Pharmacological advances of the chlorogenic acids family: current insights and future research directions

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The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review

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Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

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Antihypertensive effects and mechanisms of chlorogenic acids

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Pharmacological action and potential targets of chlorogenic acid

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Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway

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The Blood Pressure-Lowering Effect and Safety of Chlorogenic Acid from Green Coffee Bean Extract in Essential Hypertension

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Effect of chlorogenic acid covalent conjugation on the allergenicity, digestibility and functional properties of whey protein

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Antistaphylococcal and biofilm inhibitory activities of gallic, caffeic, and chlorogenic acids

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Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress

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Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway

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Chlorogenic Acid-Induced Gut Microbiota Improves Metabolic Endotoxemia

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Silencing CAFFEOYL SHIKIMATE ESTERASE Affects Lignification and Improves Saccharification in Poplar

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Effect of Different Extraction Methods on the Recovery of Chlorogenic Acids, Caffeine and Maillard Reaction Products in Coffee Beans

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Phytochemical Profile and Antioxidant Capacity of Coffee Plant Organs Compared to Green and Roasted Coffee Beans

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Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation

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<p>Chlorogenic Acid Alleviates Aβ<sub>25-35</sub>-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway</p>

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Chlorogenic Acid Protects Against oxLDL‐Induced Oxidative Damage and Mitochondrial Dysfunction by Modulating SIRT1 in Endothelial Cells

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Chlorogenic acid improves glucose tolerance, lipid metabolism, inflammation and microbiota composition in diabetic db/db mice

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Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma

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Synthesis and regulation of chlorogenic acid in potato: Rerouting phenylpropanoid flux in HQT ‐silenced lines

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Role of Degradation Products of Chlorogenic Acid in the Antioxidant Activity of Roasted Coffee

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Chlorogenic Acid Protects against Atherosclerosis in ApoE−/− Mice and Promotes Cholesterol Efflux from RAW264.7 Macrophages

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Antibacterial and Antibiofilm Activities of Chlorogenic Acid Against Yersinia enterocolitica

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Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase–dependent apoptosis in chronic myelogenous leukemic cells

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Chlorogenic acid inhibits the proliferation of human lung cancer A549 cell lines by targeting annexin A2 in vitro and in vivo

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Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages

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Chlorogenic acid induces 4T1 breast cancer tumor's apoptosis via p53, Bax, Bcl‐2, and caspase‐3 signaling pathways in BALB/c mice

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Management of psychiatric and cognitive complications in Parkinson’s disease

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The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis

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Fabrication of antioxidant emulsifiers from natural ingredients: Conjugation of egg white proteins with catechin and chlorogenic acid

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Neochlorogenic Acid Inhibits Lipopolysaccharide-Induced Activation and Pro-inflammatory Responses in BV2 Microglial Cells

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Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis

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Chlorogenic acid induces apoptotic cell death in U937 leukemia cells through caspase- and mitochondria-dependent pathways.

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Protein–Chlorogenic Acid Interactions: Mechanisms, Characteristics, and Potential Food Applications

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Isochlorogenic Acid. Isolation from Coffee and Structure Studies1

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The isolation of chlorogenic acid from the apple fruit

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Neochlorogenic Acid Attenuates Hepatic Lipid Accumulation and Inflammation via Regulating miR-34a In Vitro

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Neochlorogenic acid inhibits against LPS-activated inflammatory responses through up-regulation of Nrf2/HO-1 and involving AMPK pathway

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Potential of the chlorogenic acid as multitarget agent: Insulin-secretagogue and PPAR α/γ dual agonist

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Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects

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UFLC/MS-IT-TOF guided isolation of anti-HBV active chlorogenic acid analogues from Artemisia capillaris as a traditional Chinese herb for the treatment of hepatitis

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Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes

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Self-assembly of chlorogenic acid into hydrogel for accelerating wound healing

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A R2R3-MYB transcriptional activator LmMYB15 regulates chlorogenic acid biosynthesis and phenylpropanoid metabolism in Lonicera macranthoides

