Cited by 26Bone Tissue Engineering MaterialsOsteoarthritis Treatment and MechanismsTissue Engineering and Regenerative Medicine

A triphasic biomimetic BMSC-loaded scaffold for osteochondral integrated regeneration in rabbits and pigs

Wang, Zhaoyi, Cao, Wangbei, Wu, Fanghui, Ke, Xiurong, Wu, Xinyu, Zhou, Tong, Yang, Jun, Yang, Guojing +3 more·2023·Biomaterials Science

Abstract

A triphasic scaffold composed of BMSCs-loaded PLGA scaffold, chondroitin sulfate and BG-loaded PLCL membrane and 3D-printed ceramic scaffold was prepared to mimic the osteochondral structure and achieved good regeneration in rabbits and pigs.

Integrity signals

Registry

Crossref · 10.1039/d2bm02148j

Cites

44 of 44 references verified0 citation errors · 0 not checkable

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  • Through various fabrication techniques and by incorporating drugs, cells, or bioactive factors, PLCL has been successfully applied across diverse fields, including skin wound healing, neural repair, osteochondral regeneration, vascular and urethral graft fabrication, biological meshes, drug delivery, and stem cell culture.

    “Furthermore, through various fabrication techniques and by incorporating drugs, cells, or bioactive factors, PLCL has been successfully applied across diverse fields, including skin wound healing, neural repair, osteochondral regeneration, vascular and urethral graft fabrication, biological meshes, drug delivery, and stem cell culture [1, 18, 196, 225, 229–231].”

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Authors
Wang, Z., Cao, W., Wu, F., Ke, X., Wu, X., Zhou, T., Yang, J., Yang, G., Zhong, C., Gou, Z., & Gao, C.
Affiliations
  • Zhejiang University (CN)
  • Wenzhou Medical University (CN)
  • First Affiliated Hospital Zhejiang University (CN)
  • Second Affiliated Hospital of Zhejiang University (CN)
Corresponding author
  • Gou, Zhongru
  • Gao, Changyou
Venue
Biomaterials Science
Published
2023
Volume
11
Issue
8
Pages
2924-2934
ISSN
  • 2047-4830 (ISSN-L)
  • 2047-4849
OpenAlex
W4322095780
Cited by
26
References
44
Citations by year
2026: 13 · 2025: 4 · 2024: 8 · 2023: 1
FWCI
2.04
Type
journal article
Language
en
Open access
closed
Locations
  • Biomaterials Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Key Research and Development Program of China (2017YFE0117700)
  • National Natural Science Foundation of China (81902225)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
osteochondral regeneration, mesenchymal stem cells, biomimetic scaffolds, cartilage regeneration, fibrous membranes, bone overgrowth, tissue integration, cartilage repair
MeSH terms
Animals, Bone and Bones, Cartilage, Rabbits, Swine, Swine, Miniature, Biomimetics, Tissue Scaffolds

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