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Cited by 423

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

Open access
SCHOMBURG, Lutz, SCHWEIZER, Ulrich, HOLTMANN, Bettina, FLOHÉ, Leopold, SENDTNER, Michael, KÖHRLE, Josef·2003·Biochemical Journal
DOI 10.1042/bj20021853
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Abstract

Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.

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Crossref · 10.1042/bj20021853

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Metadata

Authors
SCHOMBURG, L., SCHWEIZER, U., HOLTMANN, B., FLOHÉ, L., SENDTNER, M., & KÖHRLE, J.
Venue
Biochemical Journal
Publisher
Portland Press Ltd.
Published
2003-03-01
Volume
370
Issue
2
Pages
397-402
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
DOI
10.1042/bj20021853
OpenAlex
W2088145955
Cited by
423
References
1
FWCI
16.84
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. https://app.cochat.ai/papers/10.1042/bj20021853
The paper
SCHOMBURG, L., SCHWEIZER, U., HOLTMANN, B., FLOHÉ, L., SENDTNER, M., & KÖHRLE, J. (2003). Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochemical Journal. https://doi.org/10.1042/bj20021853

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.