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Tubson-2 decoction ameliorates rheumatoid arthritis complicated with osteoporosis in CIA rats involving isochlorogenic acid A regulating IL-17/MAPK pathway

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Risk Assessment of Chlorogenic and Isochlorogenic Acids in Coffee By-Products

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Protective effect of isochlorogenic acid B on liver fibrosis in non‐alcoholic steatohepatitis of mice

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Sulfonated, quaternized, and chlorogenic acid composited sodium alginate hydrogels/Eucommia ulmoides rubber films as in vitro antibacterial wound dressings for accelerating wound healing

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Characterization, pharmacokinetics and tissue distribution of chlorogenic acid-loaded self-microemulsifying drug delivery system

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UNREMITTING PROBLEMS WITH CHLOROGENIC ACID NOMENCLATURE: A REVIEW

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Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression

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Chlorogenic Acid Ameliorates High-Fat and High-Fructose Diet-Induced Cognitive Impairment via Mediating the Microbiota–Gut–Brain Axis

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Demonstrating the involvement of an active efflux mechanism in the intestinal absorption of chlorogenic acid and quinic acid using a Caco-2 bidirectional permeability assay

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Chlorogenic acid induces apoptosis and cell-cycle arrest in colorectal cancer cells

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Biocompatible ι-carrageenan-γ-maghemite nanocomposite for biomedical applications – synthesis, characterization and in vitro anticancer efficacy

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Chlorogenic acid supplementation alleviates dextran sulfate sodium (DSS)-induced colitis via inhibiting inflammatory responses and oxidative stress, improving gut barrier integrity and Nrf-2/HO-1 pathway

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Cardiovascular protection effect of chlorogenic acid: focus on the molecular mechanism

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Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/miR-21/Smad7 Signaling Interactions In Vivo and In Vitro

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The transcription factor NtERF13a enhances abiotic stress tolerance and phenylpropanoid compounds biosynthesis in tobacco

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Isochlorogenic Acid A Attenuates the Progression of Liver Fibrosis Through Regulating HMGB1/TLR4/NF-κB Signaling Pathway

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The basic helix-loop-helix transcription factor TabHLH1 increases chlorogenic acid and luteolin biosynthesis in Taraxacum antungense Kitag

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Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation

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Dietary chlorogenic acid ameliorates oxidative stress and improves endothelial function in diabetic mice via Nrf2 activation

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Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6

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Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimer’s disease model mice (APP/PS1) via the SIRT1/ /PGC-1α/PPARγ signaling pathway

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Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

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Chlorogenic acid alleviate kidney fibrosis through regulating TLR4/NF-қB mediated oxidative stress and inflammation

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Anti-Inflammatory Activity and Mechanism of Cryptochlorogenic Acid from Ageratina adenophora

Ma, X., Okyere, S. K., Hu, L., Wen, J., Ren, Z., Deng, J., & Hu, Y. (2022) · Nutrients · doi:10.3390/nu14030439 · Cited by 39 · see citing works

Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis

Jiang, Y., Nan, H., Shi, N., Hao, W., Dong, J., & Chen, H. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06267-3 · Cited by 38 · see citing works

Chlorogenic acid protects against myocardial ischemia–reperfusion injury in mice by inhibiting Lnc Neat1/NLRP3 inflammasome-mediated pyroptosis

Chai, X., Liang, Z., Zhang, J., Ding, J., Zhang, Q., Lv, S., Deng, Y., Zhang, R., & Lu, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-45017-2 · Cited by 38 · see citing works

Sustainable extraction of bioactive compound from apple pomace through lactic acid bacteria (LAB) fermentation

Kalinowska, M., Gołębiewska, E., Zawadzka, M., Choińska, R., Koronkiewicz, K., Piasecka‐Jóźwiak, K., & Bujak, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-46584-0 · Cited by 38 · see citing works

Chlorogenic acid intake guidance: Sources, health benefits, and safety.

