Nano-based ocular drug delivery systems: an insight into the preclinical/clinical studies and their potential in the treatment of posterior ocular diseases

Pegaptanib for neovascular age-related macular degeneration

Gragoudas, E. S., Adamis, A. P., Cunningham, E. T., Feinsod, M., & Guyer, D. R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042760 · Cited by 2,337 · see citing works

Nanomedicine

Kim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0912273 · Cited by 1,153 · see citing works

Strategies for the intracellular delivery of nanoparticles

Chou, L. Y. T., Ming, K., & Chan, W. C. W. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00003e · Cited by 813 · see citing works

Multi-country real-life experience of anti-vascular endothelial growth factor therapy for wet age-related macular degeneration

Holz, F. G., Tadayoni, R., Beatty, S., Berger, A. R., Cereda, M. G., Cortez, R. T., Hoyng, C. B., Hykin, P. G., Staurenghi, G., Heldner, S., et al. (2014) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2014-305327 · Cited by 618 · see citing works

Nanopharmaceuticals (part 1): products on the market

Weissig, V., Pettinger, T. K., & Murdock, N. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s46900 · Cited by 591 · see citing works

A framework for designing delivery systems

Poon, W., Kingston, B. R., Ouyang, B., Ngo, W., & Chan, W. C. W. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0759-5 · Cited by 526 · see citing works

Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives

Mukherjee, A., Waters, A. K., Kalyan, P., Achrol, A. S., Kesari, S., & Yenugonda, V. M. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s198353 · Cited by 499 · see citing works

Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies

Mandal, A., Bisht, R., Rupenthal, I. D., & Mitra, A. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.012 · Cited by 481 · see citing works

Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations

Varela‐Fernández, R., Díaz-Tomé, V., Luaces-Rodríguez, A., Conde-Penedo, A., García‐Otero, X., Álvarez, A. L., Fernández‐Ferreiro, A., & Otero-Espinar, F. J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030269 · Cited by 363 · see citing works

Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb

Lallemand, F., Daull, P., Benita, S., Buggage, R. R., & Garrigue, J. (2012) · Journal of Drug Delivery · doi:10.1155/2012/604204 · Cited by 315 · see citing works

Pegaptanib Sodium for Neovascular Age-Related Macular Degeneration

D’Amico, D. J. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.02.027 · Cited by 260 · see citing works

Ocular Drug Delivery: Role of Degradable Polymeric Nanocarriers for Ophthalmic Application

Tsai, C.-H., Wang, P., Lin, I., Hu, H., Liu, G., & Tseng, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092830 · Cited by 241 · see citing works

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

Mandal, A., Pal, D., Agrahari, V., Trinh, H. M., Joseph, M. A., & Mitra, A. K. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.01.008 · Cited by 224 · see citing works

Efficacy and Safety of 0.1% Cyclosporine a Cationic Emulsion in the Treatment of Severe Dry Eye Disease: A Multicenter Randomized Trial

Leonardi, A., van Setten, G., Amrane, M., Ismail, D., Garrigue, J., Figueiredo, F. C., & Baudouin, C. (2016) · European Journal of Ophthalmology · doi:10.5301/ejo.5000779 · Cited by 199 · see citing works

Ocular Drug Delivery to the Retina: Current Innovations and Future Perspectives

Kim, H. M., & Woo, S. J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13010108 · Cited by 198 · see citing works

Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye – Part II - Ocular drug-loaded lipid nanoparticles

Sánchez‐López, E., Espina, M., Doktorovová, S., Souto, E. B., & García, M. L. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.10.013 · Cited by 186 · see citing works

Ocular Pharmacokinetics of a Topical Ophthalmic Nanomicellar Solution of Cyclosporine (Cequa®) for Dry Eye Disease

Mandal, A., Gote, V., Pal, D., Ogundele, A., & Mitra, A. K. (2019) · Pharmaceutical Research · doi:10.1007/s11095-018-2556-5 · Cited by 162 · see citing works

In Situ Gel of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles for Improved Topical Ocular Delivery: Tear Kinetics and Ocular Disposition Studies

Tatke, A., Dudhipala, N. R., Janga, K. Y., Balguri, S. P., Avula, B., Jablonski, M. M., & Majumdar, S. (2018) · Nanomaterials · doi:10.3390/nano9010033 · Cited by 160 · see citing works

