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Computational design of Bax-inhibiting peptides
Open accessPublished version of a preprint
Abstract
Cyclic peptides targeting Bax were designed and evaluated via MD simulations. The peptides bind Bax with high affinity, potentially modulating its apoptotic function. This approach offers a foundation for peptide-based therapeutics.
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Metadata
- Authors
- Vlaar, T., Mayer, B., van der Heide, L., & Ilie, I. M.
- Affiliations
- University of Amsterdam (NL)
- Corresponding author
- Ilie, Ioana M.
- Venue
- Materials Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2025
- Volume
- 6
- Issue
- 7
- Pages
- 2160-2169
- ISSN
- 2633-5409 (ISSN-L)
- OpenAlex
- W4407794468
- Cited by
- 2
- References
- 71
- Citations by year
- 2026: 2
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Materials Advances (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Funders
- Stiftung Synapsis - Alzheimer Forschung Schweiz AFS
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- Bax, cyclic peptides, peptide design, protein-peptide interactions, apoptosis, peptide therapeutics, molecular dynamics simulation
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