Yu, Y., Zhang, Z., & Chang, C. (2022) · PubMed · doi:10.6133/apjcn.202212_31(4).0003 · Cited by 38 · see citing works

Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up

Kang, Z., Li, S., Kang, X., Deng, J., Yang, H., Chen, F., Jiang, J., Zhang, J., & Li, W. (2023) · Cancer Biology & Medicine · doi:10.20892/j.issn.2095-3941.2022.0762 · Cited by 37 · see citing works

Angiotensin converting enzyme inhibitors from Cuscuta japonica Choisy

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Sustained release of chlorogenic acid-loaded nanomicelles alleviates bone loss in mouse periodontitis

Li, H., Xu, J., Hu, J., Hu, Q.-Y., Fang, X., Sun, Z., Xu, Z., & Zhang, L. (2022) · Biomaterials Science · doi:10.1039/d2bm01099b · Cited by 37 · see citing works

Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms

Chen, X., Tang, J., Feng, S., Huang, H., Lu, F.-N., Lu, X., & Wang, Y. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210111155110 · Cited by 36 · see citing works

A Comprehensive Quality Analysis of Different Colors of Medicinal and Edible Honeysuckle

Liu, Z.-Y., Cheng, Y., & Chao, Z. (2023) · Foods · doi:10.3390/foods12163126 · Cited by 34 · see citing works

Neuroprotective effect of chlorogenic acid on Parkinson's disease like symptoms through boosting the autophagy in zebrafish

Gao, X., Zhang, B., Zheng, Y., Liu, X., Panchuk, R. R., Finiuk, N. S., Attila Gabor, S. I. K., Stoika, R. S., Liu, K., & Jin, M. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175950 · Cited by 34 · see citing works

3,5-Dicaffeoylquinic acid protects H9C2 cells against oxidative stress-induced apoptosis via activation of the PI3K/Akt signaling pathway

Bi, Y., Wu, Y., Chen, L., Tan, Z., Fan, H., Xie, L., Zhang, W.-T., Chen, H., Li, J., Liu, B., et al. (2018) · Food & Nutrition Research · doi:10.29219/fnr.v62.1423 · Cited by 33 · see citing works

Fat concentration and high-pressure homogenization affect chlorogenic acid bioaccessibility and α-glucosidase inhibitory capacity of milk-based coffee beverages

Alongi, M., Calligaris, S., & Anese, M. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.04.057 · Cited by 33 · see citing works

Chlorogenic acid improves intestinal barrier function by downregulating CD14 to inhibit the NF-κB signaling pathway

Yu, L.-M., Mao, L.-Q., Wu, C., Ye, W., & Wang, X. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104640 · Cited by 33 · see citing works

Anti-inflammatory effect of chlorogenic acid in Klebsiella pneumoniae-induced pneumonia by inactivating the p38MAPK pathway

Zhang, Y., Zhu, C., Zhao, H., Sun, Z., & Wang, X. (2023) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2023.151576 · Cited by 33 · see citing works

Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha

Zhang, Z., Shi, C., & Wang, Z. (2023) · Nutrients · doi:10.3390/nu15132833 · Cited by 33 · see citing works

Isochlorogenic acid B alleviates lead-induced anxiety, depression and neuroinflammation in mice by the BDNF pathway

Shi, J.-X., Cheng, C., Ruan, H.-N., Li, J., & Liu, C. (2023) · NeuroToxicology · doi:10.1016/j.neuro.2023.06.007 · Cited by 33 · see citing works

In Vitro and In Silico Study on the Impact of Chlorogenic Acid in Colorectal Cancer Cells: Proliferation, Apoptosis, and Interaction with β-Catenin and LRP6

Vélez-Vargas, L. C., Santa-González, G. A., Uribe, D., Castañeda, I. C. H., & Pedroza-Díaz, J. (2023) · Pharmaceuticals · doi:10.3390/ph16020276 · Cited by 32 · see citing works

Control efficiency and potential mechanisms of chlorogenic acid against postharvest gray mold caused by Botrytis cinerea on peach fruit

Dai, B., Wang, Y., Zhou, H., Wang, L., Zhou, L., Mao, J., Zhang, S., Shen, S., Zheng, X., & Chen, H. (2024) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2024.113134 · Cited by 32 · see citing works