Target strategies for drug delivery bypassing ocular barriers

Suri, R., Beg, S., & Kohli, K. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101389 · Cited by 134 · see citing works

Gold nanoparticles in ophthalmology

Masse, F., Ouellette, M., Lamoureux, G., & Boisselier, É. (2018) · Medicinal Research Reviews · doi:10.1002/med.21509 · Cited by 130 · see citing works

Cell penetrating peptides in ocular drug delivery: State of the art

Pescina, S., Ostacolo, C., Gomez-Monterrey, I. M., Sala, M., Bertamino, A., Sonvico, F., Padula, C., Santi, P., Bianchera, A., & Nicoli, S. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.06.023 · Cited by 118 · see citing works

Liposomes for effective drug delivery to the ocular posterior chamber

Lai, S., Wei, Y., Wu, Q., Zhou, K., Liu, T., Zhang, Y., Jiang, N., Xiao, W. F., Chen, J., Liu, Q., et al. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0498-7 · Cited by 117 · see citing works

A Phase 3, Randomized, Double-Masked Study of OTX-101 Ophthalmic Solution 0.09% in the Treatment of Dry Eye Disease

Goldberg, D. F., Malhotra, R. P., Schechter, B. A., Justice, A., Weiss, S. L., & Sheppard, J. D. (2019) · Ophthalmology · doi:10.1016/j.ophtha.2019.03.050 · Cited by 113 · see citing works

Atorvastatin-loaded solid lipid nanoparticles as eye drops: proposed treatment option for age-related macular degeneration (AMD)

Yadav, M., Schiavone, N., Guzmán‐Aránguez, A., Giansanti, F., Papucci, L., de Lara, M. J. P., Singh, M., & Kaur, I. P. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00733-4 · Cited by 112 · see citing works

Topical, aqueous, clear cyclosporine formulation design for anterior and posterior ocular delivery

Cholkar, K., Gilger, B. C., & Mitra, A. K. (2015) · Translational Vision Science & Technology · doi:10.1167/tvst.4.3.1 · Cited by 103 · see citing works

Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: Evaluation of the surface properties and effect on their distribution

Apaolaza, P. S., Busch, M. A., Asín‐Prieto, E., Peynshaert, K., Rathod, R., Remaut, K., Dünker, N., & Göpferich, A. M. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108151 · Cited by 101 · see citing works

Eyedrop-based macromolecular ophthalmic drug delivery for ocular fundus disease treatment

Shen, J., Gao, H., Chen, L., Jiang, Y., Li, S., Chao, Y., Liu, N., Wang, Y., Wei, T., Liu, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.abq3104 · Cited by 96 · see citing works

Clinical impact of the worldwide shortage of verteporfin (Visudyne®) on ophthalmic care

Sirks, M. J., van Dijk, E. V., Rosenberg, N., Hollak, C., Aslanis, S., Cheung, C. M. G., Chowers, I., Eandi, C., Freund, K. B., Holz, F., et al. (2022) · Acta ophthalmologica · doi:10.1111/aos.15148 · Cited by 88 · see citing works

Antiangiogenic nanomicelles for the topical delivery of aflibercept to treat retinal neovascular disease

Zhao, X., Seah, I., Xue, K., Wong, W., Tan, Q. S. W., Ma, X., Lin, Q., Lim, J. Y. C., Liu, Z., Parikh, B. H., et al. (2022) · Advanced Materials · doi:10.1002/adma.202108360 · Cited by 84 · see citing works

Targeting Ocular Drug Delivery: An Examination of Local Anatomy and Current Approaches

Dosmar, E., Walsh, J., Doyel, M., Bussett, K., Oladipupo, A., Amer, S., & Goebel, K. (2022) · Bioengineering · doi:10.3390/bioengineering9010041 · Cited by 83 · see citing works

Nanoemulsion applications in photodynamic therapy

Moghassemi, S., Dadashzadeh, A., Azevedo, R. B., & Amorim, C. A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.035 · Cited by 82 · see citing works

Hyaluronic-Coated Albumin Nanoparticles for the Non-Invasive Delivery of Apatinib in Diabetic Retinopathy

Radwan, S. E.-S., El-Kamel, A. H., Zaki, E. I., Burgalassi, S., Zucchetti, E., & El‐Moslemany, R. M. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s316564 · Cited by 81 · see citing works

