Subcellular targeting and trafficking of nitric oxide synthases
Open accessAbstract
Unlike most other endogenous messengers that are deposited in vesicles, processed on demand and/or secreted in a regulated fashion, NO (nitric oxide) is a highly active molecule that readily diffuses through cell membranes and thus cannot be stored inside the producing cell. Rather, its signalling capacity must be controlled at the levels of biosynthesis and local availability. The importance of temporal and spatial control of NO production is highlighted by the finding that differential localization of NO synthases in cardiomyocytes translates into distinct effects of NO in the heart. Thus NO synthases belong to the most tightly controlled enzymes, being regulated at transcriptional and translational levels, through co- and post-translational modifications, by substrate availability and not least via specific sorting to subcellular compartments, where they are in close proximity to their target proteins. Considerable efforts have been made to elucidate the molecular mechanisms that underlie the intracellular targeting and trafficking of NO synthases, to ultimately understand the cellular pathways controlling the formation and function of this powerful signalling molecule. In the present review, we discuss the mechanisms and triggers for subcellular routing and dynamic redistribution of NO synthases and the ensuing consequences for NO production and action.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
eNOS location in the cell and activity are controlled by Ca2+ and calmodulin.
“Its location in the cell and activity are controlled by Ca2+ and calmodulin, as well as post-translational modifications such as phosphorylation and myristoylation (29, 30).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [29]
eNOS location and activity are controlled by post-translational modifications such as phosphorylation and myristoylation.
“Its location in the cell and activity are controlled by Ca2+ and calmodulin, as well as post-translational modifications such as phosphorylation and myristoylation (29, 30).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [29]
The iNOS and nNOS isoforms are soluble and predominantly found in the cytosol, while eNOS is membrane-associated.
“The iNOS and nNOS isoforms are soluble and predominantly they are found in the cytosol, while eNOS is membrane-associated [108].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [108]
NOS3 produces relatively low quantities of NO, and its activity is controlled by calcium/calmodulin, post-translational modifications, and physical forces such as shear stress.
“It produces relatively low quantities of NO, and its activity is controlled by Ca2+ and calmodulin, post-translational modifications [72, 73], and physical forces such as shear stress [74, 75].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [72]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154 · see citing works
Nitric oxide synthases: structure, function and inhibition
ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110 · see citing works
Nitric oxide synthases: structure, function and inhibition
ALDERTON, W. K., Cooper, C. E., & Knowles, R. G. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570593 · Cited by 4,106 · see citing works
Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95
Kornau, H., Schenker, L. T., Kennedy, M. B., & Seeburg, P. H. (1995) · Science · doi:10.1126/science.7569905 · Cited by 1,882 · see citing works
PDZ domain proteins of synapses
Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,566 · see citing works
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Dráb, M., Verkade, P., Elger, M., Kasper, M. E., Löhn, M., Lauterbach, B., Menne, J., Lindschau, C., Mende, F., Luft, F. C., et al. (2001) · Science · doi:10.1126/science.1062688 · Cited by 1,555 · see citing works
Resh, M. D. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00075-0 · Cited by 1,247 · see citing works
Brenman, J. E., Chao, D. S., Xia, H., Aldape, K. D., & Bredt, D. S. (1995) · Cell · doi:10.1016/0092-8674(95)90471-9 · Cited by 953 · see citing works
An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms
