Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue

Arthur, J R; Blair, H A F; Boyd, G S; Mason, J I; Suckling, K E

doi:10.1042/bj1580047

Cited by 56Steroid Chemistry and BiochemistryCholesterol and Lipid MetabolismHormonal Regulation and Hypertension

Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue

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Arthur, J R, Blair, H A F, Boyd, G S, Mason, J I, Suckling, K E·1976·Biochemical Journal

DOI 10.1042/bj1580047PMC PMC1163935

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Abstract

The rate of oxidation of cholesterol and its analogues to pregnenolone (3beta-hydroxypregn-5-en-20-one) by various mitochondrial preparations was measured. Sterols with the cholest-5-en-3beta-ol ring system and saturated side chains of different lengths were converted into pregnenolone rat rates similar to that of cholesterol. This marked lack of mitochondrial specificity towards the steroid side chains is in direct contrast with the rat liver microsomal cholesterol 7alpha-hydroxylase, which has a high specificity for the side chain. Steroids that retain the ring system, but contain hydroxyl groups at various points in the side chain, are converted into pregnenolone at rates three to eight times higher than in cholesterol. The results are discussed with reference to current ideas on the mechanism of the side-chain cleavage of cholesterol. The results are discussed with reference to current ideas on the mechanism of the side-chain cleavage of cholesterol.

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Purified CYP11A1 and/or steroidogenic mitochondria can act on a range of steroids or secosteroids other than cholesterol.
“Studies carried out over a number of years reveal that purified CYP11A1 and/or steroidogenic mitochondria that contain CYP11A1, can act on a range of steroids or secosteroids, other than cholesterol.”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [16]
Desmosterol is converted to pregnenolone by bovine, rat, and human CYP11A1 with similar catalytic efficiency to cholesterol.
“Desmosterol (5,24-cholestadien-3β-ol, see Fig. 1), which has recently come to prominence, is also converted to pregnenolone by bovine, rat, and human CYP11A1 [16,17,19], with similar catalytic efficiency to that seen for cholesterol [48].”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [16]
Purified bovine and human CYP11A1 and steroidogenic mitochondria cleave the side chains of 24-hydroxycholesterol, 25-hydroxycholesterol, and 27-hydroxycholesterol.
“These include cleaving the side chains of 24-hydroxycholesterol, 25-hydroxycholesterol, and 27-hydroxycholesterol (discussed above) [16,17,19,48].”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [16]

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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Reagents for Organic Synthesis
Maienthal, M. (1967) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/50.6.1377 · Cited by 1,488 · see citing works
The Effect of Ether Anaesthesia Stress on Cholesterol‐Side‐Chain Cleavage and Cytochrome P450 in Rat‐Adrenal Mitochondria
Simpson, E. R., Jefcoate, C. R. E., Boyd, G. S., & Brownie, A. C. (1972) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1972.tb01931.x · Cited by 159 · see citing works
The Stoichiometry of the Conversion of Cholesterol and Hydroxycholesterols to Pregnenolone (3β-Hydroxypregn-5-en-20-one) Catalysed by Adrenal Cytochrome P -450
Shikita, M., & Hall, P. F. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.4.1441 · Cited by 92 · see citing works
Radioimmunoassay of Plasma Pregnenolone
Abraham, G. E., Buster, J. E., KYLE, F. W., Corrales, P. C., & Teller, R. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-1-40 · Cited by 78 · see citing works
Partial resolution of the mixed-function oxidase involved in the cholesterol side-chain cleavage reaction in bovine adrenal mitochondria
Simpson, E. R., & Boyd, G. S. (1967) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(67)90071-x · Cited by 71 · see citing works
Studies on the Biosynthetic Conversion of Cholesterol into Pregnenolone
Luttrell, B. M., Hochberg, R. B., Dixon, W. R., McDonald, P. D., & Lieberman, S. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45581-6 · Cited by 59 · see citing works
Studies on the Biosynthetic Conversion of Cholesterol into Pregnenolone
Hochberg, R. B., McDonald, P. D., Feldman, M., & Lieberman, S. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42972-4 · Cited by 50 · see citing works
The conversion of 23,24-dinor-chol-5-en-3β-ol into steroid hormones
Tait, A. D. (1972) · Biochemical Journal · doi:10.1042/bj1280467 · Cited by 27 · see citing works
The Specificity of the Rat‐Liver Cholesterol 7α‐Hydroxylase
Brown, M. J. G., & Boyd, G. S. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03455.x · Cited by 27 · see citing works
The role of cholesterol and cytochrome P-450 in the cholesterol side chain cleavage reaction in adrenal cortex and corpora lutea
Boyd, G. S., Arthur, J. R., Beckett, G. J., Mason, J. I., & Trzeciak, W. H. (1975) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(75)90167-3 · Cited by 25 · see citing works
Cholesterol hydroxylation in the adrenal cortex and liver
Boyd, G. S., Brownie, A. C., Jefcoate, C. R. E., & Simpson, E. R. (1971) · Biochemical Journal · doi:10.1042/bj1250001p · Cited by 17 · see citing works

