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The BCL-2 Family Reunion

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Chipuk, Jerry E., Moldoveanu, Tudor, Llambi, Fabien, Parsons, Melissa J., Green, Douglas R.·2010·Molecular Cell
DOI 10.1016/j.molcel.2010.01.025
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Abstract

B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.

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Metadata

Authors
Chipuk, J. E., Moldoveanu, T., Llambi, F., Parsons, M. J., & Green, D. R.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2010-02
Volume
37
Issue
3
Pages
299-310
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2010.01.025
OpenAlex
W2036411709
Cited by
1,427
References
19
FWCI
51.40
Type
journal article
Language
en
Open access
bronze
Licence

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Chipuk, J. E., Moldoveanu, T., Llambi, F., Parsons, M. J., & Green, D. R. (2010). The BCL-2 Family Reunion. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.01.025

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