Rocks, O., Peyker, A., Kahms, M., Verveer, P., Koerner, C., Lumbierres, M., Kuhlmann, J., Waldmann, H., Wittinghofer, A., & Bastiaens, P. (2005) · Science · doi:10.1126/science.1105654 · Cited by 866 · see citing works
Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein
Sattler, R., Xiong, Z., Lu, W.-Y., Hafner, M., MacDonald, J. F., & Tymianski, M. (1999) · Science · doi:10.1126/science.284.5421.1845 · Cited by 835 · see citing works
Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin
Garcı́a-Cardeña, G., Martasek, P., Masters, B. S. S., Skidd, P. M., Couet, J., Li, S., Lisanti, M. P., & Sessa, W. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25437 · Cited by 821 · see citing works
Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae
Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I. S., Ying, Y., Anderson, R. G. W., & Michel, T. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6518 · Cited by 800 · see citing works
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
Barouch, L. A., Harrison, R. W., Skaf, M. W., Rosas, G. O., Cappola, T. P., Kobeissi, Z. A., Hobai, I. A., Lemmon, C. A., Burnett, A. L. “., O'Rourke, B. P., et al. (2002) · Nature · doi:10.1038/416337a · Cited by 760 · see citing works
García‐Cardeña, G., Oh, P., Liu, J., Schnitzer, J. E., & Sessa, W. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6448 · Cited by 679 · see citing works
Endothelial Nitric Oxide Synthase Targeting to Caveolae
Féron, O., Belhassen, L., Kobzik, L., Smith, T. W., Kelly, R. A., & Michel, T. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22810 · Cited by 670 · see citing works
Palmitoylation of Intracellular Signaling Proteins: Regulation and Function
Smotrys, J. E., & Linder, M. E. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073954 · Cited by 611 · see citing works
Reczek, D., Berryman, M. A., & Bretscher, A. P. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.1.169 · Cited by 571 · see citing works
Sessa, W. C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01165 · Cited by 561 · see citing works
The Biology and Enzymology of ProteinN-Myristoylation
Farazi, T. A., Waksman, G., & Gordon, J. I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100042200 · Cited by 556 · see citing works
Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of nNOS-Syntrophin Complex
Hillier, B. J., Christopherson, K. S., Prehoda, K. E., Bredt, D. S., & Lim, W. A. (1999) · Science · doi:10.1126/science.284.5415.812 · Cited by 549 · see citing works
Regulation of Endothelial Nitric Oxide Synthase: Location, Location, Location
Shaul, P. W. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.155952 · Cited by 541 · see citing works
Christopherson, K. S., Hillier, B. J., Lim, W. A., & Bredt, D. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27467 · Cited by 536 · see citing works
García‐Cardeña, G., Fan, R., Stern, D. F., Liu, J., & Sessa, W. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27237 · Cited by 533 · see citing works
Rybin, V. O., Xu, X., Lisanti, M. P., & Steinberg, S. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006951200 · Cited by 518 · see citing works
Fulton, D. J., Gratton, J., & Sessa, W. C. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29198-9 · Cited by 495 · see citing works
Self-citationMolecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation
Choi, Y., Tenneti, L., Le, D. A., Ortiz, J., Bai, G., Chen, H.-S. V., & Lipton, S. A. (2000) · Nature Neuroscience · doi:10.1038/71090 · Cited by 426 · see citing works
McCabe, T. J., Fulton, D., Roman, L. J., & Sessa, W. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6123 · Cited by 387 · see citing works
Self-citationEffect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans
Chen, Z.-P., Stephens, T. J., Murthy, S., Canny, B. J., Hargreaves, M., Witters, L. A., Kemp, B. E., & McConell, G. K. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2205 · Cited by 369 · see citing works
Blair, A., Shaul, P. W., Yuhanna, I. S., Conrad, P. A., & Smart, E. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32512 · Cited by 360 · see citing works
