Influence of pore architectures of silk fibroin/collagen composite scaffolds on the regeneration of osteochondral defects in vivo
Abstract
The aligned scaffolds facilitate migration of endogenous reparative cells, leading to better regeneration of osteochondral defects.
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Silk fibroin sponge-like porous scaffolds are prepared through methods such as freeze-drying, salt leaching, and chemical crosslinking.
“Silk fibroin sponge-like porous scaffolds are prepared through methods such as freeze-drying, salt leaching, and chemical crosslinking [38,62,63].”
From Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review (2025) · cites this paper as [38]
Cites
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138 · see citing works
Goldring, S. R., & Goldring, M. B. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.148 · Cited by 896 · see citing works
Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials
Sheikh, Z., Brooks, P., Barzilay, O., Fine, N., & Glogauer, M. (2015) · Materials · doi:10.3390/ma8095269 · Cited by 701 · see citing works
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Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds
Xu, Y., Zhang, F., Zhai, W., Cheng, S., Li, J., & Wang, Y. (2022) · Polymers · doi:10.3390/polym14030566 · Cited by 349 · see citing works
Zhou, W., Rahman, M. S. U., Sun, C., Li, S., Zhang, N., Chen, H., Han, C. C., Xu, S., & Liu, Y. (2024) · Advanced Materials · doi:10.1002/adma.202307805 · Cited by 65 · see citing works
Liu, X., Zhang, J., Cheng, X., Liu, P., Feng, Q., Wang, S., Li, Y., Gu, H., Zhong, L., Chen, M., et al. (2023) · Regenerative Biomaterials · doi:10.1093/rb/rbac085 · Cited by 58 · see citing works
Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review
Zhu, S., Zhang, Q., Xu, X., Liu, Z., Cheng, G., Long, D., Cheng, L., & Dai, F. (2025) · Polymers · doi:10.3390/polym17060772 · Cited by 36 · see citing works
“Silk fibroin sponge-like porous scaffolds are prepared through methods such as freeze-drying, salt leaching, and chemical crosslinking [38,62,63].”
Wang, Z., Cao, W., Wu, F., Ke, X., Wu, X., Zhou, T., Yang, J., Yang, G., Zhong, C., Gou, Z., et al. (2023) · Biomaterials Science · doi:10.1039/d2bm02148j · Cited by 26 · see citing works
Self-citationSow, W. T., Wang, Y., Chen, L., Lai, Q., Chen, Q., Chen, L., Zhang, C., & Li, H. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202201886 · Cited by 18 · see citing works
- Authors
- Feng, X., Xu, P., Shen, T., Zhang, Y., Ye, J., & Gao, C.
- Affiliations
- Zhejiang University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Corresponding author
- Gao, Changyou
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 8
- Issue
- 3
- Pages
- 391-405
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2973313434
- Cited by
- 80
- References
- 3
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 12 · 2023: 10 · 2022: 16 · 2021: 14 · 2020: 10
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Basic Research Program of China (2017YFE0117700, 2018YFC1105401)
- National Natural Science Foundation of China (21434006, 51873188)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- silk fibroin, collagen, composite scaffolds, pore structure, osteochondral defects, cartilage regeneration, thermally induced phase separation, aligned pores, cell migration, mechanical anisotropy, hyaline cartilage, fibrocartilage, tissue engineering
- MeSH terms
- Animals, Cartilage, Articular, Cattle, Cells, Cultured, Collagen, Fibroins, Male, Materials Testing, Rabbits, Regeneration, Bombyx, Tissue Scaffolds, Mesenchymal Stem Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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