A triphasic biomimetic BMSC-loaded scaffold for osteochondral integrated regeneration in rabbits and pigs
Abstract
A triphasic scaffold composed of BMSCs-loaded PLGA scaffold, chondroitin sulfate and BG-loaded PLCL membrane and 3D-printed ceramic scaffold was prepared to mimic the osteochondral structure and achieved good regeneration in rabbits and pigs.
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Through various fabrication techniques and by incorporating drugs, cells, or bioactive factors, PLCL has been successfully applied across diverse fields, including skin wound healing, neural repair, osteochondral regeneration, vascular and urethral graft fabrication, biological meshes, drug delivery, and stem cell culture.
“Furthermore, through various fabrication techniques and by incorporating drugs, cells, or bioactive factors, PLCL has been successfully applied across diverse fields, including skin wound healing, neural repair, osteochondral regeneration, vascular and urethral graft fabrication, biological meshes, drug delivery, and stem cell culture [1, 18, 196, 225, 229–231].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [196]
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Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works
“10 Three-phase bionic BMSCs scaffold loaded with TGF-β promoting the regeneration of hyalene cartilage [196] that mesenchymal stem cells in the body can be recruited to the injured area under the action of local in fl ammatory factors and differentiate into osteoblasts, which further secrete…”
Influential
- Authors
- Wang, Z., Cao, W., Wu, F., Ke, X., Wu, X., Zhou, T., Yang, J., Yang, G., Zhong, C., Gou, Z., & Gao, C.
- Affiliations
- Zhejiang University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Corresponding author
- Gou, Zhongru
- Gao, Changyou
- ORCID
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2023
- Volume
- 11
- Issue
- 8
- Pages
- 2924-2934
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W4322095780
- Cited by
- 26
- References
- 44
- Citations by year
- 2026: 13 · 2025: 4 · 2024: 8 · 2023: 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2017YFE0117700)
- National Natural Science Foundation of China (81902225)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- osteochondral regeneration, mesenchymal stem cells, biomimetic scaffolds, cartilage regeneration, fibrous membranes, bone overgrowth, tissue integration, cartilage repair
- MeSH terms
- Animals, Bone and Bones, Cartilage, Rabbits, Swine, Swine, Miniature, Biomimetics, Tissue Scaffolds
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