Fontana, J. T., Fulton, D. J., Chen, Y., Fairchild, T. A., McCabe, T. J. D., Fujita, N., Tsuruo, T., & Sessa, W. C. (2002) · Circulation Research · doi:10.1161/01.res.0000016837.26733.be · Cited by 340 · see citing works
Self-citationMartı́nez-Ruiz, A., Villanueva, L., de Orduña, C. G., López‐Ferrer, D., Higueras, M. Á., Tarín, C., Rodríguez‐Crespo, I., Vázquez, J., & Lamas, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407294102 · Cited by 330 · see citing works
A molecular basis for nitric oxide sensing by soluble guanylate cyclase
Zhao, Y., Brandish, P. E., Ballou, D. P., & Marletta, M. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14753 · Cited by 323 · see citing works
Fang, M., Jaffrey, S. R., Sawa, A., Ye, K., Luo, X., & Snyder, S. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)00095-7 · Cited by 316 · see citing works
Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO
Sun, J., Xin, C., Eu, J. P., Stamler, J. S., & Meissner, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201289098 · Cited by 306 · see citing works
Féron, O., Smith, T. W., Michel, T. M., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17744 · Cited by 282 · see citing works
Sessa, W. C., Garca-Cardea, G., Liu, J., Keh, A., Pollock, J. S., Bradley, J. R., Thiru, S., Braverman, I. M., & Desai, K. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.17641 · Cited by 258 · see citing works
Liu, J., García‐Cardeña, G., & Sessa, W. C. (1996) · Biochemistry · doi:10.1021/bi961720e · Cited by 250 · see citing works
Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase
Goetz, R. M., Thatte, H. S., Prabhakar, P., Cho, M., Michel, T. M., & Golan, D. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2788 · Cited by 234 · see citing works
Distinction between signaling mechanisms in lipid rafts vs. caveolae
Sowa, G., Pypaert, M., & Sessa, W. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241409998 · Cited by 233 · see citing works
The complex of Arl2‐GTP and PDEδ: from structure to function
Hanzal‐Bayer, M., Renault, L., Roversi, P., Wittinghofer, A., & Hillig, R. C. (2002) · The EMBO Journal · doi:10.1093/emboj/21.9.2095 · Cited by 222 · see citing works
Fulton, D. J., Fontana, J. T., Sowa, G., Gratton, J., Lin, M. I., Li, K.-X., Michell, B. J., Kemp, B. E., Rodman, D. M., & Sessa, W. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106302200 · Cited by 217 · see citing works
Self-citationErwin, P. A., Lin, A. J., Golan, D. E., & Michel, T. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413058200 · Cited by 215 · see citing works
Brouet, A., Sonveaux, P., Dessy, C., Balligand, J., & Féron, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101371200 · Cited by 213 · see citing works
Michell, B. J., Harris, M. B., Chen, Z.-P., Ju, H., Venema, V. J., Blackstone, M. A., Huang, W., Venema, R. C., & Kemp, B. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205144200 · Cited by 212 · see citing works
Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−
Kim, W.-K., Choi, Y., Posina, V. R., Das, P., Asaad, W. F., Arnelle, D. R., Stamler, J. S., & Lipton, S. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80859-4 · Cited by 206 · see citing works
Synergistic Activation of Endothelial Nitric-oxide Synthase (eNOS) by HSP90 and Akt
Takahashi, S., & Mendelsohn, M. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304471200 · Cited by 202 · see citing works
Zimmermann, K., Opitz, N., Dedio, J., Renné, C., Müller‐Esterl, W., & Oess, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252345399 · Cited by 192 · see citing works
Self-citationNOSIP, a novel modulator of endothelial nitric oxide synthase activity
Dedio, J., KÖNIG, P., Wohlfart, P., Schroeder, C., Kummer, W., & Müller‐Esterl, W. (2001) · The FASEB Journal · doi:10.1096/fj.00-0078com · Cited by 191 · see citing works
Self-citationLiu, J., Hughes, T. E., & Sessa, W. C. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.7.1525 · Cited by 191 · see citing works
Modulation of the Endothelial Nitric-oxide Synthase-Caveolin Interaction in Cardiac Myocytes
Féron, O., Dessy, C., Opel, D. J., Arstall, M. A., Kelly, R. A., & Michel, T. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30249 · Cited by 187 · see citing works