Chitosan coated liposomes (CCL) containing triamcinolone acetonide for sustained delivery: A potential topical treatment for posterior segment diseases

Khalil, M., Hashmi, M. U., Riaz, R., & Abbas, S. R. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.256 · Cited by 77 · see citing works

Penetratin-modified lutein nanoemulsion in-situ gel for the treatment of age-related macular degeneration

Ge, Y. C., Zhang, A., Sun, R., Xu, J., Yin, T., He, H., Gou, J., Kong, J., Zhang, Y. X., & Tang, X. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1735348 · Cited by 75 · see citing works

Microenvironment-Triggered Degradable Hydrogel for Imaging Diagnosis and Combined Treatment of Intraocular Choroidal Melanoma

Li, L., Zeng, Z., Chen, Z., Gao, R.-Y., Pan, L., Deng, J., Ye, X., Zhang, J., Zhang, S., Mei, C., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c06000 · Cited by 74 · see citing works

Ocular Nanomedicine

Tang, Z., Fan, X., Chen, Y., & Gu, P. (2022) · Advanced Science · doi:10.1002/advs.202003699 · Cited by 72 · see citing works

Repeated Topical Administration of 3 nm Cerium Oxide Nanoparticles Reverts Disease Atrophic Phenotype and Arrests Neovascular Degeneration in AMD Mouse Models

Badia, A. C., Duarri, A., Salas, A., Rosell, J., Ramis, J., Gustà, M. F., Casals, E., Zapata, M. Á., Puntes, V., & García‐Arumí, J. (2023) · ACS Nano · doi:10.1021/acsnano.2c05447 · Cited by 71 · see citing works

Photodynamic therapy of idiopathic and inflammatory choroidal neovascularization in young adults

Rogers, A. H., Duker, J. S., Nichols, N., & Baker, B. J. (2003) · Ophthalmology · doi:10.1016/s0161-6420(03)00466-4 · Cited by 70 · see citing works

A more efficient ocular delivery system of triamcinolone acetonide as eye drop to the posterior segment of the eye

Li, J., Cheng, T., Tian, Q., Cheng, Y., Zhao, L., Zhang, X., & Qu, Y. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1571122 · Cited by 70 · see citing works

Therapies Based on Nanoparticles for Eye Drug Delivery

Meza-Ríos, A., Navarro‐Partida, J., Armendáriz‐Borunda, J., & Santos, A. (2020) · Ophthalmology and Therapy · doi:10.1007/s40123-020-00257-7 · Cited by 64 · see citing works

Development and Characterization of Nanoemulsions for Ophthalmic Applications: Role of Cationic Surfactants

Fernandes, A. R., Sánchez‐López, E., dos Santos, T., García, M. L., Silva, A. M., & Souto, E. B. (2021) · Materials · doi:10.3390/ma14247541 · Cited by 62 · see citing works

Transcorneal iontophoresis of dendrimers: PAMAM corneal penetration and dexamethasone delivery

de Souza, J. G., Dias, K., Silva, S. A. M. E., de Rezende, L. C. D., Rocha, E. M., Emery, F. D. S., & Lopez, R. F. V. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.037 · Cited by 61 · see citing works

Dendrimers as a promising tool in ocular therapeutics: Latest advances and perspectives

Villanueva, J. R., Guzmán, M., & Villanueva, L. R. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.07.031 · Cited by 61 · see citing works

Characterization and Pharmacokinetics of Triamcinolone Acetonide-Loaded Liposomes Topical Formulations for Vitreoretinal Drug Delivery

Altamirano-Vallejo, J. C., Navarro‐Partida, J., la Rosa, A. G., Hsiao, J. H., Olguín-Gutierrez, J. S., Gonzalez-Villegas, A. C., Keller, B. C., Bouzo-Lopez, L., & Santos, A. (2018) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2017.0099 · Cited by 61 · see citing works

Novel inulin-based mucoadhesive micelles loaded with corticosteroids as potential transcorneal permeation enhancers

Prima, G. D., Saladino, S., Bongiovì, F., Adamo, G., Ghersi, G., Pitarresi, G. L., & Giammona, G. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.05.005 · Cited by 54 · see citing works

Multifunctional Nanocomposites Based on Liposomes and Layered Double Hydroxides Conjugated with Glycylsarcosine for Efficient Topical Drug Delivery to the Posterior Segment of the Eye

