The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
pH-Independent charge-reversal strategy for enhanced tumor penetration based on hyaluronidase-responsive tellurium-containing polycarbonate nanocarriers
Abstract
We present a tumor-penetration strategy involving pH-independent hyaluronidase-responsive cationic tellurium-containing polycarbonate nanoparticles (HPNTPs) that can actively infiltrate throughout the tumor tissue through transcytosis.
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In the citing paper
“Since charge reversal does not inherently reduce hydrodynamic size, diffusion through dense stroma can remain the bottleneck when activated diameters exceed about 50 nm; pairing partial downsizing with charge programming or introducing short, well-tolerated priming that preserves perfusion can mitigate this constraint [25].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [25]
In the citing paper
“This process enhances adsorption-mediated transcytosis, allowing uniform penetration through 3.6 mm thick 2,3-Dimethylmaleic Anhydride (DMMA) xenografts and achieving potent tumor inhibition via mitochondrial cisplatin release with negligible systemic toxicity compared with the control groups [25].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [25]
In the citing paper
“Hu et al. designed hyaluronidase (HAase)-responsive tellurium/quaternary ammonium polycarbonate nanoparticles coated with hyaluronic acid, which mask their cationic core during circulation (ζ ~ −27 mV, 160 nm).”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [25]
In the citing paper
“Upon HAase digestion in the tumor bed, the shell is removed, shrinking the particles to approximately 130 nm and reversing the surface charge to positive.”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [25]
In the citing paper
“This process enhances adsorption-mediated transcytosis, allowing uniform penetration through 3.6 mm thick 2,3-Dimethylmaleic Anhydride (DMMA) xenografts and achieving potent tumor inhibition via mitochondrial cisplatin release with negligible systemic toxicity compared with the control groups [25].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [25]
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Cited by
Sorted by citations
Sheng, J., Yuan, W., Zhang, M., Chen, Z., Qi, Y., Zhao, Y., & Zhang, S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04028-7 · Cited by 35
Metadata
- Authors
- Hu, J., Zhou, W., Zhou, Y., Hu, H., Ran, S., & Zhang, Y.
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2025
- Volume
- 13
- Issue
- 28
- Pages
- 8483-8495
- ISSN
- 2050-750X
- 2050-7518
- Cited by
- 4
- References
- 4
- Language
- en
- Funders
- National Natural Science Foundation of China (51873062, 52073093, 82001033, 82373391)
- Fudan University (K2025-44)
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