ROS-scavenging glyco-nanoplatform for synergistic antibacterial and wound-healing therapy of bacterial keratitis
Abstract
)-induced bacterial keratitis on a rat model showed that the drug-loaded nanoplatform could effectively cure bacterial keratitis within 5 days. Overall, this work provides an effective antibacterial and wound-healing strategy based on a ROS-scavenging polymeric nanoplatform for treating bacterial keratitis.
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PBA-DHPM moieties in glycopolymeric micelles serve as active targeting ligands facilitating epithelial penetration and bacterial anchorage, and function as ROS-scavenging agents to mitigate inflammation.
“The phenylboronic acid-(3,4-dihydropyrimidin-2(1H)-one) (PBA-DHPM) moieties not only serve as active targeting ligands that facilitating epithelial penetration and bacterial anchorage, but also function effectively as ROS-scavenging agents to mitigate inflammation.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [134]
The antioxidant glycopolymeric micelle platform is endowed with multiple functionalities encompassing bacterial eradication, ROS scavenging and promotion of wound healing.
“This antioxidant glycopolymeric micelle platform is endowed with multiple functionalities encompassing bacterial eradication, ROS scavenging and promotion of wound healing [134].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [134]
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- Authors
- Zhang, Y., Li, G., Zhang, X., & Lin, L.
- Affiliations
- Tianjin University (CN)
- Nankai University (CN)
- Corresponding author
- Lin, Ling
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 10
- Issue
- 24
- Pages
- 4575-4587
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W4282924168
- Cited by
- 29
- References
- 46
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 5 · 2023: 11 · 2022: 2
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21774062, 21975133)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- bacterial keratitis, reactive oxygen species scavenging, antibiotic therapy, wound healing, drug delivery, rat model
- MeSH terms
- Animals, Anti-Bacterial Agents, Inflammation, Keratitis, Micelles, Staphylococcus aureus, Wound Healing, Reactive Oxygen Species, Rats
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