Cited by 18Alzheimer's disease research and treatmentsCurcumin's Biomedical ApplicationsCholinesterase and Neurodegenerative Diseases

Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model

Utomo, Rohmad Yudi, Sugie, Atsushi, Okada, Satoshi, Miura, Kazuki, Nakamura, Hiroyuki·2022·Chemical Communications

Abstract

Curcumin derivatives B and N developed as disaggregation agents of amyloid β (Aβ) fibrils significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.

Integrity signals

Registry

Crossref · 10.1039/d1cc07000b

Cites

34 of 34 references verified0 citation errors · 0 not checkable

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Authors
Utomo, R. Y., Sugie, A., Okada, S., Miura, K., & Nakamura, H.
Affiliations
  • Tokyo Institute of Technology (JP)
  • Brain Research Institute, Niigata University (JP)
Corresponding author
  • Sugie, Atsushi
  • Nakamura, Hiroyuki
Venue
Chemical Communications
Published
2022
Volume
58
Issue
15
Pages
2576-2579
ISSN
  • 1359-7345 (ISSN-L)
  • 1364-548X
OpenAlex
W4205806162
Cited by
18
References
34
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5
FWCI
2.33
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Niigata University (2021-21013)
  • Ministry of Education, Culture, Sports, Science and Technology (19K22592, 20H04699, 21H02837)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
curcumin derivatives, amyloid-beta fibrils, fibril disaggregation, Alzheimer's disease, Drosophila model
MeSH terms
Alzheimer Disease, Animals, Curcumin, Disease Models, Animal, Dose-Response Relationship, Drug, Drosophila, Molecular Structure, Amyloid beta-Peptides

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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