Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation
Open accessAbstract
Background & aims In fecal samples from patients with chronic constipation, the microbiota differs from that of healthy subjects. However, the profiles of fecal microbiota only partially replicate those of the mucosal microbiota. It is not clear whether these differences are caused by variations in diet or colonic transit, or are associated with methane production (measured by breath tests). We compared the colonic mucosal and fecal microbiota in patients with chronic constipation and in healthy subjects to investigate the relationships between microbiota and other parameters.Methods Sigmoid colonic mucosal and fecal microbiota samples were collected from 25 healthy women (controls) and 25 women with chronic constipation and evaluated by 16S ribosomal RNA gene sequencing (average, 49,186 reads/sample). We assessed associations between microbiota (overall composition and operational taxonomic units) and demographic variables, diet, constipation status, colonic transit, and methane production (measured in breath samples after oral lactulose intake).Results Fourteen patients with chronic constipation had slow colonic transit. The profile of the colonic mucosal microbiota differed between constipated patients and controls (P < .05). The overall composition of the colonic mucosal microbiota was associated with constipation, independent of colonic transit (P < .05), and discriminated between patients with constipation and controls with 94% accuracy. Genera from Bacteroidetes were more abundant in the colonic mucosal microbiota of patients with constipation. The profile of the fecal microbiota was associated with colonic transit before adjusting for constipation, age, body mass index, and diet; genera from Firmicutes (Faecalibacterium, Lactococcus, and Roseburia) correlated with faster colonic transit. Methane production was associated with the composition of the fecal microbiota, but not with constipation or colonic transit.Conclusions After adjusting for diet and colonic transit, the profile of the microbiota in the colonic mucosa could discriminate patients with constipation from healthy individuals. The profile of the fecal microbiota was associated with colonic transit and methane production (measured in breath), but not constipation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Among adults with chronic constipation, the overall makeup of colonic mucosa-associated microbiota separated patients from controls regardless of transit time.
“In a study of adults with chronic constipation, overall composition of the colonic mucosa-associated microbiota could discriminate patients with constipation from control subjects independent of transit time157.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [157]
Altered mucosal and fecal microbiota have been linked to chronic constipation in the evidence.
“There is evidence supporting an association between the altered mucosal and fecal microbiota and chronic constipation156, 157.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [157]
Metabolites of various gut microbiota, especially bacteria attached to the intestinal mucosa, cause intestinal smooth muscle contraction.
“The other explanation is that the ref lexivity of metabolites of various gut microbiota (especially the bacteria attached to the intestinal mucosa) causes intestinal smooth muscle contraction [14,17].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
The gut microbiota can regulate the expression of genes involved in intestinal peristalsis.
“One explanation suggests that the gut microbiota can regulate the expression of genes involved in intestinal peristalsis.”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
When SCFA concentration surpasses a certain threshold, SCFAs stimulate electrolyte absorption, inhibit mucin secretion, and lead to the occurrence and development of constipation.
“When the concentration of SCFAs surpasses a certain threshold, they can stimulate electrolyte absorption, inhibit the secretion of mucin, and lead to the occurrence and development of constipation;”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
SCFAs, especially butyric acid, exhibit a biphasic effect on the secretion of mucin by colonic epithelial cells.
“SCFAs, especially butyric acid, exhibit a biphasic effect on the secretion of mucin by colonic epithelial cells.”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
Conversely, SCFAs can stimulate mucin secretion, regulate the neurochemical phenotype, and enhance the excitability of choline acetyltransferase-positive neurons, thereby improving constipation.
“conversely, they can stimulate mucin secretion, regulate the neurochemical phenotype, and enhance the excitability of choline acetyltransferase-positive neurons, thereby improving constipation [17,33,34].”
From Chronic constipation and gut microbiota: current research insights and therapeutic implications (2024) · cites this paper as [17]
In patients with functional constipation, methane production was associated with the gut microbial composition, but not with constipation or colonic transit.
“On the other hand, one study reported that in patients with FC, methane production was associated with the gut microbial composition, but not with constipation or colonic transit [ 77 ].”