Gu, Y., Xu, C., Wang, Y., Zhou, X., Fang, L., & Cao, F. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01136 · Cited by 53 · see citing works

A novel dendrimer-based complex co-modified with cyclic RGD hexapeptide and penetratin for noninvasive targeting and penetration of the ocular posterior segment

Yang, X., Wang, L., Li, L., Han, M., Tang, S., Wang, T., Han, J., He, X., He, X., Wang, A., et al. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1667455 · Cited by 51 · see citing works

Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa

Platania, C. B. M., Dei, M., Cianciolo, S., Fidilio, A., Lazzara, F., Paroni, R. C., Pignatello, R., Strettoi, E., Ghidoni, R., Drago, F., et al. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1574936 · Cited by 49 · see citing works

Anti-microbial Effect and in Vivo Ocular Delivery of Ciprofloxacin-loaded Liposome through Rabbit’s Eye

Feghhi, M., Makhmalzadeh, B. S., Farrahi, F., Akmali, M., & Hasanvand, N. (2020) · Current Eye Research · doi:10.1080/02713683.2020.1728777 · Cited by 48 · see citing works

Safety of KPI-121 Ophthalmic Suspension 0.25% in Patients With Dry Eye Disease: A Pooled Analysis of 4 Multicenter, Randomized, Vehicle-Controlled Studies

Korenfeld, M. S., Nichols, K. K., Goldberg, D. F., Evans, D., Sall, K. N., Foulks, G. N., Coultas, S., & Brazzell, K. (2020) · Cornea · doi:10.1097/ico.0000000000002452 · Cited by 48 · see citing works

Novel Eye Drop Delivery Systems: Advance on Formulation Design Strategies Targeting Anterior and Posterior Segments of the Eye

Wang, Y., & Wang, C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061150 · Cited by 48 · see citing works

Photostable and Biocompatible Fluorescent Silicon Nanoparticles-Based Theranostic Probes for Simultaneous Imaging and Treatment of Ocular Neovascularization

Tang, M., Ji, X., Xu, H., Zhang, L., Jiang, A., Song, B., Su, Y., & He, Y. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01580 · Cited by 47 · see citing works

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases

Platania, C. B. M., Fisichella, V., Fidilio, A., Geraci, F., Lazzara, F., Leggio, G. M., Salomone, S., Drago, F., Pignatello, R., Caraci, F., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102076 · Cited by 45 · see citing works

Octopus-like Flexible Vector for Noninvasive Intraocular Delivery of Short Interfering Nucleic Acids

Jiang, K., Hu, Y., Gao, X., Zhan, C., Zhang, Y., Yao, S., Xie, C., Wei, G., & Lu, W. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b02596 · Cited by 45 · see citing works

Triamcinolone acetonide-chitosan coated liposomes efficiently treated retinal edema as eye drops

Cheng, T., Li, J., Cheng, Y., Zhang, X., & Qu, Y. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107805 · Cited by 45 · see citing works

Penetration Enhancers for Topical Drug Delivery to the Ocular Posterior Segment—A Systematic Review

Thareja, A., Hughes, H. P., Alvarez‐Lorenzo, C., Hakkarainen, J. J., & Ahmed, Z. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020276 · Cited by 43 · see citing works

Glycopeptide-nanotransforrs eyedrops with enhanced permeability and retention for preventing fundus neovascularization

Li, K., Li, R., Zou, P., Li, L., Wang, H., Kong, D., Zheng, G., & Li, L. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121361 · Cited by 39 · see citing works

Topical treatment of diabetic macular edema using dexamethasone ophthalmic suspension: A randomized, double‐masked, vehicle‐controlled study

Stefánsson, E., Loftsson, T., Larsen, M., Papp, A., Kaarniranta, K., Munk, M. R., Dugel, P. U., Tadayoni, R., & DX‐211 study group (2022) · Acta Ophthalmologica · doi:10.1111/aos.15215 · Cited by 39 · see citing works

A novel penetratin-modified complex for noninvasive intraocular delivery of antisense oligonucleotides

Tai, L., Liu, C., Jiang, K., Chen, X., Feng, L., Pan, W., Wei, G., & Lu, W. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.06.090 · Cited by 38 · see citing works

