Bottromycins - biosynthesis, synthesis and activity

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

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PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

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Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

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The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit

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New developments in RiPP discovery, enzymology and engineering

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Patellamide A and C biosynthesis by a microcin-like pathway in <i>Prochloron didemni</i> , the cyanobacterial symbiont of <i>Lissoclinum patella</i>

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Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

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Compilation and analysis of DNA sequences associated with apparent streptomycete promoters

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Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

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Understanding transport by the major facilitator superfamily (MFS): structures pave the way

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Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

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Follow the leader: the use of leader peptides to guide natural product biosynthesis

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The Proteomics of N-terminal Methionine Cleavage

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Leucine aminopeptidases: diversity in structure and function

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How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes

Rauwerdink, A. M., & Kazlauskas, R. J. (2015) · ACS Catalysis · doi:10.1021/acscatal.5b01539 · Cited by 354 · see citing works

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

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RiPP antibiotics: biosynthesis and engineering potential

Hudson, G. A., & Mitchell, D. A. (2018) · Current Opinion in Microbiology · doi:10.1016/j.mib.2018.02.010 · Cited by 218 · see citing works

Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes

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Discovery of a widely distributed toxin biosynthetic gene cluster

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Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

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Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom

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The tert-Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for the Asymmetric Synthesis and Applications of β-Amino Acids

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In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin

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Activation of Antibiotic Biosynthesis by Specified Mutations in the rpoB Gene (Encoding the RNA Polymerase β Subunit) of Streptomyces lividans

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Radical S ‐Adenosyl Methionine Epimerases: Regioselective Introduction of Diverse D ‐Amino Acid Patterns into Peptide Natural Products

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Synthetic Biotechnology to Study and Engineer Ribosomal Bottromycin Biosynthesis

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The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics

Polikanov, Y. S., Aleksashin, N. A., Beckert, B., & Wilson, D. N. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00048 · Cited by 124 · see citing works

Novel Approach for Improving the Productivity of Antibiotic-Producing Strains by Inducing Combined Resistant Mutations

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Post-translational modification of ribosomally synthesized peptides by a radical SAM epimerase in Bacillus subtilis

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Discovery and Characterization of Bicereucin, an Unusual d -Amino Acid-Containing Mixed Two-Component Lantibiotic

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Asymmetric Synthesis of (R)-(+)-.beta.-Phenylalanine from (S)-(+)-Benzylidene-p-toluenesulfinamide. Regeneration of the Sulfinimine Precursor

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Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin

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New Pathways in Plastics Recycling

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Structure and Biosynthesis of the Antibiotic Bottromycin D

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Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus

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Stereospecific Enzymatic Transformation of α-Ketoglutarate to (2S,3R)-3-Methyl Glutamate during Acidic Lipopeptide Biosynthesis

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Synthetic riboswitches for the conditional control of gene expression in Streptomyces coelicolor

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Enantioselective systheses of α-amino acids from 10-sulfonamido-isobornyl esters and di-t-butyl azodicarboxylate

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New strategy for the synthesis of 3-substituted prolines

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Asymmetric synthesis of unusual amino acids: An efficient synthesis of optically pure isomers of β-methylphenylalanine.

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Studies on the Formation of Transfer Ribonucleic Acid-Ribosome Complexes

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Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics

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Asymmetric synthesis of unusual amino acids: Synthesis of optically pure isomers of β-methylphenylalanine

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One-Carbon Ring Expansion of Azetidines via Ammonium Ylide [1,2]-Shifts: A Simple Route to Substituted Pyrrolidines

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Regioselective Enolization and Alkylation of 4-Oxo-N-(9-phenylfluoren-9-yl)proline: Synthesis of Enantiopure Proline−Valine and Hydroxyproline−Valine Chimeras

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Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans

Young, T. S., & Walsh, C. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110435108 · Cited by 70 · see citing works

Identification and characterisation of the gene cluster for the anti-MRSA antibiotic bottromycin: expanding the biosynthetic diversity of ribosomal peptides

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Peptide Syntheses via Ugi Reactionswith Ammonia

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Thiopeptide Antibiotics Exhibit a Dual Mode of Action against Intracellular Pathogens by Affecting Both Host and Microbe

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Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics

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Structure Determination and Total Synthesis of Bottromycin A2: A Potent Antibiotic against MRSA and VRE

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Secondary metabolites overproduction through transcriptional gene cluster refactoring

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A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction

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Bottromycin. I. A New Sulfur-containing Antibiotic

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A genetic system for direct selection of gene-positive clones during recombinational cloning in yeast

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Bottromycin derivatives: Efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities

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Studies of Unusual Amino Acids and Their Peptides. VI. The Syntheses and the Optical Resolutions of β-Methylphenylalanine and Its Dipeptide Present in Bottromycin

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Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA

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Post-translational Introduction of d -Alanine into Ribosomally Synthesized Peptides by the Dehydroalanine Reductase NpnJ

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SB-203207 and SB-203208, Too Novel Isoleucyl tRNA Synthetase Inhibitors from a Streptomyces sp. II. Structure Determination.

