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In vitro fermentation characteristics of fucoidan and its regulatory effects on human gut microbiota and metabolites

Zhou, X., Zhang, Y., Li, W., Yang, Y., Wang, B., Liu, C., Bai, J., & Wang, C. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.141998 · Cited by 33 · see citing works

Structural characteristics, digestion properties, fermentation properties, and biological activities of butyrylated starch: A review

Zhang, Y., Li, L., Sun, S., Cheng, L., Gu, Z., & Hong, Y. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.121825 · Cited by 32 · see citing works

In vitro batch fermentation demonstrates variations in the regulation of gut microbiota and metabolic functions by β-glucans of differing structures

Gao, Y., Yu, L., Ye, Z., Zhang, C., Gong, Y., Zhang, Q., Zhang, C., Zhao, J., Narbad, A., Chen, W., et al. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114287 · Cited by 30 · see citing works

Soluble and insoluble dietary fiber at different ratios: Hydration characteristics, rheological properties, and ameliorative effects on constipation

Wang, L., Wang, J., Wang, J., Guo, Z., Li, Z., Qiu, J., & Wang, L. (2024) · Food Chemistry X · doi:10.1016/j.fochx.2024.101996 · Cited by 30 · see citing works

Strain-specific regulative effects of Lactobacillus plantarum on intestinal barrier dysfunction are associated with their capsular polysaccharides

Liu, Y., Liu, Q., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.136 · Cited by 29 · see citing works

The roles of different Bacteroides uniformis strains in alleviating DSS-induced ulcerative colitis and related functional genes

Wang, C., Guo, H., Bai, J., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2024) · Food & Function · doi:10.1039/d3fo04863b · Cited by 29 · see citing works

In vitro fermentation of heparin by the human gut microbiota: Changes in the microbiota community and metabolic functions

Zhang, C., Yu, L., Zhai, Q., Zhao, R., Zhao, J., Zhang, H., Chen, W., & Tian, F. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135010 · Cited by 29 · see citing works

Lactic acid bacteria in relieving constipation: mechanism, clinical application, challenge, and opportunity

Zhang, T., Liu, W., Lu, H., Cheng, T., Wang, L., Wang, G., Zhang, H., & Chen, W. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2278155 · Cited by 28 · see citing works

How do probiotics alleviate constipation? A narrative review of mechanisms

Huang, Y.-P., Shi, J.-Y., Luo, X.-T., Luo, S.-C., Cheung, P. C. K., Corke, H., Yang, Q.-Q., & Zhang, B. (2024) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2024.2336531 · Cited by 28 · see citing works

Beneficial effects of lactitol on the composition of gut microbiota in constipated patients

Li, X. Q., Zhang, X. M., Wu, X., Lan, Y., Xu, L., Meng, X. C., & Li, J. (2020) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12912 · Cited by 26 · see citing works

Torreya grandis Kernel Oil Alleviates Loperamide‐Induced Slow Transit Constipation via Up‐Regulating the Colonic Expressions of Occludin/Claudin‐1/ZO‐1 and 5‐HT3R/5‐HT4R in BALB/c Mice

Wang, X., Guo, R., Yu, Z., Zikela, L., Li, J., Li, S., & Han, Q. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300615 · Cited by 25 · see citing works

Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review

Fu, L., Wang, M., Li, D., Ma, S., Zhang, F.-L., & Zheng, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1624415 · Cited by 25 · see citing works

Bifidobacterium bifidum CCFM1163 Alleviated Cathartic Colon by Regulating the Intestinal Barrier and Restoring Enteric Nerves

Tang, N., Yu, Q., Mei, C., Wang, J., Wang, L., Wang, G., Zhao, J., & Chen, W. (2023) · Nutrients · doi:10.3390/nu15051146 · Cited by 27 · see citing works

Role of folic acid in regulating gut microbiota and short-chain fatty acids based on an in vitro fermentation model

Zheng, X., Xia, C., Liu, M., Wu, H., Yan, J., Zhang, Z., Huang, Y., Gu, Q., & Li, P. (2024) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12825-5 · Cited by 23 · see citing works

