Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237 · see citing works

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,037 · see citing works

22q11.21 Deletion Syndromes: A Review of Proximal, Central, and Distal Deletions and Their Associated Features

Burnside, R. D. (2015) · Cytogenetic and Genome Research · doi:10.1159/000438708 · Cited by 1,958 · see citing works

Actin dynamics control SRF activity by regulation of its coactivator MAL

Miralles, F., Posern, G., Zaromytidou, A.-I., & Treisman, R. (2003) · Cell · doi:10.1016/s0092-8674(03)00278-2 · Cited by 1,327 · see citing works

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

Danielian, P. S., Muccino, D. R., Rowitch, D. H., Michael, S. K., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00562-3 · Cited by 1,295 · see citing works

Fate of the mammalian cardiac neural crest

Jiang, X., Rowitch, D. H., Soriano, P. M., McMahon, A. P., & Sucov, H. M. (2000) · Development · doi:10.1242/dev.127.8.1607 · Cited by 1,163 · see citing works

DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1

Jerome, L. A., & Papaioannou, V. E. (2001) · Nature Genetics · doi:10.1038/85845 · Cited by 1,076 · see citing works

Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice

Lindsay, E. A., Vitelli, F., Su, H., Morishima, M., Huynh, T., Pramparo, T., Jurecic, V., Ogunrinu, G., Sutherland, H. F., Scambler, P. J., et al. (2001) · Nature · doi:10.1038/35065105 · Cited by 1,019 · see citing works

Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

Pandit, B., Sárközy, A., Pennacchio, L. A., Carta, C., Oishi, K., Martinelli, S., Pogna, E. A., Schackwitz, W., Ustaszewska, A., Landstrom, A. P., et al. (2007) · Nature Genetics · doi:10.1038/ng2073 · Cited by 700 · see citing works

Germline gain-of-function mutations in SOS1 cause Noonan syndrome

Roberts, A. E., Araki, T., Swanson, K. D., Montgomery, K. T., Schiripo, T. A., Joshi, V. A., Li, L., Yassin, Y., Tamburino, A. M., Neel, B. G., et al. (2007) · Nature Genetics · doi:10.1038/ng1926 · Cited by 605 · see citing works

Velocardiofacial syndrome, DiGeorge syndrome: the chromosome 22q11.2 deletion syndromes

Kobrynski, L. J., & Sullivan, K. E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61601-8 · Cited by 594 · see citing works

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome

Tartaglia, M., Pennacchio, L. A., Zhao, C., Yadav, K. K., Fodale, V., Sárközy, A., Pandit, B., Oishi, K., Martinelli, S., Schackwitz, W., et al. (2006) · Nature Genetics · doi:10.1038/ng1939 · Cited by 587 · see citing works

Actin' together: serum response factor, its cofactors and the link to signal transduction.

Posern, G., & Treisman, R. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.09.008 · Cited by 560 · see citing works

Neural Crest and Cardiovascular Patterning

Kirby, M. L., & Waldo, K. L. (1995) · Circulation Research · doi:10.1161/01.res.77.2.211 · Cited by 534 · see citing works

Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial archPreprint

Trumpp, A., Depew, M. J., Rubenstein, J. L. R., Bishop, J. M., & Martin, G. R. (1999) · Genes & Development · doi:10.1101/gad.13.23.3136 · Cited by 515 · see citing works

Germline gain-of-function mutations in RAF1 cause Noonan syndrome

Razzaque, A. M., Nishizawa, T., Komoike, Y., Yagi, H., Furutani, M., Amo, R., Kamisago, M., Momma, K., Katayama, H., Nakagawa, M., et al. (2007) · Nature Genetics · doi:10.1038/ng2078 · Cited by 501 · see citing works

The 22q11 deletion syndromes

Scambler, P. J. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.16.2421 · Cited by 490 · see citing works

Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus

Miano, J. M., Long, X., & Fujiwara, K. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00386.2006 · Cited by 482 · see citing works

Fgf8is required for pharyngeal arch and cardiovascular development in the mouse

Abu‐Issa, R., Smyth, G., Smoak, I. W., Yamamura, K., & Meyers, E. N. (2002) · Development · doi:10.1242/dev.129.19.4613 · Cited by 448 · see citing works

Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Araki, T., Mohi, G., Ismat, F. A., Bronson, R. T., Williams, I. R., Kutok, J. L., Yang, W., Pao, L. I., Gilliland, D. G., Epstein, J. A., et al. (2004) · Nature Medicine · doi:10.1038/nm1084 · Cited by 415 · see citing works

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

Corson, L. B., Yamanaka, Y., Lai, K.-M. V., & Rossant, J. (2003) · Development · doi:10.1242/dev.00669 · Cited by 390 · see citing works

AnFgf8mouse mutant phenocopies human 22q11 deletion syndrome

Frank, D. U., Fotheringham, L., Brewer, J. A., Muglia, L. J., Tristani‐Firouzi, M., Capecchi, M. R., & Moon, A. (2002) · Development · doi:10.1242/dev.129.19.4591 · Cited by 359 · see citing works