Kameya, S., Miyagoe, Y., Nonaka, I., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2193 · Cited by 183 · see citing works
Domains of high Ca2+ beneath the plasma membrane of living A7r5 cells
Marsault, R., Murgia, M., Pozzan, T., & Rizzuto, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1575 · Cited by 180 · see citing works
Yeh, D. C., Duncan, J. A., Yamashita, S., & Michel, T. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33148 · Cited by 178 · see citing works
Nitric oxide regulates endocytosis by S -nitrosylation of dynamin
Wang, G., Moniri, N. H., Ozawa, K., Stamler, J. S., & Daaka, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508354103 · Cited by 175 · see citing works
Sustained Endothelial Nitric-oxide Synthase Activation Requires Capacitative Ca2+ Entry
Lin, S., Fagan, K. A., Li, K.-X., Shaul, P. W., Cooper, D. M. F., & Rodman, D. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.24.17979 · Cited by 171 · see citing works
Sessa, W. C., Barber, C. M., & Lynch, K. R. (1993) · Circulation Research · doi:10.1161/01.res.72.4.921 · Cited by 166 · see citing works
The plasmamembrane calmodulin–dependent calcium pump
Schuh, K., Uldrijan, S., Telkamp, M., Röthlein, N., & Neyses, L. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200104131 · Cited by 158 · see citing works
Receptor-regulated Translocation of Endothelial Nitric-oxide Synthase
Prabhakar, P., Thatte, H. S., Goetz, R. M., Cho, M., Golan, D. E., & Michel, T. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27383 · Cited by 156 · see citing works
Cao, J., Viholainen, J. I., Dart, C., Warwick, H. K., Leyland, M. L., & Courtney, M. J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407024 · Cited by 147 · see citing works
Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity
Predescu, D. N., Predescu, S. A., Shimizu, J., Miyawaki-Shimizu, K., & Malik, A. B. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00175.2004 · Cited by 143 · see citing works
Robinson, L. J., & Michel, T. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11776 · Cited by 141 · see citing works
Nonuniformity of Endothelial Constitutive Nitric Oxide Synthase Distribution in Cardiac Endothelium
Andries, L. J., Brutsaert, D. L., & Sys, S. U. (1998) · Circulation Research · doi:10.1161/01.res.82.2.195 · Cited by 140 · see citing works
Vesicle membrane association of nitric oxide synthase in primary mouse macrophages.
Yoram Vodovotz, B., Russell, D. G., Xie, Q. W., Bogdan, C., & Nathan, C. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2914 · Cited by 138 · see citing works
Felley‐Bosco, E., Bender, F. C., Courjault, F., Bron, C., & Quest, A. F. G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250406797 · Cited by 134 · see citing works
Fulton, D. J., Babbitt, R. W., Zoellner, S., Fontana, J. T., Acevedo, L. M., McCabe, T. J. D., Iwakiri, Y., & Sessa, W. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402155200 · Cited by 133 · see citing works
Self-citationLiu, J., García‐Cardeña, G., & Sessa, W. C. (1995) · Biochemistry · doi:10.1021/bi00038a029 · Cited by 131 · see citing works
Thuringer, D., Maulon, L., & Frelin, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109493200 · Cited by 128 · see citing works
Protein–protein interactions controlling nitric oxide synthases
Kone (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00629.x · Cited by 127 · see citing works
Subcellular Targeting and Differential S-Nitrosylation of Endothelial Nitric-oxide Synthase
Erwin, P. A., Mitchell, D. A., Sartoretto, J. L., Marletta, M. A., & Michel, T. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510421200 · Cited by 121 · see citing works
Calcium-independent activation of endothelial nitric oxide synthase by ceramide
Igarashi, J., Thatte, H. S., Prabhakar, P., Golan, D. E., & Michel, T. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12583 · Cited by 120 · see citing works
Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase
Venema, R. C., Venema, V. J., Ju, H., Harris, M. B., Snead, C. M., Jilling, T., Dimitropoulou, C., Maragoudakis, M. E., & Catravas, J. D. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01025.2002 · Cited by 120 · see citing works
