06.041 · Cited by 108 · see citing works
Sinha, R. R., Cross, A. J., Daniel, C. R., Graubard, B. I., Wu, J. W., Hollenbeck, A. R., Gunter, M. J., Park, Y., & Freedman, N. D. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.031328 · Cited by 107 · see citing works
Dried Plums and Their Products: Composition and Health Effects–An Updated Review
Stacewicz‐Sapuntzakis, M. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.563880 · Cited by 105 · see citing works
Jiménez, V. M., Gruschwitz, M., Schweiggert, R. M., Carle, R., & Esquivel, P. (2014) · Food Research International · doi:10.1016/j.foodres.2014.05.051 · Cited by 105 · see citing works
Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer
Shimoyama, A. T., Santin, J. R., Machado, I. D., Silva, A. M. D. O. E., de Melo, I. L. P., Mancini-Filho, J., & Farsky, S. H. P. (2012) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-012-0807-2 · Cited by 104 · see citing works
Comparison of antioxidant activity between green and roasted coffee beans using molecular methods
Priftis, A., Stagos, D., Konstantinopoulos, K., Tsitsimpikou, C., Spandidos, D. A., Tsatsakis, A. M., Tzatzarakis, M. N., & Kouretas, D. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4377 · Cited by 102 · see citing works
Selenium increases chlorogenic acid, chlorophyll and carotenoids of Lycium chinense leaves
Dong, J. Z., Wang, Y., Wang, S. H., Yin, L. P., Xu, G. J., Zheng, C. C., Lei, C., & Zhang, M. Z. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5758 · Cited by 101 · see citing works
Świeca, M., Gawlik‐Dziki, U., Dziki, D., & Baraniak, B. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.11.006 · Cited by 100 · see citing works
Zhang, Y.-J., Huang, X., Wang, Y., Xie, Y., Qiu, X.-J., Ren, P., Gao, L., Zhou, H., Zhang, H.-Y., & Qiao, M.-Q. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.07.002 · Cited by 99 · see citing works
Puangpraphant, S., Berhow, M. A., Vermillion, K. E., Potts, G., & de Mejı́a, E. G. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100128 · Cited by 96 · see citing works
Precision medicine for suicidality: from universality to subtypes and personalization
Niculescu, A. B., Le-Niculescu, H., Levey, D. F., Phalen, P. L., Dainton‐Howard, H., Roseberry, K., Niculescu, E. M., Niezer, J., Williams, A., Graham, D. L., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.128 · Cited by 93 · see citing works
Bułdak, R. J., Hejmo, T., Osowski, M., Bułdak, Ł., Kukla, M., Polaniak, R., & Birkner, E. (2018) · Molecules · doi:10.3390/molecules23123309 · Cited by 89 · see citing works
“Some researchers have reported high amounts of intact 3-, 4-, and 5-CQA [129,147], while others have reported their absence [130,148].”
