What dictates the accumulation of desmosterol in the developing brain?

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works

CNS synaptogenesis promoted by glia-derived cholesterol

Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works

High cholesterol level is essential for myelin membrane growth

Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R.-I., Wehr, M. C., Wieland, F., Ishibashi, S., & Nave, K.-A. (2005) · Nature Neuroscience · doi:10.1038/nn1426 · Cited by 799 · see citing works

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

Lütjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Sidén, A., Diczfalusy, U., & Björkhem, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9799 · Cited by 682 · see citing works

cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

Lund, E. G., Guileyardo, J. M., & Russell, D. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7238 · Cited by 668 · see citing works

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

Spann, N. J., Garmire, L. X., McDonald, J. G., Myers, D. S., Milne, S. B., Shibata, N., Reichart, D. R., Fox, J. N., Shaked, I., Heudobler, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.054 · Cited by 605 · see citing works

Cholesterol metabolism in neurons and astrocytes

Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500 · see citing works

Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands

Yang, C., McDonald, J. G., Patel, A. C., Zhang, Y., Umetani, M., Xu, F., Westover, E. J., Covey, D. F., Mangelsdorf, D. J., Cohen, J. C., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603781200 · Cited by 309 · see citing works

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

Nieweg, K., Schaller, H., & Pfrieger, F. W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05917.x · Cited by 307 · see citing works

Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain.

Konkle, A., & McCarthy, M. (2011) · Endocrinology · doi:10.1210/en.2010-0607 · Cited by 307 · see citing works

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

Gill, S., Stevenson, J., Kristiana, I., & Brown, A. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.015 · Cited by 304 · see citing works

Cholesterol for synthesis of myelin is made locally, not imported into brain

Jurevics, H., & Morell, P. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020895.x · Cited by 302 · see citing works

The Human DIMINUTO/DWARF1 Homolog Seladin-1 Confers Resistance to Alzheimer's Disease-Associated Neurodegeneration and Oxidative Stress

Greeve, I., Hermans‐Borgmeyer, I., Brellinger, C., Kasper, D., Gómez‐Isla, T., Behl, C., Levkau, B., & Nitsch, R. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07345.2000 · Cited by 300 · see citing works

Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination

Schumacher, M., Guennoun, R., Robert, F., Carelli, C., Gago, N., Ghoumari, A. M., Deniselle, M. C. G., González, S. L., Ibanez, C., Labombarda, F., et al. (2004) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2004.03.007 · Cited by 230 · see citing works

Syndromal and nonsyndromal primary trigonocephaly: Analysis of a series of 237 patients

Lajeunie, E., Merrer, M. F. L., Marchac, D., & Rénier, D. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980113)75:2 · Cited by 191 · see citing works

ATP‐binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain

Wang, N., Yvan‐Charvet, L., Lütjohann, D., Mulder, M., Vanmierlo, T., Kim, T., & Tall, A. R. (2008) · The FASEB Journal · doi:10.1096/fj.07-9944com · Cited by 184 · see citing works

Generation of Viable Cholesterol-Free Mice

Wechsler, A. S., Brafman, A., Shafir, M., Heverin, M., Gottlieb, H., Damari, G. M., Gozlan-Kelner, S., Spivak, I., Moshkin, O., Fridman, E., et al. (2003) · Science · doi:10.1126/science.1090776 · Cited by 179 · see citing works

Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse

Quan, G., Xie, C., Dietschy, J. M., & Turley, S. D. (2003) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.09.015 · Cited by 177 · see citing works

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

Lütjohann, D., Brzezinka, A., Barth, E., Abramowski, D., Staufenbiel, M., von Bergmann, K., Beyreuther, K., Multhaup, G., & Bayer, T. A. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200071-jlr200 · Cited by 158 · see citing works

Cholesterol Precursors Stabilize Ordinary and Ceramide-rich Ordered Lipid Domains (Lipid Rafts) to Different Degrees

Megha, M., Bakht, O., & London, E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600395200 · Cited by 145 · see citing works

Studies on the Transcriptional Regulation of Cholesterol 24-Hydroxylase (CYP46A1)

Ohyama, Y., Meaney, S., Heverin, M., Ekström, L., Brafman, A., Shafir, M., Andersson, U., Olin, M., Eggertsen, G., Diczfalusy, U., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505179200 · Cited by 142 · see citing works

