The Stat family in cytokine signaling
Abstract
During the past few years studies from several laboratories have utilized gene disruption approaches to define the function of members of the Stat family of transcription factors. The results have demonstrated that each family member has unique, critical, non-redundant functions in signal transduction through members of the cytokine receptor superfamily. Many of the family members mediate functions associated with innate or acquired immunity. With the availability of mice deficient in one or more of the Stats, critical experiments are possible to evaluate the roles of Stat signal transduction pathways in cellular transformation as well as evaluating their specific roles in a range of cellular responses to cytokines.
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The differences in phosphorylation of STAT1 and STAT3 by IFNγ and IL-6 are consistent with the role of STAT1 as an important mediator of the response to IFNγ and the role of STAT3 as an important mediator of the response to IL-6.
“These differences in the phosphorylation of STAT1 and STAT3 by IFN␥ and IL-6 are consistent with the role of STAT1 as an important mediator of the response to IFN␥ and the role of STAT3 as an important mediator of the response to IL-6 (21).”
From The Comparative Roles of Suppressor of Cytokine Signaling-1 and -3 in the Inhibition and Desensitization of Cytokine Signaling (2006) · cites this paper as [21]
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Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
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- Authors
- Ihle, J. N.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Ihle, James N
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 13
- Issue
- 2
- Pages
- 211-217
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W1969218281
- Cited by
- 713
- References
- 2
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 16 · 2023: 16 · 2022: 15 · 2021: 15 · 2020: 24 · 2019: 14 · 2018: 18 · 2017: 22 · 2016: 21 · 2015: 18 · 2014: 32 · 2013: 41 · 2012: 26
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- STAT family, signal transducer and activator of transcription, cytokine signaling, cytokine receptor superfamily, gene disruption, innate immunity, adaptive immunity, cell transformation, transcription factors, signal transduction
- MeSH terms
- Animals, DNA-Binding Proteins, Humans, Milk Proteins, Signal Transduction, Trans-Activators, Receptors, Cytokine, STAT1 Transcription Factor, STAT2 Transcription Factor, STAT3 Transcription Factor, STAT4 Transcription Factor, STAT5 Transcription Factor, STAT6 Transcription Factor
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