From Role of gut microbiota in functional constipation (2021) · cites this paper as [77]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Breiman, L. (2001) · Machine Learning · doi:10.1023/a:1010933404324 · Cited by 133,538 · see citing works
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 20,966 · see citing works
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,587 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
Self-citationFastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
Price, M. N., Dehal, P. S., & Arkin, A. P. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp077 · Cited by 5,602 · see citing works
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856 · see citing works
Shekhar, C., Monaghan, P. J., Morris, J., Issa, B., Whorwell, P. J., Keevil, B. G., & Houghton, L. A. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.014 · Cited by 2,891 · see citing works
Lozupone, C., Hamady, M., Kelley, S. T., & Knight, R. D. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01996-06 · Cited by 2,717 · see citing works
Microbial degradation of complex carbohydrates in the gut
Flint, H. J., Scott, K. P., Duncan, S. H., Louis, P., & Forano, E. (2012) · Gut Microbes · doi:10.4161/gmic.19897 · Cited by 2,331 · see citing works
Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179 · see citing works
The NIH Human Microbiome ProjectPreprint
The NIH HMP Working Group, Peterson, J. L., Garges, S., Giovanni, M. Y., McInnes, P., Wang, L., Schloss, J. A., Bonazzi, V. R., McEwen, J. E., Wetterstrand, K. A., et al. (2009) · Genome Research · doi:10.1101/gr.096651.109 · Cited by 2,104 · see citing works
Infernal 1.0: inference of RNA alignments
Nawrocki, E. P., Kolbe, D. L., & Eddy, S. R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp157 · Cited by 1,428 · see citing works
Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335 · see citing works
Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192 · see citing works
Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041 · see citing works
Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002 · see citing works
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939 · see citing works
Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats
Islam, K. B. M. S., Fukiya, S., Hagio, M., Fujii, N., Ishizuka, S., Ooka, T., Ogura, Y., Hayashi, T., & Yokota, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.046 · Cited by 918 · see citing works
American Gastroenterological Association Technical Review on Constipation
Bharucha, A. E., Pembérton, J. H., & Locke, G. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.028 · Cited by 914 · see citing works
Self-citationBoruta – A System for Feature Selection
Kursa, M. B., Jankowski, A., & Rudnicki, W. R. (2010) · Fundamenta Informaticae · doi:10.3233/fi-2010-288 · Cited by 900 · see citing works
An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works
Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699 · see citing works
Diets that differ in their FODMAP content alter the colonic luminal microenvironment
Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2015) · Gut · doi:10.1136/gutjnl-2014-307264 · Cited by 681 · see citing works
Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome
Saulnier, D. M., Riehle, K., Mistretta, T., Diaz, M., Mandal, D., Raza, S., Weidler, E. M., Qin, X., Coarfa, C., Milosavljevic, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.072 · Cited by 672 · see citing works
Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats
Soret, R., Chevalier, J., De Coppet, P., Poupeau, G., Derkinderen, P., Segain, J. P., & Neunlist, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.053 · Cited by 530 · see citing works
Pimentel, M., Lin, H. C., Enayati, P., van den Burg, B., Lee, H.-R., Chen, J. H., Park, S., Kong, Y., & Conklin, J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00574.2004 · Cited by 508 · see citing works
Self-citationtana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01427.x · Cited by 474 · see citing works
Power and sample-size estimation for microbiome studies using pairwise distances and PERMANOVA
Kelly, B. J., Gross, R., Bittinger, K. L., Sherrill-Mix, S. A., Lewis, J. D., Collman, R. G., Bushman, F. D., & Li, H. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv183 · Cited by 457 · see citing works
Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
Kashyap, P. C., Marcobal, A., Ursell, L. K., Larauche, M., Duboc, H., Earle, K. A., Sonnenburg, E. D., Ferreyra, J. A., Higginbottom, S. K., Million, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.047 · Cited by 451 · see citing works
Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., & Ringel, Y. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01891.x · Cited by 425 · see citing works
KHALIF, I., QUIGLEY, E., KONOVITCH, E., & MAXIMOVA, I. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.06.008 · Cited by 382 · see citing works
Structural changes in the gut microbiome of constipated patients
Zhu, L., Liu, W., Alkhouri, R., Baker, R. D., Bard, J. E., Quigley, E. M., & Baker, S. S. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00082.2014 · Cited by 381 · see citing works
Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon
Barcelo, A., Claustre, J., Moro, F., Chayvialle, J.-A., Cuber, J.-C., & Plaisancié, P. (2000) · Gut · doi:10.1136/gut.46.2.218 · Cited by 375 · see citing works
Functional dysbiosis within the gut microbiota of patients with constipated‐irritable bowel syndrome
Chassard, C., Dapoigny, M. C., Scott, K. P., Crouzet, L., Del’Homme, C., Marquet, P., Martin, J. C., Pickering, G. P., Ardid, D., Eschalier, A., et al. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05007.x · Cited by 366 · see citing works
Obesity is Associated with Increased Risk of Gastrointestinal Symptoms: A Population-Based Study
Delgado-Aros, S., Locke, G. R., Camilleri, M., Talley, N. J., Fett, S. L., Zinsmeister, A. R., & Melton, L. J. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30887.x · Cited by 333 · see citing works
A Taxonomic Signature of Obesity in the Microbiome? Getting to the Guts of the Matter
Finucane, M. M., Sharpton, T. J., Laurent, T. J., & Pollard, K. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084689 · Cited by 321 · see citing works
Krogius-Kurikka, L., Lyra, A., Malinen, E., Aarnikunnas, J., Tuimala, J., Paulin, L. G., Mäkivuokko, H., Kajander, K., & Palva, A. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-95 · Cited by 307 · see citing works
Binder, H. J., & Mehta, P. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)91614-4 · Cited by 303 · see citing works
Carroll, I. M., Ringel-Kulka, T., Keku, T. O., Chang, Y.-H., Packey, C. D., Sartor, R. B., & Ringel, Y. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00154.2011 · Cited by 292 · see citing works
Lepage, P., Seksik, P., Sutren, M., de la Cochetière, M.-F., Jian, R., Marteau, P., & Doré, J. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000159662.62651.06 · Cited by 270 · see citing works
Attaluri, A., Jackson, M., Valestin, J., & Rao, S. S. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.655 · Cited by 261 · see citing works
Lavelle, A., Lennon, G., O'Sullivan, Ó., Docherty, N., Balfe, Á., Maguire, A., Mulcahy, H., Doherty, G., O'Donoghue, D., Hyland, J., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307873 · Cited by 259 · see citing works
Alternative pathways for hydrogen disposal during fermentation in the human colon.