Effects and Mechanism of Chlorogenic Acid on Weight Loss

Zhong, Y., Ding, Y., Li, L., Ge, M., Guangguo, B., Yang, H., Dai, J., & Zhang, L. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666200318124922 · Cited by 31 · see citing works

Chlorogenic Acid Protects against Advanced Alcoholic Steatohepatitis in Rats via Modulation of Redox Homeostasis, Inflammation, and Lipogenesis

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Chlorogenic Acid Modulates Autophagy by Inhibiting the Activity of ALKBH5 Demethylase, Thereby Ameliorating Hepatic Steatosis

Meng, F., Song, C., Liu, J., Chen, F., Zhu, Y., Fang, X., Cao, Q., Ma, D., Wang, Y., & Zhang, C. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c03710 · Cited by 31 · see citing works

Water-in-oil-in-water double emulsions loaded with chlorogenic acid: release mechanisms and oxidative stability

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Isochlorogenic acid C prevents enterovirus 71 infection via modulating redox homeostasis of glutathione

Cao, Z., Ding, Y., Cao, L., Ding, G., Wang, Z., & Xiao, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-16446-7 · Cited by 30 · see citing works

Combination immunotherapy of chlorogenic acid liposomes modified with sialic acid and PD-1 blockers effectively enhances the anti-tumor immune response and therapeutic effects

Li, X., Zhu, S., Yin, P., Zhang, S., Xu, J., Zhang, Q., Shi, S., & Zhang, T. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1971797 · Cited by 30 · see citing works

TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity

Badr, A. M., Al‐Kharashi, L. A., Attia, H., Alshehri, S., Alajami, H. N., Ali, R., & Mahran, Y. F. (2023) · Pharmaceuticals · doi:10.3390/ph16030337 · Cited by 29 · see citing works

Three common caffeoylquinic acids as potential hypoglycemic nutraceuticals: Evaluation of α‐glucosidase inhibitory activity and glucose consumption in HepG2 cells

Chen, Y., Geng, S., & Liu, B. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13361 · Cited by 28 · see citing works

Chlorogenic acid enhances endothelial barrier function and promotes endothelial tube formation: A proteomics approach and functional validation

Wuttimongkolchai, N., Kanlaya, R., Nanthawuttiphan, S., Subkod, C., & Thongboonkerd, V. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113471 · Cited by 28 · see citing works

Study on the Anticancer Effect of an Astragaloside‐ and Chlorogenic Acid‐Containing Herbal Medicine (RLT‐03) in Breast Cancer

Li, Y., Li, X., Chen, C., Pu, R., & Weihua, Y. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/1515081 · Cited by 28 · see citing works

Caffeine and Chlorogenic Acid Combination Attenuate Early-Stage Chemically Induced Colon Carcinogenesis in Mice: Involvement of oncomiR miR-21a-5p

Bartolomeu, A. R., Romualdo, G. R., Griñán‐Lisón, C., Besharat, Z. M., Marchal, J. A., García, M. Á., & Barbisan, L. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116292 · Cited by 27 · see citing works

Antifibrotic and Antioxidant Effects of a Tetrahedral Framework Nucleic Acid-Based Chlorogenic Acid Delivery System

Yao, L., Li, J., Qin, X., Liu, Z., Jiang, Y., Zhang, T., & Lin, Y. (2023) · ACS Materials Letters · doi:10.1021/acsmaterialslett.2c00839 · Cited by 27 · see citing works

Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX2

Zhan, Y., Li, R. P., Feng, C., Li, X., Huang, S., Wang, L., Liu, Z., Jiang, J., & Han, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109602 · Cited by 26 · see citing works

THE PROTEIDS OF THE SUNFLOWER SEED.