Consumption of Wheat Peptides Improves Functional Constipation: A Translational Study in Humans and Mice

Wang, Q., Shen, F., Zhang, J., Cai, H., Pan, Y., Sun, T., Gong, Y., Du, J., Zhong, H., & Feng, F. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200313 · Cited by 21 · see citing works

Lactobacillus reuteri CCFM1072 and CCFM1040 with the role of Treg cells regulation alleviate airway inflammation through modulating gut microbiota in allergic asthma mice

Li, L., Fang, Z., Liu, Z., Zhao, J., Zhang, H., Wang, S., He, J., Lu, W., & Chen, W. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104286 · Cited by 21 · see citing works

Compendium of Bifidobacterium-based probiotics: characteristics and therapeutic impact on human diseases

Bocchio, F., Mancabelli, L., Milani, C., Lugli, G. A., Tarracchini, C., Longhi, G., Conto, F. D., Turroni, F., & Ventura, M. (2024) · Microbiome Research Reports · doi:10.20517/mrr.2024.52 · Cited by 26 · see citing works

Novel Phocaeicola Strain Ameliorates Dextran Sulfate Sodium-induced Colitis in Mice

Sun, Z., Jiang, X., Wang, B., Tian, F., Zhang, H., & Yu, L. (2022) · Current Microbiology · doi:10.1007/s00284-022-03054-6 · Cited by 20 · see citing works

Alleviating effects of gut micro-ecologically regulatory treatments on mice with constipation

Zhao, Y., Liu, Q., Hou, Y., & Zhao, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.956438 · Cited by 18 · see citing works

Strain-specific ameliorating effect of Bifidobacterium longum on atopic dermatitis in mice

Fang, Z., Li, L., Liu, X., Lu, W., Zhao, J., Zhang, H., & Chen, W. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103426 · Cited by 19 · see citing works

Perinatal transmission of a probiotic Bifidobacterium strain protects against early life stress-induced mood and gastrointestinal motility disorders

Zhu, H., Tian, P., Qian, X., Gu, L., Zhao, J., Wang, G., & Chen, W. (2022) · Food & Function · doi:10.1039/d2fo01164f · Cited by 18 · see citing works

Bifidobacterium Treated by Electrostatic Spray Drying Relieved Constipation by Changing the Relative Abundance of Bacteria Associated With Gastrointestinal Regulatory Peptides

Jiang, T., Lu, W., Fang, Z., Wang, H., Zhu, J., Zhang, H., & Zhao, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.894216 · Cited by 18 · see citing works

Therapeutic effects ofBombax ceibaflower aqueous extracts against loperamide-induced constipation in mice

Wang, L., Xie, S., Jiang, X., Xu, C., Wang, Y., Feng, J., & Yang, B. (2022) · Pharmaceutical Biology · doi:10.1080/13880209.2022.2157841 · Cited by 18 · see citing works

Milk fermented by combined starter cultures comprising three Lactobacillus strains exerts an alleviating effect on loperamide-induced constipation in BALB/c mice

Jiang, Y. L., Guo, H., Sun, M., Jiang, C., Jiang, S., Mu, G., Tuo, Y., & Gao, P. (2023) · Food & Function · doi:10.1039/d3fo00222e · Cited by 18 · see citing works

Bifidobacterium longum S3 alleviates loperamide-induced constipation by modulating intestinal acetic acid and stearic acid levels in mice

Zhang, T., Lu, H., Cheng, T., Wang, L., Wang, G., Zhang, H., & Chen, W. (2024) · Food & Function · doi:10.1039/d4fo00695j · Cited by 18 · see citing works

Effects of Lactiplantibacillus plantarum GUANKE on Diphenoxylate-Induced Slow Transit Constipation and Gut Microbiota in Mice

Huang, Y., Guo, Y., Li, X., Xiao, Y., Wang, Z., Song, L., & Ren, Z. (2023) · Nutrients · doi:10.3390/nu15173741 · Cited by 16 · see citing works