Gibson, G. R., Cummings, J. H., Macfarlane, G. T., Allison, C., Segal, I., Vorster, H. H., & Walker, A. R. (1990) · Gut · doi:10.1136/gut.31.6.679 · Cited by 255 · see citing works
A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome
Codling, C., O’Mahony, L., Shanahan, F., Quigley, E. M. M., & Marchesi, J. R. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0934-x · Cited by 243 · see citing works
Methane on Breath Testing Is Associated with Constipation: A Systematic Review and Meta-analysis
Kunkel, D. C., Basseri, R. J., Makhani, M. D., Chong, K., Chang, C., & Pimentel, M. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1590-5 · Cited by 219 · see citing works
Wong, R. K., Palsson, O. S., Turner, M. J., Levy, R. L., Feld, A. D., von Korff, M., & Whitehead, W. E. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.200 · Cited by 204 · see citing works
Carroll, I. M., Chang, Y.-H., Park, J., Sartor, R. B., & Ringel, Y. (2010) · Gut Pathogens · doi:10.1186/1757-4749-2-19 · Cited by 203 · see citing works
Parkes, G. C., Rayment, N. B., Hudspith, B. N., Petrovska, L., Lomer, M. C., Brostoff, J., Whelan, K., & Sanderson, J. D. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01803.x · Cited by 200 · see citing works
Camilleri, M., Iturrino, J., Bharucha, A. E., Burton, D. D., Shin, A., Jeong, I. D., & Zinsmeister, A. R. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01972.x · Cited by 181 · see citing works
Self-citationCrosstalk at the mucosal border: importance of the gut microenvironment in IBS
Öhman, L., Törnblom, H., & Simrén, M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.200 · Cited by 181 · see citing works
The intestinal ecosystem in chronic functional constipation
Zoppi, G., Cinquetti, M., Luciano, A., Benini, A., Muner, A., & Minelli, E. B. (1998) · Acta Paediatrica · doi:10.1111/j.1651-2227.1998.tb01547.x · Cited by 169 · see citing works
Lyra, A., Rinttilä, T., Nikkilä, J., Krogius-Kurikka, L., Kajander, K., Malinen, E., Mättö, J., Mäkelä, L., & Palva, A. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5936 · Cited by 160 · see citing works
Deiteren, A., Camilleri, M., Bharucha, A. E., Burton, D. D., McKinzie, S., Rao, A. S., & Zinsmeister, A. R. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01441.x · Cited by 111 · see citing works
Self-citationDurbán, A., Abellan, J. J., Jiménez‐Hernández, N., Salgado, P., Ponce, M., Ponce, J. D. C., Garrigues, V., Latorre, A., & Moyá, A. (2012) · Environmental Microbiology Reports · doi:10.1111/j.1758-2229.2012.00327.x · Cited by 110 · see citing works
Characteristics of mucosally projecting myenteric neurones in the guinea‐pig proximal colon
Neunlist, M., Dobreva, G., & Schemann, M. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0533t.x · Cited by 105 · see citing works
Accelerated Regional Bowel Transit and Overweight Shown in Idiopathic Bile Acid Malabsorption
Sadik, R., Abrahamsson, H., Ung, K., & Stotzer, P. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04139.x · Cited by 103 · see citing works
IM-TORNADO: A Tool for Comparison of 16S Reads from Paired-End Libraries
Jeraldo, P., Kalari, K. R., Chen, X., Bhavsar, J., Mangalam, A. K., White, B. A., Nelson, H., Kocher, J.-P. A., & Chia, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114804 · Cited by 99 · see citing works
Self-citationEffect of short-chain fatty acids on contractile activity and fluid flow in rat colon in vitro
Squires, P. E., Rumsey, R. D. E., Edwards, C. A., & Read, N. W. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.262.5.g813 · Cited by 78 · see citing works
High body mass alters colonic sensory-motor function and transit in humans
Delgado-Aros, S., Camilleri, M., Garcia, M. A., Burton, D. D., & Busciglio, I. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90286.2008 · Cited by 73 · see citing works
Kang, D.-W., DiBaise, J. K., Ilhan, Z. E., Crowell, M. D., Rideout, J. R., Caporaso, J. G., Rittmann, B. E., & Krajmalnik-Brown, R. (2015) · Anaerobe · doi:10.1016/j.anaerobe.2015.01.005 · Cited by 55 · see citing works
On the suitability of short reads of 16S rRNA for phylogeny‐based analyses in environmental surveys
Jeraldo, P., Chia, N., & Goldenfeld, N. D. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02577.x · Cited by 54 · see citing works
Self-citationOptimal sampling of the intestinal microbiota for research
Sartor, R. B. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.46 · Cited by 48 · see citing works
Küley, E., Özoğul, F., Özoğul, Y., & Akyol, İ. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.05.113 · Cited by 33 · see citing works
Stefano, M. D., Mengoli, C., Bergonzi, M., Klersy, C., Pagani, E., Miceli, E., & Corazza, G. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2015.47 · Cited by 30 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Longstreth GF, Thompson WG, Chey WD, et al. Func- tional bowel disorders. Gastroenterology 2006;130: 1480-1491.
