Metronidazole-Loaded Polydopamine Nanomedicine With Antioxidant and Antibacterial Bioactivity for Periodontitis
Open accessAbstract
Aim: This study focused on treating periodontitis with bacterial infection and local over accumulation of reactive oxygen species. Materials & methods: Polydopamine nanoparticles (PDA NPs) were exploited as efficient carriers for encapsulated metronidazole (MNZ). The therapeutic efficacy and biocompatibility of PDA@MNZ NPs were investigated through both in vitro and in vivo studies. Results: The nanodrug PDA@MNZ NPs were successfully fabricated, with well-defined physicochemical characteristics. In vitro, the PDA@MNZ NPs effectively eliminated intracellular reactive oxygen species and inhibited the growth of Porphyromonas gingivalis. Moreover, the PDA@MNZ NPs exhibited synergistic therapy for periodontitisin in vivo. Conclusion: PDA@MNZ NPs were confirmed with exceptional antimicrobial and antioxidant functions, offering a promising avenue for synergistic therapy in periodontitis.
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PDA is capable of loading conventional antibiotics used in periodontitis treatment, such as metronidazole and minocycline, through covalent coupling or physical adsorption onto PDA coatings or nanoparticles.
“Furthermore, PDA is capable of loading conventional antibiotics used in periodontitis treatment, such as metronidazole and minocycline, through covalent coupling or physical adsorption onto PDA coatings or nanoparticles.68”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [68]
The Abstract (no page indicated) says that polydopamine nanoparticles carried encapsulated metronidazole for periodontitis treatment. The available passages do not mention minocycline or establish covalent coupling or physical adsorption as loading mechanisms. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThese intelligent PDA-based delivery systems suppress periodontal inflammation.
“Specifically, these systems have been shown to suppress periodontal inflammation, attenuate alveolar bone resorption, and promote periodontal tissue regeneration.68,73,78”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [68]
The Abstract (page not provided) reports that metronidazole-loaded PDA nanoparticles reduced reactive oxygen species and showed therapeutic efficacy against periodontitis in vivo. It does not specifically report suppression of periodontal inflammation, so the claimed effect is more specific than the evidence in our copy. (LLM, conf=0.75)
Experimental — accuracy not yet measuredExtensive in vitro release studies and in vivo evaluations, including rat models of periodontitis, have consistently demonstrated the effectiveness of these intelligent PDA-based delivery platforms.
“Extensive in vitro release studies and in vivo evaluations, including rat models of periodontitis, have consistently demonstrated the effectiveness of these intelligent PDA-based delivery platforms.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [68]
The Abstract (page unavailable) reports in vitro antibacterial and antioxidant effects and in vivo therapeutic efficacy for one metronidazole-loaded PDA formulation. Our copy does not report in vitro release studies or identify a rat model, and this single study does not establish consistent effectiveness across multiple PDA-based delivery platforms. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThese intelligent PDA-based delivery systems attenuate alveolar bone resorption.
“Specifically, these systems have been shown to suppress periodontal inflammation, attenuate alveolar bone resorption, and promote periodontal tissue regeneration.68,73,78”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [68]
The Abstract reports that PDA@MNZ nanoparticles showed therapeutic effects against periodontitis in vivo, but it does not report an alveolar-bone outcome. Searches for “alveolar bone resorption” and “bone loss micro-CT alveolar bone periodontitis” found no passage addressing whether the treatment attenuated bone resorption. (LLM, conf=0.72)
Experimental — accuracy not yet measuredThese intelligent PDA-based delivery systems promote periodontal tissue regeneration.
“Specifically, these systems have been shown to suppress periodontal inflammation, attenuate alveolar bone resorption, and promote periodontal tissue regeneration.68,73,78”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [68]
The Abstract (page not given) reports that PDA@MNZ nanoparticles treated periodontitis in vivo, but does not report periodontal tissue regeneration. Searches for periodontal tissue regeneration and alveolar bone resorption found no passage in our copy addressing a regenerative effect. (LLM, conf=0.72)
Experimental — accuracy not yet measured
Such localized drug delivery systems markedly increase drug concentrations at lesion sites while minimizing adverse effects associated with systemic administration.
“Such localized drug delivery systems markedly increase drug concentrations at lesion sites while minimizing adverse effects associated with systemic administration.”
From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [68]
The Abstract (page not provided) describes metronidazole-loaded nanoparticles and reports therapeutic activity and biocompatibility. Our copy does not say that localized delivery markedly increases drug concentrations at lesions or reduces adverse effects compared with systemic administration; searches for those claims found no supporting passage. (LLM, conf=0.72)
Experimental — accuracy not yet measured
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Polyphenols-based functional nanomaterial systems for the treatment of periodontitis
Li, Y., Ma, J., Tang, J., Wang, L., Li, H., Tian, E., Pan, J., Peng, Q., & Han, X. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.214869 · Cited by 2 · see citing works
Yang, Z., Song, W., Lv, L., Zhai, S., Liu, Y., Cui, H., Li, X., Gao, F., & Chu, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s611922
“68 Such localized drug delivery systems markedly increase drug concentrations at lesion sites while minimizing adverse effects associated with systemic administration.”
- Authors
- Yan, M., Liang, W., Du, L., Guo, R., Cao, Y., Ni, S., Zhong, Y., Zhang, K., Qu, K., Qin, X., Chen, L., & Wu, W.
- Affiliations
- Chongqing University (CN)
- Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China
- Stomatological Hospital of Chongqing Medical University (CN)
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2023-12
- Volume
- 18
- Issue
- 29
- Pages
- 2143-2157
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- OpenAlex
- W4390062351
- Cited by
- 1
- References
- 58
- Citations by year
- 2026: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Nanomedicine (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31971301, 32171324)
- China Postdoctoral Science Foundation (2020M683271)
- Natural Science Foundation of Chongqing Municipality (cstc2021jcyj-msxmX0149)
- Fundamental Research Funds for Central Universities (2018CDHB1B08, 2020CDJQY-A061)
- The Fund of Biosecurity Specialized Project of PLA (19SWAQ18)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- periodontitis, metronidazole, polydopamine nanoparticles, Porphyromonas gingivalis, reactive oxygen species, antioxidant activity, antibacterial activity, drug delivery, synergistic therapy, biocompatibility
- MeSH terms
- Anti-Bacterial Agents, Antioxidants, Humans, Indoles, Metronidazole, Periodontitis, Polymers, Reactive Oxygen Species, Nanomedicine, Nanoparticles
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