Hemp seeds attenuate loperamide-induced constipation in mice

Huang, H., Yongtong, W., Ding, X., Fang, L., Jing, G., Fumao, Z., Jie, J., & Ji, L. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1353015 · Cited by 16 · see citing works

Arecoline alleviated loperamide induced constipation by regulating gut microbes and the expression of colonic genome

Xu, M. Y., Wang, W., Su, S., Li, W., Hu, X., & Zhang, J. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115423 · Cited by 15 · see citing works

Gastrointestinal Fermentable Polysaccharide Is Beneficial in Alleviating Loperamide-Induced Constipation in Mice

Liu, B., Zhang, Z., Liu, X., Hu, W., & Wu, W. (2023) · Nutrients · doi:10.3390/nu15204364 · Cited by 15 · see citing works

The Anti-Constipation Effects of Raffino-Oligosaccharide on Gut Function in Mice Using Neurotransmitter Analyses, 16S rRNA Sequencing and Targeted Screening

Liang, Y., Wang, Y., Wen, P., Chen, Y., Ouyang, D., Wang, D., Zhang, B., Deng, J., Chen, Y., Sun, Y., et al. (2022) · Molecules · doi:10.3390/molecules27072235 · Cited by 15 · see citing works

Fecal fermentation behaviors of Konjac glucomannan and its impacts on human gut microbiota

Tan, X., Wang, B., Zhou, X., Liu, C., Wang, C., & Bai, J. (2024) · Food Chemistry X · doi:10.1016/j.fochx.2024.101610 · Cited by 14 · see citing works

Gut microbiota: The pivotal conduit in the onset of constipation and its alleviation by tea flower polysaccharides (TFP) in a mouse model

Wu, T., Song, F., Huang, J., Cui, S., Wang, L., Yang, Q., Wu, Y., Li, B., Tu, Y., Wan, X., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140808 · Cited by 14 · see citing works

Potential Targets in Constipation Research: A Review

Ravichandiran, V., Arumugam, S., Bisht, P., Dagar, N., & Kumar, N. (2022) · Current Drug Targets · doi:10.2174/1389450124666221209123541 · Cited by 15 · see citing works

Different effects of Bacillus coagulans vegetative cells and spore isolates on constipation-induced gut microbiota dysbiosis in mice

Li, L., Liu, B., Cao, J., Zhang, H., Tian, F., Yu, L., Chen, W., & Zhai, Q. (2022) · Food & Function · doi:10.1039/d2fo01668k · Cited by 13 · see citing works

Alleviation effects of Lactobacillus plantarum in colitis aggravated by a high-salt diet depend on intestinal barrier protection, NF-κB pathway regulation, and oxidative stress improvement

Chen, Y., Liu, N., Chen, F., Liu, M., Yang, M., Wang, C., Xia, L., Peng, M., & Zhou, M. (2025) · Food & Function · doi:10.1039/d4fo06377e · Cited by 13 · see citing works

Preventive effect of kiwi berry ( Actinidia arguta ) on loperamide-induced constipation

Zhang, J., Li, B., Gao, N., Li, H., Cui, X., Jiang, H., Tang, S., Jin, C., & Tian, J. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250119 · Cited by 12 · see citing works

Bifidobacterium bifidum CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP 3 pathway to reconstruct the intestinal nerve and barrier

Zhu, S., Yu, Q., Xue, Y., Li, J., Huang, Y. C., Liu, W., Wang, G., Wang, L., Zhai, Q., Zhao, J., et al. (2025) · Food & Function · doi:10.1039/d4fo05835f · Cited by 12 · see citing works

A Screening Model for Probiotics Against Specific Metabolic Diseases Based on Caco-2 Monolayer Membrane

Liu, Y., Jiang, P., Zhu, S., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2022) · Engineering · doi:10.1016/j.eng.2022.02.014 · Cited by 11 · see citing works

Protective effect of a combination of multiple strains of Lactobacillus acidophilus on collagen-induced arthritis