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Role of chlorogenic acid in the toxicity induced by Chinese herbal injections

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Chlorogenic acid depresses cellular bioenergetics to suppress pancreatic carcinoma through modulating c‐Myc‐TFR1 axis

Yang, H., Said, A. M., Huang, H., Papa, A. P. D., Jin, G., Wu, S., Ma, N., Lan, L., Shangguan, F., & Zhang, Q. (2020) · Phytotherapy Research · doi:10.1002/ptr.6971 · Cited by 25 · see citing works

The Regulatory Effects of Traditional Chinese Medicine on Ferroptosis

Gao, Q., Yin, X., Zhang, F., Zhu, Y. Z., & Li, Z. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4578381 · Cited by 25 · see citing works

Chlorogenic Acid Derivatives: Structural Modifications, Drug Design, and Biological Activities: A Review

joneidi, S., Alizadeh, S. R., & Ebrahimzadeh, M. A. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230822095959 · Cited by 25 · see citing works

Neuroprotective effects of chlorogenic acid: Modulation of Akt/Erk1/2 signaling to prevent neuronal apoptosis in Parkinson's disease

He, S., Chen, Y., Wang, H., Li, S., Wei, Y., Zhang, H., Gao, Q., Wang, F., & Zhang, R.-J. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.06.018 · Cited by 25 · see citing works

Chlorogenic acid alleviates renal fibrosis by reducing lipid accumulation in diabetic kidney disease through suppressing the Notch1 and Stat3 signaling pathway

Yang, X., Jiang, D., Wang, Y.-Z., Duan, M.-Y., Huang, Y., Wang, X., Xiang, Z.-M., Sheng, J., & Zhu, Q. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2371988 · Cited by 25 · see citing works

Development of an LC-MS/MS method for quantitative analysis of Chlorogenic acid in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor

Yang, F., Gong, J. F., Shen, L., Zhang, C., Kou, F. R., Gao, J., Li, Y., & bing Xu, G. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.112809 · Cited by 25 · see citing works

Chlorogenic Acid: Further Evidence for its Antigenic and Allergenic Activity

Bariana, D. S., Krupey, J., SCARPATI, L. M., Freedman, S. O., & Sehon, A. H. (1965) · Nature · doi:10.1038/2071155a0 · Cited by 25 · see citing works

Mulberry leaf extract and neochlorogenic acid ameliorate glucolipotoxicity-induced diabetic nephropathy in high-fat diet-fed db/db mice

Hung, T., Yang, M., Yu, M.-H., Tsai, I.-N., Tsai, Y.-C., Chan, K., & Wang, C. (2023) · Food & Function · doi:10.1039/d3fo02640j · Cited by 24 · see citing works

Isochlorogenic acid A ameliorated lead-induced anxiety-like behaviors in mice by inhibiting ferroptosis-mediated neuroinflammation via the BDNF/Nrf2/GPX4 pathways

Guo, J., Li, H., Cheng, C., Shi, J.-X., Ruan, H.-N., Li, J., & Liu, C. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114814 · Cited by 24 · see citing works

Chlorogenic acid inhibits NLRP3 inflammasome activation through Nrf2 activation in diabetic nephropathy

Bao, L., Gong, Y., Xu, W., Dao, J., Rao, J., & Yang, H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0316615 · Cited by 24 · see citing works

Global Trade Pattern of Traditional Chinese Medicines and China's Trade Position

Xiang, L., Chen, Z., Wei, S., & Zhou, H. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.865887 · Cited by 23 · see citing works

Moringa oleifera Lam. leaf extract safely inhibits periodontitis by regulating the expression of p38α/MAPK14-OPG/RANKL

Wang, F., Long, S., & Zhang, J. (2021) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2021.105280 · Cited by 22 · see citing works

Chlorogenic acid-optimized nanophytovesicles: a novel approach for enhanced permeability and oral bioavailability

Trivedi, H. R., & Puranik, P. K. (2023) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-023-00559-0 · Cited by 22 · see citing works

Comparison of the effects of chlorogenic acid isomers and their compounds on alleviating oxidative stress injury in broilers

Song, D., Zhang, S., Chen, A., Song, Z., & Shi, S. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103649 · Cited by 22 · see citing works

Functional Characteristics of Caffeoyl Shikimate Esterase in Larix Kaempferi and Monolignol Biosynthesis in Gymnosperms