Cited by
Sorted by citations
Roseburia Spp.: A Marker of Health?
Tamanai‐Shacoori, Z., Smida, I., Bousarghin, L., Loréal, O., Meuric, V., Fong, S. B., Bonnaure‐Mallet, M., & Jolivet‐Gougeon, A. (2017) · Future Microbiology · doi:10.2217/fmb-2016-0130 · Cited by 751 · see citing works
Mechanisms, evaluation, and management of chronic constipation
Bharucha, A. E., & Lacy, B. E. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.034 · Cited by 655 · see citing works
Self-citationGlobal burden of irritable bowel syndrome: trends, predictions and risk factors
Black, C. J., & Ford, A. C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0286-8 · Cited by 643 · see citing works
Sex differences in gut microbiota
Kim, Y. S., Unno, T., Kim, B.-Y., & Park, M.-S. (2020) · The World Journal of Men s Health · doi:10.5534/wjmh.190009 · Cited by 610 · see citing works
Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species
Nie, K., Ma, K., Luo, W., Shen, Z., Yang, Z., Xiao, M., Tong, T., Yang, Y., & Wang, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.757718 · Cited by 514 · see citing works
Oscillospira - a candidate for the next-generation probiotics
Yang, J., Li, Y., Wen, Z., Liu, W., Meng, L., & Huang, H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1987783 · Cited by 484 · see citing works
Dimidi, E., Christodoulides, S., Scott, S. M., & Whelan, K. (2017) · Advances in Nutrition · doi:10.3945/an.116.014407 · Cited by 468 · see citing works
Tang, R., Wei, Y., Li, Y., Chen, W., Chen, H., Wang, Q., Yang, F., Miao, Q., Xiao, X., Zhang, H., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313332 · Cited by 434 · see citing works
<i>Oscillospira</i> and related bacteria – From metagenomic species to metabolic features
Gophna, U., Konikoff, T., & Nielsen, H. B. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13658 · Cited by 409 · see citing works
Prebiotics and Probiotics in Digestive Health
Quigley, E. M. M. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.09.028 · Cited by 387 · see citing works
<scp>Meta‐Analysis</scp> of Gut Dysbiosis in Parkinson's Disease
Nishiwaki, H., Ito, M., Ishida, T., Hamaguchi, T., Maeda, T., Kashihara, K., Tsuboi, Y., Ueyama, J., Shimamura, T., Mori, H., et al. (2020) · Movement Disorders · doi:10.1002/mds.28119 · Cited by 370 · see citing works
Gut Microbiota and Chronic Constipation: A Review and Update
Ohkusa, T., Koido, S., Nishikawa, Y., & Sato, N. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00019 · Cited by 357 · see citing works
Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications
Zhao, L.-Y., Mei, J.-X., Yu, G., Lei, L., Zhang, W.-H., Liu, K., Chen, X.-L., Kołat, D., Yang, K., & Hu, J.-K. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01406-7 · Cited by 359 · see citing works
Self-citationAdvancing human gut microbiota research by considering gut transit time
Procházková, N., Falony, G., Dragsted, L. O., Licht, T. R., Raes, J., & Roager, H. M. (2022) · Gut · doi:10.1136/gutjnl-2022-328166 · Cited by 322 · see citing works
Gut microbiota diversity across ethnicities in the United States
Brooks, A. W., Priya, S., Blekhman, R., & Bordenstein, S. R. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2006842 · Cited by 304 · see citing works
Constipation and risk of death and cardiovascular events
Sumida, K., Molnar, M. Z., Potukuchi, P. K., Thomas, F., Lü, J., Yamagata, K., Kalantar‐Zadeh, K., & Kovesdy, C. P. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.021 · Cited by 289 · see citing works
Cao, H., Liu, X., An, Y., Zhou, G., Liu, Y., Xu, M., Dong, W., Wang, S., Yan, F., Jiang, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10835-8 · Cited by 253 · see citing works
Irritable bowel syndrome, the microbiota and the gut-brain axis
Raskov, H., Burcharth, J., Pommergaard, H.-C., & Rosenberg, J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1218585 · Cited by 243 · see citing works
Ge, X., Zhao, W., Ding, C., Tian, H., Xu, L., Wang, H., Ni, L., Jiang, J., Gong, J., Zhu, W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00612-y · Cited by 232 · see citing works
Bharucha, A. E., & Wald, A. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.01.031 · Cited by 238 · see citing works
Self-citationBlack, C. J., & Ford, A. C. (2018) · The Medical Journal of Australia · doi:10.5694/mja18.00241 · Cited by 231 · see citing works
The effect of psyllium husk on intestinal microbiota in constipated patients and healthy controls