Regulation of endothelial nitric oxide synthase by the actin cytoskeleton
Su, Y., Edwards-Bennett, S. M., Bubb, M., & Block, E. R. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00248.2002 · Cited by 120 · see citing works
Hurshman, A. R., & Marletta, M. A. (1995) · Biochemistry · doi:10.1021/bi00016a038 · Cited by 120 · see citing works
Docking of Endothelial Nitric Oxide Synthase (eNOS) to the Mitochondrial Outer Membrane
Gao, S., Chen, J., Brodsky, S. V., Huang, H., Adler, S., Lee, J. H., Dhadwal, N., Cohen‐Gould, L., Gross, S. S., & Goligorsky, M. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308504200 · Cited by 119 · see citing works
Trafficking of Endothelial Nitric-oxide Synthase in Living Cells
Sowa, G., Liu, J., Papapetropoulos, A., Rex‐Haffner, M., Hughes, T. E., & Sessa, W. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22524 · Cited by 119 · see citing works
Darby, P. J., Kwan, C. Y., & Daniel, E. E. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1226 · Cited by 116 · see citing works
Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON
Jaffrey, S. R., Benfenati, F., Snowman, A. M., Czernik, A. J., & Snyder, S. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261705799 · Cited by 115 · see citing works
Hansen, S. H., Olsson, A., & Casanova, J. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28425 · Cited by 113 · see citing works
Fatty acylation and prenylation of proteins: what's hot in fat
Magee, T., & Seabra, M. C. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.003 · Cited by 112 · see citing works
Jiang, J., Cyr, D., Babbitt, R. W., Sessa, W. C., & Patterson, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304738200 · Cited by 110 · see citing works
Nuszkowski, A., Gräbner, R., Marsche, G., Unbehaun, A., Malle, E., & Heller, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007659200 · Cited by 106 · see citing works
nNOS at a glance: implications for brain and brawn
Mungrue, I. N., & Bredt, D. S. (2004) · Journal of Cell Science · doi:10.1242/jcs.01187 · Cited by 106 · see citing works
Endothelial nitric oxide synthase interactions with G-protein-coupled receptors
Marrero, M. B., Venema, V. J., Ju, H., He, H., Liang, H., Caldwell, R. B., & Venema, R. C. (1999) · Biochemical Journal · doi:10.1042/bj3430335 · Cited by 105 · see citing works
Zhang, J., Jin, B., Li, L., Block, E. R., & Patel, J. M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00325.2004 · Cited by 102 · see citing works
Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles
Grange, R. W., Isotani, E., Lau, K. S., Kamm, K. E., Huang, P. L., & Stull, J. T. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.2001.5.1.35 · Cited by 98 · see citing works
Liu, J., & Sessa, W. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32626-1 · Cited by 96 · see citing works
Gonzalez, E., Kou, R., Lin, A. J., Golan, D. E., & Michel, T. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207299200 · Cited by 96 · see citing works
Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide
Eu, J. P., Hare, J. M., Hess, D. T., Skaf, M. W., Sun, J., Cardenas-Navina, I., Sun, Q.-A., Dewhirst, M. W., Meissner, G., & Stamler, J. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2433468100 · Cited by 89 · see citing works
PECAM-1 Interacts With Nitric Oxide Synthase in Human Endothelial Cells
Dusserre, N., L’Heureux, N., Bell, K. S., Stevens, H. Y., Yeh, J., Otte, L. A., Loufrani, L., & Frangos, J. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000141133.32496.41 · Cited by 87 · see citing works
Aarts, M. M., & Tymianski, M. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00297-1 · Cited by 86 · see citing works
Jagnandan, D., Sessa, W. C., & Fulton, D. J. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00162.2005 · Cited by 86 · see citing works
Self-citationDreyer, J., Schleicher, M., Tappe‐Theodor, A., Schilling, K., Kuner, T., Kusumawidijaja, G., Müller‐Esterl, W., Oess, S., & Kuner, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2265-04.2004 · Cited by 85 · see citing works
Self-citationSong, Y. H., Zweier, J. L., & Xia, Y. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3550357 · Cited by 85 · see citing works