Significance of Sterol Structural Specificity

Vainio, S., Jansen, M., Koivusalo, M., Róg, T., Karttunen, M., Vattulainen, I., & Ikonen, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509530200 · Cited by 137 · see citing works

Expression of liver X receptor β is essential for formation of superficial cortical layers and migration of later-born neurons

Fan, X., Kim, H.-J., Bouton, D., Warner, M., & Gustafsson, J.-Å. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806974105 · Cited by 103 · see citing works

Seladin-1 transcription is linked to neuronal degeneration in Alzheimer’s disease

Iivonen, S., Hiltunen, M., Alafuzoff, I. I., Mannermaa, A., Kerokoski, P., Puoliväli, J. T., Salminen, A., Helisalmi, S., & Soininen, H. S. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00180-x · Cited by 96 · see citing works

The sterol substrate specificity of acyl CoA: :cholesterol acyltransferase from rat liver.

Tavani, D. M., Nes, W. R., & Billheimer, J. T. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38112-8 · Cited by 92 · see citing works

The identification and significance of desmosterol in the developing human and animal brain

Fumagalli, R., & Paoletti, R. (1963) · Life Sciences · doi:10.1016/0024-3205(63)90159-0 · Cited by 90 · see citing works

Progesterone is neuroprotective following cerebral ischaemia in reproductively ageing female mice

Gibson, C. L., Coomber, B., & Murphy, S. P. (2011) · Brain · doi:10.1093/brain/awr132 · Cited by 82 · see citing works

Occurrence of desmosterol in developing rat brain

Kritchevsky, D., & Holmes, W. L. (1962) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(62)90160-2 · Cited by 69 · see citing works

Oxidation of cholesterol and cholesterol analogues by mitochondrial preparations of steroid-hormone-producing tissue

Arthur, J. R., Blair, H. A. F., Boyd, G. S., Mason, J. I., & Suckling, K. E. (1976) · Biochemical Journal · doi:10.1042/bj1580047 · Cited by 56 · see citing works

Secretion of Sterols and the NPC2 Protein from Primary Astrocytes

Mutka, A.-L., Lusa, S., Linder, M. D., Jokitalo, E., Kopra, O., Jauhiainen, M., & Ikonen, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405345200 · Cited by 56 · see citing works

Developmental expression of genes involved in neurosteroidogenesis: 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase in the rat brain

Ibanez, C., Guennoun, R., Liere, P., Eychenne, B., Pianos, A., El-Etr, M., Baulieu, E.-E., & Schumacher, M. (2003) · Endocrinology · doi:10.1210/en.2002-0073 · Cited by 56 · see citing works

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)

Zerenturk, E. J., Kristiana, I., Gill, S., & Brown, A. J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.11.009 · Cited by 55 · see citing works

Direct Regulation of Pitx3 Expression by Nurr1 in Culture and in Developing Mouse Midbrain

Volpicelli, F., Gregorio, R. D., Pulcrano, S., Perrone‐Capano, C., di Porzio, U., & Bellenchi, G. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030661 · Cited by 52 · see citing works

Progestins block cholesterol synthesis to produce meiosis‐activating sterols

Lindenthal, B., Holleran, A. L., Aldaghlas, T., Ruan, B. H., Schroepfer, G. J., Wilson, W. K., & Kelleher, J. K. (2001) · The FASEB Journal · doi:10.1096/fj.00-0214com · Cited by 50 · see citing works

Studies on the Cholesterol-Free Mouse

Heverin, M., Meaney, S., Brafman, A., Shafir, M., Olin, M., Shafaati, M., von Bahr, S., Larsson, L., Lövgren‐Sandblom, A., Diczfalusy, U., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.149823 · Cited by 47 · see citing works

Cholesterol Substitution Increases the Structural Heterogeneity of Caveolae

Jansen, M., Pietiäinen, V. M., Pölönen, H., Rasilainen, L., Koivusalo, M., Ruotsalainen, U., Jokitalo, E., & Ikonen, E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710355200 · Cited by 45 · see citing works

THE DESMOSTEROL REDUCTASE ACTIVITY OF RAT BRAIN DURING DEVELOPMENT1

Hinse, C. H., & Shah, S. (1971) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1971.tb09604.x · Cited by 45 · see citing works

Regulation of sterol biosynthesis and of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in cultured cells by progesterone.