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The Structure of the Sulfur-containing Moiety of Bottromycin

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Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the <i>Escherichia coli</i> ribosome

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Acyclic Stereoselective Boron Alkylation Reactions for the Asymmetric Synthesis of β-Substituted α-Amino Acid Derivatives

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Synthesis of homochiral 3-substituted glutamic acids and prolines from pyroglutamic acid

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Preparative separation and identification of derivatized β-methylphenylalanine enantiomers by chiral SFC, HPLC and NMR for development of new peptide ligand mimetics in drug discovery

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The revised structure of bottromycin A2.

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An efficient method for the stereoselective synthesis of cis -3-substituted prolines: conformationally constrained α-amino acids

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Mode of action of bottromycin A2. Release of aminoacyl- or peptidyl-tRNA from ribosomes.

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Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm

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Stereoinversion of β- and γ-substituted α-amino acids using a chemo-enzymatic oxidation–reduction procedure

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Practical Stereoselective Synthesis of β-Branched α-Amino Acids through Efficient Kinetic Resolution in the Phase-Transfer-Catalyzed Asymmetric Alkylations

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Synthesis and Evaluation of Antibacterial Activity of Bottromycins

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Chiral separation of β-methyl-amino acids by ligand exchange using capillary electrophoresis and HPLC

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Nouvelles synthèses de l-amino-acids—I

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In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily

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Rapid and Robust Yeast-Mediated Pathway Refactoring Generates Multiple New Bottromycin-Related Metabolites

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Mode of action of bottromycin A2: Effect of bottromycin A2 on polysomes

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An efficient and stereodivergent synthesis of threo- and erythro-β-methylphenylalanine. Resolution of each racemic pair by semipreparative HPLC

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Total Synthesis and Stereochemistry Revision of Mannopeptimycin Aglycone

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Macroamidine Formation in Bottromycins Is Catalyzed by a Divergent YcaO Enzyme

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An Enzymatic Route to Selenazolines

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Direct chiral separation of unnatural amino acids by high‐performance liquid chromatography on a ristocetin a‐bonded stationary phase

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Enantioselective approach to 3-substituted prolines

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Separation of enantiomeric β-methyl amino acids and of β-methyl amino acid containing peptides

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Mode of action of bottromycin A2: effect on peptide bond formation

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The revised structure of Bottromycin A2.

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Isolation and characterization of bottromycins A2, B2, C2.

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Studies of Unusual Amino Acids and Their Peptides. V. The Synthesis and the Absolute Configuration of β(2-Thiazolyl)-β-alanine Present in Bottromycin

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Synthesis ofN-Boc-β-Aryl Alanines and ofN-Boc-β-Methyl-β-aryl Alanines by Regioselective Ring-Opening of Enantiomerically PureN-Boc-Aziridines

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Studies on bottromycins. I. 1H and 13C NMR assignments of bottromycin A2, the main component of the complex.

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Isolation, Characterization and Structural Elucidation of New Amino Acids from Bottromycin A

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The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes

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Indirect high-performance liquid chromatographic separation of stereoisomers of β-alkyl-substituted amino acids by the application of (S)-N-(4-nitrophenoxycarbonyl)phenylalanine methoxyethyl ester as chiral derivatizing agent

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Screening and Identification of Antimicrobial Compounds from Streptomyces bottropensis Suppressing Rice Bacterial Blight

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In Vitro Biosynthesis of Peptides Containing Exotic Azoline Analogues

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Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP

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Ammonia in Ugi Reactions - Four-Component versus Six-Component Couplings

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Regulation of Bottromycin Biosynthesis Involves an Internal Transcriptional Start Site and a Cluster-Situated Modulator

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Characterization of the Stereoselective P450 Enzyme BotCYP Enables the In Vitro Biosynthesis of the Bottromycin Core Scaffold

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The Long, Long Way to Bottromycin

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Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces

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ФОРМИРОВAНИЕ ГОТОВНОСТИ БУДУЩИХ ПЕДAГОГОВ К ОРГAНИЗAЦИИ РAБОТЫ ПО РAЗВИТИЮ ВAЛЕОЛОГИЧЕСКОЙ КУЛЬТУРЫ ШКОЛЬНИКОВ

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Коммуникaтивно- прaгмaтический aнaлиз дипломaтических бумaг (нa основе вербaльных нот)

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DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

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Susquehanna Chorale Spring Concert "Roots and Wings"

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A GEOMETRIC MEAN IN THE FURUTA INEQUALITY

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