Endothelial nitric oxide synthase activity is linked to its presence at cell‒cell contacts
Govers, R., Bevers, L. M., de Bree, P., & Rabelink, T. J. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3610193 · Cited by 84 · see citing works
Self-citationLuminal flow induces eNOS activation and translocation in the rat thick ascending limb
Ortiz, P. A., Hong, N. J., & Garvin, J. L. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00382.2003 · Cited by 83 · see citing works
Church, J. E., & Fulton, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505968200 · Cited by 78 · see citing works
Self-citationNOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS
Icking, A., Matt, S., Opitz, N., Wiesenthal, A., Müller‐Esterl, W., & Schilling, K. (2005) · Journal of Cell Science · doi:10.1242/jcs.02620 · Cited by 75 · see citing works
Self-citationSong, Y. H., Zweier, J. L., & Yong, X. I. A. (2001) · Biochemical Journal · doi:10.1042/bj3550357 · Cited by 70 · see citing works
Collins, J. L., Vodovotz, Y., Hierholzer, C., et al. (2003) · Shock · doi:10.1097/00024382-200302000-00005 · Cited by 67 · see citing works
Modulation of the l -arginine/nitric oxide signalling pathway in vascular endothelial cells
Wyatt, A. W., Steinert, J. R., & Mann, G. E. (2004) · Biochemical Society Symposia · doi:10.1042/bss0710143 · Cited by 64 · see citing works
Endothelial nitric oxide synthase activity is linked to its presence at cell–cell contacts
Govers, R., BEVERS, L., de Bree, P., et al. (2002) · Biochemical Journal · doi:10.1042/bj3610193 · Cited by 60 · see citing works
Self-citationSakoda, T., Hirata, K., Kuroda, R., Miki, N., Suematsu, M., Kawashima, S., & Yokoyama, M. (1995) · Molecular and Cellular Biochemistry · doi:10.1007/bf01076076 · Cited by 59 · see citing works
Cytoskeletal regulation of the l -arginine/NO pathway in pulmonary artery endothelial cells
Zharikov, S. I., Sigova, A. A., Chen, S., Bubb, M., & Block, E. R. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.3.l465 · Cited by 58 · see citing works
Glynne, P. A., Darling, K., Picot, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205764200 · Cited by 57 · see citing works
Imamura, F., Maeda, S., Doi, T., & Fujiyoshi, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106940200 · Cited by 50 · see citing works
Navarro‐Lérida, I., Corvi, M. M., Alvarez, A. M., Gavilanes, F., Berthiaume, L. G., & Rodríguez‐Crespo, I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406621200 · Cited by 50 · see citing works
Protein–protein interactions involving inducible nitric oxide synthase
Zhang, W., Kuncewicz, T., Yu, Z. ‐., Zou, L., Xu, X., & Kone, B. C. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01119.x · Cited by 49 · see citing works
Ortiz, P. A., Hong, N. J., & Garvin, J. L. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00383.2003 · Cited by 48 · see citing works
Prabhakar, P., Cheng, V., & Michel, T. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001952200 · Cited by 48 · see citing works
Heijnen, H. F. G., Waaijenborg, S., Crapo, J. D., Bowler, R. P., Akkerman, J. N., & Slot, J. W. (2004) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540405201004 · Cited by 48 · see citing works
Schleicher, M., Brundin, F., Groß, S., Müller‐Esterl, W., & Oess, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8251-8258.2005 · Cited by 47 · see citing works
Self-citationGovers, R., van der Sluijs, P., van Donselaar, E. G., Slot, J.-W., & Rabelink, T. J. (2002) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540205000604 · Cited by 41 · see citing works
Self-citationFigueroa, X. F., González, D. R., Martı́nez, A. D., Durán, W. N., & Borić, M. P. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.021972 · Cited by 41 · see citing works
Microtubule-active agents modify nitric oxide production in pulmonary artery endothelial cells
Su, Y., Zharikov, S. I., & Block, E. R. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00388.2001 · Cited by 40 · see citing works
Zhu, Y., Liao, H., Niu, X., Yuan, Y., Lin, T., Verna, L. K., & Stemerman, M. B. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2003.10.011 · Cited by 31 · see citing works
To NO or not to NO: 'where?' is the question.