Panini, S. R., Gupta, A., Sexton, R. C., Parish, E. J., & Rudney, H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47813-1 · Cited by 42 · see citing works

Metabolism of cholesterol in the tissues and blood of the chick embryo

Connor, W. E., Johnston, R., & Lin, D. S. (1969) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43065-2 · Cited by 39 · see citing works

Silver ion high pressure liquid chromatography provides unprecedented separation of sterols: application to the enzymatic formation of cholesta-5,8-dien-3 beta-ol.

Ruan, B. H., Shey, J., Gerst, N., Wilson, W. K., & Schroepfer, G. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11603 · Cited by 31 · see citing works

Is Seladin-1 Really a Selective Alzheimer's Disease Indicator?

Sharpe, L. J., Wong, J., Garner, B., Halliday, G. M., & Brown, A. J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111955 · Cited by 24 · see citing works

Desmosterol levels in human foetal brain—a reassessment

Dennick, R. G., DEAN, P. D. G., & Abramovich, D. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb00102.x · Cited by 10 · see citing works

Liver X Receptor Modulation of Gene Expression Leading to Proluteolytic Effects in Primate Luteal Cells1

Bogan, R. L., DeBarber, A. E., & Hennebold, J. D. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.111.096347 · Cited by 10 · see citing works

Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)

Sharpe, L. J., & Brown, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.479808 · Cited by 382 · see citing works

Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis

Zerenturk, E. J., Sharpe, L. J., Ikonen, E., & Brown, A. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.09.002 · Cited by 152 · see citing works

Oxysterols: From physiological tuners to pharmacological opportunities

Brown, A. J., Sharpe, L. J., & Rogers, M. J. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15073 · Cited by 93 · see citing works

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally

Luu, W., Hart‐Smith, G., Sharpe, L. J., & Brown, A. J. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m056986 · Cited by 93 · see citing works

Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?

Mouzat, K., Chudinova, A., Polge, A. S., Kantar, J., Camu, W., Raoul, C., & Lumbroso, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163858 · Cited by 83 · see citing works

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis

Luu, W., Zerenturk, E. J., Kristiana, I., Bucknall, M. P., Sharpe, L. J., & Brown, A. J. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m043257 · Cited by 76 · see citing works

Post-translational control of the long and winding road to cholesterol.

Sharpe, L. J., Coates, H., & Brown, A. J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.010723 · Cited by 46 · see citing works

Current trends in oxysterol research

Griffiths, W. J., Abdel‐Khalik, J., Hearn, T., Yutuc, E., Morgan, A. H., & Wang, Y. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150255 · Cited by 53 · see citing works

Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active Compounds in Neuro2a Cells

Kim, H.-Y. H., Korade, Z., Tallman, K. A., Liu, W., Weaver, C. D., Mirnics, K., & Porter, N. A. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00054 · Cited by 53 · see citing works

Exposure to intrauterine inflammation alters metabolomic profiles in the amniotic fluid, fetal and neonatal brain in the mouse

Brown, A. G., Tulina, N. M., Barila, G., Hester, M. S., & Elovitz, M. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186656 · Cited by 41 · see citing works

Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development

Cunningham, D., DeBarber, A. E., Bir, N., Binkley, L., Merkens, L. S., Steiner, R. D., & Herman, G. E. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv042 · Cited by 38 · see citing works

Cholesterol in Brain Development and Perinatal Brain Injury: More than a Building Block

Lu, F., Ferriero, D. M., & Jiang, X. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666211111122311 · Cited by 37 · see citing works

Plant sterols, cholesterol precursors and oxysterols: Minute concentrations—Major physiological effects

Olkkonen, V. M., Gylling, H., & Ikonen, E. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.12.026 · Cited by 35 · see citing works

Balancing cholesterol in the brain: from synthesis to disposal

Qian, L., Chai, A. B., Gelissen, I. C., & Brown, A. J. (2022) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2022.00015 · Cited by 36 · see citing works

Desmosterolosis and desmosterol homeostasis in the developing mouse brain

Allen, L. B., Genaro‐Mattos, T. C., Porter, N. A., Mirnics, K., & Korade, Z. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12088 · Cited by 31 · see citing works

Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases

Zhan, N., Wang, B., Martens, N., Liu, Y., Zhao, S., Voortman, G. J., van Rooij, J., Leijten, F. P. J., Vanmierlo, T., Kuipers, F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021290 · Cited by 22 · see citing works

Intrauterine inflammation reduces postnatal neurogenesis in the hippocampal subgranular zone and leads to accumulation of hilar ectopic granule cells

Hester, M. S., Tulina, N. M., Brown, A. G., Barila, G., & Elovitz, M. A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.005 · Cited by 18 · see citing works

DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review

Fu, X., & Wang, Z. (2024) · Technology in Cancer Research & Treatment · doi:10.1177/15330338241259780 · Cited by 18 · see citing works

Estimating fetal cholesterol synthesis rates by cord blood analysis in intrauterine growth restriction and normally grown fetuses

Pecks, U., Bornemann, V., Klein, A., Segger, L., Maass, N., Alkatout, İ., Eckmann-Scholz, C., Elessawy, M., & Lütjohann, D. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1117-1 · Cited by 15 · see citing works

The Mevalonate Pathway in Alzheimer’s Disease — Cholesterol and Non-Sterol Isoprenoids

Mohamed, A., Smith, K. T., & Chaves, E. (2015) · InTech eBooks · doi:10.5772/59904 · Cited by 14 · see citing works

Effect of gestational diabetes mellitus on newborn cholesterol metabolism

Miettinen, H. E., Rönö, K., Koivusalo, S. B., Eriksson, J. G., & Gylling, H. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.06.879 · Cited by 12 · see citing works

Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats

Smiljanić, K., Vanmierlo, T., Mladenović, A., Perović, M., Ivković, S., Lütjohann, D., & Kanazir, S. (2014) · AGE · doi:10.1007/s11357-014-9654-z · Cited by 12 · see citing works

Regulation of ABCG4 transporter expression by sterols and LXR ligands

Yang, A., Alrosan, A. Z., Sharpe, L. J., Brown, A. J., Callaghan, R., & Gelissen, I. C. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129769 · Cited by 12 · see citing works

Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging

Smiljanić, K., Todorovic, S. T., Mladenović, A., Vanmierlo, T., Lütjohann, D., Ivković, S., & Kanazir, S. (2018) · Biogerontology · doi:10.1007/s10522-018-9743-y · Cited by 11 · see citing works

Cholesterol metabolism: Towards a therapeutic approach for multiple sclerosis

Gao, Y., & Li, X. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105501 · Cited by 9 · see citing works

High fat diet induces brain injury and neuronal apoptosis via down-regulating 3-β hydroxycholesterol 24 reductase (DHCR24)

Lu, Z., Wang, H., Zhang, X., Huang, X., Jiang, S., Li, Y., Liu, T., Lu, X., & Gao, B. (2023) · Cell and Tissue Research · doi:10.1007/s00441-023-03804-3 · Cited by 9 · see citing works

Cholesterol metabolism and brain injury in neonatal encephalopathy

Dave, A. M., & Peeples, E. S. (2020) · Pediatric Research · doi:10.1038/s41390-020-01218-3 · Cited by 9 · see citing works

An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis

Talvio, K., Wagner, V. A., Minkeviciene, R., Kirkwood, J. S., Kulinich, A. O., Umemori, J., Bhatia, A., Hur, M., Käkelä, R., Ethell, I. M., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05147-9 · Cited by 8 · see citing works

Desmosterol Incorporation Into Ram Sperm Membrane Before Cryopreservation Improves in vitro and in vivo Fertility

Carro, M. D. L. M., Ramírez-Vasquez, R. R. A., Peñalva, D. A., Buschiazzo, J., & Hozbor, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.660165 · Cited by 7 · see citing works

Analysis of Photosynthetic Characteristics and UV-B Absorbing Compounds in Mung Bean Using UV-B and Red LED Radiation

Li, F.-M., Lü, Z., & Yue, M. (2014) · Journal of Analytical Methods in Chemistry · doi:10.1155/2014/378242 · Cited by 7 · see citing works

Desmosterol in Brain Is Elevated because DHCR24 Needs REST for Robust Expression but REST Is Poorly Expressed

Tint, G. S., Pan, L., Shang, Q., Sharpe, L. J., Brown, A. J., Li, M., & Yu, H. (2014) · Developmental Neuroscience · doi:10.1159/000362363 · Cited by 6 · see citing works