Jalanka, J., Major, G., Murray, K., Singh, G., Nowak, A., Kurtz, C., Silos-Santiago, I., Johnston, J. M., de Vos, W. M., & Spiller, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020433 · Cited by 219 · see citing works
Race-dependent association of sulfidogenic bacteria with colorectal cancer
Yazici, C., Wolf, P. G., Kim, H., Cross, T.-W. L., Vermillion, K., Carroll, T., Augustus, G. J., Mutlu, E., Tussing-Humphreys, L., Braunschweig, C., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313321 · Cited by 215 · see citing works
Self-citationBlue poo: impact of gut transit time on the gut microbiome using a novel marker
Asnicar, F., Leeming, E. R., Dimidi, E., Mazidi, M., Franks, P. W., Khatib, H. A., Valdes, A. M., Davies, R., Bakker, E., Francis, L., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323877 · Cited by 208 · see citing works
Intestinal microbiota and chronic constipation
Zhao, Y., & Yu, Y. (2016) · SpringerPlus · doi:10.1186/s40064-016-2821-1 · Cited by 212 · see citing works
Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 217 · see citing works
Fang, Z., Li, L., Zhang, H., Zhao, J., Lu, W., & Chen, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720393 · Cited by 200 · see citing works
Role of gut microbiota in functional constipation
Zhang, S., Wang, R., Li, D., Zhao, L., & Zhu, L. (2021) · Gastroenterology Report · doi:10.1093/gastro/goab035 · Cited by 175 · see citing works
Mancabelli, L., Milani, C., Lugli, G. A., Turroni, F., Mangifesta, M., Viappiani, A., Ticinesi, A., Nouvenne, A., Meschi, T., van Sinderen, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10663-w · Cited by 182 · see citing works
The gut Microbiome in adult and pediatric functional gastrointestinal disorders
Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163 · see citing works
Gut physiology and environment explain variations in human gut microbiome composition and metabolism
Procházková, N., Laursen, M. F., Barbera, G. L., Tsekitsidi, E., Jørgensen, M. S., Rasmussen, M. A., Raes, J., Licht, T. R., Dragsted, L. O., & Roager, H. M. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01856-x · Cited by 174 · see citing works
The effect of gut microbiome on tolerance to morphine mediated antinociception in mice
Kang, M., Mischel, R. A., Bhave, S., Komla, E., Cho, A., Huang, C., Dewey, W. L., & Akbarali, H. I. (2017) · Scientific Reports · doi:10.1038/srep42658 · Cited by 154 · see citing works
Pan, R., Wang, L., Xu, X., Chen, Y., Wang, H., Wang, G., Zhao, J., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14183704 · Cited by 149 · see citing works
Sumida, K., Yamagata, K., & Kovesdy, C. P. (2019) · Kidney International Reports · doi:10.1016/j.ekir.2019.11.002 · Cited by 148 · see citing works
A potential role for the gut microbiome in substance use disorders
Meckel, K. R., & Kiraly, D. D. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05232-0 · Cited by 141 · see citing works
Body Mass Index and Sex Affect Diverse Microbial Niches within the Gut
Borgo, F., Garbossa, S., Riva, A., Severgnini, M., Luigiano, C., Benetti, A., Pontiroli, A. E., Morace, G., & Borghi, E. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00213 · Cited by 143 · see citing works
Understanding the physiology of human defaecation and disorders of continence and evacuation
Heitmann, P. T., Vollebregt, P. F., Knowles, C. H., Lunniss, P. J., Dinning, P. G., & Scott, S. M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00487-5 · Cited by 145 · see citing works
Characterization of Microbiota in Children with Chronic Functional Constipation
de Meij, T. G. J., de Groot, E. F. J., Eck, A., Budding, A. E., Kneepkens, C. M. F., Benninga, M. A., Bodegraven, A. A. V., & Savelkoul, P. H. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164731 · Cited by 141 · see citing works
Tian, H., Ge, X., Nie, Y., Yang, L., Ding, C., McFarland, L. V., Zhang, X., Chen, Q., Gong, J., & Li, N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171308 · Cited by 131 · see citing works
The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)
Boddy, S. L., Giovannelli, I., Sassani, M., Cooper-Knock, J., Snyder, M. P., Segal, E., Elinav, E., Barker, L. A., Shaw, P. J., & McDermott, C. J. (2021) · BMC Medicine · doi:10.1186/s12916-020-01885-3 · Cited by 127 · see citing works
Liu, Y., Liu, B., Li, D., Hu, Y., Zhao, L., Zhang, M., Ge, S., Pang, J., Li, Y., Wang, R., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202001157 · Cited by 125 · see citing works
Zhang, X., Yang, H., Zheng, J., Jiang, N., Sun, G., Bao, X., Lin, A., & Liu, H. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117218 · Cited by 120 · see citing works
Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity
Montgomery, T. L., Künstner, A., Kennedy, J. J., Fang, Q., Asarian, L., Culp‐Hill, R., D’Alessandro, A., Teuscher, C., Busch, H. S., & Krementsov, D. N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002817117 · Cited by 117 · see citing works
Prebiotics and Probiotics for Gastrointestinal Disorders
Rau, S., Gregg, A., Yaceczko, S. D., & Limketkai, B. N. (2024) · Nutrients · doi:10.3390/nu16060778 · Cited by 121 · see citing works
Hu, T., Wen, P., Fu, H.-Z., Guangyue, L., Liao, S., & Zou, Y. (2019) · Food & Function · doi:10.1039/c9fo00132h · Cited by 106 · see citing works
Carco, C., Young, W., Gearry, R. B., Talley, N. J., McNabb, W. C., & Roy, N. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00468 · Cited by 97 · see citing works
Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation
Wang, J.-K., & Yao, S.-K. (2021) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2021/5560310 · Cited by 98 · see citing works
Wang, J., Liang, Q., Zhao, Q., Tang, Q., Ahmed, A. F., Zhang, Y., & Kang, W. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112305 · Cited by 96 · see citing works
Fruits and their impact on the gut microbiota, gut motility and constipation
Katsirma, Z., Dimidi, E., Rodriguez‐Mateos, A., & Whelan, K. (2021) · Food & Function · doi:10.1039/d1fo01125a · Cited by 95 · see citing works
Dimidi, E., Scott, S. M., & Whelan, K. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000934 · Cited by 89 · see citing works
Next‐Generation Probiotics: Microflora Intervention to Human Diseases
Zhang, H., Duan, Y., Cai, F., Cao, D., Wang, L., Qiao, Z., Hong, Q., Li, N., Zheng, Y., Su, M., et al. (2022) · BioMed Research International · doi:10.1155/2022/5633403 · Cited by 91 · see citing works
Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice
Jing, Y., Yang, D., Bai, F., Zhang, C., Qin, C., Li, D., Wang, L., Yang, M., Chen, Z., & Li, J. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6012 · Cited by 87 · see citing works
Scott, S. M., Simrén, M., Farmer, A. D., Dinning, P. G., Carrington, E. V., Benninga, M. A., Burgell, R., Dimidi, E., Fikree, A., Ford, A. C., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14050 · Cited by 93 · see citing works
The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy
Engen, P. A., Dodiya, H. B., Naqib, A. D., Forsyth, C. B., Green, S. J., Voigt, R. M., Kordower, J. H., Mutlu, E., Shannon, K. M., & Keshavarzian, A. (2017) · Journal of Parkinson s Disease · doi:10.3233/jpd-160991 · Cited by 84 · see citing works
Altomare, A., Putignani, L., CHIERICO, F. D., Cocca, S., Angeletti, S., Ciccozzi, M., Tripiciano, C., Piccola, B. D., Cicala, M., & Guarino, M. P. L. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.11.021 · Cited by 86 · see citing works
Zhang, Y., Yu, X., Yu, E., Wang, N., Cai, Q.-C., Shuai, Q., Yan, F., Jiang, L., Wang, H., Liu, J., et al. (2018) · BMC Microbiology · doi:10.1186/s12866-018-1232-6 · Cited by 81 · see citing works
Wang, L., Wang, L., Tian, P., Wang, B., Cui, S., Zhao, J., Zhang, H., Qian, L., Wang, Q., Chen, W., et al. (2022) · Food & Function · doi:10.1039/d1fo03896f · Cited by 81 · see citing works
The gut–kidney–heart axis in chronic kidney disease
Sumida, K., & Kovesdy, C. P. (2019) · Physiology International · doi:10.1556/2060.106.2019.19 · Cited by 79 · see citing works
Johnston, D. G. W., Williams, M. A., Thaiss, C. A., Cabrera‐Rubio, R., Raverdeau, M., McEntee, C. P., Cotter, P. D., Elinav, E., O'Neill, L. A. J., & Corr, S. C. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy038 · Cited by 77 · see citing works
Yang, Z., Ye, S., Xu, Z., Su, H., Tian, X., Han, B. R., Shen, B., Liao, Q., Xie, Z., & Hong, Y. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110569 · Cited by 74 · see citing works
Gut microbiota: a new avenue to reveal pathological mechanisms of constipation
Yang, L., Wang, Y., Zhang, Y. L., Li, W., Jiang, S., Qian, D., & Duan, J. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12197-2 · Cited by 74 · see citing works
Constipation and Fecal Incontinence in the Elderly
Deb, B., Prichard, D. O., & Bharucha, A. E. (2020) · Current Gastroenterology Reports · doi:10.1007/s11894-020-00791-1 · Cited by 71 · see citing works
Self-citationHori, T., Matsuda, K., & Oishi, K. (2020) · Microorganisms · doi:10.3390/microorganisms8091401 · Cited by 75 · see citing works
Xu, Y., Shao, M., Fang, X., Tang, W., Zhou, C., Hu, X., Zhang, X., & Su, K. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.09.014 · Cited by 70 · see citing works