Safety and efficacy of twice daily administration of KPI-121 1% for ocular inflammation and pain following cataract surgery

Kim, T., Sall, K. N., Holland, E. J., Brazzell, R. K., Coultas, S., & Gupta, P. K. (2018) · Clinical ophthalmology · doi:10.2147/opth.s185800 · Cited by 38 · see citing works

Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy

Delgado‐Tirado, S., Amarnani, D., Zhao, G., Rossin, E. J., Eliott, D., Miller, J. B., Greene, W. A., Ramos, L., Arévalo-Alquichire, S., Leyton-Cifuentes, D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77254-0 · Cited by 38 · see citing works

Development and Characterization of Curcumin-Silver Nanoparticles as a Promising Formulation to Test on Human Pterygium-Derived Keratinocytes

Stati, G., Rossi, F., Trakoolwilaiwan, T., Tung, L. D., Mourdikoudis, S., Thanh, N. T. K., & Pietro, R. D. (2022) · Molecules · doi:10.3390/molecules27010282 · Cited by 38 · see citing works

Outcomes after combination photodynamic therapy and immunosuppression for inflammatory subfoveal choroidal neovascularisation

Hogan, A. C. (2005) · British Journal of Ophthalmology · doi:10.1136/bjo.2004.063024 · Cited by 36 · see citing works

Melatonin loaded hybrid nanomedicine: DoE approach, optimization and in vitro study on diabetic retinopathy model

Romeo, A., Bonaccorso, A., Carbone, C., Lupo, G., Anfuso, C. D., Giurdanella, G., Caggia, C., Randazzo, C. L., Russo, N., Romano, G. L., et al. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122195 · Cited by 36 · see citing works

Effect of OTX-101, a Novel Nanomicellar Formulation of Cyclosporine A, on Corneal Staining in Patients With Keratoconjunctivitis Sicca: A Pooled Analysis of Phase 2b/3 and Phase 3 Studies

Malhotra, R., Devries, D. K., Luchs, J., Kabat, A. G., Schechter, B. A., Lee, B. S., Shettle, L., Smyth-Medina, R. J., Ogundele, A., Darby, C. H., et al. (2019) · Cornea · doi:10.1097/ico.0000000000001989 · Cited by 33 · see citing works

Safety and Tolerability of Topical Ophthalmic Triamcinolone Acetonide-Loaded Liposomes Formulation and Evaluation of Its Biologic Activity in Patients with Diabetic Macular Edema

Navarro‐Partida, J., Altamirano-Vallejo, J. C., la Rosa, A. G., Armendáriz‐Borunda, J., Castro‐Castañeda, C. R., & Santos, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030322 · Cited by 30 · see citing works

Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier

Zhang, F., Chen, H., Lan, J., Song, K., & Wu, X. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108313 · Cited by 29 · see citing works

Efficacy and safety of OTX-101, a novel nanomicellar formulation of cyclosporine A, for the treatment of keratoconjunctivitis sicca: pooled analysis of a phase 2b/3 and phase 3 study

Sheppard, J., Kannarr, S., Luchs, J., Malhotra, R., Justice, A., Ogundele, A., Darby, C., & Bacharach, J. (2020) · Eye & Contact Lens: Science & Clinical Practice · doi:10.1097/icl.0000000000000636 · Cited by 28 · see citing works

Emerging innovations in nano-enabled therapy against age-related macular degeneration: A paradigm shift

Dubey, S. K., Pradhan, R., Hejmady, S., Singhvi, G., Choudhury, H., Gorain, B., & Kesharwani, P. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120499 · Cited by 28 · see citing works

Neovascularization-directed bionic eye drops for noninvasive renovation of age-related macular degeneration

Ran, M., Deng, Y., Yan, J., Zhang, A., Wei, Y., Li, X., He, H., Gou, J., Yin, T., Tang, X., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138291 · Cited by 25 · see citing works

Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice

Bassetto, M., Ajoy, D., Poulhès, F., Obringer, C., Walter, A., Messadeq, N., Sadeghi, A., Puranen, J., Ruponen, M., Kettunen, M. I., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101650 · Cited by 19 · see citing works