Wang, X., Chao, N., Zhang, M., Jiang, X., & Gai, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236071 · Cited by 22 · see citing works

Copigmentation effect on red cabbage anthocyanins, investigation of their cellular viability and interaction mechanism

Singh, S., Sendri, N., Sharma, B., Kumar, P., Sharma, A., Tirpude, N. V., Purohit, R., & Bhandari, P. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115427 · Cited by 22 · see citing works

Improving the Effects of Mulberry Leaves and Neochlorogenic Acid on Glucotoxicity-Induced Hepatic Steatosis in High Fat Diet Treated db/db Mice

Tsai, M., Wang, C., Tsai, I.-N., Yu, M.-H., Yang, M., Lee, Y., Chan, K., & Wang, C. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09033 · Cited by 21 · see citing works

Metabolites of chlorogenic acid and its isomers: Metabolic pathways and activities for ameliorating myocardial hypertrophy

Chang, Y., Huang, K., Yang, F., Gao, Y., Zhang, Y., Li, S., Liu, B., & Guo, S. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105216 · Cited by 21 · see citing works

Transcription factor NtWRKY33a modulates the biosynthesis of polyphenols by targeting NtMYB4 and NtHCT genes in tobacco

Wang, Z., Ma, L., Liu, P., Luo, Z., Li, Z., Wu, M., Xu, X., Pu, W., Huang, P., & Yang, J. (2022) · Plant Science · doi:10.1016/j.plantsci.2022.111522 · Cited by 21 · see citing works

Ultrasonic Degradation Kinetics and Isomerization of 3- and 4-O-Caffeoylquinic Acid at Various Ph: The Protective Effects of Ascorbic Acid and Epigallocatechin Gallate on Their Stability

Wang, D., Liu, J., Qiu, S., Wang, J., Song, G., Chu, B., Li, L., Xiao, G., Gong, J., & Zheng, F. (2021) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2021.105812 · Cited by 21 · see citing works

Bioactive functions of chlorogenic acid and its research progress in pig industry

Dai, C., Li, H., Zhao, W., Fu, Y., & Cheng, J. (2023) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13905 · Cited by 21 · see citing works

Chlorogenic Acid Attenuates Cardiac Hypertrophy via Up-Regulating Sphingosine-1-Phosphate Receptor1 to Inhibit Endoplasmic Reticulum Stress

Ping, P., Yang, T., Ning, C., Zhao, Q., Zhao, Y., Yang, T., Gao, Z., & Fu, S. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14707 · Cited by 21 · see citing works

Multiplex Approach of Metabolomic and Transcriptomic Reveals the Biosynthetic Mechanism of Light-induced Flavonoids and CGA in Chrysanthemum

Lu, C., Liu, Y., Yan, X., Gui, A., Jiang, Y., Wang, P., Qiao, Q., & Shao, Q. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.119420 · Cited by 20 · see citing works

Mulberry Leaf and Neochlorogenic Acid Alleviates Glucolipotoxicity-Induced Oxidative Stress and Inhibits Proliferation/Migration via Downregulating Ras and FAK Signaling Pathway in Vascular Smooth Muscle Cell

Yang, T., Wu, Y.-L., Yu, M.-H., Hung, T., Chan, K., & Wang, C. (2022) · Nutrients · doi:10.3390/nu14153006 · Cited by 19 · see citing works

Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation

Ho, C., Tang, C., Ho, T., Wang, W., & Yao, C. (2024) · Aging · doi:10.18632/aging.205635 · Cited by 19 · see citing works

Isochlorogenic Acid C Alleviates High-Fat Diet-Induced Hyperlipemia by Promoting Cholesterol Reverse Transport

Zheng, L., Lin, G., Li, R., Gan, H., Huang, X., Yao, N., Cai, D., Zhao, Z., Hu, Z., Li, M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.881078 · Cited by 19 · see citing works

Chlorogenic Acid and Quercetin in a Diet with Fermentable Fiber Influence Multiple Processes Involved in DSS-Induced Ulcerative Colitis but Do Not Reduce Injury

