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Enzymic determination of d(−)-β-hydroxybutyric acid and acetoacetic acid in blood
Open accessAbstract
The current methods for the estimation of f,hydroxybutyrate (e.g.Greenberg & Lester, 1944; Thin & Robertson, 1952; Bloom, 1958; Bessman & Anderson, 1957) all involve its oxidation to acetone and the estimation of the latter.These methods are laborious and have several unsatisfactory features.They are unspecific in that other compounds also yield acetone on oxidation and they do not differ- entiate between the optical isomers.Moreover, the conversion of f-hydroxybutyrate into acetone is not quantitative and the yield varies with the con- ditions.The method described in this paper is in principle more specific and more rapid than the older procedures.It is analogous to the enzymic determination of many other metabolites.It depends on the spectrophotometric measurement of
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Citations
Cited by
Williamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871
Self-citationBrain Metabolism during Fasting*
Owen, O. E., Morgan, A. P., Kemp, H. G., Sullivan, J. M., Herrera, M. G., & Cahill, G. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105650 · Cited by 1,646
Salomon, F., Cuneo, R. C., Hesp, R., & Sönksen, P. H. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912283212605 · Cited by 1,326
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
Lloyd, B., Burrin, J., Smythe, P., & Alberti, K. G. (1978) · Clinical Chemistry · doi:10.1093/clinchem/24.10.1724 · Cited by 579
Metadata
- Authors
- WILLIAMSON, D., MELLANBY, J., & KREBS, H.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1962-01-01
- Volume
- 82
- Issue
- 1
- Pages
- 90-96
- ISSN
- 0006-2936 (ISSN-L)
- OpenAlex
- W62898540
- Cited by
- 1,397
- References
- 0
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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