RANIBIZUMAB WITH OR WITHOUT VERTEPORFIN PHOTODYNAMIC THERAPY FOR POLYPOIDAL CHOROIDAL VASCULOPATHY

Cheung, C. M. G., Tan, C. S., Patalauskaite, R., Margaron, P., & Lai, T. Y. Y. (2020) · Retina · doi:10.1097/iae.0000000000002902 · Cited by 17 · see citing works

Dendrimers for Therapeutic Delivery: Compositions, Characterizations, and Current Status

Nagpal, K., Kumar, P., Mohan, A., & Thakur, S. (2018) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2018025749 · Cited by 16 · see citing works

The Effect of OTX-101 on Tear Production in Patients with Severe Tear-deficient Dry Eye Disease: A Pooled Analysis of Phase 2b/3 and Phase 3 Studies

Toyos, M. M., Gupta, P. K., Mitchell, B., & Karpecki, P. M. (2021) · Current Eye Research · doi:10.1080/02713683.2021.1966477 · Cited by 14 · see citing works

Topical Diclofenac-Loaded Liposomes Ameliorate Laser-Induced Choroidal Neovascularization in Mice and Non-Human Primates

Shimazawa, M., Inoue, Y., Masuda, T., Onodera, R., Tahara, K., Shimizu, Y., Mibe, Y., Tsuruma, K., Takeuchi, H., & Hara, H. (2016) · Current Neurovascular Research · doi:10.2174/1567202614666161104115440 · Cited by 11 · see citing works

Nanoformulations for Ocular Delivery of Drugs - A Patent Perspective

Dogra, A., Kaur, K., Ali, J., Baboota, S., Narang, R. S., & Narang, J. K. (2020) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/1872211314666200127101149 · Cited by 9 · see citing works

Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis

Delgado‐Tirado, S., González-Buendía, L., An, M. B., Amarnani, D., Isaacs-Bernal, D., Whitmore, H. A. B., Arévalo-Alquichire, S., Leyton-Cifuentes, D., Ruiz‐Moreno, J. M., Arboleda‐Velásquez, J. F., et al. (2022) · Ophthalmology Science · doi:10.1016/j.xops.2022.100163 · Cited by 9 · see citing works

KPI-121 1% for Pain and Inflammation in Ocular Surgery

Beckman, K. A., Katz, J. A., Majmudar, P. A., Rips, A. G., Vaidya, N. S., & Rostov, A. T. (2021) · Pain Management · doi:10.2217/pmt-2021-0023 · Cited by 7 · see citing works

Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances

Xu, X., Pang, Y., & Fan, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02253-4 · Cited by 939 · see citing works

Nanoceria-Mediated Cyclosporin A Delivery for Dry Eye Disease Management through Modulating Immune–Epithelial Crosstalk

Cui, W., Chen, S., Hu, T., Zhou, T., Qiu, C., Jiang, L., Cheng, X., Ji, J., Yao, K., & Han, H. (2024) · ACS Nano · doi:10.1021/acsnano.3c11514 · Cited by 86 · see citing works

An insight on ophthalmic drug delivery systems: focus on polymeric biomaterials-based carriers

Shafiq, M., Rafique, M., Cui, Y., Pan, L., Do, C.-W., & Ho, E. A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.041 · Cited by 67 · see citing works

Light-responsive polymeric nanoparticles for retinal drug delivery: design cues, challenges and future perspectives

Guidi, L., Cascone, M. G., & Rosellini, E. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26616 · Cited by 53 · see citing works

Trimethylated chitosan-coated flexible liposomes with resveratrol for topical drug delivery to reduce blue-light-induced retinal damage

Gu, H., Chen, P., Liu, X., Lian, Y., Xi, J., Li, J., Song, J., & Li, X. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126480 · Cited by 51 · see citing works

Lycium Barbarum Polysaccharide‐Derived Nanoparticles Protect Visual Function by Inhibiting RGC Ferroptosis and Microglial Activation in Retinal Ischemia‒Reperfusion Mice

Ni, Y., Hu, Y., Zhu, L., Jiang, X., Zhang, H., Liu, J., & Zhao, Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304285 · Cited by 49 · see citing works

Up-to-date molecular medicine strategies for management of ocular surface neovascularization

Yang, Y., Zhong, J., Cui, D., & Jensen, L. D. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115084 · Cited by 41 · see citing works

Therapeutic targeting of the mitochondrial dysfunction-PANoptosis axis: Mechanistic insights and emerging strategies