Yang, Y., Hong, Q., Zhang, X., & Liu, Z. (2024) · Food & Function · doi:10.1039/d4fo05273k · Cited by 10 · see citing works

Propionate restores disturbed gut microbiota induced by methotrexate in Rheumatoid Arthritis: From clinic to experiments

Fan, Z., Yang, B. K., Ross, R. P., Stanton, C., Zhang, F., Sun, J., Zhao, J., Zhang, H., & Chen, W. (2021) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2021.101545 · Cited by 10 · see citing works

Bifidobacterium longum subsp. longum relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation

Zhang, C., Wang, L., Liu, X., Wang, G., Zhao, J., & Chen, W. (2024) · Food & Function · doi:10.1039/d4fo04660a · Cited by 9 · see citing works

Effects of chitosan and its oligosaccharide on gut microbiota and metabolites disturbed by excessive protein consumption in vivo and in vitro

Wang, L., Wang, L., Wang, N., Chen, S., Wen, C., & Song, S. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103555 · Cited by 8 · see citing works

Induction of autism-related behavior in male mice by early-life vitamin D deficiency: association with disruption of the gut microbial composition and homeostasis

Cui, J., Wang, S., Zhai, Z., Song, X., Qiu, T., Yu, L., Zhai, Q., & Zhang, H. (2024) · Food & Function · doi:10.1039/d4fo00279b · Cited by 9 · see citing works

Organ-Specific Effects of Polystyrene Nanoplastics on Deltamethrin-Induced Toxicity in Mice: Mitigated Hepatorenal Oxidative Damage But Increased Enteric Toxicity

Qi, M., Zhang, S., Fang, H., Yu, Y., Liu, J., & Zhang, L. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c10716 · Cited by 8 · see citing works

Revealing the beneficial effects of a dairy infant formula on the gut microbiota of early childhood children with autistic spectrum disorder using static and SHIME® fermentation models

de Oliveira, L. I. G., Clementino, J. R., Salgaço, M. K., de Oliveira, S. P. A., Lima, M. D. S., Mesa, V., de Souza, E. L., Vinderola, C. G., Magnani, M., & Sivieri, K. (2023) · Food & Function · doi:10.1039/d3fo01156a · Cited by 8 · see citing works

Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function

Liu, B., Tomtong, P., Charoensiddhi, S., & Vongsangnak, W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144910 · Cited by 8 · see citing works

Effect of γ-Aminobutyric acid and dietary monosodium glutamate supplementation on gut microbiota and short-chain fatty acid: Insights from an in vitro colonic fermentation model

Han, J., Zhao, X., Ye, Q., Wang, Y., Wu, Y., Hu, S., Li, P., & Gu, Q. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106304 · Cited by 7 · see citing works

Bifidobacterium Lactobacillus Triple Viable Alleviates Slow Transit Constipation by Regulating Gut Microbiota and Metabolism

Luo, M.-C., Xie, P.-W., Deng, X., Fan, J.-H., & Xiong, L.-S. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16960 · Cited by 7 · see citing works

Bottom‐Up Design of Prebiotics and Probiotics: An Intestinal Microbiota‐Centered Approach to Chronic and Functional Constipation Management

He, P., Chen, S., Lyu, C., An, R., & Wang, D. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70140 · Cited by 6 · see citing works

Positive efficacy of Lactiplantibacillus plantarum MH-301 as a postoperative adjunct to endoscopic sclerotherapy for internal hemorrhoids: a randomized, double-blind, placebo-controlled trial

Zhang, K., Liu, H., Liu, P., Feng, Q., Gan, L., Yao, L., Huang, G., Fang, Z., Chen, T., & Fang, N. (2023) · Food & Function · doi:10.1039/d3fo02936k · Cited by 6 · see citing works

Bifidobacterium longum K5 Prevents Enterohaemorrhagic Escherichia coli O157:H7 Infection in Mice through the Modulation of the Gut Microbiota

