The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The structure of pig and sheep insulins
Open accessAbstract
taken into account when considering possible configurations for the polypeptide chain in this area.It is interesting that the ring is the same size as the similar disulphide ring found in oxytocin (Tuppy & Michl, 1953; du Vigneaud, Ressler & Trippett, 1953) and vasopressin (Acher & Chauvet, 1953; du Vigneaud, Lawler & Popenoe, 1953), which suggests that it may have a possible structural or biological significance.SUMMARY 1. Insulin was subjected to partial hydrolysis with chymotrypsin, with a crude pancreatic extract and with acid under conditions in which the di- sulphide bonds were stable.2. Cystine-containing peptides in the hydroly- sates were separated and their structure determined after oxidation to cysteic acid peptides.Paper ionophoresis at high potential gradients in pyridine- acetic acid buffers was found useful for the separa- tions.3. From the structure of the cystine peptides the distribution of the disulphide bonds of insulin was deduced and is shown in Table 10.A. P.R.
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Citations
Cites
The disulphide bonds of insulin
Ryle, A. P., Sanger, F., Smith, L. F., & Kitai, R. (1955) · Biochemical Journal · doi:10.1042/bj0600541 · Cited by 927
Self-citationSanger, F., & Tuppy, H. (1951) · Biochemical Journal · doi:10.1042/bj0490463 · Cited by 784
Self-citationSanger, F., & Thompson, E. O. P. (1953) · Biochemical Journal · doi:10.1042/bj0530353 · Cited by 567
Self-citation
Cited by
Porcine Proinsulin: Characterization and Amino Acid Sequence
Chance, R. E., Ellis, R. M., & Bromer, W. W. (1968) · Science · doi:10.1126/science.161.3837.165 · Cited by 320
Sanger, F. (1959) · Science · doi:10.1126/science.129.3359.1340 · Cited by 255
Self-citationZinc, pancreatic islet cell function and diabetes: new insights into an old story
Chimienti, F. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422412000212 · Cited by 125
Metadata
- Authors
- Brown, H., Sanger, F., & Kitai, R.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1955-08-01
- Volume
- 60
- Issue
- 4
- Pages
- 556-565
- ISSN
- 0306-3283 (ISSN-L)
- OpenAlex
- W1875728332
- Cited by
- 258
- References
- 3
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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