Promoting angiogenesis in oxidative diabetic wound microenvironment using a nanozyme-reinforced self-protecting hydrogel
Open accessAbstract
Impaired diabetic wound healing represents a devastating and rapidly growing clinical problem associated with high morbidity, mortality, and recurrence rates. Engineering therapeutic angiogenesis in the wounded tissue is critical for successful wound healing. However, stimulating functional angiogenesis of the diabetic wound remains a great challenge, due to the oxidative damage and denaturation of bio-macromolecule-based angiogenic agents in the oxidative diabetic wound microenvironment. Here, we present a unique "seed-and-soil" strategy that circumvents the limitation by simultaneously reshaping the oxidative wound microenvironment into a proregenerative one (the "soil") and providing proangiogenic miRNA cues (the "seed") using an miRNA-impregnated, redox-modulatory ceria nanozyme-reinforced self-protecting hydrogel (PCN-miR/Col). The PCN-miR/Col not only reshapes the hostile oxidative wound microenvironment, but also ensures the structural integrity of the encapsulated proangiogenic miRNA in the oxidative microenvironment. Diabetic wounds treated with the PCN-miR/Col demonstrate a remarkably accelerated wound closure and enhanced quality of the healed wound as featured by highly ordered alignment of collagen fiber, skin appendage morphogenesis, functional new blood vessel growth, and oxygen saturation.
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The local response to corneal bacterial infection involves an inflammatory process featured by infiltration of inflammatory cells, overproduction of ROS and accumulation of pro-inflammatory cytokines.
“The local response to corneal bacterial infection involves an inflammatory process that is featured by the infiltration of inflammatory cells (e.g., macrophages), overproduction of ROS and accumulation of pro-inflammatory cytokines [131].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [131]
The Introduction describes excessive ROS in diabetic wounds, and the Results and Discussion section on the wound microenvironment reports macrophage infiltration and inflammation in diabetic rat wounds (page numbers unavailable). These passages support the general link between oxidative stress and inflammatory-cell infiltration, but they do not address corneal bacterial infection or report accumulation of pro-inflammatory cytokines. (LLM, conf=0.88)
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Zhang, Y., Li, G., Zhang, X., & Lin, L. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00667g · Cited by 29 · see citing works
From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics
Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7 · see citing works
“The local response to corneal bacterial infection involves an inflammatory process that is featured by the infiltration of inflammatory cells (e.g., macrophages), overproduction of ROS and accumulation of pro-inflammatory cytokines [131].”
- Authors
- Wu, H., Li, F., Shao, W., Gao, J., & Ling, D.
- Affiliations
- Zhejiang University (CN)
- Corresponding author
- Gao, Jianqing
- Ling, Daishun
- Venue
- ACS Central Science
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-02-13
- Volume
- 5
- Issue
- 3
- Pages
- 477-485
- ISSN
- 2374-7943 (ISSN-L)
- 2374-7951
- PMC
- PMC6439452
- OpenAlex
- W2914078155
- Cited by
- 338
- References
- 43
- Citations by year
- 2026: 29 · 2025: 52 · 2024: 68 · 2023: 65 · 2022: 64 · 2021: 33 · 2020: 26 · 2019: 1
- FWCI
- 21.65
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- ACS Central Science (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2016YFA0203600)
- Ministry of Education of the People's Republic of China (520002*172210161)
- National Natural Science Foundation of China (31822019, 51503180, 5161101036, 81620108028)
- Thousand Talents Program for Distinguished Young Scholars (588020*G81501/048)
- Zhejiang Province
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- diabetic wound healing, therapeutic angiogenesis, nanozymes, cerium oxide, microRNA delivery, oxidative stress, wound microenvironment, collagen fiber alignment, oxygen saturation
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