Liu, D., Li, C., Cao, T., Lv, X., Yue, Y., Li, S., Yang, C., Liu, F., Huo, G., & Li, B. (2024) · Nutrients · doi:10.3390/nu16081164 · Cited by 6 · see citing works

Strain-specific effect of Limosilactobacillus fermentum with distinct genetic lineages on loperamide-induced constipation in mice: attributing effects to certain genes

Zhao, Y., Zhang, C., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2022) · Food & Function · doi:10.1039/d2fo02675a · Cited by 6 · see citing works

The effect of kiwi berry (Actinidia arguta) on preventing and alleviating loperamide-induced constipation

Zhang, J., Li, D., Tian, Q., Ding, Y., Jiang, H., Xin, G., Cheng, S., Tang, S., Jin, C., Tian, J., et al. (2023) · Food Innovation and Advances · doi:10.48130/fia-2023-0001 · Cited by 6 · see citing works

Psyllium Husk Powder improves constipation by remodeling gut microbiota and improving intestinal metabolites

Wang, Z., Lv, Q., Liu, L., & Zhu, Z. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.105828 · Cited by 5 · see citing works

Impact of the probiotic Bacillus coagulans on loperamide-induced delayed bowel movement in Sprague–Dawley rats

Jang, J. H., Chang, Y. B., Kim, S. M., Han, K., Sim, W., Hong, K., Suh, H. J., & Han, S. (2024) · Food & Function · doi:10.1039/d4fo04237a · Cited by 6 · see citing works

Positive effect of Bifidobacterium animalis subsp. lactis VHProbi YB11 in improving gastrointestinal movement of mice having constipation

Cui, H., Wang, Q., Feng, C., Guo, C., Zhang, J., Bu, X., & Duan, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1040371 · Cited by 6 · see citing works

The Potential of Polysaccharides from Various Plants as Constipation Treatment

Sari, Y. P., & Candraruna, D. B. (2023) · Journal of Applied Food Technology · doi:10.17728/jaft.20621 · Cited by 5 · see citing works

Investigation of supplementation with a combination of fermented bean dregs and wheat bran for improving the growth performance of the sow

Liu, J., Wang, K., Zhao, L., Li, Y., Li, Z., & Li, C. (2023) · Journal of Animal Science and Technology · doi:10.5187/jast.2023.e13 · Cited by 4 · see citing works

Different microbial ecological agents change the composition of intestinal microbiota and the levels of SCFAs in mice to alleviate loperamide-induced constipation

Zhang, C., Wang, L., Liu, X., Wang, G., Guo, X., Liu, X., Zhao, J., & Chen, W. (2024) · Beneficial Microbes · doi:10.1163/18762891-bja00011 · Cited by 4 · see citing works

Functional constipation in Chinese infants: disruptions in gut microbiota and urinary metabolome revealed by a cross-sectional analysis

Zhao, H., Lu, X., Lou, H., Ye, Y., Ye, H., Li, W., Long, Z., Zhang, X., Wu, J., & Wang, J. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1649995 · Cited by 3 · see citing works

Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice

Wang, L., Hu, L., Xu, Q., Yin, B., Fang, D., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020318 · Cited by 120 · see citing works

Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation

Chai, M., Wang, L., Li, X., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2021) · Food & Function · doi:10.1039/d1fo00559f · Cited by 55 · see citing works

Adhesive Bifidobacterium Induced Changes in Cecal Microbiome Alleviated Constipation in Mice

Wang, L., Chen, C., Cui, S., Lee, Y. K., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01721 · Cited by 62 · see citing works

Strain‐dependent effects of Bifidobacterium on loperamide‐induced constipation via gut microbiota and abfA cluster

Song, X., Wang, Z., Zhang, Z., Wang, X., Xu, J., Ouyang, B., 俞兰秀, Wang, Y., Geng, W., & Jia, L. (2026) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.71070

Bifidobacterium longum subsp. longum relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation

Zhang, C., Wang, L., Liu, X., Wang, G., Zhao, J., & Chen, W. (2024) · Food & Function · doi:10.1039/d4fo04660a · Cited by 9 · see citing works