PTPN11 (Shp2) Mutations in LEOPARD Syndrome Have Dominant Negative, Not Activating, Effects

Kontaridis, M. I., Swanson, K. D., David, F. S., Barford, D., & Neel, B. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m513068200 · Cited by 340 · see citing works

Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome

Guris, D. L., Fantes, J. A., Tara, D., Druker, B. J., & Imamoto, A. (2001) · Nature Genetics · doi:10.1038/85855 · Cited by 306 · see citing works

Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function

Samuels, I. S., Karlo, J. C., Faruzzi, A. N., Pickering, K., Herrup, K., Sweatt, J. D., Saitta, S. C., & Landreth, G. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0679-08.2008 · Cited by 278 · see citing works

Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling

Park, E. J., Ogden, L. A., Talbot, A., Evans, S. M., Cai, C.-L., Black, B. L., Frank, D. U., & Moon, A. (2006) · Development · doi:10.1242/dev.02367 · Cited by 252 · see citing works

22q11.2 Distal Deletion: A Recurrent Genomic Disorder Distinct from DiGeorge Syndrome and Velocardiofacial Syndrome

Ben‐Shachar, S., Ou, Z., Shaw, C. A., Belmont, J. W., Patel, M. S., Hummel, M., Amato, S., Tartaglia, N. R., Berg, J. S., Sutton, V. R., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.014 · Cited by 248 · see citing works

Mice Lacking the ERK1 Isoform of MAP Kinase Are Unimpaired in Emotional LearningPreprint

Selcher, J. C., Nekrasova, T., Paylor, R. E., Landreth, G. E., & Sweatt, J. D. (2001) · Learning & Memory · doi:10.1101/lm.37001 · Cited by 211 · see citing works

Single and Combined Silencing of ERK1 and ERK2 Reveals Their Positive Contribution to Growth Signaling Depending on Their Expression Levels

LeFloch, R., Pouysségur, J., & Lenormand, P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00800-07 · Cited by 204 · see citing works

Stops along the RAS pathway in human genetic disease

Bentires-Alj, M., Kontaridis, M. I., & Neel, B. G. (2006) · Nature Medicine · doi:10.1038/nm0306-283 · Cited by 190 · see citing works

Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes.

Moon, A., Guris, D. L., Seo, J.-H., Li, L., Hammond, J. W., Talbot, A., & Imamoto, A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.12.003 · Cited by 150 · see citing works

Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases

Hindley, A. D., & Kölch, W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.8.1575 · Cited by 147 · see citing works

Specification of neural crest cell formation and migration in mouse embryos

Trainor, P. A. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.06.007 · Cited by 142 · see citing works

Low copy repeats mediate distal chromosome 22q11.2 deletions: Sequence analysis predicts breakpoint mechanismsPreprint

Shaikh, T. H., O’Connor, R. J., Pierpont, M. E., McGrath, J. M., Hacker, A. M., Nimmakayalu, M. A., Geiger, E. A., Emanuel, B. S., & Saitta, S. C. (2007) · Genome Research · doi:10.1101/gr.5986507 · Cited by 124 · see citing works

Ternary complex factors: prime nuclear targets for mitogen-activated protein kinases

Shaw, P. E., & Saxton, J. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00031-1 · Cited by 123 · see citing works

Mediating ERK1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome

Nakamura, T., Colbert, M. C., Krenz, M., Molkentin, J. D., Hahn, H. S., Dorn, G. W., & Robbins, J. M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30756 · Cited by 120 · see citing works

Reduced phosphatase activity of SHP‐2 in LEOPARD syndrome: Consequences for PI3K binding on Gab1

Hanna, N., Montagner, A., Lee, W. H., Miteva, M. A., Vidal, M., Vidaud, M., Parfait, B., & Raynal, P. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.088 · Cited by 117 · see citing works

Deregulated Ras signaling in developmental disorders: new tricks for an old dog

Schubbert, S., Bollag, G. E., & Shannon, K. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.004 · Cited by 116 · see citing works

A Novel 22q11.2 Microdeletion in DiGeorge Syndrome

Rauch, A. M., Pfeiffer, R. A., Leipold, G., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302235 · Cited by 105 · see citing works

From microscopes to microarrays: dissecting recurrent chromosomal rearrangements

Emanuel, B. S., & Saitta, S. C. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2136 · Cited by 101 · see citing works

Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2–Induced Gastrulation Defects

Jopling, C., van Geemen, D., & den Hertog, J. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030225 · Cited by 99 · see citing works

The Role of Neural Crest during Cardiac Development in a Mouse Model of DiGeorge Syndrome

Kochilas, L. K., Merscher, S., Lu, M. M., et al. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0819 · Cited by 85 · see citing works

Role of Megakaryoblastic Acute Leukemia-1 in ERK1/2-Dependent Stimulation of Serum Response Factor-Driven Transcription by BDNF or Increased Synaptic Activity

Kalita, K. B., Kharebava, G., Zheng, J., & Hetman, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2644-06.2006 · Cited by 83 · see citing works

ERK1-Deficient Mice Show Normal T Cell Effector Function and Are Highly Susceptible to Experimental Autoimmune Encephalomyelitis

Nekrasova, T., Shive, C. L., Gao, Y., Kawamura, K., Guardia, R., Landreth, G. E., & Forsthuber, T. G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2374 · Cited by 74 · see citing works

A 22q11.2 Deletion That Excludes UFD1L and CDC45L in a Patient with Conotruncal and Craniofacial Defects

Saitta, S. C., McGrath, J. M., Mensch, H., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302514 · Cited by 74 · see citing works

Expression of the A-raf proto-oncogene in the normal adult and embryonic mouse.