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Ali, S. A. M. (1968) Ph.D. Thesis, University of Edin- burgh
Arthur, J. R., Blair, H. A. F., Boyd, G. S., Hattersley, N. G. & Suckling, K. E. (1975) Biochem. Soc. Trans. 3, 963-964
Shikita, M. & Hall, P. F. (1974) Proc. Natl. Acad. Sci.
Tait, A. D. (1972) Biochem. J. 128, 467-470 Vol. 158

Sorted by citations

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Craig, I. F., Mason, J. I., Suckling, K. E., & Boyd, G. S. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90017-0 · Cited by 7 · see citing works
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Gower, D. B. (1988) · New comprehensive biochemistry · doi:10.1016/s0167-7306(08)60636-5 · Cited by 2 · see citing works
Specificity of the cholesterol side-chain cleavage enzyme system of adrenal cortex
Burstein, S., Nickolson, R. C., Byon, C. Y., Kimball, H. L., & Gut, M. (1977) · Steroids · doi:10.1016/0039-128x(77)90092-7 · Cited by 2 · see citing works
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Mosa, A. A. (2015) · Publications of the UdS (Saarland University) · doi:10.22028/d291-23081 · Cited by 1 · see citing works
Relationship between growth sites and content of steroids and sterols from Pikajar (Schizaea digitata)
Arifin, Y. F., Suhartono, E., & Hamidah, S. (2020) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/528/1/012030

Side-chain cleavage of cholesterol sulfate by ovarian mitochondria
Tuckey, R. C. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90380-4 · Cited by 31 · see citing works
Hydroxylation of steroids by microorganisms in the presence of 18O2
Hayano, M., Saito, A., Stone, D. A., & Dorfman, R. I. (1956) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(56)90024-5 · Cited by 51 · see citing works
The Cholesterol Side-Chain Cleavage Enzymes in Steroid Hormone-Producing Tissues
Sulimovici, S., & Boyd, G. S. (1970) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61127-9 · Cited by 45 · see citing works
The Effect of Inhibitors of Protein Synthesis on Cholesterol Side‐Chain Cleavage in the Mitochondria of Luteinized Rat Ovaries
Arthur, J. R., & Boyd, G. S. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03817.x · Cited by 77 · see citing works
Side-chain cleavage of 4-cholesten-3-one, 5-cholesten-3α-ol, β-sitosterol, and related steroids in endocrine tissues from rat and man
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Authors: Arthur, J. R., Blair, H. A. F., Boyd, G. S., Mason, J. I., & Suckling, K. E.
Affiliations: University of Edinburgh (GB)
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1976-07-15
Volume: 158
Issue: 1
Pages: 47-51
ISSN: 0264-6021 (ISSN-L)
DOI: 10.1042/bj1580047
PMC: PMC1163935
OpenAlex: W1947355021
Cited by: 56
References: 13
Citations by year: 2024: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
FWCI: 1.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: cholesterol oxidation, pregnenolone, mitochondrial preparation, cholesterol analogues, 7alpha-hydroxylase
MeSH terms: Adrenal Cortex, Adrenal Glands, Animals, Cattle, Cholanes, Cholesterol, Desmosterol, Male, Mitochondria, Oxidation-Reduction, Pregnenolone, Sitosterols, Swine, Testis, Rats

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Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue

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