Reactive oxygen species: a volatile driver of field cancerization and metastasis
Open accessAbstract
Field cancerization and metastasis are the leading causes for cancer recurrence and mortality in cancer patients. The formation of primary, secondary tumors or metastasis is greatly influenced by multifaceted tumor-stroma interactions, in which stromal components of the tumor microenvironment (TME) can affect the behavior of the cancer cells. Many studies have identified cytokines and growth factors as cell signaling molecules that aid cell to cell communication. However, the functional contribution of reactive oxygen species (ROS), a family of volatile chemicals, as communication molecules are less understood. Cancer cells and various tumor-associated stromal cells produce and secrete a copious amount of ROS into the TME. Intracellular ROS modulate cell signaling cascades that aid in the acquisition of several hallmarks of cancers. Extracellular ROS help to propagate, amplify, and effectively create a mutagenic and oncogenic field which facilitate the formation of multifoci tumors and act as a springboard for metastatic tumor cells. In this review, we summarize our current knowledge of ROS as atypical paracrine signaling molecules for field cancerization and metastasis. Field cancerization and metastasis are often discussed separately; we offer a model that placed these events with ROS as the focal instigating agent in a broader "seed-soil" hypothesis.
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Oxidative stress is strongly associated with the expression of various inflammatory transcription factors, such as nuclear factor-kB (NF-kB) that modulates proteolytic pathways and promotes inflammation.
“Oxidative stress is strongly associated with the expression of various inflammatory transcription factors, such as nuclear factor-kB (NF- kB) that modulates proteolytic pathways and promotes inflammation (29–31).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [31]
Cancer is a class of diseases resulted from external factors such as environment, diet and radiation as well as internal factors including obesity and diabetes.
“Cancer is a class of diseases resulted from external factors such as environment, diet and radiation as well as internal factors including obesity and diabetes (31, 116, 117).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [31]
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RetractedProspects of molecular hydrogen in cancer prevention and treatment
Zhou, W., Zhang, J., Chen, W., & Miao, C. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05685-7 · Cited by 25 · see citing works
Magnetic fields and apoptosis: a possible mechanism
Tofani, S. (2022) · Electromagnetic Biology and Medicine · doi:10.1080/15368378.2022.2073547 · Cited by 24 · see citing works
Ferroptosis at the crossroads of tumor-host interactions, metastasis, and therapy response
Yao, Y., Shi, Y., Gao, Z., Sun, Y., Yao, F., & Ma, L. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00148.2022 · Cited by 23 · see citing works
Feng, S., Gong, Y., Xia, L., Lang, Y., Shen, Y., Li, H., Feng, W., Chen, F., & Chen, Y. (2024) · Advanced Materials · doi:10.1002/adma.202405655 · Cited by 23 · see citing works
Jia, C., Luo, D., Zhou, J., Xie, X., Lam, H. Y. I., Li, P., Mu, Y., Zeng, Z., & Ren, C. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202419800 · Cited by 23 · see citing works
- Authors
- Liao, Z., Chua, D., & Tan, N. S.
- Affiliations
- Nanyang Technological University (SG)
- Corresponding author
- Tan, Nguan Soon
- Venue
- Molecular Cancer
- Published
- 2019-03-30
- Volume
- 18
- Issue
- 1
- Pages
- 65-65
- ISSN
- 1476-4598 (ISSN-L)
- PMC
- PMC6441160
- OpenAlex
- W2943576188
- Cited by
- 284
- References
- 106
- Citations by year
- 2026: 18 · 2025: 34 · 2024: 38 · 2023: 42 · 2022: 60 · 2021: 51 · 2020: 32 · 2019: 8
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Cancer (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DR-NTU (Nanyang Technological University) (submittedVersion, cc-by)
- Funders
- Ministry of Education, Singapore (2014-T2-1-012, 2017-T1-002-103)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- reactive oxygen species, field cancerization, metastasis, tumor microenvironment, tumor-stroma interactions, paracrine signaling, multifocal tumors, cancer hallmarks, cytokines and growth factors
- MeSH terms
- Animals, Cell Communication, Humans, Neoplasm Metastasis, Neoplasms, Signal Transduction, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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