BackgroundHouttuynia cordata Targets the Beginning Stage of Herpes Simplex Virus Infection
Hung, P.-Y., Ho, B., Lee, S.-Y., Chang, S., Kao, C., Lee, S., & Lee, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115475 · Cited by 90 · see citing works
Ground green coffee beans as a functional food supplement – Preliminary study
Dziki, D., Gawlik‐Dziki, U., Pecio, Ł., Różyło, R., Świeca, M., Krzykowski, A., & Rudy, S. (2015) · LWT · doi:10.1016/j.lwt.2015.03.076 · Cited by 90 · see citing works
Baeza, G., Amigo‐Benavent, M., Sarriá, B., Goya, L., Mateos, R., & Bravo, L. (2014) · Food Research International · doi:10.1016/j.foodres.2014.05.035 · Cited by 90 · see citing works
Interaction of chlorogenic acids and quinides from coffee with human serum albumin
Sinisi, V., Forzato, C., Cefarin, N., Navarini, L., & Berti, F. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.07.080 · Cited by 89 · see citing works
Hydroxycinnamic acids on gut microbiota and health
Leonard, W., Zhang, P., Ying, D., & Fang, Z. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12663 · Cited by 89 · see citing works
Murad, L. D., Soares, N. D. C. P., Brand, C., Monteiro, M. C., & Teodoro, A. J. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1004736 · Cited by 89 · see citing works
Self-citationPolyphenolic and Hydroxycinnamate Contents of Whole Coffee Fruits from China, India, and Mexico
Mullen, W., Nemzer, B. V., Stalmach, A., Ali, S., & Combet, E. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4003126 · Cited by 88 · see citing works
Biotransformation of polyphenols in a dynamic multistage gastrointestinal model
Ekbatan, S. S., Sleno, L., Sabally, K., Khairallah, J., Azadi, B., Rodes, L., Prakash, S., Donnelly, D. J., & Kubow, S. J. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.02.140 · Cited by 86 · see citing works
The effect of artichoke on lipid profile: A review of possible mechanisms of action
Santos, H. O., Bueno, A. A., & Mota, J. F. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.10.007 · Cited by 86 · see citing works
Zhong, S., Sandhu, A. K., Edirisinghe, I., & Burton‐Freeman, B. M. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700405 · Cited by 86 · see citing works
Chlorogenic acid–phospholipid complex improve protection against UVA induced oxidative stress
Bhattacharyya, S., Majhi, S., Saha, B. P., & Mukherjee, P. K. (2013) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2013.11.020 · Cited by 85 · see citing works
Keane, K. M., Bell, P. G., Lodge, J. K., Constantinou, C. L., Jenkinson, S. E., Bass, R., & Howatson, G. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0988-9 · Cited by 83 · see citing works
Karaköse, H., Jaiswal, R., & Kuhnert, N. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202185m · Cited by 83 · see citing works
Pagliosa, C. M., Vieira, M. A., Podestá, R., Maraschin, M., Zeni, A. L. B., Amante, E. R., & Amboni, R. D. D. M. C. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.02.040 · Cited by 82 · see citing works
Jesus, F., Gonçalves, A. C., Alves, G., & Silva, L. R. (2018) · Food Research International · doi:10.1016/j.foodres.2018.08.079 · Cited by 81 · see citing works
Henry-Vitrac, C., Ibarra, A., Roller, M., Mérillon, J., & Vitrac, X. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9044827 · Cited by 81 · see citing works
Kim, H., Pan, J. H., Kim, S. H., Lee, J. H., & Park, J. (2018) · Biochimie · doi:10.1016/j.biochi.2018.05.008 · Cited by 81 · see citing works
Impact of coffee components on inflammatory markers: A review
Frost-Meyer, N. J., & Logomarsino, J. V. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.05.010 · Cited by 79 · see citing works
Burgos‐Morón, E., Calderón‐Montaño, J. M., Orta, M. L., Pastor, N., Pérez‐Guerrero, C., Austin, C. A., Mateos, S., & López‐Lázaro, M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300999e · Cited by 78 · see citing works
- Authors
- Farah, A., Monteiro, M., Donangelo, C. M., & Lafay, S.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Naturex (France) (FR)
- Corresponding author
- Farah, Adriana
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 138
- Issue
- 12
- Pages
- 2309-2315
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2127688626
- Cited by
- 578
- References
- 50
- Citations by year
- 2026: 18 · 2025: 16 · 2024: 20 · 2023: 33 · 2022: 29 · 2021: 40 · 2020: 43 · 2019: 42 · 2018: 49 · 2017: 52 · 2016: 48 · 2015: 39 · 2014: 35 · 2013: 28 · 2012: 32
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- chlorogenic acid, green coffee bean extract, bioavailability, pharmacokinetics, caffeoylquinic acids, dicaffeoylquinic acids, cinnamic acid derivatives, urinary excretion, plasma absorption, metabolites, nutraceuticals, decaffeinated coffee
- MeSH terms
- Adult, Biological Availability, Caffeic Acids, Caffeine, Chlorogenic Acid, Cinnamates, Coffee, Coumaric Acids, Female, Humans, Male, Middle Aged, Propionates, Quinic Acid, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review