Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems

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Antioxidant enzymes and human diseases

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Toxic Heavy Metal and Metalloid Accumulation in Crop Plants and Foods

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Targeting Free Radicals in Oxidative Stress-Related Human Diseases

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The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

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Complex iii releases superoxide to both sides of the inner mitochondrial membrane

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Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

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Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

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The physiological role of zinc as an antioxidant

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Zinc transporters and the cellular trafficking of zinc

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Oxygen free radicals and metallothionein

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Zinc biochemistry: From a single zinc enzyme to a key element of life

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Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling

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Zinc in wound healing: Theoretical, experimental, and clinical aspects

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The elusive function of metallothioneins

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Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

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Structural, Chemical and Biological Aspects of Antioxidants for Strategies Against Metal and Metalloid Exposure

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Zinc homeostasis and signaling in health and diseases

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MAMMALIAN ZINC TRANSPORTERS

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The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

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Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health

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Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

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Metal and Redox Modulation of Cysteine Protein Function

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Zinc: a multipurpose trace element

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The Function of Zinc Metallothionein: A Link between Cellular Zinc and Redox State

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The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective

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Preferential Zn ²⁺ influx through Ca ²⁺ -permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

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Crosstalk between Nitric Oxide and Zinc Pathways to Neuronal Cell Death Involving Mitochondrial Dysfunction and p38-Activated K+ Channels

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New aspects in the biological role of zinc: A stabilizer of macromolecules and biological membranes

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Hypocupremia induced by zinc therapy in adults

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Metalloproteomes: A Bioinformatic Approach

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Zinc-Induced Cortical Neuronal Death: Contribution of Energy Failure Attributable to Loss of NAD+and Inhibition of Glycolysis

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Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration

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Refined crystal structure of Cd, Zn metallothionein at 2·0 Å resolution

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Induction and Activation by Zinc of NADPH Oxidase in Cultured Cortical Neurons and Astrocytes

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Cellular zinc sensors: MTF-1 regulation of gene expression

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The induction of metallothionein in rat liver by zinc injection and restriction of food intake

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Proteostasis, oxidative stress and aging

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Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling

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Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals

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Zinc metallothionein imported into liver mitochondria modulates respiration

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Crystal Structures of Mitochondrial Processing Peptidase Reveal the Mode for Specific Cleavage of Import Signal Sequences

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The important role of the apoptotic effects of zinc in the development of cancers

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A bioinformatics view of zinc enzymes

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Cellular Zinc Fluxes and the Regulation of Apoptosis/Gene-Directed Cell Death

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Antibacterial properties of nine pure metals: a laboratory study using Staphylococcus aureus and Escherichia coli

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Keap1, the Sensor for Electrophiles and Oxidants that Regulates the Phase 2 Response, Is a Zinc Metalloprotein

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Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes

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Role of Zinc in Plasma Membrane Function

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Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function

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Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria

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Insights into Zn2+ homeostasis in neurons from experimental and modeling studies

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Relationship between the architecture of zinc coordination and zinc binding affinity in proteins – insights into zinc regulation

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Zinc-induced copper deficiency

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Zinc: new clues to diverse roles in brain ischemia

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Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc

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Zinc Is a Potent Inhibitor of Thiol Oxidoreductase Activity and Stimulates Reactive Oxygen Species Production by Lipoamide Dehydrogenase

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Biochemistry of Mobile Zinc and Nitric Oxide Revealed by Fluorescent Sensors

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Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis

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Biological consequences of zinc deficiency in the pathomechanisms of selected diseases

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Zn2+ Inhibits α-Ketoglutarate-stimulated Mitochondrial Respiration and the Isolated α-Ketoglutarate Dehydrogenase Complex

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Zinc Ions Inhibit the Qp Center of Bovine Heart Mitochondrial bc1 Complex by Blocking a Protonatable Group

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Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc

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Zinc and 4-Hydroxy-2-Nonenal Mediate Lysosomal Membrane Permeabilization Induced by H2O2in Cultured Hippocampal Neurons

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The ubiquitous role of zinc in health and disease

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Effect of Dietary Zinc or Copper Deficiency on the Primary Free Radical Defense System in Rats

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Metal ionophores – An emerging class of anticancer drugs

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Different redox states of metallothionein/thionein in biological tissue

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Metallothionein in Brain Disorders

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Metallothioneins are multipurpose neuroprotectants during brain pathology

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Effects of Copper and Zinc Status of Rats on Erythrocyte Stability and Superoxide Dismutase Activity

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Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency

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Zinc Released from Injured Cells Is Acting via the Zn2+-sensing Receptor, ZnR, to Trigger Signaling Leading to Epithelial Repair

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Effect of Trivalent Metal Ions on Phase Separation and Membrane Lipid Packing: Role in Lipid Peroxidation

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Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells

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Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome

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Intracellular zinc distribution in mitochondria, ER and the Golgi apparatus.

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Some factors controlling food intake by zinc-deficient rats

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Ebselen, a Selenium-Containing Redox Drug, Releases Zinc from Metallothionein

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Zinc regulates Nox1 expression through a NF-κB and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells

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The Inhibition of Mitochondrial Complex I (NADH:Ubiquinone Oxidoreductase) by Zn2+

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Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors

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Protective effect of taurine and zinc on peroxidation‐induced damage in photoreceptor outer segments

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Zinc nutrition and apoptosis of vascular endothelial cells: implications in atherosclerosis

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Refined crystal structure of Cd, Zn metallothionein at 2.0Åresolution

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Astrocytes Are More Resistant Than Neurons to the Cytotoxic Effects of Increased [Zn2+]i

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Zn2+Inhibits Mitochondrial Movement in Neurons by Phosphatidylinositol 3-Kinase Activation

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Iron overload

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Targeting of Metallothionein by L-Homocysteine

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Zinc Signals in Cellular Functions and Disorders

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Mechanisms of Rapid Reactive Oxygen Species Generation in Response to Cytosolic Ca2+ or Zn2+ Loads in Cortical Neurons

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Interaction of Zn2+, and Cu2+, Ions with glyceraldehyde-3-phosphate dehydrogenase from bovine heart and rabbit muscle

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