Navigating the Shallows and Rapids of Cholesterol Synthesis Downstream of HMGCR

Sharpe, L. J., Howe, V., Prabhu, A. V., Luu, W., & Brown, A. J. (2015) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.61.s154 · Cited by 5 · see citing works

Recent Progress in the Identification of Non-Invasive Biomarkers to Support the Diagnosis of Alzheimer’s Disease in Clinical Practice and to Assist Human Clinical Trials

Bernier, F., Kumar, P., Sato, Y., & Oda, Y. (2015) · InTech eBooks · doi:10.5772/60008 · Cited by 4 · see citing works

The metabolic changes in the hippocampus of an atherosclerotic rat model and the regulation of aerobic training

Liu, B., Li, J., Lin, X., Hu, J., & Lou, S. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00566-7 · Cited by 4 · see citing works

Novel metabolic biomarkers for the diagnosis of acute ischemic stroke

Tang, Z., Xu, B., Wang, J., Wang, W., Sha, S., & Sun, Y. (2024) · Biomarkers in Medicine · doi:10.1080/17520363.2024.2389033 · Cited by 3 · see citing works

Dysregulation of Brain Cholesterol Biosynthetic Pathway following Hypoxia Ischemia in Neonatal Mice

Lu, F., Yen, C., Corley, C. D., McDonald, J. G., Manninen, T., Stewart, N. R., Zhu, C. M., Ferriero, D. M., & Jiang, X. (2024) · Developmental Neuroscience · doi:10.1159/000543254 · Cited by 3 · see citing works

Proteomic analysis discovers potential biomarkers of early traumatic axonal injury in the brainstem

Chen, Q., Li, L., Xu, L., Yang, B., Huang, Y., Qiao, D., & Yue, X. (2023) · International Journal of Legal Medicine · doi:10.1007/s00414-023-03039-5 · Cited by 3 · see citing works

A revised Oxysterol Hypothesis highlighting the special roles played by 24(S),25-Epoxycholesterol

Fenton, N., Sharpe, L. J., & Brown, A. J. (2025) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2025.100578 · Cited by 2 · see citing works

Cholesterol and related sterols differentially modulate lipid domain dynamics in model membranes: A dual-probe analysis of domain-specific effects

Ayala‐Sanmartín, J., & Lamazière, A. (2025) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2025.105550 · Cited by 1 · see citing works

Dysregulated lipid metabolism and hypomyelination in postnatal peroxisome-deficient Pex2 knockout Zellweger mice

Eberhart, T., Charles, K. N., Salumbides-Torres, B., Price, N., Fliesler, S. J., Faust, P. L., & Kovacs, W. J. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1636268 · Cited by 1 · see citing works

Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases

Kiriyama, Y., Nakatsuma, A., Tokumaru, H., Sadamoto, H., & Nochi, H. (2026) · Metabolites · doi:10.3390/metabo16030189

Combination of ALK2 and cholesterol targeting agents exploits linked genetic and metabolic dependencies in diffuse midline gliomaPreprint

Rogers, R., Mackay, A. G., Grabovska, Y., Carvalho, D., Dobinson, C., Burford, A., Molinari, V., Pereira, R., Bevington, L., Ruddle, R., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.23.753440

Studies on brain sterols in normal and pathological conditions

Paoletti, R., Fumagalli, R., Grossi, E., & Paoletti, P. (1965) · Journal of the American Oil Chemists' Society · doi:10.1007/bf02635575 · Cited by 48 · see citing works

Desmosterolosis and desmosterol homeostasis in the developing mouse brain

Allen, L. B., Genaro‐Mattos, T. C., Porter, N. A., Mirnics, K., & Korade, Z. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12088 · Cited by 31 · see citing works

Desmosterol in developing rat brain

Kritchevsky, D., Tepper, S. A., DiTullio, N. W., & Holmes, W. L. (1965) · Journal of the American Oil Chemists Society · doi:10.1007/bf02636896 · Cited by 35 · see citing works

Brain and Myelin Sterols Studied Using Specific Inhibitors of Sterol Synthesis

Fumagalli, R. (1971) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-7236-3_5 · Cited by 1 · see citing works

Desmosterol levels in human foetal brain—a reassessment

Dennick, R. G., DEAN, P. D. G., & Abramovich, D. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb00102.x · Cited by 10 · see citing works