Maslin, L. A., Weeks, B. R., Carroll, R. J., Byrne, D., & Turner, N. D. (2022) · Nutrients · doi:10.3390/nu14183706 · Cited by 18 · see citing works

Chlorogenic Acid Inhibits Proliferation, Migration and Invasion of Pancreatic Cancer Cells via AKT/GSK-3β/β-catenin Signaling Pathway

Chen, X., Liu, B., Tong, J., Bo, J., Feng, M., Yin, L., & Lin, X. (2023) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892818666230327134746 · Cited by 18 · see citing works

Effects of a Chlorogenic Acid-Containing Herbal Medicine (LASNB) on Colon Cancer

Li, Y., Pu, R., Zhou, L., Wang, D., & Li, X. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/9923467 · Cited by 17 · see citing works

Protection against myocardial ischemia/reperfusion injury in mice by 3-caffeoylquinic acid isomers isolated from Saxifraga tangutica

Tong, Y., Li, G., Shi, X.-B., Wang, L., Zhou, J., Chu, M., Wang, Z., El‐Aty, A. M. A., & Dang, J. (2024) · RSC Advances · doi:10.1039/d4ra00046c · Cited by 17 · see citing works

Chlorogenic Acid Inhibition of Esophageal Squamous Cell Carcinoma Metastasis via EGFR/p-Akt/Snail Signaling Pathways

Chen, Y., NGOC, N. T. M., Chang, H., Su, Y., Chen, C., Goan, Y., Chen, J. Y., Tung, C.-W., & Hour, T. (2022) · Anticancer Research · doi:10.21873/anticanres.15826 · Cited by 17 · see citing works

Construction, characterization, and in vitro hypolipidemic activity of Auricularia auricula-judae soluble dietary fiber-phenol complexes

Li, B., Wang, S., Li, F., & Liu, X. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103657 · Cited by 17 · see citing works

Soybean oil and coconut oil enhance the absorption of chlorogenic acid in humans

Weerakoon, T., Anjali, N. V. P., Jayathilaka, N., & Seneviratne, K. N. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13823 · Cited by 16 · see citing works

Level of caffeine, trigonelline and chlorogenic acids in green coffee (Coffea arabica L.) beans from Amhara region, Ethiopia

Wale, K., Tolessa, K., Atlabachew, M., Mehari, B., Alemayehu, M., Mengistu, D. A., & Kerisew, B. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101082 · Cited by 16 · see citing works

Chlorogenic acid sustained-release gel for treatment of glioma and hepatocellular carcinoma

Zhou, H., Chen, D., Gong, T., He, Q., Guo, C., Zhang, P., Song, X., Ruan, J., & Gong, T. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.05.028 · Cited by 16 · see citing works

Chlorogenic Acid: A Promising Strategy for Milk Preservation by Inhibiting Staphylococcus aureus Growth and Biofilm Formation

Yu, X., Li, Y., Xue, Y., He, J., Tang, W., Chai, Y., Duan, Z., Li, W., Zhao, D., Wang, X., et al. (2024) · Foods · doi:10.3390/foods13244104 · Cited by 15 · see citing works

Influence of seasonal and geographic variation on the anti-HSV-1 properties and chlorogenic acids content of Helichrysum aureonitens Sch. Bip

Adeosun, W. B., More, G. K., Steenkamp, P. A., & Prinsloo, G. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.961859 · Cited by 14 · see citing works

Overexpression of TaWRKY14 transcription factor enhances accumulation of chlorogenic acid in Taraxacum antungense Kitag and increases its resistance to powdery mildew

Liu, Q., Zhou, W., Ruan, Q., Cheng, H., Liu, T., Wang, L., Yuan, Y., Li, L., Wu, J., Jiang, J., et al. (2020) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-020-01950-y · Cited by 14 · see citing works

Immunomodulation effects of isochlorogenic acid a from apple on RAW264.7 cells via modulation of TLR2 and TLR4 target proteins

Xu, G. Z., Yu, Z., & Zhao, W. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103773 · Cited by 14 · see citing works

