The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways
Open accessAbstract
Human cartilage glycoprotein 39 (HC-gp39) is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Increased levels of HC-gp39 have been demonstrated in synovial fluids of patients with rheumatoid or osteoarthritis. The increased secretion of HC-gp39 under physiological and pathological conditions with elevated connective-tissue turnover suggests its involvement in the homoeostasis of these tissues. We report here that HC-gp39 promotes the growth of human synovial cells as well as skin and fetal lung fibroblasts. A dose-dependent growth stimulation was observed when each of the fibroblastic cell lines was exposed to HC-gp39 in a concentration range from 0.1 to 2nM, which is similar to the effective dose of the well-characterized mitogen, insulin-like growth factor-1. At suboptimal concentrations, the two growth factors work in a synergistic fashion. The use of selective inhibitors of the mitogen-activated protein kinase and the protein kinase B (AKT) signalling pathways indicates that both are involved in mediating the mitogenic response to HC-gp39. Phosphorylation of both extracellular signal-regulated kinases 1/2 and AKT occurred in a dose- and time-dependent fashion upon addition of HC-gp39. Activation of these signalling pathways could also be demonstrated in human chondrocytes. Thus HC-gp39 initiates a signalling cascade in connective-tissue cells which leads to increased cell proliferation, suggesting that this protein could play a major role in the pathological conditions leading to tissue fibrosis.
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Chitinase-3 like-protein-1 function and its role in diseases
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YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease
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Metadata
- Authors
- RECKLIES, A. D., WHITE, C., & LING, H.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2002-07-01
- Volume
- 365
- Issue
- 1
- Pages
- 119-126
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2058774374
- Cited by
- 388
- References
- 43
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- RECKLIES, A. D., WHITE, C., & LING, H. (2002). The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways. Biochemical Journal. https://doi.org/10.1042/bj20020075
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