Chu, J. R., Kang, S.-Y., Kim, S.-E., Lee, S.-J., Lee, Y., & Sung, M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i40.6129 · Cited by 70 · see citing works
Analysis of gut microbiome and metabolite characteristics in patients with slow transit constipation
Tian, H., Chen, Q., Yang, B., Qin, H., & Li, N. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06500-2 · Cited by 68 · see citing works
Antipsychotic-Induced Constipation: A Review of the Pathogenesis, Clinical Diagnosis, and Treatment
Xu, Y., Amdanee, N., & Zhang, X.-R. (2021) · CNS Drugs · doi:10.1007/s40263-021-00859-0 · Cited by 67 · see citing works
Effects of Prebiotics and Synbiotics on Functional Constipation
Yu, T., Zheng, Y., Tan, J., Xiong, W.-J., Wang, Y., & Lin, L. (2016) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2016.09.014 · Cited by 69 · see citing works
Martoni, C. J., Evans, M., Chow, C. T., Chan, L. S., & Leyer, G. (2019) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12797 · Cited by 67 · see citing works
Ding, C., Fan, W., Gu, L., Tian, H., Ge, X., Gong, J., Nie, Y., & Li, N. (2018) · Gastroenterology report · doi:10.1093/gastro/gox036 · Cited by 65 · see citing works
Flux, M. C., & Lowry, C. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104578 · Cited by 68 · see citing works
Intestinal Microbiota Predicts Lung Cancer Patients at Risk of Immune-Related Diarrhea
Liu, T., Xiong, Q., Li, L., & Hu, Y. (2019) · Immunotherapy · doi:10.2217/imt-2018-0144 · Cited by 64 · see citing works
Guo, M., Yao, J., Yang, F. H., Liu, W., Bai, H., Ma, J., Ma, X., Zhang, J., Fang, Y., Miao, Y., et al. (2020) · Future Microbiology · doi:10.2217/fmb-2019-0283 · Cited by 63 · see citing works
Zhang, X., Tian, H., Gu, L., Nie, Y., Ding, C., Ge, X., Yang, B. K., Gong, J., & Li, N. (2018) · Science China Life Sciences · doi:10.1007/s11427-017-9229-1 · Cited by 64 · see citing works
Characterization of gut contractility and microbiota in patients with severe chronic constipation
Рашидовна, Я. Д., Ulfatovich, S. M., Андреевич, С. К., Arzamastseva, A. A., Shaidullov, I. F., Markelova, M., Grigoryeva, T. V., Karpukhin, O. Y., & Ситдикова, Г. Ф. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235985 · Cited by 62 · see citing works
Adhesive Bifidobacterium Induced Changes in Cecal Microbiome Alleviated Constipation in Mice
Wang, L., Chen, C., Cui, S., Lee, Y. K., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01721 · Cited by 62 · see citing works
Zhang, X., Zheng, J., Jiang, N., Sun, G., Bao, X., Kong, M., Cheng, X., Lin, A., & Liu, H. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105676 · Cited by 60 · see citing works
Dietary Influences on Gut Microbiota with a Focus on Metabolic Syndrome
Thomas, M. S., Blesso, C. N., Calle, M. C., Chun, O. K., Puglisi, M. J., & Fernández, M. L. (2022) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2021.0131 · Cited by 63 · see citing works
Gu, Y., Qin, X., Zhou, G., Wang, C., Mu, C., Liu, X., Zhong, W., Xu, X. J., Wang, B., Jiang, K., et al. (2022) · Food & Function · doi:10.1039/d2fo01900k · Cited by 61 · see citing works
Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb
Yang, L., Wan, Y., Li, W., Liu, C., Li, H., Dong, Z., Zhu, K., Jiang, S., Shang, E., Qian, D., et al. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-11813-5 · Cited by 59 · see citing works
Hollister, E. B., Cain, K. C., Shulman, R. J., Jarrett, M. E., Burr, R. L., Ko, C. W., Zia, J. K., Han, C. J., & Heitkemper, M. M. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001107 · Cited by 59 · see citing works
Ma, T., Yang, N., Xie, Y., Li, Y., Xiao, Q., Li, Q., Jin, H., Zheng, L., Sun, Z., Zuo, K., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106755 · Cited by 58 · see citing works
Gut Microbiota Composition Changes in Constipated Women of Reproductive Age
Li, H., Chen, J., Ren, X., Yang, C., Liu, S., Bai, X., Shan, S., & Dong, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.557515 · Cited by 58 · see citing works
Self-citationGhaffari, P., Shoaie, S., & Nielsen, L. K. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03365-z · Cited by 58 · see citing works
Ghoshal, U. C., Srivastava, D., & Misra, A. (2018) · Indian Journal of Gastroenterology · doi:10.1007/s12664-018-0901-6 · Cited by 56 · see citing works
Chai, M., Wang, L., Li, X., Zhao, J., Zhang, H., Wang, G., & Chen, W. (2021) · Food & Function · doi:10.1039/d1fo00559f · Cited by 55 · see citing works
Efficacy of Synbiotics in Patients with Slow Transit Constipation: A Prospective Randomized Trial