Lead-induced liver fibrosis and inflammation in mice by the AMPK/MAPKs/NF-κB and STAT3/TGF-β1/Smad2/3 pathways: the role of Isochlorogenic acid a

Guo, J., Li, H., Cheng, C., Shi, J.-X., Ruan, H.-N., Li, J., & Liu, C. (2024) · Toxicology Research · doi:10.1093/toxres/tfae072 · Cited by 14 · see citing works

Exploring the potential of cryptochlorogenic acid as a dietary adjuvant for multi-target combined lung cancer treatment

Bai, X., Liu, Y., Cao, Y., Ma, Z., Chen, Y., & Guo, S. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155907 · Cited by 14 · see citing works

Coffee as a dietary strategy to prevent SARS-CoV-2 infection

Wu, C.-S., Li, Y., Peng, S., Chen, C., Chen, H., Hsueh, P., Wang, W., Liu, Y., Jiang, C.-L., Chang, W., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01154-9 · Cited by 12 · see citing works

Chlorogenic Acid Inhibited Epithelial–Mesenchymal Transition to Treat Pulmonary Fibrosis through Modulating Autophagy

Mao, X., Xie, X., Ma, J., Wei, Y., Huang, Z., Wang, T., Zhu, J., Wang, Y., Zhao, H., & Hua, J. (2023) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b23-00071 · Cited by 12 · see citing works

The Mechanisms of Neochlorogenic Acid (3-Caffeoylquinic Acid) in Improving glucose and Lipid Metabolism in Rats with Insulin Resistance Induced by A High Fat-High Fructose Diet

Singdam, P., Naowaboot, J., Senggunprai, L., Boonloh, K., Hipkaeo, W., & Pannangpetch, P. (2023) · Trends in Sciences · doi:10.48048/tis.2023.6455 · Cited by 11 · see citing works

Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration

Fang, Y., Hu, J., Zou, Y., Wang, Z., Ye, Y., & Zhang, C. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.3c00923 · Cited by 11 · see citing works

Stability and degradation of chlorogenic acids in green and roasted coffee beans during long-term storage

Badmos, S., & Kuhnert, N. (2025) · Food Research International · doi:10.1016/j.foodres.2025.117031 · Cited by 11 · see citing works

Chlorogenic Acid Inhibits Ceramide Accumulation to Restrain Hepatic Glucagon Response

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Isochlorogenic Acid C Restrains Erk/JNK/NF-κB Signaling to Alleviate Inflammatory Response and Promote Cell Apoptosis

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Chlorogenic acid attenuates aortic dissection in atherosclerotic mice by inhibiting ferroptosis via the Nrf2/HO-1/GPX4 axis

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Microbial biotransformation of plant-derived metabolites: mechanisms, pathways, and multi-omics integration

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Integrated Metabolomic and Microbiome Profiling Reveals Divergent Effects of No- and High-Fat Coffee in Mice

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Coffee as a polypharmacological modulator of mitochondrial health: from molecular mechanisms to translational implications

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Chlorogenic acid promotes macrophage phagocytosis through the METTL3–SIRPA axis in an m6A-dependent manner for colon cancer therapy

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Feruloyl substitution is associated with distinct neurogenic and metabolic signatures in cinnamoylquinic acid derivatives: An integrated transcriptomic–metabolomic analysis

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In Situ Sonoafterglow Supramolecular Hydrogel From Natural Substrate for Post‐Surgical Glioblastoma Treatment

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Chlorogenic Acid Attenuates Schizophrenia-Like Behavioral Deficits and Neuroinflammation in a Ketamine-Induced Mouse ModelPreprint

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Comprehensive Quality Standardization of Haizhixiaolin Capsules via Multi‐Component Fingerprinting and Metabolomic

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Thermochemical Valorization of Silkworm Feeding Waste: Chemical Characterization and Biological Activities of the Pyrolysis-Derived Liquid Fraction

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Redirecting Metabolic Flux to Minimize By‐Product Formation Enables Efficient De Novo Biosynthesis of Chlorogenic Acid in Escherichia coli

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Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential

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Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

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