Sharma, A., Raut, S. S., Shukla, A. K., Singh, A. K., & Mishra, A. (2026) · Translational research · doi:10.1016/j.trsl.2026.03.004 · Cited by 13 · see citing works

N-acetylcysteine and chitosan conjugate modified dexamethasone nanostructured lipid carriers: Enhanced permeability, precorneal retention and lower inflammation for the treatment of dry eye syndrome

Gu, D., Zhou, L., Zhang, Y., Jin, H., Nie, W., Zhang, M., & Dong, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140123 · Cited by 13 · see citing works

Stimulus-responsive nanomaterials for ocular antimicrobial therapy

Zhang, T., & Luo, Z. (2025) · Nanoscale · doi:10.1039/d4nr05462h · Cited by 13 · see citing works

Ferroptosis in ocular diseases: mechanisms, crosstalk with other cell death pathways, and therapeutic prospects

Huang, S., Sun, Y., Yu, X., Ren, X., Wang, L., Sun, Y., & Deng, A. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1608975 · Cited by 10 · see citing works

From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics

Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7 · see citing works

Mesenchymal Stem Cell-Derived Exosomes for Ocular Diseases: Therapeutic Mechanisms and Clinical Perspectives

Cheng, S., Ma, Y., Huang, F., Luo, R., Han, L., He, L., & Yuan, Z. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s555771 · Cited by 7 · see citing works

Self-polymerized polyphenol-based platform for the management of dry eye pathogenesis

Wang, Z., Lv, Z., Ge, Y., Xue, R., Wu, F., Han, H., & Wang, Y. (2026) · Nature Communications · doi:10.1038/s41467-026-70388-1 · Cited by 7 · see citing works

Application of Nanomaterials in the Diagnosis and Treatment of Retinal Diseases

Yao, Y., Cao, Q., Fang, H., & Tian, H. (2025) · Small · doi:10.1002/smll.202503070 · Cited by 7 · see citing works

Spanlastics ocular delivery: a comprehensive review of formulation and therapeutic potential

Sahin, S., Sarma, S., Das, A., Baishya, B., Das, A. K., & Deka, M. K. (2025) · Discover Pharmaceutical Sciences · doi:10.1007/s44395-025-00009-1 · Cited by 6 · see citing works

Mucoadhesive Chitosan in Drug Delivery

Laffleur, F. (2024) · Advances in polymer science · doi:10.1007/12_2024_180 · Cited by 4 · see citing works

Pharmacotherapy for non-infectious uveitis: spotlight on phase III clinical trials of locally injected or implanted therapeutics and systemic immunomodulatory drugs

Shields, M. K., Ferreira, L. B., Ali, S. B., Dedina, L., Lim, L. L., Suhler, E. B., & Smith, J. R. (2025) · Journal of Ophthalmic Inflammation and Infection · doi:10.1186/s12348-025-00502-9 · Cited by 3 · see citing works

Regulated cell death-targeted ocular nanomedicine

HO, S. ‐., Li, L., Zuo, S., Tang, J., Ye, F., Gu, P., Tang, Z., & Lu, L. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.08.018 · Cited by 2 · see citing works

Manufacturing consideration, scale-up, and validation in sterile ophthalmic formulation

Üner, B. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33781-9.00020-4 · Cited by 2 · see citing works

Aggregation inhibitory effect of vitamin C on cataract-associated P23T γD-crystallin

Filip, A., Cozar, B. I., Floare, C. G., Pı̂rnău, A., Mic, M., Gronenborn, A. M., & Matei, E. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140579 · Cited by 1 · see citing works

ADVANCED NANOCARRIERS FOR OCULAR DRUG DELIVERY: STRATEGIES TO OVERCOME OCULAR BARRIERS

divya, D. D., Mazumder, R., Rani, A., & Mishra, R. (2025) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2025v17i6.55388 · Cited by 1 · see citing works

Lycium barbarum Polysaccharides: Extraction, Structural Characteristics, Anti-Inflammatory Mechanisms, Safety Profiles and Applications

Bai, J., Fu, J., Huang, Y., Liu, Q., Mo, J.-Y., Zhang, Y., Zhou, B., Wu, Y., & Yuan, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167213 · Cited by 1 · see citing works

Composite nano-in-micro drug delivery system for treatment of glaucoma: design strategies and research advances

Hu, J., Shen, W., Yan, P., Ge, X., Wu, S., Mao, Y., Ao, F., Jia, X., & Wang, Y. (2025) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2025.2525672

Fundamentals of nano drug delivery systems: Principles and applications in ocular oncology

Basu, B., Rahaman, M., & Prajapati, B. G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27541-8.00013-4

Safety assessment and toxicological considerations of nanocarriers in ophthalmic drug delivery

Manchanda, N., Kaul, S., Mittal, S., & Talegaonkar, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33781-9.00017-4

[Retinal protective effects of zinc-loaded magnesium oxide nanoparticles in a glutamate-excitotoxicity glaucoma model].

