Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model
Abstract
Curcumin derivatives B and N developed as disaggregation agents of amyloid β (Aβ) fibrils significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.
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Curcumin derivatives B and N reduce locomotion dysfunction in Aβ-expressing Drosophila AD model.
“Moreover, both compounds significantly reduced locomotion dysfunction in an Aβ-expressing Drosophila model of AD [88].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [88]
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- Authors
- Utomo, R. Y., Sugie, A., Okada, S., Miura, K., & Nakamura, H.
- Affiliations
- Tokyo Institute of Technology (JP)
- Brain Research Institute, Niigata University (JP)
- Corresponding author
- Sugie, Atsushi
- Nakamura, Hiroyuki
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 58
- Issue
- 15
- Pages
- 2576-2579
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W4205806162
- Cited by
- 18
- References
- 34
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Niigata University (2021-21013)
- Ministry of Education, Culture, Sports, Science and Technology (19K22592, 20H04699, 21H02837)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- curcumin derivatives, amyloid-beta fibrils, fibril disaggregation, Alzheimer's disease, Drosophila model
- MeSH terms
- Alzheimer Disease, Animals, Curcumin, Disease Models, Animal, Dose-Response Relationship, Drug, Drosophila, Molecular Structure, Amyloid beta-Peptides
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