Ding, C., Ge, X., Zhang, X., Tian, H., Wang, H., Gu, L., Gong, J., Zhu, W., & Li, N. (2016) · Nutrients · doi:10.3390/nu8100605 · Cited by 55 · see citing works
Microbiome modulation as a novel therapeutic approach in chronic kidney disease
Sumida, K., Lau, W. L., Kovesdy, C. P., Kalantar‐Zadeh, K., & Kalantar‐Zadeh, K. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000661 · Cited by 57 · see citing works
Chronic functional constipation is strongly linked to vitamin D deficiency
Panarese, A., Pesce, F., Porcelli, P., Riezzo, G., Iacovazzi, P., Leone, C. M., Carne, M. D., Rinaldi, C., & Shahini, E. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i14.1729 · Cited by 49 · see citing works
Mars, R. A. T., Frith, M., & Kashyap, P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.10.058 · Cited by 54 · see citing works
Revisiting the intestinal microbiome and its role in Diarrhea and constipation
Iancu, M. A., Profir, M., Roşu, O. A., Ionescu, R. F., Cretoiu, S. M., & Gaspar, B. S. (2023) · Microorganisms · doi:10.3390/microorganisms11092177 · Cited by 53 · see citing works
“Parthasarathy et al. also demonstrated the correlation between a more rapid transit time and increased concentrations of Actinobacteria , Bacteroides , and Lactococcus [182].”
Yang, C., Hu, T., Xue, X., Su, X., Zhang, X., Fan, Y., Shen, X., & Dong, X. (2023) · BMC Microbiology · doi:10.1186/s12866-023-03123-1 · Cited by 53 · see citing works
Pereira, L. C., Correia, A. F., da Silva, Z. D. L., Resende, C. N., Brandão, F., Almeida, R. M., & Nóbrega, Y. K. D. M. (2021) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-021-04199-1 · Cited by 55 · see citing works
Fan, Y., Xu, C., Xie, L., Wang, Y., Zhu, S., An, J., Li, Y., Tian, Z., Yan, Y., Yu, S., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.956528 · Cited by 52 · see citing works
Functional constipation and the effect of prebiotics on the gut microbiota: a review
Erhardt, R., Harnett, J., Steels, E., & Steadman, K. J. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522003853 · Cited by 51 · see citing works
Constipation and the Microbiome: Lumen Versus Mucosa!
Quigley, E. M. M., & Spiller, R. E. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.12.023 · Cited by 51 · see citing works
Ge, X., Tian, H., Ding, C., Gu, L., Yao, W., Gong, J., Zhu, W., Li, N., & Li, J. (2016) · Archives of Medical Research · doi:10.1016/j.arcmed.2016.06.005 · Cited by 52 · see citing works
Tian, H., Cui, J., Ye, C., Zhao, J., Yang, B. K., Xu, Y., Ji, S., Wang, L., Lv, X., Ma, C., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2236362 · Cited by 51 · see citing works
The Constipation-Relieving Property of d-Tagatose by Modulating the Composition of Gut Microbiota
Liang, Y., Wen, P., Wang, Y., Ouyang, D., Da, W., Chen, Y.-Z., Song, Y., Deng, J., Sun, Y., & Wang, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225721 · Cited by 50 · see citing works
Lu, D., Pi, Y., Ye, H., Wu, Y., Bai, Y., Lian, S., Han, D., Ni, D., Zou, X., Zhao, J., et al. (2022) · Nutrients · doi:10.3390/nu14122511 · Cited by 49 · see citing works
- Authors
- Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E.
- Affiliations
- Mayo Clinic (US)
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Bharucha, Adil E.
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 150
- Issue
- 2
- Pages
- 367-379.e1
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC4727996
- OpenAlex
- W1915385926
- Cited by
- 396
- References
- 66
- Citations by year
- 2026: 22 · 2025: 37 · 2024: 51 · 2023: 52 · 2022: 60 · 2021: 41 · 2020: 44 · 2019: 37 · 2018: 20 · 2017: 21 · 2016: 9 · 2015: 1
- FWCI
- 17.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health (UL1TR000135, TR000135)
- National Cancer Institute (R01CA179243)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK78924, R01DK078924, P30DK084567)
- National Center for Advancing Translational Sciences (TR000135)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- chronic constipation, fecal microbiota, colonic transit, methane production, breath test, Bacteroidetes, Firmicutes, Faecalibacterium, Roseburia, Lactococcus, women, 16S rRNA gene sequencing
- MeSH terms
- Gastrointestinal Microbiome, Adult, Algorithms, Bacteria, Breath Tests, Chronic Disease, Colon, Constipation, Feces, Female, Gastrointestinal Transit, Humans, Intestinal Mucosa, Methane, Middle Aged, Phylogeny, Multivariate Analysis, Case-Control Studies, Nonlinear Dynamics, Ribotyping
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