Feng, L., Chen, Y., Wang, C., Zhu, W., Zhang, C., Huang, Q., & Song, W. (2025) · PubMed · doi:10.11817/j.issn.1672-7347.2025.250416

Nanotechnology-Based Treatment for Ophthalmic Diseases

Gong, J., Wang, P., Xu, Y., & Xia, X. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s597696

Iron Homeostasis Restoration via Triple-Pool-Targeted Nanotherapy for Enhanced Amelioration of Age-Related Macular Degeneration

Zhou, Y., Xu, M., Xu, Y., Shao, A., Cui, W., Shen, W., He, Y., Chen, Z., Zhang, Y., Miao, Q., et al. (2026) · ACS Nano · doi:10.1021/acsnano.6c00302

Smart Polymer‐Based Drug Delivery Systems for Managing Infective Conjunctivitis: Advances and Future Prospects

Linkang, X., Maki, M. A. A., Tayyab, S., Thakur, S. S., Kumar, P., Karwasra, R., Behare, M. H., Sharma, N., Kamal, W. H. B. W., Kobi, O., et al. (2026) · Nano Select · doi:10.1002/nano.70110

Functional Liposomal Nanocarriers for the Treatment of Antimicrobial-Resistant and Biofilm-Associated Ocular Infections

Pintilei, P. S., Binaymotlagh, R., Haghighi, F. H., Chronopoulou, L., & Palocci, C. (2026) · Macromol—A Journal of Macromolecular Research · doi:10.3390/macromol6030056

Construction and In Vitro Evaluation of a CS-PLGA/pEGFP/HA Ternary Biodegradable Nanocarrier as a Potential Candidate for Intravitreal Ocular Gene Delivery

Wang, T., Liu, Y., Xu, J., Gao, S., Zhang, S., & Yang, X. (2026) · ACS Applied Bio Materials · doi:10.1021/acsabm.6c00748

Nanosuspension-based Ocular Therapeutics for Infection Control: Integrating Mucin Interactions and Tear Film Dynamics

Datta, D., Nison, M., Colaco, V., Krishna, V., Bandi, S. P., Dhas, N. L., Biswas, S., Singh, R., & Pai, V. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-026-03531-2

Intra-vitreal drug delivery

Dias, M. F., Silva‐Cunha, A., & Fialho, S. L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36643-7.00005-6

Recent Advances in Topical Nano drug-delivery Systems for the Anterior Ocular Segment

Lakhani, P. M., Patil, A., & Majumdar, S. (2018) · Therapeutic Delivery · doi:10.4155/tde-2017-0088 · Cited by 65 · see citing works

Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

Onugwu, A. L., Nwagwu, C. S., Onugwu, S. O., Echezona, A. C., Agbo, C. P., Ihim, S. A., Emeh, P., Nnamani, P. O., Attama, A. A., & Khutoryanskiy, V. V. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.018 · Cited by 356 · see citing works

Advances in nanodrug delivery systems for posterior segment eye diseases

Jing, X., Su, Z., Wang, Z., Li, P., & Wei, Z. (2024) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.3980/j.issn.1672-5123.2024.10.09

Drug Delivery Systems to the Posterior Segment of the Eye: Implants and Nanoparticles

Sepahvandi, A., Eskandari, M., & Moztarzadeh, F. (2016) · BioNanoScience · doi:10.1007/s12668-016-0219-8 · Cited by 17 · see citing works

A review of nanocarrier-mediated drug delivery systems for posterior segment eye disease: challenges analysis and recent advances

Wang, R., Gao, Y., Liu, A., & Zhai, G. (2021) · Journal of drug targeting · doi:10.1080/1061186x.2021.1878366 · Cited by 72 · see citing works