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Cited by 12Protein Kinase Regulation and GTPase SignalingDevelopmental Biology and Gene RegulationGene Regulatory Network Analysis

Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development

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Hirashima, Tsuyoshi·2022·Biochemical Journal
DOI 10.1042/bcj20210557PMC PMC8883488
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Abstract

The chemical and mechanical responses of cells via the exchange of information during growth and development result in the formation of biological tissues. Information processing within the cells through the signaling pathways and networks inherent to the constituent cells has been well-studied. However, the cell signaling mechanisms responsible for generating dynamic multicellular responses in developing tissues remain unclear. Here, I review the dynamic multicellular response systems during the development and growth of vertebrate tissues based on the extracellular signal-regulated kinase (ERK) pathway. First, an overview of the function of the ERK signaling network in cells is provided, followed by descriptions of biosensors essential for live imaging of the quantification of ERK activity in tissues. Then adducing four examples, I highlight the contribution of live imaging techniques for studying the involvement of spatio-temporal patterns of ERK activity change in tissue development and growth. In addition, theoretical implications of ERK signaling are also discussed from the viewpoint of dynamic systems. This review might help in understanding ERK-mediated dynamic multicellular responses and tissue morphogenesis.

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  • MAPK pathways transduce critical mitogenic signals downstream of RTK-RAS during embryogenesis, essential for lineage progenitor reservoir maintenance and organ growth.

    “Developmentally, MAPK pathways transduce critical mitogenic signals downstream of RTK-RAS during embryogenesis, which are essential for lineage progenitor reservoir maintenance and organ growth37.”

    From Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis (2024) · cites this paper as [37]

    The “RTK-ERK signaling pathway” section describes signaling from RTKs through RAS to ERK and says activated ERK regulates cell proliferation and growth. The “Genetic deficiency of ERK during embryonic development” section also describes ERK as essential for development. The copy does not establish the more specific claim that these signals maintain lineage progenitor reservoirs or are essential for organ growth. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Hirashima, T.
Affiliations
Kyoto University (JP)
Corresponding author
Hirashima, Tsuyoshi
ORCID
Hirashima, Tsuyoshi
Venue
Biochemical Journal
Publisher
Portland Press Ltd.
Published
2022-01-20
Volume
479
Issue
2
Pages
129-143
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
DOI
10.1042/bcj20210557
PMC
PMC8883488
OpenAlex
W4205146628
Cited by
12
References
5
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 4
FWCI
0.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochemical Journal (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by)
  • Kyoto University Research Information Repository (Kyoto University) (submittedVersion, cc-by)
Funders
  • Japan Society for the Promotion of Science (21H05290, 21K18601)
  • Precursory Research for Embryonic Science and Technology
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords
ERK signaling, extracellular signal-regulated kinase, histogenesis, tissue morphogenesis, live imaging, biosensors, vertebrate development, dynamical systems theory, cell signaling networks
MeSH terms
Animals, Enzyme Activation, Humans, Kinetics, Morphogenesis, Protein Binding, Biosensing Techniques, Receptor Protein-Tyrosine Kinases, MAP Kinase Signaling System, Fluorescence Resonance Energy Transfer, Extracellular Signal-Regulated MAP Kinases, Mice

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