Govers, R., & Oess, S. (2004) · PubMed · doi:10.14670/hh-19.585 · Cited by 30 · see citing works
Self-citationMeder, D., & Simons, K. (2005) · Science · doi:10.1126/science.1110551 · Cited by 29 · see citing works
NMDA induces NOS 1 translocation to the cell membrane in NGF-differentiated PC 12 cells
Arundine, M., Sanelli, T. R., He, B. P., et al. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02568-x · Cited by 27 · see citing works
Wang, P., Zhang, Q., Tochio, H., et al. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01318.x · Cited by 25 · see citing works
Bulotta, S., Cerullo, A., Barsacchi, R., Palma, C. D., Rotiroti, D., Clementi, E., & Borgese, N. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.12.014 · Cited by 24 · see citing works
Navarro‐Lérida, I., Portolés, M. T., Alvarez, A. M., Gavilanes, F., Boscá, L., & Rodríguez‐Crespo, I. (2004) · Journal of Cell Science · doi:10.1242/jcs.01002 · Cited by 22 · see citing works
Martínez‐Moreno, M., Alvarez, A. M., Roncal, F., Albar, J. P., Gavilanes, F., Lamas, S., & Rodríguez‐Crespo, I. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.078 · Cited by 20 · see citing works
FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN
Icking, A., Schilling, K., Wiesenthal, A., Opitz, N., & Müller‐Esterl, W. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.11.078 · Cited by 19 · see citing works
Self-citationMichel, J. B., & Michel, T. M. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00222-6 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works
“It produces relatively low quantities of NO, and its activity is controlled by Ca2þ and calmodulin, posttranslational modifications [72,73], and physical forces such as shear stress [74,75].”
BackgroundEndothelial nitric oxide (NO) and its pathophysiologic regulation
Chatterjee, A., & Catravas, J. D. (2008) · Vascular Pharmacology · doi:10.1016/j.vph.2008.06.008 · Cited by 236 · see citing works
The Role of Reactive Species on Innate Immunity
Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142 · see citing works
The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development
Hoffmeister, M., Prelle, C., Küchler, P., Kovacevic, I., Moser, M., Müller-Esterl, W., & Oess, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116150 · Cited by 21 · see citing works
Self-citation
- Authors
- Oess, S., Icking, A., Fulton, D., Govers, R., & Müller-Esterl, W.
- Affiliations
- Goethe University Frankfurt (DE)
- Augusta University (US)
- Inserm (FR)
- Institute of Biochemistry II, University of Frankfurt Medical School, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany
- Corresponding author
- Oess, Stefanie
- Icking, Ann
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2006-05-29
- Volume
- 396
- Issue
- 3
- Pages
- 401-409
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1482820
- OpenAlex
- W2163693604
- Cited by
- 125
- References
- 124
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 11 · 2013: 6 · 2012: 18
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL AMU (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (902-26-224)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- nitric oxide synthase, subcellular targeting, protein trafficking, nitric oxide signaling, cardiomyocytes, post-translational modification, protein sorting
- MeSH terms
- Acylation, Animals, Humans, Subcellular Fractions, Nitric Oxide Synthase, Protein Transport, Nitric Oxide Synthase Type I, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