Luckett, J. C., Hüser, M., Γιαγτζόγλου, Ν., et al. (2000) · PubMed · Cited by 38 · see citing works

Mouse Models for Investigating the Developmental Basis of Human Birth Defects

Moon, A. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000218420.00525.98 · Cited by 26 · see citing works

22q11.2 deletion syndrome

McDonald-McGinn, D. M., Sullivan, K. E., Marino, B., Philip, N., Swillen, A., Vorstman, J. A. S., Zackai, E. H., Emanuel, B. S., Vermeesch, J. R., Morrow, B. E., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.71 · Cited by 2,236 · see citing works

ERK signalling: A master regulator of cell behaviour, life and fate

Lavoie, H., Gagnon, J., & Therrien, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0255-7 · Cited by 1,185 · see citing works

The Tyrosine Phosphatase Shp2 in Development and Cancer

(2010) · Advances in Cancer Research · doi:10.1016/s0065-230x(10)06002-1 · Cited by 277 · see citing works

The neural crest in cardiac congenital anomalies

Keyte, A., & Hutson, M. R. (2012) · Differentiation · doi:10.1016/j.diff.2012.04.005 · Cited by 259 · see citing works

The 16p11.2 Deletion Mouse Model of Autism Exhibits Altered Cortical Progenitor Proliferation and Brain Cytoarchitecture Linked to the ERK MAPK Pathway

Pucilowska, J., Vithayathil, J., Tavares, E. J., Kelly, C., Karlo, J. C., & Landreth, G. E. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4864-13.2015 · Cited by 207 · see citing works

Self-domestication in Homo sapiens: Insights from comparative genomics

Theofanopoulou, C., Gastaldon, S., O’Rourke, T., Samuels, B. D., Messner, A., Martins, P. T., Delogu, F., Alamri, S., & Boeckx, C. (2017) · PLOS ONE · doi:10.1371/journal.pone.0185306 · Cited by 174 · see citing works

ERK Signaling in the Pituitary Is Required for Female But Not Male Fertility

Bliss, S. P., Miller, A., Navratil, A. M., Xie, J., McDonough, S. P., Fisher, P. J., Landreth, G. E., & Roberson, M. S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0030 · Cited by 91 · see citing works

Genetic Targeting of ERK1 Suggests a Predominant Role for ERK2 in Murine Pain Models

Alter, B. J., Zhao, C., Karim, F., Landreth, G. E., & Gereau, R. W. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6103-09.2010 · Cited by 47 · see citing works

<i>HIC2</i> Is a Novel Dosage-Dependent Regulator of Cardiac Development Located Within the Distal 22q11 Deletion Syndrome Region

Dykes, I. M., van Bueren, K. L., Ashmore, R. J., Floss, T., Wurst, W., Szumska, D., Bhattacharya, S., & Scambler, P. J. (2014) · Circulation Research · doi:10.1161/circresaha.115.303300 · Cited by 33 · see citing works

Sex- and Age-Specific Impact of ERK Loss Within the Pituitary Gonadotrope in Mice

Brown, J. L., Xie, J., Brieño-Enriquez, M. A., Sones, J., Angulo, C. N., Boehm, U., Miller, A., Toufaily, C., Wang, Y., Bernard, D. J., et al. (2018) · Endocrinology · doi:10.1210/en.2017-00653 · Cited by 14 · see citing works

Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse

Brown, J. L., Sones, J. L., Angulo, C. N., Abbott, K., Miller, A. D., Boehm, U., & Roberson, M. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45997-0 · Cited by 13 · see citing works

Neural Crest Formation in Xenopus laevis: Mechanisms of Xslug Induction

Mancilla, A., & Mayor, R. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0187 · Cited by 214 · see citing works

The neural border: Induction, specification and maturation of the territory that generates neural crest cells

Pla, P., & Monsoro-Burq, A. H. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.05.018 · Cited by 115 · see citing works

Origins of the avian neural crest: the role of neural plate-epidermal interactions

Selleck, M. A. J., & Bronner-Fraser, M. E. (1995) · Development · doi:10.1242/dev.121.2.525 · Cited by 436 · see citing works

Identification of neural crest competence territory: Role of Wnt signaling

Bastidas, F., Calisto, J. D., & Mayor, R. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10486 · Cited by 53 · see citing works

Analysis of Neural Crest Cell Migration in Splotch Mice Using a Neural Crest-Specific LacZ Reporter

Serbedzija, G. N., & McMahon, A. P. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8551 · Cited by 100 · see citing works